Danio rerio

0 known processes

ctsa

cathepsin A

(Aliases: fb36c08,MGC65802,fj91g05,wu:fb36c08,Ppgb,wu:fj91g05,zgc:65802,wu:fb33g02)

ctsa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of protein complex assembly GO:0031334 2 0.237
regulation of protein complex assembly GO:0043254 3 0.110
larval development GO:0002164 2 0.104
negative regulation of biological process GO:0048519 304 0.089
regulation of biological quality GO:0065008 263 0.085
aging GO:0007568 2 0.078
regulation of protein catabolic process GO:0042176 1 0.070
positive regulation of transport GO:0051050 2 0.068
positive regulation of cellular component biogenesis GO:0044089 3 0.066
generation of neurons GO:0048699 385 0.063
cytoskeleton dependent cytokinesis GO:0061640 3 0.062
regulation of cellular component organization GO:0051128 86 0.060
positive regulation of biological process GO:0048518 253 0.057
negative regulation of cellular process GO:0048523 283 0.053
cytokinetic process GO:0032506 2 0.053
cellular protein catabolic process GO:0044257 4 0.052
rna localization GO:0006403 4 0.052
sensory organ development GO:0007423 393 0.052
positive regulation of catabolic process GO:0009896 4 0.051
signal transduction GO:0007165 455 0.050
regulation of cell shape GO:0008360 1 0.049
cellular protein metabolic process GO:0044267 129 0.048
meiotic nuclear division GO:0007126 4 0.047
cellular component morphogenesis GO:0032989 336 0.046
positive regulation of cellular process GO:0048522 201 0.044
neuron differentiation GO:0030182 353 0.044
cytokinesis GO:0000910 3 0.041
protein metabolic process GO:0019538 183 0.041
nucleic acid transport GO:0050657 2 0.040
cellular component assembly GO:0022607 170 0.039
single fertilization GO:0007338 3 0.039
regulation of metabolic process GO:0019222 359 0.038
positive regulation of apoptotic signaling pathway GO:2001235 1 0.038
negative regulation of protein kinase activity GO:0006469 4 0.038
programmed cell death GO:0012501 119 0.038
meiotic cell cycle process GO:1903046 3 0.037
protein complex assembly GO:0006461 30 0.036
cellular component biogenesis GO:0044085 178 0.036
protein complex biogenesis GO:0070271 30 0.035
mitochondrion organization GO:0007005 4 0.035
guanosine containing compound metabolic process GO:1901068 4 0.034
cell projection organization GO:0030030 284 0.034
regulation of meiotic cell cycle GO:0051445 1 0.033
blood vessel development GO:0001568 246 0.033
transport GO:0006810 220 0.033
regulation of synapse assembly GO:0051963 3 0.032
organelle organization GO:0006996 227 0.032
regulation of anatomical structure morphogenesis GO:0022603 130 0.032
positive regulation of cellular catabolic process GO:0031331 3 0.032
regulation of synapse organization GO:0050807 3 0.031
negative regulation of nuclear division GO:0051784 3 0.031
cell projection morphogenesis GO:0048858 244 0.031
nitrogen compound metabolic process GO:0006807 319 0.031
regulation of signaling GO:0023051 235 0.031
vasculature development GO:0001944 278 0.029
establishment of protein localization to organelle GO:0072594 4 0.029
nucleobase containing compound metabolic process GO:0006139 274 0.029
regulation of developmental process GO:0050793 247 0.029
regulation of synaptic plasticity GO:0048167 1 0.029
death GO:0016265 121 0.028
organonitrogen compound metabolic process GO:1901564 74 0.028
organic cyclic compound metabolic process GO:1901360 301 0.028
stem cell division GO:0017145 1 0.028
cell part morphogenesis GO:0032990 246 0.028
blood vessel morphogenesis GO:0048514 216 0.028
cellular response to external stimulus GO:0071496 2 0.028
modification dependent protein catabolic process GO:0019941 3 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.027
single organism metabolic process GO:0044710 217 0.027
cell morphogenesis GO:0000902 289 0.027
protein complex subunit organization GO:0071822 46 0.027
synaptic growth at neuromuscular junction GO:0051124 2 0.026
nuclear transport GO:0051169 4 0.026
organelle fusion GO:0048284 3 0.026
mitochondrial transport GO:0006839 2 0.026
apoptotic process GO:0006915 116 0.026
alternative mrna splicing via spliceosome GO:0000380 1 0.026
establishment of localization GO:0051234 244 0.026
protein localization to nucleus GO:0034504 3 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
gtp catabolic process GO:0006184 2 0.025
regulation of nucleotide catabolic process GO:0030811 2 0.025
positive regulation of nucleoside metabolic process GO:0045979 1 0.025
protein polymerization GO:0051258 4 0.025
response to stress GO:0006950 263 0.025
organic substance biosynthetic process GO:1901576 289 0.025
