Danio rerio

5 known processes

col1a2

collagen, type I, alpha 2

(Aliases: wu:fa98d05,wu:fb04c08,zehn2357,wu:fa99g10,alpha2(I),wu:fb11d06,hm:zehn2357)

col1a2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ossification GO:0001503 23 0.984
Zebrafish
collagen metabolic process GO:0032963 2 0.981
response to amino acid GO:0043200 2 0.979
Mouse
protein trimerization GO:0070206 4 0.978
Mouse
multicellular organismal macromolecule metabolic process GO:0044259 2 0.971
collagen fibril organization GO:0030199 1 0.950
Human
pectoral fin development GO:0033339 50 0.936
Zebrafish
response to abiotic stimulus GO:0009628 122 0.899
collagen biosynthetic process GO:0032964 2 0.893
extracellular matrix organization GO:0030198 27 0.887
Human
intramembranous ossification GO:0001957 3 0.882
response to mechanical stimulus GO:0009612 24 0.877
cellular response to retinoic acid GO:0071300 1 0.873
Rat
regulation of epithelial to mesenchymal transition GO:0010717 3 0.834
cartilage morphogenesis GO:0060536 13 0.832
Zebrafish
vasculature development GO:0001944 278 0.787
Human
multicellular organismal metabolic process GO:0044236 2 0.780
extracellular structure organization GO:0043062 27 0.727
Human
direct ossification GO:0036072 3 0.713
cartilage development GO:0051216 96 0.705
Zebrafish
response to nutrient GO:0007584 3 0.703
notochord development GO:0030903 54 0.677
Zebrafish
response to vitamin GO:0033273 3 0.663
response to wounding GO:0009611 116 0.661
Zebrafish
response to corticosteroid GO:0031960 1 0.644
response to external stimulus GO:0009605 264 0.623
trabecula formation GO:0060343 2 0.621
fin regeneration GO:0031101 51 0.620
Zebrafish
cell migration GO:0016477 237 0.593
regulation of ossification GO:0030278 5 0.563
Zebrafish
head morphogenesis GO:0060323 8 0.562
bone morphogenesis GO:0060349 11 0.529
endochondral bone morphogenesis GO:0060350 8 0.508
mesenchyme development GO:0060485 127 0.499
chondrocyte development GO:0002063 4 0.468
fin development GO:0033333 77 0.463
Zebrafish
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.453
cell adhesion GO:0007155 40 0.444
skin morphogenesis GO:0043589 7 0.437
Human
cell substrate adhesion GO:0031589 4 0.435
stem cell differentiation GO:0048863 117 0.430
regulation of cell substrate adhesion GO:0010810 1 0.427
sensory perception of mechanical stimulus GO:0050954 16 0.403
visual perception GO:0007601 17 0.401
extracellular matrix constituent secretion GO:0070278 3 0.371
cellular response to acid chemical GO:0071229 8 0.367
Mouse Rat
proteoglycan metabolic process GO:0006029 14 0.350
regulation of multicellular organismal process GO:0051239 277 0.348
Zebrafish
skin development GO:0043588 54 0.343
Human
single organism metabolic process GO:0044710 217 0.331
appendage morphogenesis GO:0035107 56 0.316
Zebrafish
cellular response to external stimulus GO:0071496 2 0.312
embryonic organ development GO:0048568 381 0.309
Zebrafish
regulation of stem cell differentiation GO:2000736 4 0.307
odontogenesis GO:0042476 9 0.303
cell motility GO:0048870 244 0.296
regulation of response to stimulus GO:0048583 269 0.281
regeneration GO:0031099 91 0.278
Zebrafish
cellular response to vitamin GO:0071295 1 0.276
digestive system development GO:0055123 289 0.259
tissue regeneration GO:0042246 74 0.258
Zebrafish
mesenchymal cell differentiation GO:0048762 87 0.254
canonical wnt signaling pathway GO:0060070 48 0.252
epithelial to mesenchymal transition GO:0001837 21 0.250
chordate embryonic development GO:0043009 271 0.242
growth GO:0040007 174 0.237
Zebrafish
cellular component assembly GO:0022607 170 0.237
Mouse
bone development GO:0060348 14 0.230
regulation of metabolic process GO:0019222 359 0.228
regulation of signaling GO:0023051 235 0.228
skeletal muscle organ development GO:0060538 78 0.226
regulation of signal transduction GO:0009966 225 0.218
response to acid chemical GO:0001101 17 0.210
Mouse Rat
system process GO:0003008 185 0.203
Human
cell morphogenesis GO:0000902 289 0.198
response to hydrogen peroxide GO:0042542 3 0.197
mesoderm development GO:0007498 88 0.188
fin morphogenesis GO:0033334 53 0.188
Zebrafish
regulation of developmental process GO:0050793 247 0.186
