Danio rerio

39 known processes

dmbx1b

diencephalon/mesencephalon homeobox 1b

(Aliases: zgc:112395,mbx2)

dmbx1b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron neuron synaptic transmission GO:0007270 1 0.319
system process GO:0003008 185 0.222
behavior GO:0007610 74 0.204
Mouse
larval development GO:0002164 2 0.175
neuron differentiation GO:0030182 353 0.173
sensory system development GO:0048880 76 0.170
head development GO:0060322 303 0.161
cellular component movement GO:0006928 335 0.139
morphogenesis of an epithelium GO:0002009 333 0.137
synaptic transmission GO:0007268 35 0.135
regulation of establishment of protein localization GO:0070201 4 0.131
neuron development GO:0048666 262 0.129
response to abiotic stimulus GO:0009628 122 0.128
regulation of macromolecule metabolic process GO:0060255 317 0.124
Zebrafish Mouse
cellular macromolecule metabolic process GO:0044260 391 0.121
Zebrafish Mouse
central nervous system development GO:0007417 387 0.120
cellular nitrogen compound biosynthetic process GO:0044271 218 0.119
Zebrafish Mouse
regulation of gene expression GO:0010468 265 0.114
Zebrafish Mouse
lateral line development GO:0048882 66 0.110
nucleocytoplasmic transport GO:0006913 4 0.097
nucleobase containing compound metabolic process GO:0006139 274 0.095
Zebrafish Mouse
response to glucocorticoid GO:0051384 1 0.088
negative regulation of biological process GO:0048519 304 0.084
Zebrafish Mouse
guanosine containing compound catabolic process GO:1901069 2 0.082
transport GO:0006810 220 0.081
establishment of localization GO:0051234 244 0.080
response to chemical GO:0042221 320 0.079
generation of neurons GO:0048699 385 0.078
anterior posterior pattern specification GO:0009952 152 0.075
embryonic skeletal system morphogenesis GO:0048704 93 0.073
adult behavior GO:0030534 2 0.072
Mouse
rna metabolic process GO:0016070 219 0.071
Zebrafish Mouse
response to wounding GO:0009611 116 0.068
positive regulation of gtpase activity GO:0043547 1 0.067
regulation of synaptic plasticity GO:0048167 1 0.065
protein modification process GO:0036211 100 0.063
gtp metabolic process GO:0046039 4 0.063
regulation of reproductive process GO:2000241 4 0.062
nuclear transport GO:0051169 4 0.061
heterocycle biosynthetic process GO:0018130 215 0.061
Zebrafish Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.061
mechanosensory lateral line system development GO:0048881 49 0.059
single organism metabolic process GO:0044710 217 0.058
response to corticosteroid GO:0031960 1 0.058
posterior lateral line system development GO:0048915 46 0.058
skeletal system morphogenesis GO:0048705 102 0.057
embryonic skeletal system development GO:0048706 97 0.057
protein localization to nucleus GO:0034504 3 0.057
endothelial cell fate commitment GO:0060839 3 0.056
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.055
signal transduction GO:0007165 455 0.054
camera type eye development GO:0043010 222 0.054
gastrulation GO:0007369 208 0.054
regulation of intracellular protein transport GO:0033157 3 0.053
metal ion transport GO:0030001 58 0.053
guanosine containing compound metabolic process GO:1901068 4 0.052
positive regulation of cellular component biogenesis GO:0044089 3 0.051
cell migration GO:0016477 237 0.051
rna biosynthetic process GO:0032774 181 0.050
Zebrafish Mouse
vasculature development GO:0001944 278 0.050
regulation of metabolic process GO:0019222 359 0.050
Zebrafish Mouse
embryonic cranial skeleton morphogenesis GO:0048701 90 0.049
chordate embryonic development GO:0043009 271 0.049
pole plasm assembly GO:0007315 4 0.049
cellular protein metabolic process GO:0044267 129 0.048
nuclear export GO:0051168 1 0.048
regulation of transcription dna templated GO:0006355 213 0.048
Zebrafish Mouse
regulation of gtp catabolic process GO:0033124 2 0.048
epithelial cell differentiation GO:0030855 116 0.048
regulation of calcium ion transport GO:0051924 2 0.047
response to stress GO:0006950 263 0.046
positive regulation of metabolic process GO:0009893 108 0.046
cellular component morphogenesis GO:0032989 336 0.046
cell projection organization GO:0030030 284 0.045
cardiac cell fate commitment GO:0060911 1 0.044
regulation of cellular metabolic process GO:0031323 320 0.044
Zebrafish Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.044
single organism nuclear import GO:1902593 3 0.044
locomotion GO:0040011 313 0.043
response to external stimulus GO:0009605 264 0.043
negative regulation of biosynthetic process GO:0009890 55 0.043
Zebrafish Mouse
regulation of cytoplasmic transport GO:1903649 4 0.043
response to light stimulus GO:0009416 46 0.043
brain development GO:0007420 293 0.042
heterocycle metabolic process GO:0046483 290 0.042
Zebrafish Mouse
nucleic acid metabolic process GO:0090304 244 0.042
Zebrafish Mouse
convergent extension GO:0060026 118 0.041
lymph vessel development GO:0001945 27 0.040
