Danio rerio

111 known processes

dnmt3

DNA (cytosine-5-)-methyltransferase 3

(Aliases: Zmt3,wu:fb73b09,wu:fa11d06)

dnmt3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h3 k9 methylation GO:0051567 5 0.591
regulation of biosynthetic process GO:0009889 250 0.554
Mouse
digestive system development GO:0055123 289 0.544
regulation of primary metabolic process GO:0080090 311 0.485
organic cyclic compound metabolic process GO:1901360 301 0.482
heterocycle metabolic process GO:0046483 290 0.478
retina layer formation GO:0010842 24 0.466
regulation of macromolecule metabolic process GO:0060255 317 0.457
nucleobase containing compound biosynthetic process GO:0034654 205 0.435
Mouse
cellular biosynthetic process GO:0044249 286 0.434
Mouse
exocrine pancreas development GO:0031017 28 0.423
chordate embryonic development GO:0043009 271 0.395
regulation of cellular biosynthetic process GO:0031326 245 0.387
Mouse
gene expression GO:0010467 252 0.379
organic substance biosynthetic process GO:1901576 289 0.376
Mouse
heterocycle biosynthetic process GO:0018130 215 0.374
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.363
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.361
organic cyclic compound biosynthetic process GO:1901362 223 0.356
Mouse
regulation of cellular metabolic process GO:0031323 320 0.355
transcription dna templated GO:0006351 181 0.332
Mouse
nucleic acid templated transcription GO:0097659 181 0.331
Mouse
histone h3 k9 modification GO:0061647 5 0.329
rna biosynthetic process GO:0032774 181 0.284
Mouse
regulation of metabolic process GO:0019222 359 0.275
aromatic compound biosynthetic process GO:0019438 217 0.271
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.271
cellular aromatic compound metabolic process GO:0006725 295 0.242
negative regulation of histone methylation GO:0031061 1 0.242
morphogenesis of an epithelium GO:0002009 333 0.237
nitrogen compound metabolic process GO:0006807 319 0.228
negative regulation of cellular process GO:0048523 283 0.206
Mouse
rna metabolic process GO:0016070 219 0.204
Mouse
regulation of histone h3 k9 methylation GO:0051570 2 0.187
meiotic chromosome segregation GO:0045132 3 0.183
larval development GO:0002164 2 0.176
cellular response to endogenous stimulus GO:0071495 68 0.163
Mouse
cellular response to chemical stimulus GO:0070887 157 0.159
Mouse
histone h3 k4 methylation GO:0051568 2 0.150
biosynthetic process GO:0009058 294 0.147
Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.137
Mouse
positive regulation of gene expression GO:0010628 71 0.134
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.128
Mouse
negative regulation of histone modification GO:0031057 1 0.128
negative regulation of chromatin modification GO:1903309 1 0.126
generation of neurons GO:0048699 385 0.124
cellular protein modification process GO:0006464 100 0.124
regulation of macromolecule biosynthetic process GO:0010556 225 0.118
Mouse
pancreas development GO:0031016 84 0.115
negative regulation of rna metabolic process GO:0051253 48 0.112
Mouse
response to chemical GO:0042221 320 0.112
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.110
organelle organization GO:0006996 227 0.110
embryo development ending in birth or egg hatching GO:0009792 271 0.108
regulation of multicellular organismal process GO:0051239 277 0.107
cell morphogenesis GO:0000902 289 0.106
meiotic cell cycle process GO:1903046 3 0.103
regulation of rna biosynthetic process GO:2001141 213 0.100
Mouse
positive regulation of chromatin modification GO:1903310 1 0.098
positive regulation of chromosome organization GO:2001252 1 0.098
eye development GO:0001654 277 0.097
translational initiation GO:0006413 3 0.093
determination of heart left right asymmetry GO:0061371 117 0.090
regulation of histone methylation GO:0031060 3 0.090
regulation of multicellular organism growth GO:0040014 4 0.086
chromatin modification GO:0016568 21 0.084
positive regulation of cellular process GO:0048522 201 0.083