regulation of mesoderm development GO:2000380 11 0.185
sensory perception of sound GO:0007605 9 0.177
muscle organ development GO:0007517 101 0.176
muscle attachment GO:0016203 9 0.174
morphogenesis of an epithelium GO:0002009 333 0.171
positive regulation of cell motility GO:2000147 11 0.171
face morphogenesis GO:0060325 6 0.169
biological adhesion GO:0022610 40 0.167
positive regulation of biological process GO:0048518 253 0.161
cellular response to organic substance GO:0071310 105 0.158
Human Mouse Rat
neurological system process GO:0050877 62 0.156
regulation of canonical wnt signaling pathway GO:0060828 34 0.155
cellular macromolecule metabolic process GO:0044260 391 0.148
inner ear development GO:0048839 126 0.144
growth plate cartilage development GO:0003417 2 0.141
response to drug GO:0042493 3 0.133
angiogenesis GO:0001525 158 0.129
tube morphogenesis GO:0035239 349 0.128
muscle structure development GO:0061061 196 0.127
negative regulation of biological process GO:0048519 304 0.126
endodermal cell fate determination GO:0007493 2 0.126
appendage development GO:0048736 80 0.121
Zebrafish
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.121
heart contraction GO:0060047 71 0.120
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.117
response to inorganic substance GO:0010035 38 0.117
eye morphogenesis GO:0048592 144 0.115
response to estradiol GO:0032355 6 0.113
positive regulation of metabolic process GO:0009893 108 0.113
hematopoietic or lymphoid organ development GO:0048534 191 0.111
formation of primary germ layer GO:0001704 62 0.111
hatching GO:0035188 4 0.110
cellular biosynthetic process GO:0044249 286 0.108
sensory perception GO:0007600 39 0.107
skeletal system development GO:0001501 181 0.106
Human Zebrafish
embryonic skeletal system development GO:0048706 97 0.105
protein heterooligomerization GO:0051291 1 0.105
Mouse
biomineral tissue development GO:0031214 13 0.104
regulation of nucleic acid templated transcription GO:1903506 213 0.102
rna metabolic process GO:0016070 219 0.099
cell morphogenesis involved in differentiation GO:0000904 195 0.098
response to cytokine GO:0034097 7 0.097
eye development GO:0001654 277 0.097
cellular response to oxygen containing compound GO:1901701 20 0.096
Mouse Rat
regulation of cell migration GO:0030334 40 0.095
gene expression GO:0010467 252 0.095
cellular response to extracellular stimulus GO:0031668 2 0.094
regulation of wnt signaling pathway GO:0030111 53 0.094
digestive tract development GO:0048565 265 0.094
cellular response to growth factor stimulus GO:0071363 39 0.094
Human
response to topologically incorrect protein GO:0035966 2 0.093
wound healing GO:0042060 90 0.091
Zebrafish
positive regulation of multicellular organismal process GO:0051240 52 0.091
sensory organ development GO:0007423 393 0.090
osteoblast differentiation GO:0001649 5 0.088
muscle cell development GO:0055001 115 0.086
positive regulation of cellular component movement GO:0051272 11 0.084
response to other organism GO:0051707 97 0.082
regulation of macromolecule metabolic process GO:0060255 317 0.081
sensory perception of light stimulus GO:0050953 19 0.078
cellular response to organic cyclic compound GO:0071407 38 0.077
cellular response to endogenous stimulus GO:0071495 68 0.077
Human Mouse Rat
heart morphogenesis GO:0003007 156 0.071
medial fin morphogenesis GO:0035141 14 0.071
cellular nitrogen compound biosynthetic process GO:0044271 218 0.071
regulation of cell motility GO:2000145 46 0.070
negative regulation of cellular process GO:0048523 283 0.070
cellular component morphogenesis GO:0032989 336 0.070
developmental growth involved in morphogenesis GO:0060560 86 0.070
regulation of protein ubiquitination GO:0031396 3 0.067
cartilage condensation GO:0001502 3 0.067
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.067
endodermal cell differentiation GO:0035987 19 0.066
positive regulation of cell migration GO:0030335 11 0.065
regulation of cell morphogenesis GO:0022604 42 0.065
embryonic limb morphogenesis GO:0030326 2 0.065
regulation of biosynthetic process GO:0009889 250 0.064
regulation of cell communication GO:0010646 232 0.063
response to estrogen GO:0043627 27 0.063