neurological system process GO:0050877 62 0.040
organic cyclic compound biosynthetic process GO:1901362 223 0.040
Zebrafish Mouse
regionalization GO:0003002 274 0.040
gtp catabolic process GO:0006184 2 0.040
startle response GO:0001964 4 0.039
positive regulation of biological process GO:0048518 253 0.039
embryonic organ morphogenesis GO:0048562 274 0.039
positive regulation of cellular biosynthetic process GO:0031328 68 0.039
regulation of cellular biosynthetic process GO:0031326 245 0.038
Zebrafish Mouse
positive regulation of nucleotide catabolic process GO:0030813 1 0.037
regulation of cell shape GO:0008360 1 0.037
macromolecule modification GO:0043412 111 0.037
segmentation GO:0035282 97 0.037
nuclear import GO:0051170 3 0.036
regulation of nucleoside metabolic process GO:0009118 2 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.036
cell cell signaling GO:0007267 52 0.035
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.035
Zebrafish Mouse
response to radiation GO:0009314 51 0.035
cognition GO:0050890 1 0.035
mitochondrial transport GO:0006839 2 0.035
glial cell development GO:0021782 20 0.034
regulation of nucleotide catabolic process GO:0030811 2 0.034
maintenance of location GO:0051235 4 0.033
regulation of nucleocytoplasmic transport GO:0046822 2 0.033
establishment of protein localization to organelle GO:0072594 4 0.033
gene expression GO:0010467 252 0.033
Zebrafish Mouse
protein import into nucleus GO:0006606 3 0.033
regulation of primary metabolic process GO:0080090 311 0.033
Zebrafish Mouse
mitochondrion organization GO:0007005 4 0.033
g protein coupled receptor signaling pathway GO:0007186 74 0.033
hematopoietic or lymphoid organ development GO:0048534 191 0.032
regeneration GO:0031099 91 0.032
regulation of protein transport GO:0051223 3 0.032
cellular macromolecule biosynthetic process GO:0034645 224 0.032
Zebrafish Mouse
somite development GO:0061053 96 0.031
lymphatic endothelial cell differentiation GO:0060836 1 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
Zebrafish Mouse
liver development GO:0001889 96 0.031
sensory perception GO:0007600 39 0.030
lateral line system development GO:0048925 76 0.030
protein targeting to nucleus GO:0044744 3 0.030
stem cell proliferation GO:0072089 4 0.029
negative regulation of nuclear division GO:0051784 3 0.029
response to endogenous stimulus GO:0009719 83 0.029
epithelial tube morphogenesis GO:0060562 148 0.029
organic acid metabolic process GO:0006082 31 0.029
negative regulation of gene expression GO:0010629 65 0.029
Zebrafish Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.029
Zebrafish Mouse
regulation of cell substrate adhesion GO:0010810 1 0.028
cellular protein modification process GO:0006464 100 0.028
embryonic organ development GO:0048568 381 0.028
regulation of multicellular organismal process GO:0051239 277 0.028
taxis GO:0042330 109 0.028
negative regulation of macromolecule metabolic process GO:0010605 76 0.027
Zebrafish Mouse
regulation of fatty acid metabolic process GO:0019217 1 0.027
cell morphogenesis GO:0000902 289 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
positive regulation of cellular process GO:0048522 201 0.027
lipid storage GO:0019915 1 0.027
negative regulation of metabolic process GO:0009892 86 0.026
Zebrafish Mouse
cellular response to external stimulus GO:0071496 2 0.026
cell projection morphogenesis GO:0048858 244 0.026
positive regulation of transport GO:0051050 2 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
Zebrafish Mouse
dopaminergic neuron differentiation GO:0071542 14 0.024
response to organic cyclic compound GO:0014070 51 0.024
cation transport GO:0006812 81 0.024
phagocytosis GO:0006909 3 0.024
embryo development ending in birth or egg hatching GO:0009792 271 0.024
regulation of meiotic cell cycle GO:0051445 1 0.024
cell part morphogenesis GO:0032990 246 0.024
transcription from rna polymerase iii promoter GO:0006383 1 0.023
regulation of purine nucleotide catabolic process GO:0033121 2 0.023
regulation of gtpase activity GO:0043087 2 0.023
negative regulation of cellular biosynthetic process GO:0031327 55 0.023
Zebrafish Mouse
regulation of catalytic activity GO:0050790 55 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
erk1 and erk2 cascade GO:0070371 4 0.023
single organism behavior GO:0044708 24 0.022
Mouse
negative regulation of epithelial cell proliferation GO:0050680 1 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
cellular response to nutrient levels GO:0031669 2 0.022
single organism intracellular transport GO:1902582 25 0.022
b cell activation GO:0042113 2 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.022
locomotory behavior GO:0007626 34 0.022
Mouse
protein phosphorylation GO:0006468 47 0.021
neuron projection development GO:0031175 180 0.021
regulation of dna replication GO:0006275 3 0.021
