Danio rerio

0 known processes

clu

clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

(Aliases: MGC73352,zgc:73352)

clu biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cognition GO:0050890 1 0.279
central nervous system development GO:0007417 387 0.269
Human
response to abiotic stimulus GO:0009628 122 0.165
embryonic organ morphogenesis GO:0048562 274 0.132
regulation of multicellular organismal process GO:0051239 277 0.126
Human
embryonic organ development GO:0048568 381 0.126
positive regulation of cell death GO:0010942 29 0.116
Human Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.114
Human Mouse
chordate embryonic development GO:0043009 271 0.103
regulation of cell communication GO:0010646 232 0.102
Human
regulation of response to stimulus GO:0048583 269 0.098
Human
skeletal system morphogenesis GO:0048705 102 0.091
embryonic skeletal system development GO:0048706 97 0.089
regulation of signaling GO:0023051 235 0.087
Human
system process GO:0003008 185 0.085
regulation of signal transduction GO:0009966 225 0.082
Human
programmed cell death GO:0012501 119 0.081
Human
response to hexose GO:0009746 3 0.079
response to carbohydrate GO:0009743 3 0.078
small molecule metabolic process GO:0044281 77 0.078
skeletal system development GO:0001501 181 0.076
cellular response to external stimulus GO:0071496 2 0.075
single organism localization GO:1902578 225 0.073
Human
positive regulation of apoptotic process GO:0043065 29 0.072
Human
embryonic skeletal system morphogenesis GO:0048704 93 0.072
embryo development ending in birth or egg hatching GO:0009792 271 0.070
response to monosaccharide GO:0034284 3 0.068
apoptotic process GO:0006915 116 0.068
Human
regulation of cellular metabolic process GO:0031323 320 0.067
Human Mouse
response to drug GO:0042493 3 0.064
response to corticosteroid GO:0031960 1 0.064
death GO:0016265 121 0.063
Human Mouse
response to glucose GO:0009749 3 0.060
regulation of cell death GO:0010941 103 0.060
Human Mouse
response to glucocorticoid GO:0051384 1 0.058
regulation of cellular component organization GO:0051128 86 0.056
Human
organonitrogen compound metabolic process GO:1901564 74 0.056
Human Mouse
regulation of muscle contraction GO:0006937 3 0.055
cellular nitrogen compound metabolic process GO:0034641 290 0.055
Human Mouse
eye morphogenesis GO:0048592 144 0.055
organic acid metabolic process GO:0006082 31 0.054
regulation of programmed cell death GO:0043067 101 0.054
Human
negative regulation of cellular process GO:0048523 283 0.052
Human
amine metabolic process GO:0009308 2 0.052
blood vessel morphogenesis GO:0048514 216 0.049
regulation of developmental process GO:0050793 247 0.048
response to chemical GO:0042221 320 0.048
Human
cellular component morphogenesis GO:0032989 336 0.048
Human
regulation of primary metabolic process GO:0080090 311 0.048
Human Mouse
regulation of apoptotic process GO:0042981 98 0.048
Human
positive regulation of blood circulation GO:1903524 2 0.047
astrocyte differentiation GO:0048708 1 0.047
cellular carbohydrate metabolic process GO:0044262 4 0.047
negative regulation of biological process GO:0048519 304 0.047
Human
regulation of gtp catabolic process GO:0033124 2 0.044
cellular amine metabolic process GO:0044106 2 0.043
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.043
collagen metabolic process GO:0032963 2 0.043
positive regulation of catabolic process GO:0009896 4 0.042
Human
cell surface receptor signaling pathway GO:0007166 325 0.042
response to amino acid GO:0043200 2 0.042
cell death GO:0008219 121 0.041
Human Mouse
maternal determination of anterior posterior axis embryo GO:0008358 4 0.041
regulation of metabolic process GO:0019222 359 0.040
Human Mouse
intracellular signal transduction GO:0035556 85 0.039
Human
generation of neurons GO:0048699 385 0.039
cellular response to chemical stimulus GO:0070887 157 0.038
vasculature development GO:0001944 278 0.038
regulation of cellular amine metabolic process GO:0033238 0 0.037
meiotic nuclear division GO:0007126 4 0.036
aging GO:0007568 2 0.036
regulation of cellular amino acid metabolic process GO:0006521 0 0.036
regulation of metal ion transport GO:0010959 4 0.035
multicellular organismal macromolecule metabolic process GO:0044259 2 0.035
circulatory system process GO:0003013 87 0.035
regulation of cell shape GO:0008360 1 0.033
head development GO:0060322 303 0.033
signal transduction GO:0007165 455 0.033
Human
carbohydrate derivative metabolic process GO:1901135 61 0.032
response to nutrient GO:0007584 3 0.032
specification of symmetry GO:0009799 204 0.032
growth GO:0040007 174 0.032
brain development GO:0007420 293 0.032
oxoacid metabolic process GO:0043436 31 0.032
cell migration GO:0016477 237 0.032