regulation of primary metabolic process GO:0080090 311 0.025
locomotion GO:0040011 313 0.025
positive regulation of response to stimulus GO:0048584 80 0.025
neuron development GO:0048666 262 0.024
atp catabolic process GO:0006200 4 0.024
spindle assembly GO:0051225 2 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
regulation of response to stimulus GO:0048583 269 0.024
regulation of signal transduction GO:0009966 225 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.023
single organism nuclear import GO:1902593 3 0.023
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.023
phosphate containing compound metabolic process GO:0006796 108 0.023
membrane fusion GO:0061025 2 0.023
immune system process GO:0002376 241 0.023
response to external stimulus GO:0009605 264 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
establishment of rna localization GO:0051236 3 0.022
protein stabilization GO:0050821 2 0.022
cellular amine metabolic process GO:0044106 2 0.022
negative regulation of kinase activity GO:0033673 4 0.022
membrane invagination GO:0010324 1 0.022
cellular protein modification process GO:0006464 100 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
intracellular signal transduction GO:0035556 85 0.022
developmental programmed cell death GO:0010623 4 0.022
fertilization GO:0009566 3 0.022
angiogenesis GO:0001525 158 0.022
regulation of reproductive process GO:2000241 4 0.021
positive regulation of cell cycle GO:0045787 3 0.021
regulation of mrna processing GO:0050684 3 0.021
secondary metabolic process GO:0019748 3 0.021
cleavage furrow formation GO:0036089 2 0.021
macromolecular complex subunit organization GO:0043933 74 0.021
regulation of protein polymerization GO:0032271 2 0.021
gtp metabolic process GO:0046039 4 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.021
adult behavior GO:0030534 2 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.021
positive regulation of cytoskeleton organization GO:0051495 3 0.020
localization of cell GO:0051674 244 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
axonogenesis GO:0007409 152 0.020
extrinsic apoptotic signaling pathway GO:0097191 3 0.020
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.020
cellular component movement GO:0006928 335 0.020
regulation of cell development GO:0060284 100 0.020
amine metabolic process GO:0009308 2 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
regulation of multicellular organismal process GO:0051239 277 0.020
regulation of binding GO:0051098 3 0.020
phagocytosis GO:0006909 3 0.020
regulation of blood pressure GO:0008217 1 0.019
regulation of cellular ph GO:0030641 1 0.019
cellular macromolecule metabolic process GO:0044260 391 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.019
cellular response to nutrient levels GO:0031669 2 0.019
ribonucleoside monophosphate catabolic process GO:0009158 4 0.019
regulation of mrna splicing via spliceosome GO:0048024 3 0.019
lipid catabolic process GO:0016042 4 0.019
synaptic vesicle localization GO:0097479 1 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.019
cellular component disassembly GO:0022411 1 0.019
negative regulation of map kinase activity GO:0043407 2 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.018
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.018
system process GO:0003008 185 0.018
positive regulation of translation GO:0045727 1 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
response to organic substance GO:0010033 153 0.018
regulation of cellular protein metabolic process GO:0032268 52 0.018
multicellular organism growth GO:0035264 4 0.018
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.018
cell cycle GO:0007049 93 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
protein modification process GO:0036211 100 0.018
positive regulation of gtpase activity GO:0043547 1 0.018
growth GO:0040007 174 0.017
small molecule metabolic process GO:0044281 77 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
endosomal transport GO:0016197 2 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
single organism membrane fusion GO:0044801 2 0.017
regulation of multicellular organism growth GO:0040014 4 0.017
macromolecule modification GO:0043412 111 0.017
muscle structure development GO:0061061 196 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.017
synaptic vesicle transport GO:0048489 1 0.017
autophagy GO:0006914 4 0.017
positive regulation of protein polymerization GO:0032273 2 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
