Danio rerio

0 known processes

creld2

cysteine-rich with EGF-like domains 2

(Aliases: MGC66383,zgc:66383)

creld2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.243
larval development GO:0002164 2 0.136
regulation of metal ion transport GO:0010959 4 0.117
response to drug GO:0042493 3 0.085
acylglycerol homeostasis GO:0055090 2 0.085
lipid storage GO:0019915 1 0.072
nucleocytoplasmic transport GO:0006913 4 0.066
maintenance of location GO:0051235 4 0.064
small molecule metabolic process GO:0044281 77 0.063
protein acetylation GO:0006473 2 0.058
growth GO:0040007 174 0.054
response to nutrient GO:0007584 3 0.053
triglyceride homeostasis GO:0070328 2 0.052
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.050
regulation of binding GO:0051098 3 0.049
cellular response to extracellular stimulus GO:0031668 2 0.048
chordate embryonic development GO:0043009 271 0.048
alcohol biosynthetic process GO:0046165 2 0.047
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.045
cellular nitrogen compound metabolic process GO:0034641 290 0.044
cell substrate adhesion GO:0031589 4 0.044
establishment of localization GO:0051234 244 0.043
regulation of cytokine production GO:0001817 3 0.043
signal transduction GO:0007165 455 0.041
regulation of cell substrate adhesion GO:0010810 1 0.040
positive regulation of cellular component biogenesis GO:0044089 3 0.040
positive regulation of catabolic process GO:0009896 4 0.039
regulation of cell matrix adhesion GO:0001952 1 0.039
steroid hormone mediated signaling pathway GO:0043401 9 0.038
positive regulation of cytoskeleton organization GO:0051495 3 0.038
long chain fatty acid metabolic process GO:0001676 1 0.037
regulation of tube size GO:0035150 2 0.037
regulation of purine nucleotide catabolic process GO:0033121 2 0.037
cell morphogenesis involved in differentiation GO:0000904 195 0.036
establishment of protein localization to organelle GO:0072594 4 0.036
response to chemical GO:0042221 320 0.035
cellular localization GO:0051641 97 0.035
positive regulation of cellular catabolic process GO:0031331 3 0.035
androgen metabolic process GO:0008209 2 0.034
single organism organelle organization GO:1902589 199 0.034
regulation of protein catabolic process GO:0042176 1 0.034
cell motility GO:0048870 244 0.033
positive regulation of cell adhesion GO:0045785 1 0.033
cell part morphogenesis GO:0032990 246 0.033
cell matrix adhesion GO:0007160 4 0.033
regulation of cytoplasmic transport GO:1903649 4 0.033
embryo development ending in birth or egg hatching GO:0009792 271 0.033
positive regulation of cellular process GO:0048522 201 0.033
positive regulation of transport GO:0051050 2 0.033
regulation of production of molecular mediator of immune response GO:0002700 1 0.033
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.032
head development GO:0060322 303 0.032
multicellular organism growth GO:0035264 4 0.032
cellular response to nutrient levels GO:0031669 2 0.031
organic acid metabolic process GO:0006082 31 0.031
hormone secretion GO:0046879 2 0.031
positive regulation of nucleoside metabolic process GO:0045979 1 0.031
gland development GO:0048732 143 0.031
oxoacid metabolic process GO:0043436 31 0.031
single organism localization GO:1902578 225 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.030
response to vitamin GO:0033273 3 0.030
gtp metabolic process GO:0046039 4 0.030
brain development GO:0007420 293 0.030
amine metabolic process GO:0009308 2 0.029
regulation of protein import into nucleus GO:0042306 2 0.029
organonitrogen compound metabolic process GO:1901564 74 0.029
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.029
mononuclear cell proliferation GO:0032943 1 0.029
regulation of carbohydrate metabolic process GO:0006109 4 0.029
nuclear transport GO:0051169 4 0.029
hematopoietic or lymphoid organ development GO:0048534 191 0.028
liver development GO:0001889 96 0.028
guanosine containing compound catabolic process GO:1901069 2 0.028
production of molecular mediator of immune response GO:0002440 2 0.028
cellular amine metabolic process GO:0044106 2 0.028
cellular ketone metabolic process GO:0042180 11 0.028
peptidyl lysine acetylation GO:0018394 2 0.028
regulation of protein complex assembly GO:0043254 3 0.027
cellular component morphogenesis GO:0032989 336 0.027
cellular response to external stimulus GO:0071496 2 0.027
guanosine containing compound metabolic process GO:1901068 4 0.027
cellular carbohydrate metabolic process GO:0044262 4 0.027
regulation of protein polymerization GO:0032271 2 0.026
