Danio rerio

0 known processes

efnb2b

ephrin B2b

(Aliases: zeh0344,wu:fc10d03,hm:zeh0344)

efnb2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleobase containing compound biosynthetic process GO:0034654 205 0.171
regulation of biosynthetic process GO:0009889 250 0.162
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.147
cellular macromolecule biosynthetic process GO:0034645 224 0.146
generation of neurons GO:0048699 385 0.142
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.136
central nervous system development GO:0007417 387 0.133
Zebrafish
brain development GO:0007420 293 0.123
Zebrafish
regulation of primary metabolic process GO:0080090 311 0.123
cell motility GO:0048870 244 0.122
Human Zebrafish
biosynthetic process GO:0009058 294 0.116
cellular biosynthetic process GO:0044249 286 0.110
regulation of metabolic process GO:0019222 359 0.104
somitogenesis GO:0001756 87 0.102
Zebrafish
regulation of rna biosynthetic process GO:2001141 213 0.100
cellular macromolecule metabolic process GO:0044260 391 0.093
regulation of rna metabolic process GO:0051252 224 0.091
macromolecule biosynthetic process GO:0009059 227 0.089
regulation of cellular biosynthetic process GO:0031326 245 0.086
regulation of macromolecule metabolic process GO:0060255 317 0.084
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.083
organic cyclic compound biosynthetic process GO:1901362 223 0.082
tube morphogenesis GO:0035239 349 0.081
regulation of multicellular organismal process GO:0051239 277 0.080
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.080
gastrulation GO:0007369 208 0.079
stem cell proliferation GO:0072089 4 0.078
regionalization GO:0003002 274 0.077
Zebrafish
stem cell maintenance GO:0019827 4 0.077
cellular component movement GO:0006928 335 0.076
Human Zebrafish
organic substance biosynthetic process GO:1901576 289 0.075
transcription dna templated GO:0006351 181 0.074
aging GO:0007568 2 0.074
morphogenesis of an epithelium GO:0002009 333 0.074
anterior posterior pattern specification GO:0009952 152 0.074
Zebrafish
segmentation GO:0035282 97 0.073
Zebrafish
signal transduction GO:0007165 455 0.071
Human Worm
nucleic acid templated transcription GO:0097659 181 0.067
heterocycle biosynthetic process GO:0018130 215 0.063
larval development GO:0002164 2 0.062
cell surface receptor signaling pathway GO:0007166 325 0.062
Human Worm
aromatic compound biosynthetic process GO:0019438 217 0.062
cellular nitrogen compound biosynthetic process GO:0044271 218 0.061
regulation of cellular metabolic process GO:0031323 320 0.061
rna biosynthetic process GO:0032774 181 0.060
sensory organ development GO:0007423 393 0.060
somite development GO:0061053 96 0.060
Zebrafish
nucleobase containing compound metabolic process GO:0006139 274 0.060
regulation of gene expression GO:0010468 265 0.060
head development GO:0060322 303 0.059
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.058
nucleic acid metabolic process GO:0090304 244 0.058
nitrogen compound metabolic process GO:0006807 319 0.057
transcription from rna polymerase ii promoter GO:0006366 80 0.056
immune system process GO:0002376 241 0.055
embryo development ending in birth or egg hatching GO:0009792 271 0.055
Zebrafish Worm
neuron differentiation GO:0030182 353 0.055
Zebrafish
cell migration GO:0016477 237 0.055
Human Zebrafish
regulation of developmental process GO:0050793 247 0.055
Mouse
mesenchyme development GO:0060485 127 0.055
gene expression GO:0010467 252 0.052
cell morphogenesis involved in differentiation GO:0000904 195 0.051
Zebrafish
specification of symmetry GO:0009799 204 0.051
organic cyclic compound metabolic process GO:1901360 301 0.050
response to external stimulus GO:0009605 264 0.048
Human
cellular aromatic compound metabolic process GO:0006725 295 0.047
dorsal ventral pattern formation GO:0009953 125 0.047
locomotion GO:0040011 313 0.047
Human Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.046
muscle structure development GO:0061061 196 0.046
Mouse
heterocycle metabolic process GO:0046483 290 0.043
regulation of response to stimulus GO:0048583 269 0.043
Human
regulation of nucleic acid templated transcription GO:1903506 213 0.043
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.043
eye development GO:0001654 277 0.042
cell projection morphogenesis GO:0048858 244 0.042
Zebrafish
response to chemical GO:0042221 320 0.042
Human
rhombomere 5 development GO:0021571 4 0.042
muscle cell differentiation GO:0042692 139 0.042
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.041
rna metabolic process GO:0016070 219 0.040
localization of cell GO:0051674 244 0.040
Human Zebrafish
negative regulation of biological process GO:0048519 304 0.040
Mouse
rhombomere development GO:0021546 19 0.039
Zebrafish
modification dependent protein catabolic process GO:0019941 3 0.039
protein metabolic process GO:0019538 183 0.039
cell morphogenesis GO:0000902 289 0.039
Zebrafish
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.038
