Danio rerio

5 known processes

ctsk

cathepsin K

(Aliases: wu:fb08b05,zgc:110367,wu:fa95f03)

ctsk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
collagen metabolic process GO:0032963 2 0.822
Human
multicellular organismal macromolecule metabolic process GO:0044259 2 0.634
Human
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.534
Human
multicellular organismal metabolic process GO:0044236 2 0.534
Human
response to abiotic stimulus GO:0009628 122 0.475
signal transduction GO:0007165 455 0.378
protein targeting to nucleus GO:0044744 3 0.287
response to chemical GO:0042221 320 0.285
gene expression GO:0010467 252 0.284
cell proliferation GO:0008283 80 0.273
response to amino acid GO:0043200 2 0.269
regulation of multicellular organismal development GO:2000026 223 0.223
response to external stimulus GO:0009605 264 0.189
neuron development GO:0048666 262 0.185
response to organic substance GO:0010033 153 0.184
protein import into nucleus GO:0006606 3 0.179
regulation of rna metabolic process GO:0051252 224 0.174
aromatic compound biosynthetic process GO:0019438 217 0.171
tissue regeneration GO:0042246 74 0.168
nuclear import GO:0051170 3 0.158
negative regulation of cellular process GO:0048523 283 0.152
response to mechanical stimulus GO:0009612 24 0.150
stem cell maintenance GO:0019827 4 0.149
regulation of epithelial cell proliferation GO:0050678 3 0.146
angiogenesis GO:0001525 158 0.144
regulation of anatomical structure morphogenesis GO:0022603 130 0.143
regulation of cell proliferation GO:0042127 37 0.137
negative regulation of biological process GO:0048519 304 0.132
regeneration GO:0031099 91 0.131
cell morphogenesis GO:0000902 289 0.130
regulation of macromolecule metabolic process GO:0060255 317 0.127
cell death GO:0008219 121 0.125
intestinal cholesterol absorption GO:0030299 2 0.125
immune system process GO:0002376 241 0.124
ameboidal type cell migration GO:0001667 143 0.119
regulation of rna biosynthetic process GO:2001141 213 0.110
positive regulation of macromolecule metabolic process GO:0010604 93 0.109
cellular component morphogenesis GO:0032989 336 0.103
nuclear transport GO:0051169 4 0.100
localization of cell GO:0051674 244 0.099
protein import GO:0017038 3 0.097
chordate embryonic development GO:0043009 271 0.096
nucleocytoplasmic transport GO:0006913 4 0.095
regulation of protein targeting GO:1903533 2 0.090
muscle structure development GO:0061061 196 0.089
regulation of cell differentiation GO:0045595 142 0.087
positive regulation of biological process GO:0048518 253 0.082
larval development GO:0002164 2 0.081
blood vessel morphogenesis GO:0048514 216 0.080
morphogenesis of an epithelium GO:0002009 333 0.080
blood vessel development GO:0001568 246 0.079
regulation of biological quality GO:0065008 263 0.079
Rat
single organism nuclear import GO:1902593 3 0.078
cellular response to chemical stimulus GO:0070887 157 0.077
intestinal absorption GO:0050892 2 0.076
cellular protein metabolic process GO:0044267 129 0.076
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.075
organic acid metabolic process GO:0006082 31 0.074
hematopoietic or lymphoid organ development GO:0048534 191 0.073
regulation of nucleic acid templated transcription GO:1903506 213 0.073
positive regulation of signal transduction GO:0009967 56 0.073
regulation of binding GO:0051098 3 0.072
regulation of gene expression GO:0010468 265 0.071
regulation of cell motility GO:2000145 46 0.070
cellular macromolecule metabolic process GO:0044260 391 0.070
Human
heterocycle biosynthetic process GO:0018130 215 0.069
protein metabolic process GO:0019538 183 0.069
Human
fin regeneration GO:0031101 51 0.065
cellular component biogenesis GO:0044085 178 0.065
cellular component assembly GO:0022607 170 0.062
regulation of protein localization to nucleus GO:1900180 2 0.061
regulation of protein import into nucleus GO:0042306 2 0.061
cellular component movement GO:0006928 335 0.061
embryonic organ morphogenesis GO:0048562 274 0.061
regulation of biosynthetic process GO:0009889 250 0.057
regulation of cytoplasmic transport GO:1903649 4 0.056
cellular response to organic substance GO:0071310 105 0.056
generation of neurons GO:0048699 385 0.056
neuron differentiation GO:0030182 353 0.056
