Danio rerio

61 known processes

dab2

disabled homolog 2 (Drosophila)

(Aliases: sb:cb778,zgc:77136)

dab2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vasculature development GO:0001944 278 0.707
blood vessel morphogenesis GO:0048514 216 0.621
hematopoietic or lymphoid organ development GO:0048534 191 0.559
Mouse
blood vessel development GO:0001568 246 0.356
angiogenesis GO:0001525 158 0.229
adherens junction organization GO:0034332 4 0.197
immune system development GO:0002520 191 0.186
Mouse
hemopoiesis GO:0030097 183 0.169
Mouse
myeloid cell differentiation GO:0030099 86 0.132
Mouse
response to drug GO:0042493 3 0.123
regulation of signaling GO:0023051 235 0.119
immune response GO:0006955 28 0.118
response to stress GO:0006950 263 0.115
Mouse
synaptic vesicle transport GO:0048489 1 0.115
regulation of endothelial cell proliferation GO:0001936 1 0.115
heart development GO:0007507 313 0.110
regulation of neurotransmitter transport GO:0051588 1 0.107
embryonic organ development GO:0048568 381 0.105
positive regulation of endothelial cell proliferation GO:0001938 1 0.098
anion transport GO:0006820 38 0.092
signal transduction GO:0007165 455 0.083
tube morphogenesis GO:0035239 349 0.081
regulation of cell substrate adhesion GO:0010810 1 0.080
Mouse
nitrogen compound metabolic process GO:0006807 319 0.078
Human Mouse
osteoclast development GO:0036035 1 0.077
positive regulation of cell substrate adhesion GO:0010811 1 0.071
Mouse
regulation of developmental process GO:0050793 247 0.070
Human Mouse
immune system process GO:0002376 241 0.069
Mouse
negative regulation of biological process GO:0048519 304 0.067
Human Mouse
cellular component assembly GO:0022607 170 0.064
Mouse
endothelial cell proliferation GO:0001935 11 0.064
ion transport GO:0006811 114 0.063
positive regulation of transport GO:0051050 2 0.063
Human Mouse
generation of neurons GO:0048699 385 0.062
embryonic heart tube development GO:0035050 133 0.061
camera type eye development GO:0043010 222 0.061
cell surface receptor signaling pathway GO:0007166 325 0.061
carboxylic acid metabolic process GO:0019752 22 0.060
embryonic hemopoiesis GO:0035162 53 0.058
localization of cell GO:0051674 244 0.057
Human Mouse Worm
positive regulation of map kinase activity GO:0043406 3 0.055
Mouse
organic anion transport GO:0015711 15 0.054
lymph vessel development GO:0001945 27 0.053
homeostatic process GO:0042592 142 0.052
regulation of multicellular organismal process GO:0051239 277 0.051
Human Mouse
positive regulation of macrophage chemotaxis GO:0010759 1 0.051
amine metabolic process GO:0009308 2 0.050
synaptic growth at neuromuscular junction GO:0051124 2 0.049
regulation of cell matrix adhesion GO:0001952 1 0.048
renal absorption GO:0070293 1 0.047
response to monosaccharide GO:0034284 3 0.047
cellular amine metabolic process GO:0044106 2 0.047
gas transport GO:0015669 3 0.046
positive regulation of cell matrix adhesion GO:0001954 1 0.046
regulation of multicellular organismal development GO:2000026 223 0.046
Human Mouse
synaptic vesicle localization GO:0097479 1 0.045
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.045
response to carbohydrate GO:0009743 3 0.045
single organism metabolic process GO:0044710 217 0.044
Mouse
digestive tract morphogenesis GO:0048546 231 0.044
neuron development GO:0048666 262 0.044
regulation of erk1 and erk2 cascade GO:0070372 4 0.044
sprouting angiogenesis GO:0002040 53 0.042
oxoacid metabolic process GO:0043436 31 0.042
cell motility GO:0048870 244 0.042
Human Mouse Worm
organic acid metabolic process GO:0006082 31 0.041
cellular component morphogenesis GO:0032989 336 0.040
Human Mouse
cell morphogenesis GO:0000902 289 0.040
Human Mouse
hypothalamus cell differentiation GO:0021979 4 0.040
cell projection organization GO:0030030 284 0.040
establishment of localization GO:0051234 244 0.039
chemical homeostasis GO:0048878 49 0.039
regulation of intracellular signal transduction GO:1902531 57 0.038
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.037
Human Mouse
heterocycle biosynthetic process GO:0018130 215 0.037
Human Mouse
tissue remodeling GO:0048771 4 0.037
regulation of biological quality GO:0065008 263 0.037
single organism transport GO:0044765 206 0.036