regulation of apoptotic process GO:0042981 98 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
response to hexose GO:0009746 3 0.017
regulation of catalytic activity GO:0050790 55 0.017
regulation of cell death GO:0010941 103 0.017
hatching GO:0035188 4 0.017
regulation of synaptic vesicle transport GO:1902803 1 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.016
multi organism process GO:0051704 134 0.016
cilium assembly GO:0042384 58 0.016
glial cell migration GO:0008347 3 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
actin filament polymerization GO:0030041 2 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
regulation of programmed cell death GO:0043067 101 0.016
macromolecular complex assembly GO:0065003 35 0.016
regulation of cell communication GO:0010646 232 0.016
negative regulation of protein complex assembly GO:0031333 1 0.016
positive regulation of programmed cell death GO:0043068 29 0.016
regulation of protein metabolic process GO:0051246 56 0.015
nucleobase containing compound transport GO:0015931 2 0.015
compound eye development GO:0048749 2 0.015
stem cell proliferation GO:0072089 4 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
regulation of gene expression GO:0010468 265 0.015
regulation of filopodium assembly GO:0051489 2 0.015
centrosome organization GO:0051297 1 0.015
regulation of intracellular ph GO:0051453 1 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
embryonic organ development GO:0048568 381 0.015
single organism localization GO:1902578 225 0.015
regulation of cytokine production GO:0001817 3 0.015
golgi vesicle transport GO:0048193 3 0.015
vacuolar transport GO:0007034 2 0.015
phosphorus metabolic process GO:0006793 109 0.015
mitotic cytokinesis GO:0000281 3 0.015
female sex differentiation GO:0046660 4 0.015
synaptic vesicle endocytosis GO:0048488 1 0.015
nuclear import GO:0051170 3 0.015
regulation of cell morphogenesis GO:0022604 42 0.015
post embryonic morphogenesis GO:0009886 4 0.014
mitotic cell cycle GO:0000278 64 0.014
regulation of protein targeting GO:1903533 2 0.014
signal transduction in absence of ligand GO:0038034 1 0.014
nuclear export GO:0051168 1 0.014
cell growth GO:0016049 57 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
lipid storage GO:0019915 1 0.014
oxoacid metabolic process GO:0043436 31 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
protein targeting to nucleus GO:0044744 3 0.014
regulation of ph GO:0006885 3 0.014
heart development GO:0007507 313 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
developmental growth GO:0048589 166 0.014
biosynthetic process GO:0009058 294 0.014
cognition GO:0050890 1 0.014
response to glucocorticoid GO:0051384 1 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
single organism transport GO:0044765 206 0.014
cell motility GO:0048870 244 0.014
response to corticosteroid GO:0031960 1 0.014
actin polymerization or depolymerization GO:0008154 2 0.014
positive regulation of jun kinase activity GO:0043507 2 0.014
maintenance of location GO:0051235 4 0.014
regulation of protein transport GO:0051223 3 0.014
antimicrobial humoral response GO:0019730 2 0.013
response to topologically incorrect protein GO:0035966 2 0.013
regulation of blood vessel size GO:0050880 2 0.013
cellular ketone metabolic process GO:0042180 11 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
phosphorylation GO:0016310 69 0.013
female gonad development GO:0008585 4 0.013
activation of mapk activity GO:0000187 3 0.013
negative regulation of reproductive process GO:2000242 3 0.013
germ line stem cell division GO:0042078 1 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
interspecies interaction between organisms GO:0044419 4 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
heart morphogenesis GO:0003007 156 0.013
response to glucose GO:0009749 3 0.013
regulation of dendrite development GO:0050773 3 0.013
response to carbohydrate GO:0009743 3 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
lytic vacuole organization GO:0080171 1 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
apoptotic process involved in development GO:1902742 2 0.013
circulatory system process GO:0003013 87 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
immune response GO:0006955 28 0.013
response to monosaccharide GO:0034284 3 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.013
tissue remodeling GO:0048771 4 0.013
phagocytosis engulfment GO:0006911 1 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
regulation of jun kinase activity GO:0043506 3 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