sensory organ development GO:0007423 393 0.055
response to antibiotic GO:0046677 1 0.055
septum transversum development GO:0003343 4 0.055
cartilage development GO:0051216 96 0.054
central nervous system development GO:0007417 387 0.054
muscle cell differentiation GO:0042692 139 0.053
protein localization to nucleus GO:0034504 3 0.052
regulation of signal transduction GO:0009966 225 0.052
establishment of protein localization to organelle GO:0072594 4 0.052
nucleic acid templated transcription GO:0097659 181 0.052
cell migration involved in gastrulation GO:0042074 79 0.051
response to stress GO:0006950 263 0.051
protein modification process GO:0036211 100 0.050
tube morphogenesis GO:0035239 349 0.050
regulation of cellular ketone metabolic process GO:0010565 7 0.049
positive regulation of cellular process GO:0048522 201 0.048
cell motility GO:0048870 244 0.048
cell surface receptor signaling pathway GO:0007166 325 0.048
nitrogen compound metabolic process GO:0006807 319 0.048
myeloid cell differentiation GO:0030099 86 0.048
regulation of chondrocyte differentiation GO:0032330 1 0.046
cellular nitrogen compound biosynthetic process GO:0044271 218 0.046
response to wounding GO:0009611 116 0.045
photoreceptor cell fate commitment GO:0046552 1 0.044
regulation of endothelial cell proliferation GO:0001936 1 0.044
germ line stem cell maintenance GO:0030718 2 0.043
cell migration GO:0016477 237 0.043
regulation of response to stimulus GO:0048583 269 0.042
negative regulation of gene expression GO:0010629 65 0.042
regulation of multicellular organism growth GO:0040014 4 0.042
rna metabolic process GO:0016070 219 0.042
regulation of primary metabolic process GO:0080090 311 0.042
head development GO:0060322 303 0.042
response to corticosteroid GO:0031960 1 0.041
cell projection morphogenesis GO:0048858 244 0.041
transport GO:0006810 220 0.041
response to oxygen containing compound GO:1901700 55 0.041
mesenchymal cell proliferation GO:0010463 1 0.040
regulation of intracellular protein transport GO:0033157 3 0.040
skeletal system development GO:0001501 181 0.040
determination of heart left right asymmetry GO:0061371 117 0.039
striated muscle cell differentiation GO:0051146 129 0.039
blood circulation GO:0008015 87 0.039
negative regulation of multicellular organismal process GO:0051241 69 0.038
response to monosaccharide GO:0034284 3 0.038
regulation of protein complex assembly GO:0043254 3 0.038
notochord development GO:0030903 54 0.038
positive regulation of cell communication GO:0010647 56 0.038
regulation of cellular component movement GO:0051270 55 0.037
immune system development GO:0002520 191 0.037
regulation of nucleocytoplasmic transport GO:0046822 2 0.037
positive regulation of cell adhesion GO:0045785 1 0.036
hemopoiesis GO:0030097 183 0.036
positive regulation of cell death GO:0010942 29 0.036
cell projection organization GO:0030030 284 0.036
negative regulation of metabolic process GO:0009892 86 0.036
convergent extension involved in gastrulation GO:0060027 71 0.035
programmed cell death GO:0012501 119 0.035
convergent extension GO:0060026 118 0.035
sensory organ morphogenesis GO:0090596 200 0.034
biosynthetic process GO:0009058 294 0.034
regulation of cell death GO:0010941 103 0.034
muscle cell development GO:0055001 115 0.034
protein localization GO:0008104 40 0.034
glial cell migration GO:0008347 3 0.034
response to hexose GO:0009746 3 0.033
reactive oxygen species metabolic process GO:0072593 6 0.033
extrinsic apoptotic signaling pathway GO:0097191 3 0.033
heart process GO:0003015 71 0.032
positive regulation of cellular component biogenesis GO:0044089 3 0.032
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.032
rna biosynthetic process GO:0032774 181 0.032
membrane fusion GO:0061025 2 0.032
regulation of localization GO:0032879 104 0.032
cell part morphogenesis GO:0032990 246 0.032
regulation of apoptotic process GO:0042981 98 0.031
positive regulation of notch signaling pathway GO:0045747 3 0.031
outflow tract morphogenesis GO:0003151 1 0.031
regulation of signaling GO:0023051 235 0.031
positive regulation of signaling GO:0023056 56 0.030
regulation of cell activation GO:0050865 1 0.030
apoptotic process GO:0006915 116 0.030
