Danio rerio

40 known processes

dsg2

desmoglein 2

(Aliases: wu:fj23f02)

dsg2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
morphogenesis of an epithelium GO:0002009 333 0.242
embryonic organ morphogenesis GO:0048562 274 0.217
desmosome organization GO:0002934 3 0.193
rna splicing GO:0008380 16 0.148
keratinocyte differentiation GO:0030216 0 0.128
cognition GO:0050890 1 0.123
adherens junction organization GO:0034332 4 0.119
skeletal system morphogenesis GO:0048705 102 0.108
embryonic organ development GO:0048568 381 0.103
response to wounding GO:0009611 116 0.098
desmosome assembly GO:0002159 2 0.097
regeneration GO:0031099 91 0.097
embryo development ending in birth or egg hatching GO:0009792 271 0.091
response to external stimulus GO:0009605 264 0.089
negative regulation of response to stimulus GO:0048585 104 0.084
muscle tissue development GO:0060537 110 0.081
neuron differentiation GO:0030182 353 0.080
regulation of muscle contraction GO:0006937 3 0.077
neural crest cell migration GO:0001755 42 0.076
regionalization GO:0003002 274 0.075
neural crest cell development GO:0014032 62 0.073
actin filament based movement GO:0030048 1 0.072
regulation of establishment of protein localization GO:0070201 4 0.072
polarized epithelial cell differentiation GO:0030859 4 0.070
cellular component biogenesis GO:0044085 178 0.068
generation of neurons GO:0048699 385 0.068
regulation of multicellular organismal process GO:0051239 277 0.068
tissue remodeling GO:0048771 4 0.067
cellular response to starvation GO:0009267 1 0.067
renal system development GO:0072001 94 0.066
chordate embryonic development GO:0043009 271 0.066
digestive system development GO:0055123 289 0.065
epithelial tube morphogenesis GO:0060562 148 0.064
photoreceptor cell differentiation GO:0046530 55 0.064
skeletal system development GO:0001501 181 0.063
sensory organ development GO:0007423 393 0.063
carbohydrate biosynthetic process GO:0016051 1 0.061
larval development GO:0002164 2 0.061
tube morphogenesis GO:0035239 349 0.061
epidermal cell differentiation GO:0009913 36 0.061
developmental growth GO:0048589 166 0.060
regulation of photoreceptor cell differentiation GO:0046532 2 0.059
cellular response to nutrient levels GO:0031669 2 0.058
regulation of neural precursor cell proliferation GO:2000177 3 0.058
sleep GO:0030431 1 0.058
regulation of cardiac muscle cell contraction GO:0086004 1 0.056
intracellular signal transduction GO:0035556 85 0.056
wound healing GO:0042060 90 0.055
neuron migration GO:0001764 22 0.054
camera type eye development GO:0043010 222 0.053
mononuclear cell proliferation GO:0032943 1 0.053
growth GO:0040007 174 0.053
eye development GO:0001654 277 0.052
hematopoietic or lymphoid organ development GO:0048534 191 0.052
neuron development GO:0048666 262 0.051
locomotion GO:0040011 313 0.050
regulation of synapse assembly GO:0051963 3 0.050
organelle organization GO:0006996 227 0.049
regulation of biological quality GO:0065008 263 0.049
single organism organelle organization GO:1902589 199 0.049
heart morphogenesis GO:0003007 156 0.048
response to corticosteroid GO:0031960 1 0.048
inner ear morphogenesis GO:0042472 63 0.048
photoreceptor cell development GO:0042461 40 0.048
somitogenesis GO:0001756 87 0.046
cartilage development GO:0051216 96 0.045
head development GO:0060322 303 0.045
heart development GO:0007507 313 0.045
mesenchyme development GO:0060485 127 0.045
regulation of stem cell differentiation GO:2000736 4 0.044
central nervous system development GO:0007417 387 0.043
regulation of nervous system development GO:0051960 90 0.043
cellular response to extracellular stimulus GO:0031668 2 0.042
segmentation GO:0035282 97 0.042
regulation of multicellular organism growth GO:0040014 4 0.040
somite development GO:0061053 96 0.040
muscle structure development GO:0061061 196 0.040
pronephros development GO:0048793 69 0.040
oocyte maturation GO:0001556 4 0.039
cell migration GO:0016477 237 0.039
multi organism process GO:0051704 134 0.038
regulation of response to stimulus GO:0048583 269 0.038
establishment of epithelial cell polarity GO:0090162 2 0.038
connective tissue development GO:0061448 99 0.037
mesenchymal cell development GO:0014031 78 0.037
anterior posterior pattern specification GO:0009952 152 0.037