negative regulation of synapse assembly GO:0051964 2 0.013
regulation of molecular function GO:0065009 70 0.013
synaptic vesicle recycling GO:0036465 1 0.013
protein homooligomerization GO:0051260 3 0.013
positive regulation of secretion GO:0051047 1 0.013
cell cycle process GO:0022402 53 0.013
stem cell maintenance GO:0019827 4 0.013
microtubule organizing center organization GO:0031023 1 0.013
immune system development GO:0002520 191 0.013
tube morphogenesis GO:0035239 349 0.013
rna biosynthetic process GO:0032774 181 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
response to chemical GO:0042221 320 0.012
protein import into nucleus GO:0006606 3 0.012
dorsal ventral pattern formation GO:0009953 125 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
neuron projection development GO:0031175 180 0.012
protein phosphorylation GO:0006468 47 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
er nucleus signaling pathway GO:0006984 2 0.012
chemosensory behavior GO:0007635 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
regulation of gtpase activity GO:0043087 2 0.012
neuron projection morphogenesis GO:0048812 161 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
organic substance transport GO:0071702 58 0.012
rna transport GO:0050658 2 0.012
gene expression GO:0010467 252 0.012
cell death GO:0008219 121 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
protein import GO:0017038 3 0.012
regulation of dendrite morphogenesis GO:0048814 3 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
cortical actin cytoskeleton organization GO:0030866 1 0.012
endoplasmic reticulum unfolded protein response GO:0030968 2 0.012
regeneration GO:0031099 91 0.011
eye development GO:0001654 277 0.011
homeostatic process GO:0042592 142 0.011
response to unfolded protein GO:0006986 2 0.011
exocytosis GO:0006887 1 0.011
cellular localization GO:0051641 97 0.011
negative regulation of rna splicing GO:0033119 1 0.011
positive regulation of cell activation GO:0050867 1 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
rna metabolic process GO:0016070 219 0.011
regulation of nervous system development GO:0051960 90 0.011
hemopoiesis GO:0030097 183 0.011
regulation of neuron projection development GO:0010975 40 0.011
lamellipodium organization GO:0097581 1 0.011
regulation of receptor activity GO:0010469 2 0.011
negative regulation of secretion GO:0051048 2 0.011
regulation of metal ion transport GO:0010959 4 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
innate immune response GO:0045087 13 0.011
positive regulation of multi organism process GO:0043902 3 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.011
rna splicing GO:0008380 16 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
central nervous system development GO:0007417 387 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
double strand break repair GO:0006302 3 0.011
regulation of inflammatory response GO:0050727 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
somatic muscle development GO:0007525 4 0.011
ph reduction GO:0045851 1 0.011
guanosine containing compound catabolic process GO:1901069 2 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
erk1 and erk2 cascade GO:0070371 4 0.010
cellular response to unfolded protein GO:0034620 2 0.010
cellular response to organic substance GO:0071310 105 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010
heterocycle metabolic process GO:0046483 290 0.010
positive regulation of reproductive process GO:2000243 2 0.010
positive regulation of chromatin modification GO:1903310 1 0.010
cellular transition metal ion homeostasis GO:0046916 3 0.010
striated muscle tissue development GO:0014706 110 0.010
single organism organelle organization GO:1902589 199 0.010
posttranscriptional regulation of gene expression GO:0010608 14 0.010
hormone biosynthetic process GO:0042446 3 0.010
protein localization to plasma membrane GO:0072659 1 0.010
regulation of organ growth GO:0046620 3 0.010
negative regulation of secretion by cell GO:1903531 2 0.010
development of primary female sexual characteristics GO:0046545 4 0.010
cytoskeleton organization GO:0007010 96 0.010
cell division GO:0051301 20 0.010
recombinational repair GO:0000725 1 0.010

ctsa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.375
lysosomal storage disease DOID:3211 0 0.375
inherited metabolic disorder DOID:655 0 0.375
disease of anatomical entity DOID:7 0 0.116
lipid storage disease DOID:9455 0 0.037
nervous system disease DOID:863 0 0.035
musculoskeletal system disease DOID:17 0 0.015