Human Worm
macrophage chemotaxis GO:0048246 3 0.036
regulation of retina development in camera type eye GO:1902866 2 0.036
regulation of cytokine production GO:0001817 3 0.035
neuroblast proliferation GO:0007405 2 0.035
epithelial cell differentiation GO:0030855 116 0.035
Human
cellular amino acid metabolic process GO:0006520 7 0.034
cellular component biogenesis GO:0044085 178 0.034
Mouse
cell migration GO:0016477 237 0.033
Human Mouse Worm
regulation of programmed cell death GO:0043067 101 0.033
Human Mouse
positive regulation of stress activated mapk cascade GO:0032874 3 0.033
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.032
Human
positive regulation of cellular component movement GO:0051272 11 0.032
Human Mouse
regulation of protein metabolic process GO:0051246 56 0.032
Human Mouse
morphogenesis of an epithelium GO:0002009 333 0.032
negative regulation of programmed cell death GO:0043069 58 0.032
Human Mouse
regulation of intracellular protein transport GO:0033157 3 0.031
Human
epithelial cell development GO:0002064 42 0.031
meiosis ii GO:0007135 1 0.031
synaptic vesicle recycling GO:0036465 1 0.031
response to external stimulus GO:0009605 264 0.031
negative regulation of cell communication GO:0010648 96 0.031
Human Mouse
eye development GO:0001654 277 0.030
microglia differentiation GO:0014004 1 0.030
positive regulation of epithelial cell migration GO:0010634 2 0.030
regulation of neural retina development GO:0061074 2 0.030
positive regulation of multicellular organismal process GO:0051240 52 0.029
Human Mouse
response to wounding GO:0009611 116 0.029
sensory organ morphogenesis GO:0090596 200 0.029
regulation of mononuclear cell migration GO:0071675 1 0.029
positive regulation of biological process GO:0048518 253 0.029
Human Mouse Worm
synaptic vesicle endocytosis GO:0048488 1 0.029
system process GO:0003008 185 0.029
Mouse
cellular component movement GO:0006928 335 0.029
Human Mouse Worm
regulation of cellular amine metabolic process GO:0033238 0 0.029
digestive tract development GO:0048565 265 0.028
homeostasis of number of cells GO:0048872 62 0.028
response to chemical GO:0042221 320 0.028
Human Mouse
negative regulation of response to stimulus GO:0048585 104 0.028
Human Mouse
monovalent inorganic cation transport GO:0015672 42 0.028
xenobiotic metabolic process GO:0006805 4 0.028
cell junction maintenance GO:0034331 2 0.028
positive regulation of endothelial cell migration GO:0010595 2 0.027
organic cyclic compound metabolic process GO:1901360 301 0.027
Human Mouse
response to organic substance GO:0010033 153 0.027
Human Mouse
regulation of localization GO:0032879 104 0.027
Human Mouse
cellular response to external stimulus GO:0071496 2 0.027
cellular nitrogen compound biosynthetic process GO:0044271 218 0.027
Human Mouse
stem cell proliferation GO:0072089 4 0.027
tissue homeostasis GO:0001894 25 0.026
regulation of protein transport GO:0051223 3 0.026
Human
regulation of lymphangiogenesis GO:1901490 4 0.026
vesicle localization GO:0051648 27 0.026
tissue migration GO:0090130 37 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
response to biotic stimulus GO:0009607 97 0.025
regulation of molecular function GO:0065009 70 0.025
Human Mouse
positive regulation of cellular component biogenesis GO:0044089 3 0.025
epithelial cell migration GO:0010631 25 0.025
regulation of vasculogenesis GO:2001212 1 0.025
amino acid transport GO:0006865 2 0.025
regulation of immune system process GO:0002682 34 0.024
regulation of anatomical structure morphogenesis GO:0022603 130 0.024
Human Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.024
anatomical structure homeostasis GO:0060249 36 0.024
erythrocyte differentiation GO:0030218 54 0.024
positive regulation of stem cell proliferation GO:2000648 1 0.024
multicellular organismal homeostasis GO:0048871 29 0.023
cell aggregation GO:0098743 3 0.023
response to glucose GO:0009749 3 0.023
nuclear transport GO:0051169 4 0.023
Human
iron ion homeostasis GO:0055072 4 0.023
ameboidal type cell migration GO:0001667 143 0.023
vasculogenesis GO:0001570 41 0.023
single organism membrane fusion GO:0044801 2 0.023
axon development GO:0061564 166 0.023
cation transport GO:0006812 81 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