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.021
neuroblast differentiation GO:0014016 1 0.021
aging GO:0007568 2 0.021
positive regulation of biosynthetic process GO:0009891 68 0.021
positive regulation of gene expression GO:0010628 71 0.021
regulation of protein localization to nucleus GO:1900180 2 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.020
Zebrafish Mouse
cell motility GO:0048870 244 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.020
phosphorus metabolic process GO:0006793 109 0.020
sensory perception of chemical stimulus GO:0007606 3 0.020
regulation of binding GO:0051098 3 0.020
positive regulation of catabolic process GO:0009896 4 0.020
positive regulation of cellular metabolic process GO:0031325 94 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
Zebrafish Mouse
negative regulation of mitosis GO:0045839 3 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.019
cellular ketone metabolic process GO:0042180 11 0.019
regulation of protein import into nucleus GO:0042306 2 0.019
localization of cell GO:0051674 244 0.019
regulation of cell matrix adhesion GO:0001952 1 0.019
heart development GO:0007507 313 0.019
hemopoiesis GO:0030097 183 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
Mouse
regulation of cell activation GO:0050865 1 0.019
regulation of molecular function GO:0065009 70 0.019
meiotic nuclear division GO:0007126 4 0.019
protein metabolic process GO:0019538 183 0.019
immune system process GO:0002376 241 0.019
glutamate receptor signaling pathway GO:0007215 1 0.019
small molecule metabolic process GO:0044281 77 0.019
regulation of biological quality GO:0065008 263 0.019
ion transport GO:0006811 114 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
Zebrafish Mouse
organic cyclic compound metabolic process GO:1901360 301 0.018
Zebrafish Mouse
aromatic compound biosynthetic process GO:0019438 217 0.018
Zebrafish Mouse
nitrogen compound metabolic process GO:0006807 319 0.018
Zebrafish Mouse
cellular response to starvation GO:0009267 1 0.018
cytoplasm organization GO:0007028 4 0.018
sensory perception of pain GO:0019233 1 0.018
regulation of cytokine production GO:0001817 3 0.018
neuromuscular process controlling balance GO:0050885 3 0.018
muscle system process GO:0003012 20 0.018
lymphangiogenesis GO:0001946 25 0.018
circulatory system process GO:0003013 87 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
cellular response to stress GO:0033554 62 0.017
calcium ion transport into cytosol GO:0060402 3 0.017
cytosolic calcium ion transport GO:0060401 3 0.017
single organism localization GO:1902578 225 0.017
neuron projection morphogenesis GO:0048812 161 0.017
wound healing GO:0042060 90 0.017
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.017
neuron projection regeneration GO:0031102 16 0.017
regulation of metal ion transport GO:0010959 4 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.016
Zebrafish Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.016
Zebrafish Mouse
cellular response to chemical stimulus GO:0070887 157 0.016
lymphocyte proliferation GO:0046651 1 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
retina layer formation GO:0010842 24 0.016
multicellular organism growth GO:0035264 4 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
peripheral nervous system neuron differentiation GO:0048934 28 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
cellular response to oxygen levels GO:0071453 1 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
negative regulation of intracellular protein transport GO:0090317 3 0.015
transmembrane transport GO:0055085 120 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
transmission of nerve impulse GO:0019226 19 0.015
regulation of stem cell proliferation GO:0072091 2 0.015
regulation of nucleotide metabolic process GO:0006140 17 0.015
regulation of ras gtpase activity GO:0032318 2 0.015
regulation of cell projection assembly GO:0060491 4 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
positive regulation of rna metabolic process GO:0051254 59 0.015
regulation of cell cycle GO:0051726 52 0.014
fertilization GO:0009566 3 0.014
regulation of protein targeting GO:1903533 2 0.014
regulation of rho protein signal transduction GO:0035023 2 0.014
somitogenesis GO:0001756 87 0.014
collateral sprouting in absence of injury GO:0048669 4 0.014
exocytosis GO:0006887 1 0.014
cell death in response to oxidative stress GO:0036473 2 0.014
positive regulation of ras gtpase activity GO:0032320 1 0.014
blood vessel morphogenesis GO:0048514 216 0.014
chemosensory behavior GO:0007635 1 0.014
nucleoside monophosphate catabolic process GO:0009125 4 0.014
epithelial cell fate commitment GO:0072148 11 0.014
response to steroid hormone GO:0048545 35 0.014
myeloid cell differentiation GO:0030099 86 0.014