stem cell proliferation GO:0072089 4 0.030
extracellular structure organization GO:0043062 27 0.030
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.029
tissue migration GO:0090130 37 0.029
response to nutrient GO:0007584 3 0.029
transcription dna templated GO:0006351 181 0.029
multicellular organism growth GO:0035264 4 0.029
cellular ketone metabolic process GO:0042180 11 0.029
regulation of vasculature development GO:1901342 33 0.029
cellular nitrogen compound metabolic process GO:0034641 290 0.029
regulation of establishment of protein localization GO:0070201 4 0.029
cellular response to external stimulus GO:0071496 2 0.029
cell adhesion GO:0007155 40 0.029
response to carbohydrate GO:0009743 3 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
establishment of localization in cell GO:0051649 77 0.028
liver development GO:0001889 96 0.028
positive regulation of epithelial cell proliferation GO:0050679 1 0.028
regulation of cellular component organization GO:0051128 86 0.027
system process GO:0003008 185 0.027
regulation of embryonic development GO:0045995 47 0.027
regulation of neuron differentiation GO:0045664 56 0.027
negative regulation of epithelial cell proliferation GO:0050680 1 0.027
response to hormone GO:0009725 48 0.027
regulation of cell migration GO:0030334 40 0.027
aging GO:0007568 2 0.027
cellular biosynthetic process GO:0044249 286 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.026
negative regulation of cellular metabolic process GO:0031324 77 0.026
cellular component disassembly GO:0022411 1 0.026
response to estrogen GO:0043627 27 0.026
organic substance biosynthetic process GO:1901576 289 0.026
cell cycle arrest GO:0007050 1 0.026
regulation of protein transport GO:0051223 3 0.025
regulation of stem cell proliferation GO:0072091 2 0.025
phagocytosis GO:0006909 3 0.025
regulation of macromolecule biosynthetic process GO:0010556 225 0.025
carboxylic acid metabolic process GO:0019752 22 0.024
wound healing GO:0042060 90 0.024
single organism organelle organization GO:1902589 199 0.024
negative regulation of macromolecule metabolic process GO:0010605 76 0.024
cellular component assembly involved in morphogenesis GO:0010927 107 0.024
establishment of protein localization to plasma membrane GO:0090002 1 0.024
segmentation GO:0035282 97 0.023
response to glucose GO:0009749 3 0.023
positive regulation of developmental process GO:0051094 50 0.023
positive regulation of cell substrate adhesion GO:0010811 1 0.023
regulation of cytokine production GO:0001817 3 0.022
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.022
cellular response to retinoic acid GO:0071300 1 0.022
proteolysis GO:0006508 38 0.022
Human
regulation of locomotion GO:0040012 55 0.022
positive regulation of endothelial cell proliferation GO:0001938 1 0.022
circulatory system process GO:0003013 87 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
cardiac atrium morphogenesis GO:0003209 2 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
regulation of metabolic process GO:0019222 359 0.022
peptide transport GO:0015833 1 0.022
negative regulation of protein phosphorylation GO:0001933 4 0.022
plasma membrane repair GO:0001778 2 0.022
positive regulation of leukocyte differentiation GO:1902107 1 0.021
cell morphogenesis involved in differentiation GO:0000904 195 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.021
i kappab kinase nf kappab signaling GO:0007249 4 0.021
cellular protein localization GO:0034613 20 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.021
multi organism process GO:0051704 134 0.021
negative regulation of cell death GO:0060548 60 0.021
neural retina development GO:0003407 49 0.021
collagen fibril organization GO:0030199 1 0.021
muscle tissue development GO:0060537 110 0.021
modification dependent protein catabolic process GO:0019941 3 0.021
regulation of transcription dna templated GO:0006355 213 0.021
protein complex biogenesis GO:0070271 30 0.020
neuron projection development GO:0031175 180 0.020
cellular protein catabolic process GO:0044257 4 0.020
Human
locomotion GO:0040011 313 0.020
positive regulation of response to stimulus GO:0048584 80 0.020
positive regulation of immune effector process GO:0002699 3 0.020