multicellular organism growth GO:0035264 4 0.038
cell fate commitment GO:0045165 99 0.037
maintenance of location GO:0051235 4 0.037
positive regulation of cellular process GO:0048522 201 0.036
Mouse
germ line stem cell maintenance GO:0030718 2 0.036
determination of bilateral symmetry GO:0009855 204 0.036
negative regulation of cellular process GO:0048523 283 0.035
Mouse
regulation of synapse assembly GO:0051963 3 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
cellular protein metabolic process GO:0044267 129 0.035
embryonic organ development GO:0048568 381 0.034
embryonic organ morphogenesis GO:0048562 274 0.034
digestive tract morphogenesis GO:0048546 231 0.033
secondary metabolic process GO:0019748 3 0.033
cellular protein catabolic process GO:0044257 4 0.033
positive regulation of cell cycle GO:0045787 3 0.033
blood vessel morphogenesis GO:0048514 216 0.033
Human Zebrafish Mouse
stem cell development GO:0048864 82 0.033
heart development GO:0007507 313 0.032
Mouse
chordate embryonic development GO:0043009 271 0.032
Zebrafish
establishment of localization GO:0051234 244 0.032
cellular component morphogenesis GO:0032989 336 0.032
Zebrafish
positive regulation of biological process GO:0048518 253 0.032
Mouse
mesenchymal cell differentiation GO:0048762 87 0.031
stem cell division GO:0017145 1 0.031
angiogenesis GO:0001525 158 0.031
Human
compound eye development GO:0048749 2 0.031
axon development GO:0061564 166 0.031
Zebrafish
neuroblast proliferation GO:0007405 2 0.030
sensory organ morphogenesis GO:0090596 200 0.030
modification dependent macromolecule catabolic process GO:0043632 3 0.030
regulation of transcription dna templated GO:0006355 213 0.030
cell fate specification GO:0001708 68 0.030
regulation of multicellular organismal development GO:2000026 223 0.030
Mouse
axonogenesis GO:0007409 152 0.029
Zebrafish
chemotaxis GO:0006935 104 0.029
Human
skeletal system development GO:0001501 181 0.028
digestive system development GO:0055123 289 0.028
regulation of cell communication GO:0010646 232 0.027
ubiquitin dependent protein catabolic process GO:0006511 3 0.027
b cell activation GO:0042113 2 0.027
regulation of epithelial cell proliferation GO:0050678 3 0.027
Mouse
phagocytosis GO:0006909 3 0.027
regulation of cell activation GO:0050865 1 0.027
regulation of reproductive process GO:2000241 4 0.026
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.026
Zebrafish
bmp signaling pathway GO:0030509 52 0.026
cellular response to external stimulus GO:0071496 2 0.026
spermatid development GO:0007286 2 0.025
regulation of cytokine production GO:0001817 3 0.025
regulation of signal transduction GO:0009966 225 0.025
female sex differentiation GO:0046660 4 0.025
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.024
immune system development GO:0002520 191 0.024
positive regulation of metabolic process GO:0009893 108 0.024
somatic muscle development GO:0007525 4 0.024
developmental growth GO:0048589 166 0.024
nuclear transport GO:0051169 4 0.024
stem cell differentiation GO:0048863 117 0.024
positive regulation of transport GO:0051050 2 0.023
spermatid differentiation GO:0048515 2 0.023
nucleocytoplasmic transport GO:0006913 4 0.022
embryonic heart tube development GO:0035050 133 0.022
forebrain development GO:0030900 96 0.022
connective tissue development GO:0061448 99 0.022
oxoacid metabolic process GO:0043436 31 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
regulation of synapse organization GO:0050807 3 0.022
hematopoietic or lymphoid organ development GO:0048534 191 0.021
regulation of embryonic development GO:0045995 47 0.021
mesenchymal cell development GO:0014031 78 0.021
positive regulation of gene expression GO:0010628 71 0.021
vasculature development GO:0001944 278 0.021
Human Zebrafish Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.021
inner ear development GO:0048839 126 0.021
regulation of cell differentiation GO:0045595 142 0.021
Mouse
cell projection organization GO:0030030 284 0.020
Zebrafish
sensory system development GO:0048880 76 0.020
organic acid metabolic process GO:0006082 31 0.020
convergent extension GO:0060026 118 0.020
guanosine containing compound metabolic process GO:1901068 4 0.020
muscle tissue development GO:0060537 110 0.020
Mouse
regulation of stem cell differentiation GO:2000736 4 0.020
neural crest cell differentiation GO:0014033 72 0.020
regulation of biological quality GO:0065008 263 0.020
growth GO:0040007 174 0.020
olfactory bulb development GO:0021772 4 0.020
response to organic substance GO:0010033 153 0.020
organelle assembly GO:0070925 110 0.020
neuron development GO:0048666 262 0.020
Zebrafish
nuclear import GO:0051170 3 0.019
cell part morphogenesis GO:0032990 246 0.019
Zebrafish
digestive tract development GO:0048565 265 0.019
taxis GO:0042330 109 0.019
Human
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
regulation of stem cell proliferation GO:0072091 2 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.019