spermatid differentiation GO:0048515 2 0.061
embryo development ending in birth or egg hatching GO:0009792 271 0.061
stem cell development GO:0048864 82 0.061
macromolecule biosynthetic process GO:0009059 227 0.060
regulation of gene expression GO:0010468 265 0.058
response to fibroblast growth factor GO:0071774 22 0.058
response to oxygen levels GO:0070482 25 0.055
spermatid development GO:0007286 2 0.055
skeletal system morphogenesis GO:0048705 102 0.054
positive regulation of epithelial cell migration GO:0010634 2 0.053
mucopolysaccharide metabolic process GO:1903510 2 0.053
negative regulation of epithelial cell proliferation GO:0050680 1 0.050
embryonic organ morphogenesis GO:0048562 274 0.049
cellular response to organonitrogen compound GO:0071417 5 0.048
Mouse
response to steroid hormone GO:0048545 35 0.048
cellular aromatic compound metabolic process GO:0006725 295 0.048
basement membrane assembly GO:0070831 3 0.047
response to glucocorticoid GO:0051384 1 0.046
mesenchymal cell development GO:0014031 78 0.046
aging GO:0007568 2 0.045
negative regulation of protein processing GO:0010955 10 0.045
inner ear morphogenesis GO:0042472 63 0.045
blood vessel morphogenesis GO:0048514 216 0.045
regulation of multicellular organismal development GO:2000026 223 0.044
locomotion GO:0040011 313 0.044
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.043
eye photoreceptor cell development GO:0042462 30 0.043
nitrogen compound metabolic process GO:0006807 319 0.043
regulation of cellular metabolic process GO:0031323 320 0.043
leukocyte homeostasis GO:0001776 2 0.042
cellular response to chemical stimulus GO:0070887 157 0.042
Human Mouse Rat
regulation of chondrocyte differentiation GO:0032330 1 0.042
blood vessel development GO:0001568 246 0.042
Human
nucleobase containing compound metabolic process GO:0006139 274 0.042
regulation of nitrogen compound metabolic process GO:0051171 251 0.041
connective tissue development GO:0061448 99 0.041
Zebrafish
cellular response to lipid GO:0071396 39 0.041
Rat
bone mineralization GO:0030282 9 0.039
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.039
positive regulation of cell activation GO:0050867 1 0.038
organic cyclic compound metabolic process GO:1901360 301 0.038
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.037
cell aggregation GO:0098743 3 0.037
regulation of endodermal cell differentiation GO:1903224 15 0.037
cellular component movement GO:0006928 335 0.036
cellular response to nutrient GO:0031670 1 0.036
regulation of notch signaling pathway GO:0008593 16 0.036
positive regulation of cell adhesion GO:0045785 1 0.036
positive regulation of macromolecule metabolic process GO:0010604 93 0.036
regulation of endothelial cell proliferation GO:0001936 1 0.035
lipid digestion GO:0044241 3 0.034
endoderm formation GO:0001706 29 0.033
regulation of rna metabolic process GO:0051252 224 0.033
striated muscle cell development GO:0055002 108 0.033
anatomical structure homeostasis GO:0060249 36 0.032
macrophage chemotaxis GO:0048246 3 0.032
positive regulation of locomotion GO:0040017 14 0.032
regulation of cytokine production GO:0001817 3 0.031
face development GO:0060324 8 0.031
immune system development GO:0002520 191 0.031
response to biotic stimulus GO:0009607 97 0.030
regulation of cysteine type endopeptidase activity GO:2000116 21 0.030
organic substance biosynthetic process GO:1901576 289 0.030
negative regulation of metabolic process GO:0009892 86 0.029
response to organic substance GO:0010033 153 0.029
Human Mouse Rat
regulation of locomotion GO:0040012 55 0.029
body morphogenesis GO:0010171 16 0.029
positive regulation of response to stimulus GO:0048584 80 0.029
regulation of primary metabolic process GO:0080090 311 0.029
response to lipid GO:0033993 60 0.028
Rat
developmental growth GO:0048589 166 0.028
Zebrafish
response to chemical GO:0042221 320 0.028
Human Mouse Rat
response to external biotic stimulus GO:0043207 97 0.028
nucleoside monophosphate catabolic process GO:0009125 4 0.028
regulation of cellular biosynthetic process GO:0031326 245 0.027
neuron differentiation GO:0030182 353 0.027
response to growth factor GO:0070848 39 0.027
Human
