Danio rerio

0 known processes

cops4

COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)

(Aliases: wu:fc90c08,zgc:77137,fc90c08)

cops4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.491
Worm
modification dependent protein catabolic process GO:0019941 3 0.183
Fly
gene expression GO:0010467 252 0.179
Fly
cellular protein catabolic process GO:0044257 4 0.167
Fly
modification dependent macromolecule catabolic process GO:0043632 3 0.154
Fly
nucleic acid metabolic process GO:0090304 244 0.146
cellular nitrogen compound metabolic process GO:0034641 290 0.109
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.106
Fly
dna templated transcription initiation GO:0006352 1 0.105
cellular macromolecule biosynthetic process GO:0034645 224 0.103
cellular macromolecule metabolic process GO:0044260 391 0.096
Human Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.088
Worm
ubiquitin dependent protein catabolic process GO:0006511 3 0.088
Fly
nitrogen compound metabolic process GO:0006807 319 0.081
heterocycle metabolic process GO:0046483 290 0.072
aging GO:0007568 2 0.072
rna metabolic process GO:0016070 219 0.072
organic cyclic compound biosynthetic process GO:1901362 223 0.070
proteasomal protein catabolic process GO:0010498 2 0.063
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.062
macromolecule biosynthetic process GO:0009059 227 0.060
positive regulation of cellular catabolic process GO:0031331 3 0.059
autophagy GO:0006914 4 0.056
biosynthetic process GO:0009058 294 0.056
rna biosynthetic process GO:0032774 181 0.055
heterocycle biosynthetic process GO:0018130 215 0.055
regulation of gene expression GO:0010468 265 0.054
Fly
organic cyclic compound metabolic process GO:1901360 301 0.052
zymogen activation GO:0031638 3 0.052
response to stress GO:0006950 263 0.052
Fly
protein localization to nucleus GO:0034504 3 0.051
meiotic cell cycle process GO:1903046 3 0.050
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.048
cellular protein metabolic process GO:0044267 129 0.048
Human Fly
transcription dna templated GO:0006351 181 0.047
membrane fusion GO:0061025 2 0.047
regulation of nitrogen compound metabolic process GO:0051171 251 0.047
single organism organelle organization GO:1902589 199 0.045
protein metabolic process GO:0019538 183 0.045
Human Fly
aromatic compound biosynthetic process GO:0019438 217 0.044
regulation of nucleic acid templated transcription GO:1903506 213 0.044
regulation of biological quality GO:0065008 263 0.042
Fly
nuclear transport GO:0051169 4 0.040
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.040
Fly
cellular transition metal ion homeostasis GO:0046916 3 0.040
meiotic nuclear division GO:0007126 4 0.039
nucleic acid templated transcription GO:0097659 181 0.039
nucleobase containing compound biosynthetic process GO:0034654 205 0.038
cell death GO:0008219 121 0.037
cellular response to external stimulus GO:0071496 2 0.037
transcription from rna polymerase ii promoter GO:0006366 80 0.037
death GO:0016265 121 0.036
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
multicellular organism growth GO:0035264 4 0.036
regulation of macromolecule metabolic process GO:0060255 317 0.035
Fly
protein secretion GO:0009306 1 0.034
regulation of cellular metabolic process GO:0031323 320 0.034
Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.034
nucleoside monophosphate catabolic process GO:0009125 4 0.034
camera type eye development GO:0043010 222 0.032
regulation of primary metabolic process GO:0080090 311 0.032
Fly
amine metabolic process GO:0009308 2 0.032
protein complex disassembly GO:0043241 1 0.031
negative regulation of protein phosphorylation GO:0001933 4 0.031
regulation of cellular amine metabolic process GO:0033238 0 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
regulation of protein catabolic process GO:0042176 1 0.031
Fly
internal protein amino acid acetylation GO:0006475 2 0.031
regulation of cellular biosynthetic process GO:0031326 245 0.030
lipid storage GO:0019915 1 0.030
protein targeting to nucleus GO:0044744 3 0.030
nucleocytoplasmic transport GO:0006913 4 0.030
purine nucleoside monophosphate catabolic process GO:0009128 4 0.030
protein acetylation GO:0006473 2 0.029
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
locomotion GO:0040011 313 0.028
Worm
cellular component disassembly GO:0022411 1 0.028
nuclear import GO:0051170 3 0.028
positive regulation of catabolic process GO:0009896 4 0.028
regulation of establishment of protein localization GO:0070201 4 0.027
regulation of transcription dna templated GO:0006355 213 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
positive regulation of cellular component biogenesis GO:0044089 3 0.027
cellular response to extracellular stimulus GO:0031668 2 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.026
cellular biosynthetic process GO:0044249 286 0.026
organonitrogen compound metabolic process GO:1901564 74 0.026
skeletal system development GO:0001501 181 0.026
organelle fusion GO:0048284 3 0.025
single organism membrane fusion GO:0044801 2 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.025
regulation of rna biosynthetic process GO:2001141 213 0.024
regulation of nucleoside metabolic process GO:0009118 2 0.024
regulation of cellular protein catabolic process GO:1903362 1 0.024
Fly
cellular component biogenesis GO:0044085 178 0.024
rrna catabolic process GO:0016075 1 0.024
response to other organism GO:0051707 97 0.024
organelle organization GO:0006996 227 0.024