ameboidal type cell migration GO:0001667 143 0.019
Human
establishment of protein localization to organelle GO:0072594 4 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
programmed cell death GO:0012501 119 0.018
regulation of jun kinase activity GO:0043506 3 0.018
eye morphogenesis GO:0048592 144 0.018
regulation of cell shape GO:0008360 1 0.018
ear development GO:0043583 127 0.018
lipid storage GO:0019915 1 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
negative regulation of rna metabolic process GO:0051253 48 0.018
epithelial cell differentiation GO:0030855 116 0.018
diencephalon development GO:0021536 58 0.017
protein modification process GO:0036211 100 0.017
regulation of protein ubiquitination GO:0031396 3 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
determination of left right symmetry GO:0007368 179 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
amine metabolic process GO:0009308 2 0.017
neuron projection guidance GO:0097485 86 0.017
skin development GO:0043588 54 0.017
Worm
neural precursor cell proliferation GO:0061351 20 0.017
striated muscle tissue development GO:0014706 110 0.017
Mouse
cartilage development GO:0051216 96 0.017
epidermal cell fate specification GO:0009957 4 0.017
tissue remodeling GO:0048771 4 0.017
regulation of bmp signaling pathway GO:0030510 39 0.017
blood vessel development GO:0001568 246 0.017
Human Zebrafish Mouse
hindbrain development GO:0030902 91 0.017
Zebrafish
positive regulation of rna metabolic process GO:0051254 59 0.017
single organism metabolic process GO:0044710 217 0.017
negative regulation of gene expression GO:0010629 65 0.017
protein import GO:0017038 3 0.016
immune response GO:0006955 28 0.016
positive regulation of biosynthetic process GO:0009891 68 0.016
regulation of protein transport GO:0051223 3 0.016
regulation of signaling GO:0023051 235 0.016
neuron projection morphogenesis GO:0048812 161 0.016
Zebrafish
regulation of tube size GO:0035150 2 0.016
mesoderm morphogenesis GO:0048332 51 0.016
enzyme linked receptor protein signaling pathway GO:0007167 106 0.016
Human Worm
mitotic cell cycle GO:0000278 64 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
positive regulation of neural precursor cell proliferation GO:2000179 1 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.015
meiotic nuclear division GO:0007126 4 0.015
regulation of binding GO:0051098 3 0.015
rostrocaudal neural tube patterning GO:0021903 29 0.015
neuron projection development GO:0031175 180 0.015
Zebrafish
protein targeting to nucleus GO:0044744 3 0.015
response to external biotic stimulus GO:0043207 97 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.015
multi organism process GO:0051704 134 0.015
cell cycle GO:0007049 93 0.015
protein secretion GO:0009306 1 0.015
heart morphogenesis GO:0003007 156 0.015
striated muscle cell differentiation GO:0051146 129 0.015
Mouse
i kappab kinase nf kappab signaling GO:0007249 4 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
heart looping GO:0001947 94 0.015
positive regulation of rna biosynthetic process GO:1902680 57 0.015
skeletal muscle organ development GO:0060538 78 0.015
chemosensory behavior GO:0007635 1 0.014
negative regulation of developmental process GO:0051093 65 0.014
lateral line development GO:0048882 66 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
negative regulation of response to stimulus GO:0048585 104 0.014
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.014
regulation of neurogenesis GO:0050767 87 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
single organism transport GO:0044765 206 0.014
cell migration involved in gastrulation GO:0042074 79 0.014
phagocytosis engulfment GO:0006911 1 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.014
negative regulation of metabolic process GO:0009892 86 0.014
cellular component assembly GO:0022607 170 0.014
hemopoiesis GO:0030097 183 0.014
negative regulation of cell differentiation GO:0045596 46 0.014
positive regulation of catabolic process GO:0009896 4 0.014
rhombomere formation GO:0021594 12 0.013
Zebrafish
epidermis development GO:0008544 48 0.013
Worm
kidney development GO:0001822 92 0.013
epidermal cell differentiation GO:0009913 36 0.013
camera type eye development GO:0043010 222 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
regulation of cell projection assembly GO:0060491 4 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
small molecule metabolic process GO:0044281 77 0.013
negative regulation of signal transduction GO:0009968 94 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
negative regulation of defense response GO:0031348 2 0.013
positive regulation of jnk cascade GO:0046330 3 0.013
homeostatic process GO:0042592 142 0.013
cellular ketone metabolic process GO:0042180 11 0.013
regulation of protein targeting GO:1903533 2 0.013
positive regulation of notch signaling pathway GO:0045747 3 0.013
lamellipodium organization GO:0097581 1 0.013
positive regulation of nucleic acid templated transcription GO:1903508 57 0.013