innate immune response GO:0045087 13 0.022
erk1 and erk2 cascade GO:0070371 4 0.022
apoptotic process GO:0006915 116 0.022
Human Mouse
cytokinesis GO:0000910 3 0.022
cell part morphogenesis GO:0032990 246 0.022
regulation of cellular component movement GO:0051270 55 0.022
Human Mouse
membrane fusion GO:0061025 2 0.022
aging GO:0007568 2 0.021
dicarboxylic acid transport GO:0006835 1 0.021
regulation of neurotransmitter secretion GO:0046928 1 0.021
biological adhesion GO:0022610 40 0.021
Mouse
regulation of reproductive process GO:2000241 4 0.021
sensory organ development GO:0007423 393 0.021
regulation of locomotion GO:0040012 55 0.021
Human Mouse Worm
smooth muscle contraction GO:0006939 2 0.021
primitive hemopoiesis GO:0060215 27 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
negative regulation of protein complex assembly GO:0031333 1 0.021
peptidyl serine phosphorylation GO:0018105 1 0.021
establishment of synaptic vesicle localization GO:0097480 1 0.020
retina development in camera type eye GO:0060041 146 0.020
response to external biotic stimulus GO:0043207 97 0.020
positive regulation of leukocyte chemotaxis GO:0002690 1 0.020
striated muscle tissue development GO:0014706 110 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
regulation of synapse organization GO:0050807 3 0.020
cell adhesion GO:0007155 40 0.020
Mouse
head development GO:0060322 303 0.020
gene expression GO:0010467 252 0.020
Human Mouse
response to other organism GO:0051707 97 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
regulation of establishment of protein localization GO:0070201 4 0.020
Human
guanosine containing compound metabolic process GO:1901068 4 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
adherens junction maintenance GO:0034334 2 0.019
rna localization GO:0006403 4 0.019
lipid homeostasis GO:0055088 3 0.019
vascular endothelial growth factor signaling pathway GO:0038084 3 0.019
positive regulation of cytoskeleton organization GO:0051495 3 0.019
mitotic cell cycle GO:0000278 64 0.019
regulation of cell activation GO:0050865 1 0.019
single organism membrane organization GO:0044802 20 0.019
Human Mouse
definitive hemopoiesis GO:0060216 18 0.019
regulation of cell shape GO:0008360 1 0.019
transport GO:0006810 220 0.019
signal transduction in absence of ligand GO:0038034 1 0.019
gastrulation GO:0007369 208 0.019
venous blood vessel development GO:0060841 9 0.019
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.018
cellular protein modification process GO:0006464 100 0.018
Human Mouse
autophagy GO:0006914 4 0.018
regulation of vasculature development GO:1901342 33 0.018
brain development GO:0007420 293 0.018
defense response GO:0006952 47 0.018
eye morphogenesis GO:0048592 144 0.018
small molecule metabolic process GO:0044281 77 0.018
regulation of signal transduction GO:0009966 225 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
Human
membrane lipid biosynthetic process GO:0046467 2 0.018
positive regulation of cell adhesion GO:0045785 1 0.018
Mouse
endothelial cell migration GO:0043542 19 0.018
biosynthetic process GO:0009058 294 0.018
Human Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.018
pole plasm assembly GO:0007315 4 0.018
hepaticobiliary system development GO:0061008 98 0.018
regulation of peptidase activity GO:0052547 23 0.017
regulation of metal ion transport GO:0010959 4 0.017
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
cellular response to hormone stimulus GO:0032870 39 0.017
negative regulation of cellular process GO:0048523 283 0.017
Human Mouse
lipid metabolic process GO:0006629 52 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
phosphorus metabolic process GO:0006793 109 0.017
Human Mouse
chordate embryonic development GO:0043009 271 0.017
Mouse
regulation of cell differentiation GO:0045595 142 0.017
Human Mouse
renal tubule morphogenesis GO:0061333 1 0.017
primitive erythrocyte differentiation GO:0060319 5 0.017
growth GO:0040007 174 0.017
Worm
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
Human
catechol containing compound metabolic process GO:0009712 2 0.017
positive regulation of secretion GO:0051047 1 0.016
regulation of synaptic plasticity GO:0048167 1 0.016