organic acid catabolic process GO:0016054 3 0.026
protein import into nucleus GO:0006606 3 0.026
single organism nuclear import GO:1902593 3 0.026
regulation of epithelial cell proliferation GO:0050678 3 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
regulation of cell activation GO:0050865 1 0.025
nuclear import GO:0051170 3 0.025
regulation of primary metabolic process GO:0080090 311 0.025
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
epidermis development GO:0008544 48 0.024
regulation of stem cell proliferation GO:0072091 2 0.024
gene expression GO:0010467 252 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.024
positive regulation of biological process GO:0048518 253 0.023
internal protein amino acid acetylation GO:0006475 2 0.023
stem cell maintenance GO:0019827 4 0.023
transport GO:0006810 220 0.023
protein localization to plasma membrane GO:0072659 1 0.023
transmembrane transport GO:0055085 120 0.023
regulation of nucleic acid templated transcription GO:1903506 213 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
protein import GO:0017038 3 0.022
modification dependent macromolecule catabolic process GO:0043632 3 0.022
response to vitamin b3 GO:0033552 2 0.022
programmed cell death GO:0012501 119 0.022
urogenital system development GO:0001655 97 0.022
regulation of dendrite morphogenesis GO:0048814 3 0.022
regulation of rho protein signal transduction GO:0035023 2 0.022
regulation of protein ubiquitination GO:0031396 3 0.022
nitrogen compound metabolic process GO:0006807 319 0.022
cellular amide metabolic process GO:0043603 4 0.022
leukocyte proliferation GO:0070661 1 0.022
phagocytosis GO:0006909 3 0.022
regulation of blood pressure GO:0008217 1 0.022
positive regulation of secretion GO:0051047 1 0.022
regulation of protein localization to nucleus GO:1900180 2 0.022
internal peptidyl lysine acetylation GO:0018393 2 0.021
negative regulation of biological process GO:0048519 304 0.021
cellular response to topologically incorrect protein GO:0035967 2 0.021
carboxylic acid catabolic process GO:0046395 3 0.021
cellular aromatic compound metabolic process GO:0006725 295 0.021
positive regulation of gtpase activity GO:0043547 1 0.020
lipid homeostasis GO:0055088 3 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
lateral line system development GO:0048925 76 0.020
ion transport GO:0006811 114 0.020
xenobiotic metabolic process GO:0006805 4 0.020
lymphocyte proliferation GO:0046651 1 0.020
heterocycle metabolic process GO:0046483 290 0.020
single organism metabolic process GO:0044710 217 0.020
skeletal system development GO:0001501 181 0.020
positive regulation of nucleotide catabolic process GO:0030813 1 0.020
positive regulation of cell substrate adhesion GO:0010811 1 0.020
cellular macromolecule metabolic process GO:0044260 391 0.019
positive regulation of secretion by cell GO:1903532 1 0.019
protein heterooligomerization GO:0051291 1 0.019
sensory organ development GO:0007423 393 0.019
establishment of protein localization to plasma membrane GO:0090002 1 0.019
regulation of developmental process GO:0050793 247 0.019
system process GO:0003008 185 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
regulation of catalytic activity GO:0050790 55 0.019
regulation of jun kinase activity GO:0043506 3 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
b cell activation GO:0042113 2 0.018
negative regulation of signal transduction GO:0009968 94 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
cellular modified amino acid metabolic process GO:0006575 3 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.018
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
protein targeting to nucleus GO:0044744 3 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
negative regulation of defense response GO:0031348 2 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.017
protein localization to nucleus GO:0034504 3 0.017
protein metabolic process GO:0019538 183 0.017
cell projection morphogenesis GO:0048858 244 0.017
cellular protein catabolic process GO:0044257 4 0.017
negative regulation of intracellular protein transport GO:0090317 3 0.017
stem cell proliferation GO:0072089 4 0.017
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
mitochondrion organization GO:0007005 4 0.017
apoptotic process GO:0006915 116 0.017
regulation of neural precursor cell proliferation GO:2000177 3 0.017
regulation of blood vessel size GO:0050880 2 0.017
cellular response to organic substance GO:0071310 105 0.017