cellular component morphogenesis GO:0032989 336 0.083
retina morphogenesis in camera type eye GO:0060042 79 0.082
macromolecule biosynthetic process GO:0009059 227 0.082
Mouse
response to endogenous stimulus GO:0009719 83 0.081
Mouse
stem cell fate commitment GO:0048865 1 0.081
retina development in camera type eye GO:0060041 146 0.081
embryonic heart tube development GO:0035050 133 0.081
response to organic substance GO:0010033 153 0.079
Mouse
regulation of apoptotic process GO:0042981 98 0.079
regulation of nitrogen compound metabolic process GO:0051171 251 0.079
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.077
positive regulation of biological process GO:0048518 253 0.076
specification of symmetry GO:0009799 204 0.076
protein metabolic process GO:0019538 183 0.076
negative regulation of biological process GO:0048519 304 0.076
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.075
Mouse
circulatory system process GO:0003013 87 0.075
tube morphogenesis GO:0035239 349 0.072
cellular protein metabolic process GO:0044267 129 0.072
heart development GO:0007507 313 0.071
nucleic acid metabolic process GO:0090304 244 0.070
negative regulation of chromosome organization GO:2001251 1 0.067
digestive tract development GO:0048565 265 0.066
cellular response to organic substance GO:0071310 105 0.066
Mouse
eye photoreceptor cell development GO:0042462 30 0.066
neuron development GO:0048666 262 0.064
microtubule organizing center organization GO:0031023 1 0.064
positive regulation of histone modification GO:0031058 1 0.064
regulation of transcription dna templated GO:0006355 213 0.062
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.058
cellular nitrogen compound metabolic process GO:0034641 290 0.058
dna methylation or demethylation GO:0044728 8 0.057
regulation of translational initiation GO:0006446 1 0.056
positive regulation of dna metabolic process GO:0051054 1 0.056
regulation of nucleic acid templated transcription GO:1903506 213 0.055
Mouse
exocrine system development GO:0035272 28 0.055
skeletal system development GO:0001501 181 0.055
heart morphogenesis GO:0003007 156 0.055
positive regulation of macromolecule metabolic process GO:0010604 93 0.055
sensory organ morphogenesis GO:0090596 200 0.054
response to amino acid GO:0043200 2 0.054
Mouse
stem cell proliferation GO:0072089 4 0.054
embryonic skeletal system morphogenesis GO:0048704 93 0.053
central nervous system development GO:0007417 387 0.053
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.051
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.051
system process GO:0003008 185 0.050
cell migration GO:0016477 237 0.050
hemopoiesis GO:0030097 183 0.050
stem cell differentiation GO:0048863 117 0.049
g2 dna damage checkpoint GO:0031572 3 0.048
positive regulation of cellular component biogenesis GO:0044089 3 0.048
mitotic dna integrity checkpoint GO:0044774 4 0.046
histone lysine methylation GO:0034968 12 0.046
determination of bilateral symmetry GO:0009855 204 0.046
photoreceptor cell differentiation GO:0046530 55 0.045
negative regulation of rna biosynthetic process GO:1902679 45 0.045
Mouse
sensory organ development GO:0007423 393 0.044
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.044
Mouse
regulation of signal transduction GO:0009966 225 0.044
cellular nitrogen compound biosynthetic process GO:0044271 218 0.044
Mouse
blood circulation GO:0008015 87 0.043
regulation of rna metabolic process GO:0051252 224 0.043
Mouse
positive regulation of metabolic process GO:0009893 108 0.043
regulation of stem cell proliferation GO:0072091 2 0.042
anterior posterior pattern specification GO:0009952 152 0.042
regulation of heart growth GO:0060420 2 0.042
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.042
Mouse
reciprocal dna recombination GO:0035825 1 0.041
dna methylation on cytosine GO:0032776 3 0.041
negative regulation of macromolecule metabolic process GO:0010605 76 0.041
Mouse