single fertilization GO:0007338 3 0.037
establishment of protein localization to organelle GO:0072594 4 0.037
stem cell proliferation GO:0072089 4 0.037
multicellular organismal signaling GO:0035637 22 0.036
cell motility GO:0048870 244 0.036
actin mediated cell contraction GO:0070252 1 0.035
neuron neuron synaptic transmission GO:0007270 1 0.035
striated muscle tissue development GO:0014706 110 0.035
cardiac conduction GO:0061337 3 0.035
stem cell maintenance GO:0019827 4 0.035
regulation of epithelial cell proliferation GO:0050678 3 0.034
sensory organ morphogenesis GO:0090596 200 0.034
negative regulation of signal transduction GO:0009968 94 0.034
neural crest cell differentiation GO:0014033 72 0.034
cell projection organization GO:0030030 284 0.034
positive regulation of synapse assembly GO:0051965 1 0.033
response to uv GO:0009411 3 0.033
female sex differentiation GO:0046660 4 0.033
cell aggregation GO:0098743 3 0.033
multicellular organism growth GO:0035264 4 0.033
ear morphogenesis GO:0042471 64 0.032
regulation of multicellular organismal development GO:2000026 223 0.032
stem cell development GO:0048864 82 0.032
enzyme linked receptor protein signaling pathway GO:0007167 106 0.031
eye morphogenesis GO:0048592 144 0.031
hormone secretion GO:0046879 2 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.030
energy reserve metabolic process GO:0006112 2 0.030
response to glucocorticoid GO:0051384 1 0.030
lateral line system development GO:0048925 76 0.030
response to abiotic stimulus GO:0009628 122 0.030
regulation of reproductive process GO:2000241 4 0.030
neuron projection development GO:0031175 180 0.029
action potential GO:0001508 19 0.029
cellular protein metabolic process GO:0044267 129 0.029
notochord development GO:0030903 54 0.029
cardiac muscle cell contraction GO:0086003 1 0.029
cartilage condensation GO:0001502 3 0.028
brain development GO:0007420 293 0.028
mesendoderm development GO:0048382 10 0.028
hemopoiesis GO:0030097 183 0.028
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.028
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.028
regulation of cell communication GO:0010646 232 0.028
cell part morphogenesis GO:0032990 246 0.028
regulation of synapse organization GO:0050807 3 0.028
aging GO:0007568 2 0.027
response to biotic stimulus GO:0009607 97 0.027
tissue regeneration GO:0042246 74 0.027
regulation of developmental process GO:0050793 247 0.027
sexual reproduction GO:0019953 36 0.027
determination of heart left right asymmetry GO:0061371 117 0.027
single organism localization GO:1902578 225 0.027
cellular component assembly GO:0022607 170 0.027
positive regulation of cell activation GO:0050867 1 0.027
nucleic acid metabolic process GO:0090304 244 0.027
protein import into nucleus GO:0006606 3 0.026
cell projection morphogenesis GO:0048858 244 0.026
signal transduction GO:0007165 455 0.026
retina development in camera type eye GO:0060041 146 0.026
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.026
mesenchymal cell differentiation GO:0048762 87 0.026
regulation of actin filament based movement GO:1903115 1 0.026
positive regulation of catabolic process GO:0009896 4 0.026
somatic stem cell maintenance GO:0035019 1 0.025
negative regulation of cell communication GO:0010648 96 0.025
striated muscle cell differentiation GO:0051146 129 0.025
negative regulation of wnt signaling pathway GO:0030178 30 0.025
cellular component movement GO:0006928 335 0.025
cardiac cell fate commitment GO:0060911 1 0.025
regulation of signal transduction GO:0009966 225 0.025
regulation of circadian rhythm GO:0042752 4 0.025
regulation of striated muscle contraction GO:0006942 2 0.024
cellular response to external stimulus GO:0071496 2 0.024
anatomical structure arrangement GO:0048532 2 0.024
regulation of nucleocytoplasmic transport GO:0046822 2 0.024
neuroblast differentiation GO:0014016 1 0.024
odontogenesis of dentin containing tooth GO:0042475 1 0.024
determination of bilateral symmetry GO:0009855 204 0.024
digestive tract development GO:0048565 265 0.024
negative regulation of defense response GO:0031348 2 0.024
blood vessel morphogenesis GO:0048514 216 0.024
response to endogenous stimulus GO:0009719 83 0.023