axon ensheathment in central nervous system GO:0032291 2 0.017
protein polymerization GO:0051258 4 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
positive regulation of ras gtpase activity GO:0032320 1 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
organelle organization GO:0006996 227 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.016
negative regulation of protein transport GO:0051224 3 0.016
response to organic substance GO:0010033 153 0.016
cellular protein metabolic process GO:0044267 129 0.016
ion transmembrane transport GO:0034220 91 0.016
phagocytosis engulfment GO:0006911 1 0.016
positive regulation of cytokine production GO:0001819 2 0.016
hormone transport GO:0009914 2 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
regulation of epidermis development GO:0045682 2 0.016
energy reserve metabolic process GO:0006112 2 0.016
negative regulation of epithelial cell proliferation GO:0050680 1 0.016
specification of symmetry GO:0009799 204 0.015
negative regulation of cellular process GO:0048523 283 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
negative regulation of cytokine production GO:0001818 1 0.015
cellular response to oxygen levels GO:0071453 1 0.015
double strand break repair GO:0006302 3 0.015
lipid oxidation GO:0034440 1 0.015
single organism transport GO:0044765 206 0.015
cell morphogenesis GO:0000902 289 0.015
gtp catabolic process GO:0006184 2 0.015
establishment of rna localization GO:0051236 3 0.015
camera type eye development GO:0043010 222 0.015
skin development GO:0043588 54 0.015
rna metabolic process GO:0016070 219 0.015
embryonic organ morphogenesis GO:0048562 274 0.015
organic cyclic compound metabolic process GO:1901360 301 0.015
biosynthetic process GO:0009058 294 0.015
cellular component assembly GO:0022607 170 0.015
renal system development GO:0072001 94 0.015
amino acid transport GO:0006865 2 0.015
positive regulation of immune effector process GO:0002699 3 0.015
interspecies interaction between organisms GO:0044419 4 0.015
regulation of protein targeting GO:1903533 2 0.015
regulation of gtpase activity GO:0043087 2 0.015
negative regulation of intracellular transport GO:0032387 3 0.015
fat soluble vitamin metabolic process GO:0006775 4 0.015
cell substrate junction assembly GO:0007044 2 0.014
negative regulation of dna metabolic process GO:0051053 4 0.014
retinoic acid receptor signaling pathway GO:0048384 16 0.014
axonogenesis GO:0007409 152 0.014
positive regulation of multi organism process GO:0043902 3 0.014
mitochondrial transport GO:0006839 2 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
blood circulation GO:0008015 87 0.014
lipid catabolic process GO:0016042 4 0.014
peptide transport GO:0015833 1 0.014
cellular response to starvation GO:0009267 1 0.014
cell projection organization GO:0030030 284 0.014
determination of left right symmetry GO:0007368 179 0.014
rna localization GO:0006403 4 0.014
positive regulation of cell activation GO:0050867 1 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
regulation of ras gtpase activity GO:0032318 2 0.014
regulation of metabolic process GO:0019222 359 0.014
establishment of localization in cell GO:0051649 77 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.013
keratinocyte differentiation GO:0030216 0 0.013
regulation of neurogenesis GO:0050767 87 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
modification dependent protein catabolic process GO:0019941 3 0.013
rna transport GO:0050658 2 0.013
collagen biosynthetic process GO:0032964 2 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
cellular response to retinoic acid GO:0071300 1 0.013
regulation of protein transport GO:0051223 3 0.013
regulation of calcium ion transport GO:0051924 2 0.013
negative regulation of cytoplasmic transport GO:1903650 2 0.013
regulation of hormone secretion GO:0046883 2 0.013
response to lipid GO:0033993 60 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
response to acid chemical GO:0001101 17 0.013
peptide metabolic process GO:0006518 1 0.013
water homeostasis GO:0030104 4 0.013
regulation of cell development GO:0060284 100 0.013
positive regulation of cell cycle GO:0045787 3 0.013
hormone mediated signaling pathway GO:0009755 9 0.013
negative regulation of immune response GO:0050777 2 0.013
eye development GO:0001654 277 0.013
response to amino acid GO:0043200 2 0.013
fatty acid transport GO:0015908 1 0.013
ubiquitin dependent protein catabolic process GO:0006511 3 0.013
kidney development GO:0001822 92 0.013