positive regulation of gene expression GO:0010628 71 0.027
positive regulation of apoptotic process GO:0043065 29 0.027
tissue remodeling GO:0048771 4 0.027
limb bud formation GO:0060174 2 0.027
meiotic nuclear division GO:0007126 4 0.027
regulation of cellular component organization GO:0051128 86 0.026
positive regulation of immune system process GO:0002684 17 0.026
striated muscle cell differentiation GO:0051146 129 0.026
heart development GO:0007507 313 0.026
regulation of cell activation GO:0050865 1 0.026
cell projection organization GO:0030030 284 0.025
glial cell migration GO:0008347 3 0.025
transcription dna templated GO:0006351 181 0.025
regulation of cellular component movement GO:0051270 55 0.024
response to carbohydrate GO:0009743 3 0.024
negative regulation of cell adhesion GO:0007162 6 0.024
striated muscle tissue development GO:0014706 110 0.024
cell growth GO:0016049 57 0.023
regionalization GO:0003002 274 0.023
negative regulation of multicellular organismal process GO:0051241 69 0.023
gastrulation GO:0007369 208 0.023
sensory organ morphogenesis GO:0090596 200 0.023
embryonic eye morphogenesis GO:0048048 30 0.023
eye photoreceptor cell differentiation GO:0001754 45 0.022
positive regulation of nucleic acid templated transcription GO:1903508 57 0.022
negative regulation of embryonic development GO:0045992 11 0.021
positive regulation of rna biosynthetic process GO:1902680 57 0.021
response to extracellular stimulus GO:0009991 10 0.021
positive regulation of cell differentiation GO:0045597 30 0.021
positive regulation of cell death GO:0010942 29 0.021
camera type eye development GO:0043010 222 0.021
heterocycle biosynthetic process GO:0018130 215 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.021
cellular response to cytokine stimulus GO:0071345 7 0.020
dendrite guidance GO:0070983 0 0.020
positive regulation of cellular biosynthetic process GO:0031328 68 0.020
muscle tissue development GO:0060537 110 0.020
regulation of cell projection assembly GO:0060491 4 0.020
organic acid metabolic process GO:0006082 31 0.020
positive regulation of stress activated mapk cascade GO:0032874 3 0.019
response to stress GO:0006950 263 0.019
Zebrafish
regulation of cell adhesion GO:0030155 15 0.019
positive regulation of signaling GO:0023056 56 0.019
endodermal digestive tract morphogenesis GO:0061031 2 0.019
long chain fatty acid transport GO:0015909 1 0.019
camera type eye morphogenesis GO:0048593 108 0.018
cellular response to nitrogen compound GO:1901699 6 0.018
Mouse
biosynthetic process GO:0009058 294 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
regulation of cell differentiation GO:0045595 142 0.018
somitogenesis GO:0001756 87 0.017
er nucleus signaling pathway GO:0006984 2 0.017
signal transduction GO:0007165 455 0.017
Human
phagocytosis GO:0006909 3 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
negative regulation of mesoderm development GO:2000381 5 0.016
positive regulation of leukocyte differentiation GO:1902107 1 0.016
nucleic acid templated transcription GO:0097659 181 0.016
positive regulation of developmental process GO:0051094 50 0.016
positive regulation of lipase activity GO:0060193 1 0.016
blood circulation GO:0008015 87 0.016
Human
nitric oxide biosynthetic process GO:0006809 2 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
positive regulation of programmed cell death GO:0043068 29 0.015
single organism biosynthetic process GO:0044711 71 0.015
smoothened signaling pathway GO:0007224 30 0.015
negative regulation of wound healing GO:0061045 1 0.015
rna biosynthetic process GO:0032774 181 0.015
ear morphogenesis GO:0042471 64 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.015
Human
negative regulation of cytokine production GO:0001818 1 0.015
mitochondrion organization GO:0007005 4 0.015
membrane invagination GO:0010324 1 0.014
positive regulation of cellular process GO:0048522 201 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
glycoprotein metabolic process GO:0009100 23 0.014
cardioblast migration GO:0003260 7 0.014
actin filament based process GO:0030029 64 0.014
positive regulation of cytokine production GO:0001819 2 0.014
protein localization GO:0008104 40 0.014