axis elongation involved in somitogenesis GO:0090245 2 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
embryonic cranial skeleton morphogenesis GO:0048701 90 0.023
regulation of signaling GO:0023051 235 0.023
negative regulation of biological process GO:0048519 304 0.023
response to oxygen levels GO:0070482 25 0.023
regulation of protein catabolic process GO:0042176 1 0.023
hepaticobiliary system development GO:0061008 98 0.022
positive regulation of cell cycle GO:0045787 3 0.022
urogenital system development GO:0001655 97 0.022
circadian sleep wake cycle process GO:0022410 2 0.022
negative regulation of protein kinase b signaling GO:0051898 2 0.022
response to monosaccharide GO:0034284 3 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.022
cell morphogenesis GO:0000902 289 0.022
inner ear development GO:0048839 126 0.022
g1 s transition of mitotic cell cycle GO:0000082 1 0.022
single organism nuclear import GO:1902593 3 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.021
regulation of stem cell proliferation GO:0072091 2 0.021
lymphocyte proliferation GO:0046651 1 0.021
immune system process GO:0002376 241 0.021
sensory system development GO:0048880 76 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
protein targeting to nucleus GO:0044744 3 0.021
gonadotropin secretion GO:0032274 1 0.021
embryonic appendage morphogenesis GO:0035113 30 0.021
response to hexose GO:0009746 3 0.021
regulation of cell projection assembly GO:0060491 4 0.021
protein metabolic process GO:0019538 183 0.021
gastrulation GO:0007369 208 0.020
response to organic substance GO:0010033 153 0.020
nuclear import GO:0051170 3 0.020
regulation of behavior GO:0050795 24 0.020
complement activation GO:0006956 3 0.020
response to other organism GO:0051707 97 0.020
phagocytosis GO:0006909 3 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
establishment or maintenance of cell polarity GO:0007163 29 0.020
kidney development GO:0001822 92 0.020
cellular response to oxygen levels GO:0071453 1 0.020
specification of symmetry GO:0009799 204 0.020
blood circulation GO:0008015 87 0.020
regulation of cell differentiation GO:0045595 142 0.019
digestive tract morphogenesis GO:0048546 231 0.019
insulin like growth factor receptor signaling pathway GO:0048009 4 0.019
regulation of carbohydrate biosynthetic process GO:0043255 1 0.019
regulation of cardiac muscle contraction GO:0055117 2 0.019
cellular component morphogenesis GO:0032989 336 0.019
response to stress GO:0006950 263 0.019
wnt signaling pathway GO:0016055 80 0.019
cellular amine metabolic process GO:0044106 2 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
nuclear transport GO:0051169 4 0.019
protein localization to nucleus GO:0034504 3 0.019
regulation of mrna processing GO:0050684 3 0.019
negative regulation of protein transport GO:0051224 3 0.019
eye photoreceptor cell development GO:0042462 30 0.019
leukocyte proliferation GO:0070661 1 0.018
gland development GO:0048732 143 0.018
regulation of blood vessel size GO:0050880 2 0.018
developmental pigmentation GO:0048066 48 0.018
amine metabolic process GO:0009308 2 0.018
heart looping GO:0001947 94 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
circulatory system process GO:0003013 87 0.018
embryonic skeletal system development GO:0048706 97 0.018
medial fin development GO:0033338 16 0.018
cell cycle g1 s phase transition GO:0044843 1 0.017
cell cell adhesion involved in gastrulation GO:0070586 4 0.017
response to carbohydrate GO:0009743 3 0.017
cardiac chamber development GO:0003205 19 0.017
segment polarity determination GO:0007367 1 0.017
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
negative regulation of cytokine production GO:0001818 1 0.017
mesoderm morphogenesis GO:0048332 51 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
vasculogenesis GO:0001570 41 0.017
regulation of autophagy GO:0010506 3 0.017
female gonad development GO:0008585 4 0.017
regulation of gene expression GO:0010468 265 0.017
cellular aromatic compound metabolic process GO:0006725 295 0.017
regulation of eye photoreceptor cell development GO:0042478 2 0.017
regulation of protein transport GO:0051223 3 0.017
pigmentation GO:0043473 85 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.017