regulation of endopeptidase activity GO:0052548 23 0.016
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.016
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
Mouse Worm
negative regulation of developmental process GO:0051093 65 0.016
cellular lipid metabolic process GO:0044255 36 0.016
regulation of angiogenesis GO:0045765 26 0.016
glucose import GO:0046323 2 0.016
proteolysis GO:0006508 38 0.016
Human
ammonium transmembrane transport GO:0072488 2 0.016
ion homeostasis GO:0050801 41 0.016
death GO:0016265 121 0.015
Human Mouse
lymph vessel morphogenesis GO:0036303 25 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
Human Mouse
negative regulation of signal transduction GO:0009968 94 0.015
Human Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
female sex differentiation GO:0046660 4 0.015
positive regulation of lipid metabolic process GO:0045834 1 0.015
exocytosis GO:0006887 1 0.015
transmembrane transport GO:0055085 120 0.015
b cell activation GO:0042113 2 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
Human Mouse
mesoderm development GO:0007498 88 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of cell death GO:0010941 103 0.015
Human Mouse
intracellular transport GO:0046907 32 0.015
Human
pigmentation GO:0043473 85 0.015
sphingolipid biosynthetic process GO:0030148 2 0.015
positive regulation of molecular function GO:0044093 33 0.014
Mouse
regulation of cellular protein metabolic process GO:0032268 52 0.014
Human Mouse
astrocyte differentiation GO:0048708 1 0.014
single organism localization GO:1902578 225 0.014
Human Mouse Worm
leukocyte chemotaxis GO:0030595 12 0.014
lipid catabolic process GO:0016042 4 0.014
pericardium development GO:0060039 1 0.014
heart contraction GO:0060047 71 0.014
xanthophore differentiation GO:0050936 3 0.014
macromolecule modification GO:0043412 111 0.014
Human Mouse
endocrine system development GO:0035270 65 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of catalytic activity GO:0050790 55 0.014
Mouse
regulation of cellular component organization GO:0051128 86 0.014
Human Mouse
regulation of cell development GO:0060284 100 0.014
Human Mouse
negative regulation of apoptotic process GO:0043066 55 0.014
Human Mouse
epithelium migration GO:0090132 25 0.014
anterior posterior pattern specification GO:0009952 152 0.014
blood vessel endothelial cell migration GO:0043534 18 0.014
melanocyte migration GO:0097324 4 0.014
sodium ion transport GO:0006814 24 0.014
neurotransmitter secretion GO:0007269 2 0.014
negative regulation of gene expression GO:0010629 65 0.013
Human
regulation of neural precursor cell proliferation GO:2000177 3 0.013
protein localization to nucleus GO:0034504 3 0.013
Human
positive regulation of cellular process GO:0048522 201 0.013
Human Mouse
regulation of embryonic development GO:0045995 47 0.013
positive regulation of leukocyte migration GO:0002687 2 0.013
sulfur compound transport GO:0072348 3 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
Human
organonitrogen compound biosynthetic process GO:1901566 47 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
cell substrate junction assembly GO:0007044 2 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
positive regulation of developmental process GO:0051094 50 0.013
Human Mouse
cell cycle arrest GO:0007050 1 0.013
erythrocyte homeostasis GO:0034101 55 0.013
peptidyl serine modification GO:0018209 2 0.013
meiotic cell cycle process GO:1903046 3 0.013
positive regulation of retina development in camera type eye GO:1902868 1 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
Human Mouse
neuron differentiation GO:0030182 353 0.013
cofactor metabolic process GO:0051186 15 0.013
antimicrobial humoral response GO:0019730 2 0.013
g2 m transition of mitotic cell cycle GO:0000086 4 0.013
muscle system process GO:0003012 20 0.013
cell cell signaling GO:0007267 52 0.013
actin cytoskeleton organization GO:0030036 63 0.013
cellular response to organic substance GO:0071310 105 0.013
Human Mouse
ion transmembrane transport GO:0034220 91 0.012
negative regulation of angiogenesis GO:0016525 7 0.012
locomotion GO:0040011 313 0.012
Human Mouse Worm
positive regulation of neural retina development GO:0061075 1 0.012
pancreas development GO:0031016 84 0.012