embryonic eye morphogenesis GO:0048048 30 0.013
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.013
regulation of catalytic activity GO:0050790 55 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
macromolecule modification GO:0043412 111 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
reproduction GO:0000003 40 0.013
Worm
system process GO:0003008 185 0.013
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
epithelial to mesenchymal transition GO:0001837 21 0.012
mesoderm development GO:0007498 88 0.012
neural tube development GO:0021915 62 0.012
nuclear export GO:0051168 1 0.012
cognition GO:0050890 1 0.012
protein acetylation GO:0006473 2 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
cellular protein modification process GO:0006464 100 0.012
protein localization to nucleus GO:0034504 3 0.012
positive regulation of secretion GO:0051047 1 0.012
cellular response to biotic stimulus GO:0071216 3 0.012
leukocyte proliferation GO:0070661 1 0.012
morphogenesis of an epithelial sheet GO:0002011 49 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
negative regulation of kinase activity GO:0033673 4 0.012
single organism localization GO:1902578 225 0.012
protein stabilization GO:0050821 2 0.012
cell proliferation GO:0008283 80 0.012
Mouse
organelle organization GO:0006996 227 0.012
protein complex localization GO:0031503 1 0.012
cellular response to organic substance GO:0071310 105 0.012
protein import into nucleus GO:0006606 3 0.012
lateral line system development GO:0048925 76 0.012
regulation of protein complex assembly GO:0043254 3 0.012
gtp catabolic process GO:0006184 2 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
single organism nuclear import GO:1902593 3 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
central nervous system neuron differentiation GO:0021953 74 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
hormone transport GO:0009914 2 0.012
regulation of wnt signaling pathway GO:0030111 53 0.012
lamellipodium assembly GO:0030032 1 0.012
response to wounding GO:0009611 116 0.012
camera type eye morphogenesis GO:0048593 108 0.012
somite specification GO:0001757 12 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.012
regulation of protein catabolic process GO:0042176 1 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
startle response GO:0001964 4 0.011
cellular amine metabolic process GO:0044106 2 0.011
b cell differentiation GO:0030183 1 0.011
response to carbohydrate GO:0009743 3 0.011
positive regulation of cell activation GO:0050867 1 0.011
female gonad development GO:0008585 4 0.011
pituitary gland development GO:0021983 16 0.011
positive regulation of immune effector process GO:0002699 3 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.011
mechanosensory lateral line system development GO:0048881 49 0.011
neural crest formation GO:0014029 14 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
inner ear morphogenesis GO:0042472 63 0.011
post embryonic organ development GO:0048569 4 0.011
neurotransmitter transport GO:0006836 2 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
circulatory system process GO:0003013 87 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
peptide transport GO:0015833 1 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
negative regulation of cytokine production GO:0001818 1 0.011
cellular component biogenesis GO:0044085 178 0.011
embryonic pattern specification GO:0009880 44 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
gland development GO:0048732 143 0.011
regulation of organ growth GO:0046620 3 0.011
exocytosis GO:0006887 1 0.011
single organism organelle organization GO:1902589 199 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
determination of dorsal ventral asymmetry GO:0048262 34 0.011
positive regulation of striated muscle tissue development GO:0045844 1 0.011
Mouse
organonitrogen compound metabolic process GO:1901564 74 0.011
otic vesicle morphogenesis GO:0071600 34 0.011
wound healing GO:0042060 90 0.011
apoptotic process GO:0006915 116 0.011
muscle cell development GO:0055001 115 0.010
renal system development GO:0072001 94 0.010
positive regulation of cellular component biogenesis GO:0044089 3 0.010
regulation of locomotion GO:0040012 55 0.010
Human
development of primary female sexual characteristics GO:0046545 4 0.010
epithelial tube morphogenesis GO:0060562 148 0.010
neural tube patterning GO:0021532 33 0.010
regulation of programmed cell death GO:0043067 101 0.010
wnt signaling pathway GO:0016055 80 0.010
somatic cell dna recombination GO:0016444 1 0.010
somatic stem cell maintenance GO:0035019 1 0.010
guanosine containing compound catabolic process GO:1901069 2 0.010
gtp metabolic process GO:0046039 4 0.010
transport GO:0006810 220 0.010
axon guidance GO:0007411 86 0.010

efnb2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
nervous system disease DOID:863 0 0.031
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014