Danio rerio

99 known processes

dnmt1

DNA (cytosine-5-)-methyltransferase 1

(Aliases: cb1075,cb983,fb05h01,dmnt1,wu:fb05h01,mta)

dnmt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic cyclic compound metabolic process GO:1901360 301 0.825
nucleic acid metabolic process GO:0090304 244 0.814
larval development GO:0002164 2 0.746
camera type eye development GO:0043010 222 0.739
nucleobase containing compound metabolic process GO:0006139 274 0.725
heterocycle metabolic process GO:0046483 290 0.718
cellular nitrogen compound biosynthetic process GO:0044271 218 0.713
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.708
retina development in camera type eye GO:0060041 146 0.699
cellular aromatic compound metabolic process GO:0006725 295 0.680
cellular macromolecule metabolic process GO:0044260 391 0.635
meiotic nuclear division GO:0007126 4 0.603
cellular biosynthetic process GO:0044249 286 0.578
Mouse
dna biosynthetic process GO:0071897 3 0.547
dna metabolic process GO:0006259 27 0.525
nitrogen compound metabolic process GO:0006807 319 0.465
mitotic dna integrity checkpoint GO:0044774 4 0.446
cellular macromolecule biosynthetic process GO:0034645 224 0.442
Mouse
organelle organization GO:0006996 227 0.432
sensory organ development GO:0007423 393 0.427
chromatin modification GO:0016568 21 0.395
organic cyclic compound biosynthetic process GO:1901362 223 0.385
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.354
dna alkylation GO:0006305 8 0.351
nucleobase containing compound biosynthetic process GO:0034654 205 0.331
Mouse
methylation GO:0032259 22 0.325
retina morphogenesis in camera type eye GO:0060042 79 0.307
regulation of cellular metabolic process GO:0031323 320 0.306
biosynthetic process GO:0009058 294 0.305
Mouse
rna metabolic process GO:0016070 219 0.304
Mouse
negative regulation of cellular process GO:0048523 283 0.301
Human Mouse
aromatic compound biosynthetic process GO:0019438 217 0.300
Mouse
regulation of gene expression GO:0010468 265 0.290
double strand break repair GO:0006302 3 0.280
dna methylation on cytosine GO:0032776 3 0.277
dna methylation GO:0006306 8 0.275
cellular component biogenesis GO:0044085 178 0.270
meiotic chromosome segregation GO:0045132 3 0.254
regulation of dna replication GO:0006275 3 0.230
embryo development ending in birth or egg hatching GO:0009792 271 0.227
single organism metabolic process GO:0044710 217 0.221
cell cycle GO:0007049 93 0.221
eye development GO:0001654 277 0.220
regulation of histone h3 k9 methylation GO:0051570 2 0.220
Human
hepaticobiliary system development GO:0061008 98 0.218
macromolecule modification GO:0043412 111 0.216
single organism organelle organization GO:1902589 199 0.213
regulation of nitrogen compound metabolic process GO:0051171 251 0.211
gene expression GO:0010467 252 0.206
meiotic cell cycle process GO:1903046 3 0.201
macromolecule biosynthetic process GO:0009059 227 0.201
Mouse
meiosis i GO:0007127 1 0.198
cellular modified amino acid metabolic process GO:0006575 3 0.195
organic substance biosynthetic process GO:1901576 289 0.187
Mouse
liver development GO:0001889 96 0.174
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.166
Mouse
response to amino acid GO:0043200 2 0.165
Mouse
reproduction GO:0000003 40 0.163
regulation of transcription dna templated GO:0006355 213 0.157
Mouse
maintenance of dna repeat elements GO:0043570 2 0.152
dna methylation or demethylation GO:0044728 8 0.150
digestive tract development GO:0048565 265 0.147
mitotic cell cycle process GO:1903047 48 0.147
digestive system development GO:0055123 289 0.141
gene silencing GO:0016458 4 0.138
Mouse
immune system process GO:0002376 241 0.136
dna modification GO:0006304 8 0.136
heterocycle biosynthetic process GO:0018130 215 0.132
Mouse
modification dependent protein catabolic process GO:0019941 3 0.130
response to stress GO:0006950 263 0.129
negative regulation of histone methylation GO:0031061 1 0.126
Human
gland development GO:0048732 143 0.126