gtp metabolic process GO:0046039 4 0.024
positive regulation of protein complex assembly GO:0031334 2 0.024
response to external biotic stimulus GO:0043207 97 0.023
iron ion homeostasis GO:0055072 4 0.023
regulation of metabolic process GO:0019222 359 0.023
Fly
regulation of dna templated transcription elongation GO:0032784 3 0.023
phagocytosis GO:0006909 3 0.023
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.023
double strand break repair GO:0006302 3 0.022
mitochondrion organization GO:0007005 4 0.022
protein import into nucleus GO:0006606 3 0.022
dna biosynthetic process GO:0071897 3 0.022
regulation of intracellular protein transport GO:0033157 3 0.022
response to chemical GO:0042221 320 0.022
single organism metabolic process GO:0044710 217 0.022
single organism nuclear import GO:1902593 3 0.022
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.022
cellular amino acid metabolic process GO:0006520 7 0.022
positive regulation of rna biosynthetic process GO:1902680 57 0.022
regulation of protein complex assembly GO:0043254 3 0.022
regulation of protein transport GO:0051223 3 0.021
macromolecular complex disassembly GO:0032984 1 0.021
regulation of biosynthetic process GO:0009889 250 0.021
neuroblast proliferation GO:0007405 2 0.021
glucose homeostasis GO:0042593 1 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
organic substance biosynthetic process GO:1901576 289 0.021
guanosine containing compound catabolic process GO:1901069 2 0.021
cellular amine metabolic process GO:0044106 2 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.020
Fly
protein modification process GO:0036211 100 0.020
Human Fly
peptide transport GO:0015833 1 0.020
regulation of developmental process GO:0050793 247 0.020
cellular ketone metabolic process GO:0042180 11 0.020
protein stabilization GO:0050821 2 0.020
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.020
programmed cell death GO:0012501 119 0.020
ribonucleoside monophosphate catabolic process GO:0009158 4 0.020
macromolecule modification GO:0043412 111 0.020
Human Fly
stem cell division GO:0017145 1 0.020
positive regulation of secretion GO:0051047 1 0.020
ncrna catabolic process GO:0034661 1 0.020
gtp catabolic process GO:0006184 2 0.020
protein acylation GO:0043543 3 0.019
organic acid metabolic process GO:0006082 31 0.019
cellular response to nutrient levels GO:0031669 2 0.019
carbohydrate homeostasis GO:0033500 1 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.019
protein import GO:0017038 3 0.019
regulation of rna metabolic process GO:0051252 224 0.019
regulation of response to stimulus GO:0048583 269 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
positive regulation of cell division GO:0051781 2 0.019
regulation of binding GO:0051098 3 0.019
stem cell proliferation GO:0072089 4 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
mitotic dna integrity checkpoint GO:0044774 4 0.018
Fly
response to organic substance GO:0010033 153 0.018
positive regulation of transcription dna templated GO:0045893 57 0.018
single organism localization GO:1902578 225 0.018
regulation of cytokine production GO:0001817 3 0.018
positive regulation of nucleic acid templated transcription GO:1903508 57 0.018
atp catabolic process GO:0006200 4 0.017
negative regulation of biological process GO:0048519 304 0.017
Fly
apoptotic process GO:0006915 116 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
regulation of cell cycle GO:0051726 52 0.017
Fly
negative regulation of chromosome organization GO:2001251 1 0.017
positive regulation of cellular biosynthetic process GO:0031328 68 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
growth GO:0040007 174 0.017
regulation of cell projection assembly GO:0060491 4 0.017
positive regulation of transport GO:0051050 2 0.017
maintenance of location GO:0051235 4 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.016
regulation of blood vessel size GO:0050880 2 0.016
oxoacid metabolic process GO:0043436 31 0.016
response to external stimulus GO:0009605 264 0.016
adult behavior GO:0030534 2 0.016
cellular response to stress GO:0033554 62 0.016
Fly
membrane invagination GO:0010324 1 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
protein dephosphorylation GO:0006470 3 0.016
positive regulation of biological process GO:0048518 253 0.016
internal peptidyl lysine acetylation GO:0018393 2 0.016
organic substance catabolic process GO:1901575 28 0.016
Fly
dna templated transcription elongation GO:0006354 3 0.016
positive regulation of metabolic process GO:0009893 108 0.016
transport GO:0006810 220 0.016
negative regulation of signal transduction GO:0009968 94 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
small molecule metabolic process GO:0044281 77 0.015
sensory organ development GO:0007423 393 0.015
Fly
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
retina development in camera type eye GO:0060041 146 0.015
response to monosaccharide GO:0034284 3 0.015
multicellular organismal metabolic process GO:0044236 2 0.015
chordate embryonic development GO:0043009 271 0.015
liver development GO:0001889 96 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
cell migration GO:0016477 237 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
nucleic acid transport GO:0050657 2 0.014
cell motility GO:0048870 244 0.014
spindle assembly GO:0051225 2 0.014
digestive system development GO:0055123 289 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