heart looping GO:0001947 94 0.040
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.039
positive regulation of epithelial cell proliferation GO:0050679 1 0.039
ribonucleoside monophosphate catabolic process GO:0009158 4 0.038
macromolecule methylation GO:0043414 19 0.038
multi organism process GO:0051704 134 0.038
axonogenesis GO:0007409 152 0.036
regulation of gene expression GO:0010468 265 0.036
negative regulation of nucleic acid templated transcription GO:1903507 45 0.036
Mouse
protein localization GO:0008104 40 0.035
Mouse
synaptic growth at neuromuscular junction GO:0051124 2 0.035
atp catabolic process GO:0006200 4 0.034
multicellular organism growth GO:0035264 4 0.034
histone methylation GO:0016571 13 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.033
Mouse
cellular component assembly involved in morphogenesis GO:0010927 107 0.033
negative regulation of cellular biosynthetic process GO:0031327 55 0.033
Mouse
regionalization GO:0003002 274 0.032
positive regulation of cell cycle GO:0045787 3 0.032
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.032
mitotic g2 dna damage checkpoint GO:0007095 3 0.032
hepaticobiliary system development GO:0061008 98 0.031
dna metabolic process GO:0006259 27 0.031
embryonic organ development GO:0048568 381 0.030
reciprocal meiotic recombination GO:0007131 1 0.030
pharyngeal system development GO:0060037 18 0.030
negative regulation of cellular metabolic process GO:0031324 77 0.030
Mouse
protein alkylation GO:0008213 13 0.029
immune system process GO:0002376 241 0.029
neural retina development GO:0003407 49 0.029
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.028
cell projection morphogenesis GO:0048858 244 0.028
response to hormone GO:0009725 48 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
mitotic sister chromatid segregation GO:0000070 6 0.028
macromolecule modification GO:0043412 111 0.028
stem cell maintenance GO:0019827 4 0.027
positive regulation of neural precursor cell proliferation GO:2000179 1 0.027
dna methylation GO:0006306 8 0.027
cardiac cell fate commitment GO:0060911 1 0.027
embryonic organ morphogenesis GO:0048562 274 0.026
regulation of reproductive process GO:2000241 4 0.026
protein localization to nucleus GO:0034504 3 0.026
negative regulation of gene expression GO:0010629 65 0.026
Mouse
negative regulation of cellular protein metabolic process GO:0032269 16 0.026
eye morphogenesis GO:0048592 144 0.026
dna modification GO:0006304 8 0.026
fin morphogenesis GO:0033334 53 0.026
eye photoreceptor cell differentiation GO:0001754 45 0.025
signal transduction GO:0007165 455 0.025
spindle assembly involved in mitosis GO:0090307 1 0.025
meiotic nuclear division GO:0007126 4 0.025
growth GO:0040007 174 0.025
appendage morphogenesis GO:0035107 56 0.025
centrosome organization GO:0051297 1 0.024
cell projection organization GO:0030030 284 0.024
regulation of organelle assembly GO:1902115 4 0.024
response to external biotic stimulus GO:0043207 97 0.024
anterior posterior axis specification GO:0009948 20 0.024
negative regulation of cell differentiation GO:0045596 46 0.024
lateral inhibition GO:0046331 1 0.024
embryonic limb morphogenesis GO:0030326 2 0.024
embryonic skeletal system development GO:0048706 97 0.024
developmental process involved in reproduction GO:0003006 27 0.023
regulation of stem cell differentiation GO:2000736 4 0.023
muscle structure development GO:0061061 196 0.023
regulation of cell death GO:0010941 103 0.023
cell motility GO:0048870 244 0.023
lateral line system development GO:0048925 76 0.023
cilium morphogenesis GO:0060271 85 0.023
cellular response to oxygen levels GO:0071453 1 0.022
regulation of cellular protein metabolic process GO:0032268 52 0.022
regulation of developmental process GO:0050793 247 0.022
positive regulation of jun kinase activity GO:0043507 2 0.022
developmental growth GO:0048589 166 0.022
regulation of binding GO:0051098 3 0.022
phosphorus metabolic process GO:0006793 109 0.022