negative regulation of macromolecule metabolic process GO:0010605 76 0.125
Human Mouse
regulation of meiotic cell cycle GO:0051445 1 0.125
rna biosynthetic process GO:0032774 181 0.124
Mouse
neuron differentiation GO:0030182 353 0.120
positive regulation of histone modification GO:0031058 1 0.115
Human
mitotic nuclear division GO:0007067 18 0.114
regulation of cell cycle GO:0051726 52 0.112
cellular protein metabolic process GO:0044267 129 0.110
negative regulation of chromosome organization GO:2001251 1 0.100
Human
regulation of histone methylation GO:0031060 3 0.095
Human
centrosome organization GO:0051297 1 0.094
negative regulation of cellular metabolic process GO:0031324 77 0.092
Human Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.089
immune system development GO:0002520 191 0.089
regulation of gene expression epigenetic GO:0040029 11 0.088
regulation of primary metabolic process GO:0080090 311 0.087
chromosome organization GO:0051276 31 0.086
positive regulation of chromatin modification GO:1903310 1 0.086
Human
regulation of macromolecule biosynthetic process GO:0010556 225 0.085
Mouse
regulation of multicellular organism growth GO:0040014 4 0.085
cellular component assembly GO:0022607 170 0.084
protein localization to nucleus GO:0034504 3 0.083
multicellular organism growth GO:0035264 4 0.083
cell cycle process GO:0022402 53 0.082
carboxylic acid metabolic process GO:0019752 22 0.082
macromolecular complex assembly GO:0065003 35 0.080
response to organic substance GO:0010033 153 0.080
Mouse
regulation of metabolic process GO:0019222 359 0.079
double strand break repair via nonhomologous end joining GO:0006303 1 0.077
sister chromatid cohesion GO:0007062 2 0.075
cellular protein modification process GO:0006464 100 0.075
histone h3 k4 methylation GO:0051568 2 0.074
Human
pyrimidine containing compound metabolic process GO:0072527 3 0.074
cellular protein catabolic process GO:0044257 4 0.068
reciprocal meiotic recombination GO:0007131 1 0.065
negative regulation of dna metabolic process GO:0051053 4 0.065
chromosome segregation GO:0007059 12 0.063
negative regulation of biosynthetic process GO:0009890 55 0.063
Mouse
generation of neurons GO:0048699 385 0.063
positive regulation of catabolic process GO:0009896 4 0.062
chromatin organization GO:0006325 22 0.060
cellular macromolecular complex assembly GO:0034622 24 0.058
ribosome assembly GO:0042255 1 0.056
pronuclear migration GO:0035046 1 0.055
rna dependent dna replication GO:0006278 2 0.055
regulation of biosynthetic process GO:0009889 250 0.054
Mouse
negative regulation of metabolic process GO:0009892 86 0.053
Human Mouse
negative regulation of biological process GO:0048519 304 0.053
Human Mouse
regulation of stem cell proliferation GO:0072091 2 0.053
g1 s transition of mitotic cell cycle GO:0000082 1 0.053
non recombinational repair GO:0000726 2 0.052
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.051
regulation of growth rate GO:0040009 1 0.051
single organism nuclear import GO:1902593 3 0.051
positive regulation of immune effector process GO:0002699 3 0.050
photoreceptor cell differentiation GO:0046530 55 0.049
chromosome organization involved in meiosis GO:0070192 1 0.048
mitotic cell cycle GO:0000278 64 0.048
dna catabolic process GO:0006308 1 0.047
ubiquitin dependent protein catabolic process GO:0006511 3 0.047
regulation of binding GO:0051098 3 0.046
regulation of mitotic cell cycle GO:0007346 25 0.046
negative regulation of dna recombination GO:0045910 2 0.046
nuclear import GO:0051170 3 0.046
protein metabolic process GO:0019538 183 0.046
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.046
Mouse
aging GO:0007568 2 0.046
response to chemical GO:0042221 320 0.045
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.045
Mouse
cytokinesis GO:0000910 3 0.044
cardiac atrium development GO:0003230 4 0.044
organelle assembly GO:0070925 110 0.044
transcription dna templated GO:0006351 181 0.044