regulation of multicellular organismal development GO:2000026 223 0.031
cellular response to nutrient levels GO:0031669 2 0.031
blood circulation GO:0008015 87 0.031
organic cyclic compound biosynthetic process GO:1901362 223 0.031
Human
morphogenesis of an epithelium GO:0002009 333 0.030
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.029
gene expression GO:0010467 252 0.029
Human
larval development GO:0002164 2 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.029
Human
maintenance of location GO:0051235 4 0.028
response to lipid GO:0033993 60 0.028
cellular amino acid metabolic process GO:0006520 7 0.028
mitochondrion organization GO:0007005 4 0.028
establishment of localization GO:0051234 244 0.028
Human
embryonic cranial skeleton morphogenesis GO:0048701 90 0.027
regulation of skeletal muscle tissue development GO:0048641 4 0.027
regulation of binding GO:0051098 3 0.027
cellular response to hypoxia GO:0071456 1 0.027
response to organic substance GO:0010033 153 0.027
Human
cellular response to oxygen levels GO:0071453 1 0.027
regulation of purine nucleotide catabolic process GO:0033121 2 0.026
macromolecule biosynthetic process GO:0009059 227 0.026
Human
regulation of reproductive process GO:2000241 4 0.026
regulation of blood pressure GO:0008217 1 0.026
macromolecular complex assembly GO:0065003 35 0.026
Human
single organism metabolic process GO:0044710 217 0.026
cellular response to decreased oxygen levels GO:0036294 1 0.026
regulation of synaptic plasticity GO:0048167 1 0.025
positive regulation of transport GO:0051050 2 0.025
regulation of nucleoside metabolic process GO:0009118 2 0.025
meiotic cell cycle process GO:1903046 3 0.025
response to vitamin GO:0033273 3 0.025
cellular biosynthetic process GO:0044249 286 0.025
Human
regulation of reactive oxygen species metabolic process GO:2000377 2 0.024
regulation of nucleotide catabolic process GO:0030811 2 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.024
Human
mesenchyme development GO:0060485 127 0.024
regulation of cellular ketone metabolic process GO:0010565 7 0.023
response to transition metal nanoparticle GO:1990267 28 0.023
oocyte anterior posterior axis specification GO:0007314 4 0.023
protein polymerization GO:0051258 4 0.023
mesenchymal cell differentiation GO:0048762 87 0.023
embryonic skeletal joint morphogenesis GO:0060272 3 0.022
regulation of nucleic acid templated transcription GO:1903506 213 0.022
Human
regulation of cell activation GO:0050865 1 0.022
regulation of system process GO:0044057 40 0.022
response to oxygen levels GO:0070482 25 0.022
neurological system process GO:0050877 62 0.022
epithelial tube morphogenesis GO:0060562 148 0.022
transmembrane transport GO:0055085 120 0.021
negative regulation of signaling GO:0023057 96 0.021
Human
cell projection organization GO:0030030 284 0.021
cytokinesis GO:0000910 3 0.021
behavior GO:0007610 74 0.021
multicellular organismal metabolic process GO:0044236 2 0.021
blood vessel development GO:0001568 246 0.021
biosynthetic process GO:0009058 294 0.021
Human
multicellular organism growth GO:0035264 4 0.020
regulation of tube size GO:0035150 2 0.020
b cell activation GO:0042113 2 0.020
response to organic cyclic compound GO:0014070 51 0.020
neuron development GO:0048666 262 0.020
cellular response to extracellular stimulus GO:0031668 2 0.020
cellular response to starvation GO:0009267 1 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
response to decreased oxygen levels GO:0036293 25 0.020
regulation of sodium ion transport GO:0002028 2 0.020
sympathetic nervous system development GO:0048485 3 0.020
nucleobase containing compound biosynthetic process GO:0034654 205 0.020
Human
regulation of cell differentiation GO:0045595 142 0.020
protein localization to nucleus GO:0034504 3 0.019
macromolecule modification GO:0043412 111 0.019
Human
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.019
heterocycle metabolic process GO:0046483 290 0.019
Human
carboxylic acid metabolic process GO:0019752 22 0.019
protein heterooligomerization GO:0051291 1 0.019
regulation of biosynthetic process GO:0009889 250 0.019
Human
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
Human
regulation of cellular biosynthetic process GO:0031326 245 0.019
Human
neuron neuron synaptic transmission GO:0007270 1 0.019
organelle organization GO:0006996 227 0.019
response to hormone GO:0009725 48 0.018
branching morphogenesis of a nerve GO:0048755 4 0.018
protein import GO:0017038 3 0.018
Human
regulation of cell migration GO:0030334 40 0.018
cytoplasm organization GO:0007028 4 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
regulation of nucleotide metabolic process GO:0006140 17 0.018
response to endogenous stimulus GO:0009719 83 0.018