cell morphogenesis involved in differentiation GO:0000904 195 0.017
determination of left right symmetry GO:0007368 179 0.017
regulation of inflammatory response GO:0050727 2 0.016
autophagy GO:0006914 4 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
directional locomotion GO:0033058 1 0.016
positive regulation of transport GO:0051050 2 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
signal transduction in absence of ligand GO:0038034 1 0.016
positive regulation of stem cell proliferation GO:2000648 1 0.016
response to chemical GO:0042221 320 0.016
cardiocyte differentiation GO:0035051 44 0.016
gene expression GO:0010467 252 0.016
cardiac ventricle development GO:0003231 9 0.016
establishment of protein localization to plasma membrane GO:0090002 1 0.016
epithelial cell development GO:0002064 42 0.016
regulation of epidermis development GO:0045682 2 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
regulation of protein complex assembly GO:0043254 3 0.015
cellular nitrogen compound metabolic process GO:0034641 290 0.015
regulation of organ growth GO:0046620 3 0.015
localization of cell GO:0051674 244 0.015
regulation of circadian sleep wake cycle GO:0042749 1 0.015
regulation of rna splicing GO:0043484 8 0.015
regulation of protein targeting GO:1903533 2 0.015
multi organism reproductive process GO:0044703 36 0.015
protein kinase b signaling GO:0043491 9 0.015
hormone transport GO:0009914 2 0.015
morphogenesis of an epithelial fold GO:0060571 1 0.015
positive regulation of carbohydrate metabolic process GO:0045913 1 0.015
response to glucose GO:0009749 3 0.015
circadian sleep wake cycle GO:0042745 2 0.015
biosynthetic process GO:0009058 294 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
tube formation GO:0035148 25 0.015
protein import GO:0017038 3 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
endoderm development GO:0007492 49 0.015
regulation of cytoplasmic transport GO:1903649 4 0.014
ventricular cardiac muscle tissue development GO:0003229 3 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.014
regulation of heart rate GO:0002027 5 0.014
stem cell differentiation GO:0048863 117 0.014
regulation of organ morphogenesis GO:2000027 35 0.014
regulation of metabolic process GO:0019222 359 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
retina morphogenesis in camera type eye GO:0060042 79 0.014
establishment of apical basal cell polarity GO:0035089 2 0.014
embryonic heart tube development GO:0035050 133 0.014
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.014
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.014
forebrain development GO:0030900 96 0.014
single organism reproductive process GO:0044702 40 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
muscle cell differentiation GO:0042692 139 0.014
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.014
apoptotic process GO:0006915 116 0.014
regulation of tube size GO:0035150 2 0.014
regulation of cellular component organization GO:0051128 86 0.014
neuronal action potential GO:0019228 18 0.014
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
axial mesoderm development GO:0048318 10 0.014
muscle cell development GO:0055001 115 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
epithelial cell differentiation GO:0030855 116 0.013
cellular macromolecule metabolic process GO:0044260 391 0.013
regulation of metal ion transport GO:0010959 4 0.013
reproductive process GO:0022414 40 0.013
embryonic pattern specification GO:0009880 44 0.013
liver development GO:0001889 96 0.013
pigment cell differentiation GO:0050931 38 0.013
morphogenesis of a branching epithelium GO:0061138 16 0.013
lens fiber cell morphogenesis GO:0070309 3 0.013
chemotaxis GO:0006935 104 0.013
response to nutrient GO:0007584 3 0.013
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.013
cell proliferation GO:0008283 80 0.013
dorsal convergence GO:0060030 14 0.013
organic acid metabolic process GO:0006082 31 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
stem cell fate commitment GO:0048865 1 0.013
transport GO:0006810 220 0.013
ras protein signal transduction GO:0007265 7 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.013
rna metabolic process GO:0016070 219 0.013
hair cell differentiation GO:0035315 32 0.013