striated muscle tissue development GO:0014706 110 0.020
epithelium migration GO:0090132 25 0.019
macromolecule biosynthetic process GO:0009059 227 0.019
muscle organ development GO:0007517 101 0.019
positive regulation of wound healing GO:0090303 1 0.019
organelle assembly GO:0070925 110 0.019
single organism metabolic process GO:0044710 217 0.019
Human
response to organic cyclic compound GO:0014070 51 0.019
response to vitamin GO:0033273 3 0.019
lateral inhibition GO:0046331 1 0.019
organelle fusion GO:0048284 3 0.019
vasculature development GO:0001944 278 0.019
superoxide metabolic process GO:0006801 2 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.018
response to lipid GO:0033993 60 0.018
intracellular signal transduction GO:0035556 85 0.018
heart formation GO:0060914 13 0.018
bleb assembly GO:0032060 1 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
regulation of developmental process GO:0050793 247 0.018
positive regulation of transport GO:0051050 2 0.018
purine ribonucleoside biosynthetic process GO:0046129 2 0.018
regulation of multicellular organismal process GO:0051239 277 0.018
cellular amine metabolic process GO:0044106 2 0.018
death GO:0016265 121 0.018
negative regulation of response to stimulus GO:0048585 104 0.018
brain development GO:0007420 293 0.018
urogenital system development GO:0001655 97 0.018
digestive system development GO:0055123 289 0.018
heterocycle metabolic process GO:0046483 290 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.017
single organism membrane organization GO:0044802 20 0.017
taxis GO:0042330 109 0.017
regulation of cell shape GO:0008360 1 0.017
response to ketone GO:1901654 1 0.017
positive regulation of nervous system development GO:0051962 25 0.017
response to acid chemical GO:0001101 17 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
negative chemotaxis GO:0050919 1 0.017
response to drug GO:0042493 3 0.017
connective tissue development GO:0061448 99 0.017
macromolecule modification GO:0043412 111 0.017
regulation of programmed cell death GO:0043067 101 0.017
positive regulation of cellular protein metabolic process GO:0032270 22 0.017
cytosolic calcium ion transport GO:0060401 3 0.017
peptidyl serine modification GO:0018209 2 0.017
heart jogging GO:0003146 40 0.017
positive regulation of myeloid cell differentiation GO:0045639 2 0.017
regulation of protein metabolic process GO:0051246 56 0.017
release of sequestered calcium ion into cytosol GO:0051209 3 0.016
caudal fin morphogenesis GO:0035143 7 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
biological adhesion GO:0022610 40 0.016
cellular response to stress GO:0033554 62 0.016
positive regulation of metabolic process GO:0009893 108 0.016
carbohydrate homeostasis GO:0033500 1 0.016
hepaticobiliary system development GO:0061008 98 0.016
regulation of blood vessel size GO:0050880 2 0.016
regulation of mesenchymal cell proliferation GO:0010464 1 0.016
pharyngeal system development GO:0060037 18 0.016
sequestering of metal ion GO:0051238 3 0.016
proteasomal protein catabolic process GO:0010498 2 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
organic substance catabolic process GO:1901575 28 0.015
Human
phosphate containing compound metabolic process GO:0006796 108 0.015
regulation of neuron projection development GO:0010975 40 0.015
negative regulation of blood circulation GO:1903523 2 0.015
nitric oxide metabolic process GO:0046209 2 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
regulation of reproductive process GO:2000241 4 0.015
negative regulation of intracellular protein transport GO:0090317 3 0.015
endodermal cell differentiation GO:0035987 19 0.015
regulation of erk1 and erk2 cascade GO:0070372 4 0.015
cellular protein modification process GO:0006464 100 0.015
glucose homeostasis GO:0042593 1 0.015
nephron epithelium morphogenesis GO:0072088 1 0.015
response to endogenous stimulus GO:0009719 83 0.015
single organism cellular localization GO:1902580 46 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
signal transduction in absence of ligand GO:0038034 1 0.014
cartilage morphogenesis GO:0060536 13 0.014
cellular response to nutrient levels GO:0031669 2 0.014