Mouse
cation transport GO:0006812 81 0.043
neuron development GO:0048666 262 0.042
reciprocal dna recombination GO:0035825 1 0.041
regulation of signaling GO:0023051 235 0.041
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.040
cell proliferation GO:0008283 80 0.039
Mouse
microtubule polymerization GO:0046785 2 0.039
negative regulation of histone modification GO:0031057 1 0.039
Human
mitotic sister chromatid segregation GO:0000070 6 0.038
single organism localization GO:1902578 225 0.038
nuclear migration GO:0007097 3 0.037
meiotic spindle organization GO:0000212 1 0.037
cellular catabolic process GO:0044248 27 0.037
nuclear division GO:0000280 23 0.037
histone h3 k9 methylation GO:0051567 5 0.036
negative regulation of dna replication GO:0008156 2 0.036
organelle fission GO:0048285 23 0.036
negative regulation of gene expression GO:0010629 65 0.036
Mouse
protein modification process GO:0036211 100 0.036
phagocytosis GO:0006909 3 0.036
exocrine pancreas development GO:0031017 28 0.035
macromolecular complex subunit organization GO:0043933 74 0.035
double strand break repair via homologous recombination GO:0000724 1 0.035
positive regulation of cellular catabolic process GO:0031331 3 0.034
positive regulation of metabolic process GO:0009893 108 0.033
Human
dna replication GO:0006260 6 0.033
amine metabolic process GO:0009308 2 0.033
regulation of protein catabolic process GO:0042176 1 0.032
signal transduction GO:0007165 455 0.032
spindle assembly GO:0051225 2 0.031
positive regulation of leukocyte mediated immunity GO:0002705 1 0.031
spindle assembly involved in meiosis GO:0090306 1 0.031
regulation of purine nucleotide catabolic process GO:0033121 2 0.031
proteasomal protein catabolic process GO:0010498 2 0.031
protein import GO:0017038 3 0.031
intracellular signal transduction GO:0035556 85 0.029
negative regulation of transcription dna templated GO:0045892 45 0.029
Mouse
connective tissue development GO:0061448 99 0.029
g2 m transition of mitotic cell cycle GO:0000086 4 0.029
negative regulation of catabolic process GO:0009895 3 0.029
regulation of cellular biosynthetic process GO:0031326 245 0.029
Mouse
negative regulation of cellular biosynthetic process GO:0031327 55 0.029
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.029
Mouse
cell cycle g1 s phase transition GO:0044843 1 0.029
regulation of biological quality GO:0065008 263 0.028
protein complex localization GO:0031503 1 0.028
nuclear envelope organization GO:0006998 2 0.028
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.027
pyrimidine containing compound biosynthetic process GO:0072528 2 0.027
dna repair GO:0006281 6 0.027
response to endogenous stimulus GO:0009719 83 0.027
Mouse
regulation of rna metabolic process GO:0051252 224 0.027
Mouse
positive regulation of hydrolase activity GO:0051345 13 0.027
cellular response to stress GO:0033554 62 0.027
vesicle mediated transport GO:0016192 22 0.027
death GO:0016265 121 0.027
neuron projection morphogenesis GO:0048812 161 0.027
eye photoreceptor cell differentiation GO:0001754 45 0.026
organic acid metabolic process GO:0006082 31 0.026
cellular amine metabolic process GO:0044106 2 0.026
production of molecular mediator of immune response GO:0002440 2 0.025
cellular macromolecule catabolic process GO:0044265 12 0.025
negative regulation of cytoplasmic transport GO:1903650 2 0.025
regulation of protein import into nucleus GO:0042306 2 0.025
positive regulation of macromolecule metabolic process GO:0010604 93 0.025
Human
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.025
lens development in camera type eye GO:0002088 22 0.024
cell cycle g2 m phase transition GO:0044839 4 0.024
mitotic metaphase plate congression GO:0007080 1 0.024
cellular amino acid metabolic process GO:0006520 7 0.024
protein complex assembly GO:0006461 30 0.024
dna recombination GO:0006310 5 0.023
cellular ketone metabolic process GO:0042180 11 0.023
protein targeting to nucleus GO:0044744 3 0.023