regulation of cysteine type endopeptidase activity GO:2000116 21 0.012
lymphangiogenesis GO:0001946 25 0.012
regulation of calcium mediated signaling GO:0050848 1 0.012
organic substance transport GO:0071702 58 0.012
Human Worm
osteoclast differentiation GO:0030316 1 0.012
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.012
protein import into nucleus GO:0006606 3 0.012
Human
negative regulation of reproductive process GO:2000242 3 0.012
cellular response to dna damage stimulus GO:0006974 24 0.012
cellular component maintenance GO:0043954 3 0.012
behavior GO:0007610 74 0.012
Worm
cell type specific apoptotic process GO:0097285 22 0.012
cell substrate adhesion GO:0031589 4 0.012
Mouse
glucose homeostasis GO:0042593 1 0.012
pigment cell differentiation GO:0050931 38 0.012
cellular response to nutrient levels GO:0031669 2 0.012
lymphocyte proliferation GO:0046651 1 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
Human Mouse
cardiac atrium morphogenesis GO:0003209 2 0.012
regulation of muscle contraction GO:0006937 3 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
Human Mouse
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.012
renal system development GO:0072001 94 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
Human
regulation of gene expression GO:0010468 265 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
Human Mouse
ventricular cardiac muscle tissue development GO:0003229 3 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
Human Mouse
monoamine transport GO:0015844 1 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
Human Mouse
regulation of phosphorylation GO:0042325 26 0.011
Human Mouse
positive regulation of secretion by cell GO:1903532 1 0.011
regulation of protein binding GO:0043393 3 0.011
Human
tetrapyrrole metabolic process GO:0033013 10 0.011
response to organic cyclic compound GO:0014070 51 0.011
carbon dioxide transport GO:0015670 3 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
Human Mouse
negative regulation of cytoplasmic transport GO:1903650 2 0.011
catecholamine metabolic process GO:0006584 2 0.011
protein import GO:0017038 3 0.011
Human
establishment of protein localization to organelle GO:0072594 4 0.011
Human
cell projection morphogenesis GO:0048858 244 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
regulation of photoreceptor cell differentiation GO:0046532 2 0.011
granulocyte chemotaxis GO:0071621 11 0.011
urogenital system development GO:0001655 97 0.011
organelle fusion GO:0048284 3 0.011
regulation of protein processing GO:0070613 10 0.011
skeletal muscle organ development GO:0060538 78 0.011
positive regulation of histone modification GO:0031058 1 0.011
establishment of endothelial barrier GO:0061028 3 0.011
regulation of translational initiation GO:0006446 1 0.011
selective angioblast sprouting GO:0035474 5 0.011
central nervous system development GO:0007417 387 0.011
regulation of cellular component biogenesis GO:0044087 12 0.010
mononuclear cell migration GO:0071674 1 0.010
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.010
regulation of protein complex assembly GO:0043254 3 0.010
adherens junction assembly GO:0034333 1 0.010
regulation of kinase activity GO:0043549 15 0.010
Mouse
regulation of cardiac muscle tissue development GO:0055024 1 0.010
trabecula morphogenesis GO:0061383 2 0.010
mitotic metaphase plate congression GO:0007080 1 0.010
wound healing GO:0042060 90 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
small molecule catabolic process GO:0044282 3 0.010
locomotory behavior GO:0007626 34 0.010
modification of morphology or physiology of other organism GO:0035821 4 0.010
response to endogenous stimulus GO:0009719 83 0.010
Human Mouse
actin filament based movement GO:0030048 1 0.010
cell projection assembly GO:0030031 64 0.010
metal ion transport GO:0030001 58 0.010
adrenal gland development GO:0030325 10 0.010

dab2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.083
immune system disease DOID:2914 0 0.027
hematopoietic system disease DOID:74 0 0.019
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.016
organ system cancer DOID:0050686 0 0.016
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013
disease of metabolism DOID:0014667 0 0.012