organism emergence from protective structure GO:0071684 4 0.014
cell surface receptor signaling pathway GO:0007166 325 0.014
Human
protein complex subunit organization GO:0071822 46 0.014
Human Mouse
regulation of gastrulation GO:0010470 24 0.014
negative regulation of developmental process GO:0051093 65 0.014
endomembrane system organization GO:0010256 13 0.013
regulation of cell death GO:0010941 103 0.013
epithelial cell morphogenesis GO:0003382 2 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
cellular component biogenesis GO:0044085 178 0.013
Mouse
cell projection assembly GO:0030031 64 0.013
cellular response to abiotic stimulus GO:0071214 4 0.013
cardiac chamber morphogenesis GO:0003206 12 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
response to monosaccharide GO:0034284 3 0.013
positive regulation of signal transduction GO:0009967 56 0.013
positive regulation of wnt signaling pathway GO:0030177 13 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
ameboidal type cell migration GO:0001667 143 0.013
cell fate specification GO:0001708 68 0.013
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
ear development GO:0043583 127 0.013
positive regulation of immune effector process GO:0002699 3 0.012
heart process GO:0003015 71 0.012
cellular response to xenobiotic stimulus GO:0071466 35 0.012
alternative mrna splicing via spliceosome GO:0000380 1 0.012
response to hormone GO:0009725 48 0.012
Rat
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.012
cell projection morphogenesis GO:0048858 244 0.012
fatty acid transport GO:0015908 1 0.012
response to peptide GO:1901652 6 0.012
nitric oxide metabolic process GO:0046209 2 0.012
regulation of rna biosynthetic process GO:2001141 213 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
protein localization to nucleus GO:0034504 3 0.011
positive regulation of leukocyte migration GO:0002687 2 0.011
response to endogenous stimulus GO:0009719 83 0.011
Human Mouse Rat
positive regulation of endopeptidase activity GO:0010950 10 0.011
foregut morphogenesis GO:0007440 4 0.011
negative regulation of gastrulation GO:2000542 11 0.011
renal system vasculature development GO:0061437 2 0.011
small molecule metabolic process GO:0044281 77 0.011
regulation of immune system process GO:0002682 34 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
zymogen activation GO:0031638 3 0.011
cranial suture morphogenesis GO:0060363 1 0.011
embryonic digestive tract morphogenesis GO:0048557 3 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
glomerulus vasculature development GO:0072012 2 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
negative regulation of mesodermal cell fate specification GO:0042662 3 0.011
regulation of mrna processing GO:0050684 3 0.010
axonogenesis involved in innervation GO:0060385 1 0.010
cellular protein catabolic process GO:0044257 4 0.010
cardiac atrium development GO:0003230 4 0.010
transport GO:0006810 220 0.010
beta amyloid metabolic process GO:0050435 1 0.010
positive regulation of cell communication GO:0010647 56 0.010
regulation of wound healing GO:0061041 2 0.010
circulatory system process GO:0003013 87 0.010
Human
cell proliferation GO:0008283 80 0.010
regulation of anatomical structure morphogenesis GO:0022603 130 0.010

col1a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.968
Human
bone development disease DOID:0080006 0 0.968
Human
bone disease DOID:0080001 0 0.968
Human
disease of anatomical entity DOID:7 0 0.968
Human
musculoskeletal system disease DOID:17 0 0.968
Human
connective tissue disease DOID:65 0 0.968
Human
bone remodeling disease DOID:0080005 0 0.903
Human
bone resorption disease DOID:0080011 0 0.903
Human
osteoporosis DOID:11476 0 0.726
Human
osteogenesis imperfecta DOID:12347 0 0.410
Human
charcot marie tooth disease type 4 DOID:0050541 0 0.039
neuromuscular disease DOID:440 0 0.039
charcot marie tooth disease DOID:10595 0 0.039
nervous system disease DOID:863 0 0.039
neuropathy DOID:870 0 0.039
gastrointestinal system cancer DOID:3119 0 0.023
cancer DOID:162 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
organ system cancer DOID:0050686 0 0.023
reproductive organ cancer DOID:193 0 0.010