meiotic chromosome segregation GO:0045132 3 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
positive regulation of cell cycle GO:0045787 3 0.014
regulation of reproductive process GO:2000241 4 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
regulation of inflammatory response GO:0050727 2 0.014
positive regulation of dna templated transcription elongation GO:0032786 1 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
Fly
negative regulation of cellular process GO:0048523 283 0.013
Fly
cellular component movement GO:0006928 335 0.013
phosphorus metabolic process GO:0006793 109 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
regulation of protein targeting GO:1903533 2 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of blood pressure GO:0008217 1 0.013
extrinsic apoptotic signaling pathway GO:0097191 3 0.013
central nervous system development GO:0007417 387 0.013
regulation of tube size GO:0035150 2 0.013
positive regulation of gene expression GO:0010628 71 0.013
multi organism process GO:0051704 134 0.013
ovulation cycle GO:0042698 2 0.013
regulation of wound healing GO:0061041 2 0.012
positive regulation of cytokine production GO:0001819 2 0.012
regulation of organ growth GO:0046620 3 0.012
digestive tract development GO:0048565 265 0.012
pole plasm assembly GO:0007315 4 0.012
hormone secretion GO:0046879 2 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
head development GO:0060322 303 0.012
germ line stem cell division GO:0042078 1 0.012
positive regulation of cell activation GO:0050867 1 0.012
pronephros development GO:0048793 69 0.012
cell cycle GO:0007049 93 0.012
Worm Fly
regulation of epithelial cell proliferation GO:0050678 3 0.012
protein complex localization GO:0031503 1 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
peptidyl serine phosphorylation GO:0018105 1 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
lipid catabolic process GO:0016042 4 0.012
cellular response to topologically incorrect protein GO:0035967 2 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
negative regulation of cell communication GO:0010648 96 0.012
mitotic nuclear division GO:0007067 18 0.012
mitotic g2 dna damage checkpoint GO:0007095 3 0.012
Fly
negative regulation of kinase activity GO:0033673 4 0.012
regulation of chromosome segregation GO:0051983 1 0.012
exocytosis GO:0006887 1 0.012
negative regulation of catabolic process GO:0009895 3 0.012
Fly
immune system process GO:0002376 241 0.012
mononuclear cell proliferation GO:0032943 1 0.012
cellular component morphogenesis GO:0032989 336 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.012
lymphocyte proliferation GO:0046651 1 0.011
ribose phosphate metabolic process GO:0019693 27 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
Fly
response to biotic stimulus GO:0009607 97 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
single fertilization GO:0007338 3 0.011
regulation of synapse organization GO:0050807 3 0.011
response to topologically incorrect protein GO:0035966 2 0.011
regulation of postsynaptic membrane potential GO:0060078 1 0.011
golgi vesicle transport GO:0048193 3 0.011
action potential GO:0001508 19 0.011
ovulation cycle process GO:0022602 2 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
female sex differentiation GO:0046660 4 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
response to glucose GO:0009749 3 0.011
negative regulation of gene expression GO:0010629 65 0.011
Fly
response to hexose GO:0009746 3 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
positive regulation of rna metabolic process GO:0051254 59 0.011
peptidyl serine modification GO:0018209 2 0.011
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.011
signal transduction GO:0007165 455 0.011
cellular response to starvation GO:0009267 1 0.011
negative regulation of metabolic process GO:0009892 86 0.011
Fly
chromosome organization involved in meiosis GO:0070192 1 0.011
cellular catabolic process GO:0044248 27 0.011
Fly
regulation of cellular component organization GO:0051128 86 0.011
multicellular organismal macromolecule metabolic process GO:0044259 2 0.011
negative regulation of cytokine production GO:0001818 1 0.011
regulation of cell death GO:0010941 103 0.011
regulation of stem cell proliferation GO:0072091 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
cytoplasm organization GO:0007028 4 0.011
urogenital system development GO:0001655 97 0.011
b cell activation GO:0042113 2 0.011
localization of cell GO:0051674 244 0.011
establishment of localization GO:0051234 244 0.010
mitotic cell cycle GO:0000278 64 0.010
Fly
positive regulation of immune effector process GO:0002699 3 0.010
interspecies interaction between organisms GO:0044419 4 0.010
tissue remodeling GO:0048771 4 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
protein modification by small protein removal GO:0070646 1 0.010
Human Fly
nucleotide metabolic process GO:0009117 28 0.010
er to golgi vesicle mediated transport GO:0006888 1 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
rna 3 end processing GO:0031123 2 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.010
system process GO:0003008 185 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010

cops4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
cancer DOID:162 0 0.023
organ system cancer DOID:0050686 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
nervous system disease DOID:863 0 0.018
disease of metabolism DOID:0014667 0 0.015