single organism metabolic process GO:0044710 217 0.022
cardiac atrium development GO:0003230 4 0.022
convergent extension involved in gastrulation GO:0060027 71 0.021
camera type eye morphogenesis GO:0048593 108 0.021
nerve development GO:0021675 45 0.021
camera type eye development GO:0043010 222 0.021
regulation of multicellular organismal development GO:2000026 223 0.021
cellular response to decreased oxygen levels GO:0036294 1 0.021
phosphorylation GO:0016310 69 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.021
Mouse
positive regulation of epithelial cell migration GO:0010634 2 0.021
carboxylic acid metabolic process GO:0019752 22 0.020
positive regulation of cellular biosynthetic process GO:0031328 68 0.020
photoreceptor cell development GO:0042461 40 0.020
mitotic cell cycle GO:0000278 64 0.020
chromatin organization GO:0006325 22 0.020
response to other organism GO:0051707 97 0.020
amine metabolic process GO:0009308 2 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
embryonic hemopoiesis GO:0035162 53 0.020
methylation GO:0032259 22 0.020
positive regulation of cell fate commitment GO:0010455 1 0.019
protein modification process GO:0036211 100 0.019
negative regulation of striated muscle tissue development GO:0045843 2 0.019
axon development GO:0061564 166 0.019
determination of left right symmetry GO:0007368 179 0.019
response to biotic stimulus GO:0009607 97 0.019
regulation of programmed cell death GO:0043067 101 0.018
negative regulation of muscle tissue development GO:1901862 2 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.018
response to external stimulus GO:0009605 264 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.018
positive regulation of programmed cell death GO:0043068 29 0.018
cell fate specification GO:0001708 68 0.018
endoderm formation GO:0001706 29 0.018
positive regulation of catabolic process GO:0009896 4 0.017
protein complex localization GO:0031503 1 0.017
Mouse
cellular response to radiation GO:0071478 4 0.017
positive regulation of rna biosynthetic process GO:1902680 57 0.017
axis specification GO:0009798 43 0.017
negative regulation of transcription dna templated GO:0045892 45 0.017
Mouse
aging GO:0007568 2 0.017
regulation of dna replication GO:0006275 3 0.017
cardiac conduction system development GO:0003161 1 0.017
cardiac atrium morphogenesis GO:0003209 2 0.017
digestive tract morphogenesis GO:0048546 231 0.017
positive regulation of cellular protein metabolic process GO:0032270 22 0.016
blood vessel development GO:0001568 246 0.016
oocyte maturation GO:0001556 4 0.016
segmentation GO:0035282 97 0.016
cardiac chamber formation GO:0003207 4 0.016
cellular ketone metabolic process GO:0042180 11 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
cell death GO:0008219 121 0.016
regulation of organ growth GO:0046620 3 0.016
mitotic g2 m transition checkpoint GO:0044818 3 0.016
regulation of protein complex assembly GO:0043254 3 0.016
death GO:0016265 121 0.015
cellular response to hypoxia GO:0071456 1 0.015
dna alkylation GO:0006305 8 0.015
response to wounding GO:0009611 116 0.015
chromosome segregation GO:0007059 12 0.015
macromolecule localization GO:0033036 54 0.015
Mouse
maintenance of location GO:0051235 4 0.015
protein import into nucleus GO:0006606 3 0.015
forebrain dorsal ventral pattern formation GO:0021798 1 0.015
polarized epithelial cell differentiation GO:0030859 4 0.014
germ cell development GO:0007281 22 0.014
peptidyl lysine dimethylation GO:0018027 1 0.014
brain development GO:0007420 293 0.014
primary neural tube formation GO:0014020 1 0.014
single organism organelle organization GO:1902589 199 0.014
regulation of protein metabolic process GO:0051246 56 0.014
positive regulation of multi organism process GO:0043902 3 0.014
septum transversum development GO:0003343 4 0.014
negative regulation of translation GO:0017148 1 0.014
protein import GO:0017038 3 0.014
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.014