protein heterooligomerization GO:0051291 1 0.014
amine metabolic process GO:0009308 2 0.014
regulation of cellular protein metabolic process GO:0032268 52 0.014
locus ceruleus development GO:0021703 3 0.014
gland development GO:0048732 143 0.014
regulation of response to stress GO:0080134 36 0.014
regulation of collagen metabolic process GO:0010712 2 0.014
positive regulation of cell activation GO:0050867 1 0.014
regulation of dna replication GO:0006275 3 0.014
viral process GO:0016032 1 0.013
fat soluble vitamin biosynthetic process GO:0042362 2 0.013
negative regulation of signaling GO:0023057 96 0.013
oxidation reduction process GO:0055114 41 0.013
positive regulation of cell differentiation GO:0045597 30 0.013
macromolecule localization GO:0033036 54 0.013
protein localization to plasma membrane GO:0072659 1 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
epithelial cell migration GO:0010631 25 0.013
nucleic acid metabolic process GO:0090304 244 0.013
craniofacial suture morphogenesis GO:0097094 2 0.013
neuron projection morphogenesis GO:0048812 161 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
negative regulation of response to dna damage stimulus GO:2001021 3 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
sequestering of calcium ion GO:0051208 3 0.013
cardiac atrium development GO:0003230 4 0.012
regulation of muscle contraction GO:0006937 3 0.012
multi organism cellular process GO:0044764 2 0.012
stem cell differentiation GO:0048863 117 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
regulation of cell communication GO:0010646 232 0.012
cellular response to acid chemical GO:0071229 8 0.012
growth GO:0040007 174 0.012
gastrulation GO:0007369 208 0.012
negative regulation of leukocyte differentiation GO:1902106 1 0.012
positive regulation of phosphate metabolic process GO:0045937 21 0.012
collagen biosynthetic process GO:0032964 2 0.012
extracellular matrix organization GO:0030198 27 0.012
digestive tract morphogenesis GO:0048546 231 0.012
oxoacid metabolic process GO:0043436 31 0.012
regulation of protein catabolic process GO:0042176 1 0.012
cellular macromolecule localization GO:0070727 21 0.012
organelle organization GO:0006996 227 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
radial glial cell differentiation GO:0060019 2 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
reproductive process GO:0022414 40 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
macrophage chemotaxis GO:0048246 3 0.011
response to inorganic substance GO:0010035 38 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
cellular localization GO:0051641 97 0.011
single organism biosynthetic process GO:0044711 71 0.011
response to alcohol GO:0097305 14 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
spermatid differentiation GO:0048515 2 0.011
nuclear export GO:0051168 1 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
regulation of synapse assembly GO:0051963 3 0.011
negative regulation of rna biosynthetic process GO:1902679 45 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
mesenchyme development GO:0060485 127 0.011
hindbrain development GO:0030902 91 0.011
morphogenesis of a branching epithelium GO:0061138 16 0.011
morphogenesis of a branching structure GO:0001763 21 0.011
regulation of blood pressure GO:0008217 1 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
regulation of tube size GO:0035150 2 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
negative regulation of cell proliferation GO:0008285 8 0.010
response to hydrogen peroxide GO:0042542 3 0.010
medial fin development GO:0033338 16 0.010
phagosome maturation GO:0090382 1 0.010
cellular response to oxygen containing compound GO:1901701 20 0.010
cell activation GO:0001775 16 0.010
regulation of carbohydrate metabolic process GO:0006109 4 0.010
macromolecular complex assembly GO:0065003 35 0.010
cellular response to oxygen levels GO:0071453 1 0.010
leukocyte homeostasis GO:0001776 2 0.010
cellular amino acid metabolic process GO:0006520 7 0.010

ctsk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.037
developmental disorder of mental health DOID:0060037 0 0.037
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.021
immune system disease DOID:2914 0 0.010