nitrogen compound metabolic process GO:0006807 319 0.018
Human Mouse
muscle organ development GO:0007517 101 0.018
organic substance biosynthetic process GO:1901576 289 0.018
Human
embryonic heart tube morphogenesis GO:0003143 108 0.018
regulation of blood vessel size GO:0050880 2 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.018
regulation of wound healing GO:0061041 2 0.017
positive regulation of protein kinase b signaling GO:0051897 1 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
positive regulation of cytokine production GO:0001819 2 0.017
Human
negative regulation of protein phosphorylation GO:0001933 4 0.017
regulation of catalytic activity GO:0050790 55 0.017
Human
cation transmembrane transport GO:0098655 65 0.017
response to alkaloid GO:0043279 2 0.017
cell morphogenesis GO:0000902 289 0.017
Human
cellular aromatic compound metabolic process GO:0006725 295 0.017
Human
regulation of inflammatory response GO:0050727 2 0.017
carbon dioxide transport GO:0015670 3 0.017
regulation of cell development GO:0060284 100 0.017
regulation of response to external stimulus GO:0032101 31 0.017
notochord development GO:0030903 54 0.017
carbohydrate homeostasis GO:0033500 1 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
cellular aldehyde metabolic process GO:0006081 4 0.017
gtp metabolic process GO:0046039 4 0.016
phagocytosis GO:0006909 3 0.016
embryonic skeletal joint development GO:0072498 3 0.016
regulation of protein metabolic process GO:0051246 56 0.016
Human Mouse
regulation of gene expression GO:0010468 265 0.016
Human
cellular response to stress GO:0033554 62 0.016
Human
camera type eye development GO:0043010 222 0.016
cellular macromolecule metabolic process GO:0044260 391 0.016
Human
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.016
response to stress GO:0006950 263 0.016
Human
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
rna metabolic process GO:0016070 219 0.016
Human
determination of heart left right asymmetry GO:0061371 117 0.016
meiotic chromosome segregation GO:0045132 3 0.016
positive regulation of heart contraction GO:0045823 2 0.015
regulation of gtpase activity GO:0043087 2 0.015
membrane fusion GO:0061025 2 0.015
central nervous system myelination GO:0022010 2 0.015
Human
pole plasm assembly GO:0007315 4 0.015
energy reserve metabolic process GO:0006112 2 0.015
multi organism process GO:0051704 134 0.015
Human
neural crest cell differentiation GO:0014033 72 0.015
positive regulation of biological process GO:0048518 253 0.015
Human Mouse
neurotransmitter transport GO:0006836 2 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
endocrine process GO:0050886 2 0.015
organelle fusion GO:0048284 3 0.015
cell cycle arrest GO:0007050 1 0.015
nuclear transport GO:0051169 4 0.015
intracellular mrna localization GO:0008298 1 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
reactive nitrogen species metabolic process GO:2001057 0 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
positive regulation of lipid metabolic process GO:0045834 1 0.015
positive regulation of cell activation GO:0050867 1 0.014
atp catabolic process GO:0006200 4 0.014
nucleoside monophosphate catabolic process GO:0009125 4 0.014
adult behavior GO:0030534 2 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
retina development in camera type eye GO:0060041 146 0.014
rna localization GO:0006403 4 0.014
sequestering of metal ion GO:0051238 3 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
ras protein signal transduction GO:0007265 7 0.014
smooth muscle contraction GO:0006939 2 0.014
gtp catabolic process GO:0006184 2 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
regulation of neuronal synaptic plasticity GO:0048168 1 0.014
response to uv GO:0009411 3 0.014
connective tissue development GO:0061448 99 0.014
response to xenobiotic stimulus GO:0009410 45 0.014
localization of cell GO:0051674 244 0.014
guanosine containing compound catabolic process GO:1901069 2 0.014
transport GO:0006810 220 0.014
Human
ion transport GO:0006811 114 0.014
response to mechanical stimulus GO:0009612 24 0.013
neuron differentiation GO:0030182 353 0.013
phosphorylation GO:0016310 69 0.013
Human
regulation of oocyte development GO:0060281 3 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
regulation of protein complex assembly GO:0043254 3 0.013
Human
regulation of molecular function GO:0065009 70 0.013
Human
long chain fatty acid metabolic process GO:0001676 1 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.013
single organism membrane fusion GO:0044801 2 0.013
tube morphogenesis GO:0035239 349 0.013
sleep GO:0030431 1 0.013
cellular component disassembly GO:0022411 1 0.013