oxoacid metabolic process GO:0043436 31 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
negative regulation of metabolic process GO:0009892 86 0.012
proximal distal pattern formation GO:0009954 1 0.012
endocrine process GO:0050886 2 0.012
endocrine hormone secretion GO:0060986 2 0.012
morphogenesis of a branching structure GO:0001763 21 0.012
positive regulation of cellular process GO:0048522 201 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
axon development GO:0061564 166 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.012
gtp metabolic process GO:0046039 4 0.012
cell cycle process GO:0022402 53 0.012
regulation of dendrite development GO:0050773 3 0.012
developmental maturation GO:0021700 34 0.012
circadian sleep wake cycle sleep GO:0050802 1 0.012
canonical wnt signaling pathway involved in heart development GO:0061316 1 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
neural tube formation GO:0001841 16 0.012
reproduction GO:0000003 40 0.012
positive regulation of neuron apoptotic process GO:0043525 1 0.012
gtp catabolic process GO:0006184 2 0.011
negative regulation of rna splicing GO:0033119 1 0.011
angiogenesis GO:0001525 158 0.011
nucleotide biosynthetic process GO:0009165 21 0.011
primary neural tube formation GO:0014020 1 0.011
oocyte anterior posterior axis specification GO:0007314 4 0.011
regulation of cell activation GO:0050865 1 0.011
small molecule metabolic process GO:0044281 77 0.011
system process GO:0003008 185 0.011
positive regulation of biological process GO:0048518 253 0.011
cell cell adhesion involved in mesendodermal cell migration GO:0003370 1 0.011
vasculature development GO:0001944 278 0.011
endodermal cell fate specification GO:0001714 17 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
peptide transport GO:0015833 1 0.011
establishment of localization GO:0051234 244 0.011
post golgi vesicle mediated transport GO:0006892 1 0.011
alpha amino acid metabolic process GO:1901605 3 0.011
negative regulation of catabolic process GO:0009895 3 0.011
rna localization GO:0006403 4 0.011
cell substrate adhesion GO:0031589 4 0.011
semicircular canal development GO:0060872 24 0.011
regulation of erythrocyte differentiation GO:0045646 2 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
camera type eye morphogenesis GO:0048593 108 0.011
cellular response to organic substance GO:0071310 105 0.011
sodium ion transport GO:0006814 24 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
cellular component disassembly GO:0022411 1 0.011
protein modification process GO:0036211 100 0.011
neural tube development GO:0021915 62 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
regulation of oocyte development GO:0060281 3 0.010
positive regulation of protein kinase b signaling GO:0051897 1 0.010
macromolecule modification GO:0043412 111 0.010
developmental growth involved in morphogenesis GO:0060560 86 0.010
nephron tubule morphogenesis GO:0072078 1 0.010
nerve development GO:0021675 45 0.010
regulation of erk1 and erk2 cascade GO:0070372 4 0.010
establishment of cell polarity GO:0030010 18 0.010
microtubule based process GO:0007017 60 0.010
cellular nitrogen compound biosynthetic process GO:0044271 218 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
adherens junction assembly GO:0034333 1 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
response to mechanical stimulus GO:0009612 24 0.010
hindbrain development GO:0030902 91 0.010
ear development GO:0043583 127 0.010
regulation of membrane potential GO:0042391 23 0.010
fin regeneration GO:0031101 51 0.010
maintenance of location GO:0051235 4 0.010
response to alcohol GO:0097305 14 0.010

dsg2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.183
muscular disease DOID:0080000 0 0.183
heart disease DOID:114 0 0.183
cardiomyopathy DOID:0050700 0 0.183
disease of anatomical entity DOID:7 0 0.183
cardiovascular system disease DOID:1287 0 0.183
musculoskeletal system disease DOID:17 0 0.183
muscle tissue disease DOID:66 0 0.183
intrinsic cardiomyopathy DOID:0060036 0 0.044
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.016
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.016
nervous system disease DOID:863 0 0.016
eye disease DOID:5614 0 0.016
organ system cancer DOID:0050686 0 0.012