sequestering of calcium ion GO:0051208 3 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
central nervous system development GO:0007417 387 0.013
membrane invagination GO:0010324 1 0.013
neuroblast proliferation GO:0007405 2 0.012
regulation of protein binding GO:0043393 3 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
oxidation reduction process GO:0055114 41 0.012
secondary metabolic process GO:0019748 3 0.012
negative regulation of catabolic process GO:0009895 3 0.012
regulation of response to stimulus GO:0048583 269 0.012
positive regulation of metabolic process GO:0009893 108 0.012
ear development GO:0043583 127 0.012
regulation of cell morphogenesis GO:0022604 42 0.012
regulation of dna replication GO:0006275 3 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
intestinal absorption GO:0050892 2 0.012
regulation of biosynthetic process GO:0009889 250 0.012
response to stress GO:0006950 263 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
hindbrain development GO:0030902 91 0.012
centrosome organization GO:0051297 1 0.012
regulation of striated muscle contraction GO:0006942 2 0.012
positive regulation of cell matrix adhesion GO:0001954 1 0.012
protein modification by small protein removal GO:0070646 1 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
determination of bilateral symmetry GO:0009855 204 0.012
macromolecule modification GO:0043412 111 0.012
transmission of nerve impulse GO:0019226 19 0.012
gastrulation GO:0007369 208 0.012
response to monosaccharide GO:0034284 3 0.012
regulation of transporter activity GO:0032409 2 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
regulation of response to biotic stimulus GO:0002831 2 0.012
protein modification process GO:0036211 100 0.012
regulation of molecular function GO:0065009 70 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
endoplasmic reticulum unfolded protein response GO:0030968 2 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
positive regulation of biosynthetic process GO:0009891 68 0.011
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
aflatoxin b1 metabolic process GO:0043390 1 0.011
carbohydrate homeostasis GO:0033500 1 0.011
locomotion GO:0040011 313 0.011
organic substance biosynthetic process GO:1901576 289 0.011
positive regulation of muscle cell differentiation GO:0051149 1 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
regulation of cell shape GO:0008360 1 0.011
camera type eye morphogenesis GO:0048593 108 0.011
cytokinesis GO:0000910 3 0.011
regulation of wnt signaling pathway GO:0030111 53 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
respiratory electron transport chain GO:0022904 2 0.011
regulation of nervous system development GO:0051960 90 0.011
digestive tract development GO:0048565 265 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
microtubule organizing center organization GO:0031023 1 0.011
adherens junction organization GO:0034332 4 0.011
negative regulation of cell communication GO:0010648 96 0.011
meiotic nuclear division GO:0007126 4 0.011
regulation of jak stat cascade GO:0046425 3 0.011
diterpenoid metabolic process GO:0016101 15 0.011
estrogen metabolic process GO:0008210 2 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
cartilage development GO:0051216 96 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
adherens junction assembly GO:0034333 1 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
regulation of transcription dna templated GO:0006355 213 0.010
response to metal ion GO:0010038 34 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
regulation of inflammatory response GO:0050727 2 0.010
organophosphate metabolic process GO:0019637 37 0.010
protein acylation GO:0043543 3 0.010
positive regulation of leukocyte mediated immunity GO:0002705 1 0.010
protein complex disassembly GO:0043241 1 0.010
long chain fatty acid transport GO:0015909 1 0.010
rna 3 end processing GO:0031123 2 0.010
heterocycle biosynthetic process GO:0018130 215 0.010
ribosome assembly GO:0042255 1 0.010
regulation of localization GO:0032879 104 0.010
cellular cation homeostasis GO:0030003 17 0.010
regulation of organelle assembly GO:1902115 4 0.010
negative regulation of multi organism process GO:0043901 3 0.010

creld2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
disease of metabolism DOID:0014667 0 0.021
musculoskeletal system disease DOID:17 0 0.020
connective tissue disease DOID:65 0 0.017
organ system cancer DOID:0050686 0 0.015
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
inherited metabolic disorder DOID:655 0 0.012