cellular component assembly involved in morphogenesis GO:0010927 107 0.023
response to uv GO:0009411 3 0.022
modification dependent macromolecule catabolic process GO:0043632 3 0.022
cell cycle arrest GO:0007050 1 0.022
intra s dna damage checkpoint GO:0031573 1 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.022
Mouse
sensory organ morphogenesis GO:0090596 200 0.022
positive regulation of biological process GO:0048518 253 0.022
Human
leukocyte proliferation GO:0070661 1 0.022
male meiosis GO:0007140 2 0.021
multi organism reproductive process GO:0044703 36 0.021
maintenance of location GO:0051235 4 0.021
protein complex biogenesis GO:0070271 30 0.021
multicellular organismal homeostasis GO:0048871 29 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
regulation of establishment of protein localization GO:0070201 4 0.020
histone h3 k9 modification GO:0061647 5 0.020
positive regulation of rna biosynthetic process GO:1902680 57 0.020
cardiac cell development GO:0055006 21 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.020
Mouse
nucleic acid templated transcription GO:0097659 181 0.019
Mouse
immunoglobulin mediated immune response GO:0016064 3 0.019
regulation of protein complex assembly GO:0043254 3 0.019
catabolic process GO:0009056 32 0.019
pancreas development GO:0031016 84 0.019
transport GO:0006810 220 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
cellular response to reactive oxygen species GO:0034614 2 0.019
positive regulation of cellular metabolic process GO:0031325 94 0.018
Human
single organism biosynthetic process GO:0044711 71 0.018
macromolecule localization GO:0033036 54 0.018
muscle cell development GO:0055001 115 0.018
transcription from rna polymerase ii promoter GO:0006366 80 0.018
Mouse
regulation of response to stimulus GO:0048583 269 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
mitotic sister chromatid cohesion GO:0007064 2 0.018
wnt signaling pathway GO:0016055 80 0.017
developmental growth GO:0048589 166 0.017
cellular amino acid biosynthetic process GO:0008652 2 0.017
positive regulation of cell cycle GO:0045787 3 0.017
negative regulation of nucleic acid templated transcription GO:1903507 45 0.017
Mouse
establishment of localization GO:0051234 244 0.017
protein polymerization GO:0051258 4 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
neural retina development GO:0003407 49 0.017
regulation of gene silencing GO:0060968 1 0.017
rna processing GO:0006396 25 0.017
regulation of cell activation GO:0050865 1 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
histone modification GO:0016570 20 0.016
cell part morphogenesis GO:0032990 246 0.016
deoxyribonucleotide biosynthetic process GO:0009263 1 0.016
regulation of hydrolase activity GO:0051336 28 0.016
blood circulation GO:0008015 87 0.016
negative regulation of meiotic cell cycle GO:0051447 1 0.016
oxoacid metabolic process GO:0043436 31 0.016
histone lysine methylation GO:0034968 12 0.016
g2 dna damage checkpoint GO:0031572 3 0.016
camera type eye morphogenesis GO:0048593 108 0.016
sister chromatid segregation GO:0000819 6 0.016
regulation of histone modification GO:0031056 5 0.016
Human
cellular response to dna damage stimulus GO:0006974 24 0.015
regulation of dna recombination GO:0000018 2 0.015
system process GO:0003008 185 0.015
b cell differentiation GO:0030183 1 0.015
circulatory system process GO:0003013 87 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
muscle organ development GO:0007517 101 0.015
immunoglobulin production GO:0002377 1 0.015
regulation of molecular function GO:0065009 70 0.015
peptidyl threonine phosphorylation GO:0018107 1 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
dna damage checkpoint GO:0000077 6 0.014
somatic cell dna recombination GO:0016444 1 0.014
organic substance catabolic process GO:1901575 28 0.014
negative regulation of chromatin modification GO:1903309 1 0.014
Human