macromolecule localization GO:0033036 54 0.013
Human
gliogenesis GO:0042063 45 0.013
Human
cell growth GO:0016049 57 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
nerve development GO:0021675 45 0.013
single organism transport GO:0044765 206 0.013
Human
regulation of protein transport GO:0051223 3 0.013
olfactory bulb development GO:0021772 4 0.013
regulation of receptor activity GO:0010469 2 0.013
cellular component assembly GO:0022607 170 0.013
Human
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
Human
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
regulation of biological quality GO:0065008 263 0.012
Human
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
Human
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
regulation of cellular component movement GO:0051270 55 0.012
regulation of ras gtpase activity GO:0032318 2 0.012
glucose import GO:0046323 2 0.012
regulation of rna metabolic process GO:0051252 224 0.012
Human
cytosolic calcium ion transport GO:0060401 3 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
positive regulation of metabolic process GO:0009893 108 0.012
Human Mouse
heterocycle biosynthetic process GO:0018130 215 0.012
Human
trabecula formation GO:0060343 2 0.012
hormone secretion GO:0046879 2 0.012
gas transport GO:0015669 3 0.012
protein localization to plasma membrane GO:0072659 1 0.012
organelle assembly GO:0070925 110 0.012
positive regulation of gene expression GO:0010628 71 0.012
fatty acid transport GO:0015908 1 0.012
hindbrain development GO:0030902 91 0.012
regulation of calcium ion transport GO:0051924 2 0.012
cellular protein modification process GO:0006464 100 0.012
Human
purine nucleotide metabolic process GO:0006163 27 0.012
monoamine transport GO:0015844 1 0.011
positive regulation of immune effector process GO:0002699 3 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.011
heart contraction GO:0060047 71 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
nucleic acid templated transcription GO:0097659 181 0.011
Human
single organism biosynthetic process GO:0044711 71 0.011
locomotion GO:0040011 313 0.011
protein metabolic process GO:0019538 183 0.011
Human Mouse
nucleocytoplasmic transport GO:0006913 4 0.011
synaptic vesicle recycling GO:0036465 1 0.011
mitotic cytokinesis GO:0000281 3 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
anterior posterior pattern specification GO:0009952 152 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
positive regulation of cell cycle GO:0045787 3 0.011
synaptic vesicle endocytosis GO:0048488 1 0.011
camera type eye morphogenesis GO:0048593 108 0.011
regulation of transporter activity GO:0032409 2 0.011
cellular protein metabolic process GO:0044267 129 0.011
Human
stem cell proliferation GO:0072089 4 0.011
lymph vessel development GO:0001945 27 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
Human
cell matrix adhesion GO:0007160 4 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
Human
mononuclear cell proliferation GO:0032943 1 0.011
regulation of cytokine production GO:0001817 3 0.011
Human
response to oxygen containing compound GO:1901700 55 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
regulation of dendrite development GO:0050773 3 0.010
skeletal muscle organ development GO:0060538 78 0.010
positive regulation of gtpase activity GO:0043547 1 0.010
regulation of ph GO:0006885 3 0.010
type b pancreatic cell proliferation GO:0044342 1 0.010
cellular localization GO:0051641 97 0.010
immune system development GO:0002520 191 0.010
positive regulation of signal transduction GO:0009967 56 0.010
Human
carbohydrate biosynthetic process GO:0016051 1 0.010
negative regulation of map kinase activity GO:0043407 2 0.010
negative regulation of developmental process GO:0051093 65 0.010
heart process GO:0003015 71 0.010
axis specification GO:0009798 43 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.010
cellular response to retinoic acid GO:0071300 1 0.010
lateral line system development GO:0048925 76 0.010
response to estrogen GO:0043627 27 0.010
neuron projection morphogenesis GO:0048812 161 0.010
actin filament polymerization GO:0030041 2 0.010
peptidyl serine modification GO:0018209 2 0.010
cellular protein catabolic process GO:0044257 4 0.010
Human
interspecies interaction between organisms GO:0044419 4 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010

clu disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013
charcot marie tooth disease type 4 DOID:0050541 0 0.011
neuropathy DOID:870 0 0.011
nervous system disease DOID:863 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
neuromuscular disease DOID:440 0 0.011
organ system cancer DOID:0050686 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010