oocyte anterior posterior axis specification GO:0007314 4 0.014
regulation of oligodendrocyte differentiation GO:0048713 1 0.014
establishment of synaptic vesicle localization GO:0097480 1 0.014
angiogenesis GO:0001525 158 0.014
negative regulation of reproductive process GO:2000242 3 0.013
cellular protein catabolic process GO:0044257 4 0.013
regulation of neuron differentiation GO:0045664 56 0.013
cell substrate adhesion GO:0031589 4 0.013
heart morphogenesis GO:0003007 156 0.013
regulation of cell differentiation GO:0045595 142 0.013
protein import GO:0017038 3 0.013
skeletal system development GO:0001501 181 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
Mouse
lipid metabolic process GO:0006629 52 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
Zebrafish Mouse
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
biosynthetic process GO:0009058 294 0.013
Zebrafish Mouse
amine metabolic process GO:0009308 2 0.013
establishment of endothelial blood brain barrier GO:0014045 2 0.013
regulation of signaling GO:0023051 235 0.013
cellular response to lipid GO:0071396 39 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
directional locomotion GO:0033058 1 0.013
nucleic acid templated transcription GO:0097659 181 0.013
Zebrafish Mouse
lymphatic endothelial cell fate commitment GO:0060838 1 0.013
ras protein signal transduction GO:0007265 7 0.012
lymph vessel morphogenesis GO:0036303 25 0.012
forebrain development GO:0030900 96 0.012
posttranscriptional regulation of gene expression GO:0010608 14 0.012
regulation of membrane potential GO:0042391 23 0.012
peripheral nervous system development GO:0007422 55 0.012
detection of temperature stimulus GO:0016048 0 0.012
developmental growth GO:0048589 166 0.012
Mouse
membrane invagination GO:0010324 1 0.012
regulation of filopodium assembly GO:0051489 2 0.012
axon cargo transport GO:0008088 2 0.012
receptor internalization GO:0031623 2 0.012
protein localization to plasma membrane GO:0072659 1 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of oocyte development GO:0060281 3 0.012
positive regulation of camp biosynthetic process GO:0030819 2 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
heart contraction GO:0060047 71 0.012
positive regulation of cell substrate adhesion GO:0010811 1 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
Zebrafish Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
blood vessel development GO:0001568 246 0.012
cellular amine metabolic process GO:0044106 2 0.012
peptide transport GO:0015833 1 0.012
photoreceptor cell differentiation GO:0046530 55 0.012
negative regulation of cellular catabolic process GO:0031330 3 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.011
Zebrafish Mouse
intracellular signal transduction GO:0035556 85 0.011
cellular component assembly GO:0022607 170 0.011
regulation of tube size GO:0035150 2 0.011
action potential GO:0001508 19 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
positive regulation of rna biosynthetic process GO:1902680 57 0.011
antimicrobial humoral response GO:0019730 2 0.011
posterior lateral line development GO:0048916 38 0.011
regulation of glial cell differentiation GO:0045685 4 0.011
multicellular organismal reproductive process GO:0048609 35 0.011
negative regulation of multi organism process GO:0043901 3 0.011
apical junction assembly GO:0043297 1 0.011
detection of stimulus GO:0051606 29 0.011
regulation of inflammatory response GO:0050727 2 0.011
cellular lipid metabolic process GO:0044255 36 0.011
epidermis development GO:0008544 48 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
locomotor rhythm GO:0045475 3 0.011
entrainment of circadian clock by photoperiod GO:0043153 1 0.011
myelination GO:0042552 18 0.011
rho protein signal transduction GO:0007266 5 0.011
adherens junction assembly GO:0034333 1 0.011
regulation of cell maturation GO:1903429 1 0.011
mononuclear cell proliferation GO:0032943 1 0.011
regulation of synapse assembly GO:0051963 3 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
developmental maturation GO:0021700 34 0.011
multi organism process GO:0051704 134 0.011
olfactory bulb development GO:0021772 4 0.011
response to drug GO:0042493 3 0.011
centrosome organization GO:0051297 1 0.010
organic substance biosynthetic process GO:1901576 289 0.010
Zebrafish Mouse
synapse organization GO:0050808 21 0.010
regulation of synapse organization GO:0050807 3 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
pharyngeal system development GO:0060037 18 0.010
tube closure GO:0060606 1 0.010
response to ketone GO:1901654 1 0.010
response to acid chemical GO:0001101 17 0.010
multicellular organismal signaling GO:0035637 22 0.010

dmbx1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
cardiovascular system disease DOID:1287 0 0.016
nervous system disease DOID:863 0 0.015
organ system cancer DOID:0050686 0 0.013