response to nitrogen compound GO:1901698 19 0.014
Mouse
cell death in response to oxidative stress GO:0036473 2 0.014
response to organic cyclic compound GO:0014070 51 0.014
regulation of cell development GO:0060284 100 0.014
gastrulation GO:0007369 208 0.013
muscle organ development GO:0007517 101 0.013
primitive hemopoiesis GO:0060215 27 0.013
negative regulation of protein transport GO:0051224 3 0.013
negative regulation of metabolic process GO:0009892 86 0.013
Mouse
regulation of cytokine production GO:0001817 3 0.013
mesenchyme development GO:0060485 127 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
neuroblast proliferation GO:0007405 2 0.013
cellular response to organic cyclic compound GO:0071407 38 0.013
production of molecular mediator of immune response GO:0002440 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
stem cell division GO:0017145 1 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
regulation of calcium ion transport GO:0051924 2 0.012
cell fate commitment GO:0045165 99 0.012
head development GO:0060322 303 0.012
sprouting angiogenesis GO:0002040 53 0.012
nuclear import GO:0051170 3 0.012
multicellular organism reproduction GO:0032504 35 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
neurological system process GO:0050877 62 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
angiogenesis GO:0001525 158 0.012
regulation of cellular amine metabolic process GO:0033238 0 0.012
cell part morphogenesis GO:0032990 246 0.012
neuroblast differentiation GO:0014016 1 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
homeostatic process GO:0042592 142 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.012
Mouse
developmental programmed cell death GO:0010623 4 0.011
heart contraction GO:0060047 71 0.011
regulation of response to stimulus GO:0048583 269 0.011
mesenchymal cell proliferation GO:0010463 1 0.011
muscle cell differentiation GO:0042692 139 0.011
organic acid metabolic process GO:0006082 31 0.011
cell substrate junction assembly GO:0007044 2 0.011
peptidyl lysine methylation GO:0018022 3 0.011
regulation of gene expression epigenetic GO:0040029 11 0.011
regulation of immune system process GO:0002682 34 0.011
mesenchymal cell differentiation GO:0048762 87 0.011
negative regulation of developmental process GO:0051093 65 0.011
positive regulation of cellular catabolic process GO:0031331 3 0.011
response to amphetamine GO:0001975 1 0.011
locomotion GO:0040011 313 0.011
positive regulation of cytokine production GO:0001819 2 0.011
mesodermal cell fate specification GO:0007501 12 0.011
epidermal cell fate specification GO:0009957 4 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
peptidyl threonine modification GO:0018210 1 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
covalent chromatin modification GO:0016569 20 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
endodermal cell differentiation GO:0035987 19 0.011
compound eye development GO:0048749 2 0.011
single organism nuclear import GO:1902593 3 0.011
cellular amine metabolic process GO:0044106 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
positive regulation of map kinase activity GO:0043406 3 0.010
chromosome organization involved in meiosis GO:0070192 1 0.010
pectoral fin development GO:0033339 50 0.010
mitochondrion organization GO:0007005 4 0.010
oogenesis GO:0048477 14 0.010
regulation of cardiac muscle tissue development GO:0055024 1 0.010
positive regulation of transport GO:0051050 2 0.010
nucleoside monophosphate catabolic process GO:0009125 4 0.010
embryonic pattern specification GO:0009880 44 0.010
nucleocytoplasmic transport GO:0006913 4 0.010
camera type eye photoreceptor cell differentiation GO:0060219 19 0.010
regulation of endothelial cell proliferation GO:0001936 1 0.010
regulation of molecular function GO:0065009 70 0.010

dnmt3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.019
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012