positive regulation of cell activation GO:0050867 1 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
b cell mediated immunity GO:0019724 3 0.014
eye morphogenesis GO:0048592 144 0.014
response to metal ion GO:0010038 34 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
regulation of chromatin modification GO:1903308 5 0.014
Human
protein import into nucleus GO:0006606 3 0.014
protein localization GO:0008104 40 0.014
protein modification by small protein conjugation or removal GO:0070647 14 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
regulation of chromatin organization GO:1902275 5 0.013
Human
regulation of cellular protein metabolic process GO:0032268 52 0.013
Human
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of catalytic activity GO:0050790 55 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
chordate embryonic development GO:0043009 271 0.013
lymphocyte proliferation GO:0046651 1 0.013
nuclear transport GO:0051169 4 0.013
meiotic cell cycle GO:0051321 5 0.013
rna catabolic process GO:0006401 7 0.013
cellular component disassembly GO:0022411 1 0.013
negative regulation of nuclear division GO:0051784 3 0.012
cartilage development GO:0051216 96 0.012
axon development GO:0061564 166 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
spindle assembly involved in female meiosis GO:0007056 1 0.012
stem cell proliferation GO:0072089 4 0.012
protein heterooligomerization GO:0051291 1 0.012
negative regulation of cell cycle GO:0045786 14 0.012
negative regulation of mitotic cell cycle GO:0045930 11 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
regulation of chromosome organization GO:0033044 5 0.012
Human
regulation of cell communication GO:0010646 232 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
Mouse
positive regulation of embryonic development GO:0040019 3 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
regulation of chromosome segregation GO:0051983 1 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
Human
lymphocyte mediated immunity GO:0002449 5 0.011
mitotic cell cycle phase transition GO:0044772 9 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
protein complex subunit organization GO:0071822 46 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
atp catabolic process GO:0006200 4 0.011
actin mediated cell contraction GO:0070252 1 0.011
negative regulation of signaling GO:0023057 96 0.011
regulation of protein transport GO:0051223 3 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
multicellular organism reproduction GO:0032504 35 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
regulation of protein modification process GO:0031399 29 0.011
Human
multicellular organismal signaling GO:0035637 22 0.011
dna integrity checkpoint GO:0031570 6 0.011
reproductive process GO:0022414 40 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
Mouse
response to drug GO:0042493 3 0.011
neuron projection development GO:0031175 180 0.011
regulation of developmental growth GO:0048638 38 0.010
negative regulation of rna biosynthetic process GO:1902679 45 0.010
Mouse
positive regulation of muscle organ development GO:0048636 1 0.010

dnmt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.080
disease of cellular proliferation DOID:14566 0 0.080
organ system cancer DOID:0050686 0 0.080
physical disorder DOID:0080015 0 0.070
gastrointestinal system cancer DOID:3119 0 0.043
large intestine cancer DOID:5672 0 0.038
intestinal cancer DOID:10155 0 0.038
colorectal cancer DOID:9256 0 0.038
congenital hypoplastic anemia DOID:1342 0 0.013
immune system disease DOID:2914 0 0.013
aplastic anemia DOID:12449 0 0.013
disease of anatomical entity DOID:7 0 0.013
Human
bone marrow disease DOID:4961 0 0.013
anemia DOID:2355 0 0.013
hematopoietic system disease DOID:74 0 0.013
retinal disease DOID:5679 0 0.010
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010
nervous system disease DOID:863 0 0.010
Human
eye disease DOID:5614 0 0.010
reproductive organ cancer DOID:193 0 0.010