Danio rerio

0 known processes

egfl6

EGF-like-domain, multiple 6

(Aliases: sb:cb3,wu:fc66b04,zgc:92328)

egfl6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.401
larval development GO:0002164 2 0.288
morphogenesis of an epithelium GO:0002009 333 0.259
positive regulation of cellular component biogenesis GO:0044089 3 0.215
regulation of cell communication GO:0010646 232 0.208
locomotion GO:0040011 313 0.180
cartilage development GO:0051216 96 0.177
regulation of response to stimulus GO:0048583 269 0.153
positive regulation of biological process GO:0048518 253 0.135
cellular aromatic compound metabolic process GO:0006725 295 0.131
regulation of cellular metabolic process GO:0031323 320 0.129
organic substance biosynthetic process GO:1901576 289 0.129
nitrogen compound metabolic process GO:0006807 319 0.125
cellular component biogenesis GO:0044085 178 0.122
regulation of anatomical structure morphogenesis GO:0022603 130 0.119
regulation of blood pressure GO:0008217 1 0.114
regulation of metabolic process GO:0019222 359 0.114
response to external stimulus GO:0009605 264 0.108
tube morphogenesis GO:0035239 349 0.101
positive regulation of cellular process GO:0048522 201 0.099
cellular nitrogen compound biosynthetic process GO:0044271 218 0.097
nucleobase containing compound metabolic process GO:0006139 274 0.095
regulation of synapse organization GO:0050807 3 0.091
cell motility GO:0048870 244 0.090
organonitrogen compound metabolic process GO:1901564 74 0.089
biosynthetic process GO:0009058 294 0.083
reproductive process GO:0022414 40 0.083
regulation of signal transduction GO:0009966 225 0.081
stem cell proliferation GO:0072089 4 0.078
embryo development ending in birth or egg hatching GO:0009792 271 0.074
rhombomere 4 morphogenesis GO:0021661 5 0.074
dorsal ventral pattern formation GO:0009953 125 0.073
connective tissue development GO:0061448 99 0.071
stem cell maintenance GO:0019827 4 0.071
mesodermal cell differentiation GO:0048333 21 0.071
protein localization to nucleus GO:0034504 3 0.071
regulation of developmental process GO:0050793 247 0.071
regulation of biological quality GO:0065008 263 0.068
response to stress GO:0006950 263 0.066
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.066
sensory organ development GO:0007423 393 0.065
signal transduction GO:0007165 455 0.064
single organism metabolic process GO:0044710 217 0.064
skeletal muscle organ development GO:0060538 78 0.064
cellular macromolecule biosynthetic process GO:0034645 224 0.063
muscle organ development GO:0007517 101 0.061
cellular component assembly GO:0022607 170 0.061
regulation of signaling GO:0023051 235 0.060
wound healing GO:0042060 90 0.059
skeletal system development GO:0001501 181 0.058
cell surface receptor signaling pathway GO:0007166 325 0.058
heterocycle metabolic process GO:0046483 290 0.057
cellular biosynthetic process GO:0044249 286 0.057
small molecule metabolic process GO:0044281 77 0.056
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.054
regulation of gene expression GO:0010468 265 0.052
response to organic substance GO:0010033 153 0.052
response to drug GO:0042493 3 0.051
rhombomere 4 development GO:0021570 5 0.050
regulation of transcription dna templated GO:0006355 213 0.050
synaptic growth at neuromuscular junction GO:0051124 2 0.050
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.049
cellular amino acid metabolic process GO:0006520 7 0.048
protein modification process GO:0036211 100 0.048
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.046
multi organism process GO:0051704 134 0.045
immune system development GO:0002520 191 0.045
positive regulation of cell communication GO:0010647 56 0.045
response to chemical GO:0042221 320 0.045
negative regulation of kinase activity GO:0033673 4 0.044
hematopoietic progenitor cell differentiation GO:0002244 23 0.044
regionalization GO:0003002 274 0.044
response to wounding GO:0009611 116 0.042
positive regulation of metabolic process GO:0009893 108 0.042
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.042
oxoacid metabolic process GO:0043436 31 0.042
stem cell differentiation GO:0048863 117 0.042
central nervous system development GO:0007417 387 0.041
tissue regeneration GO:0042246 74 0.041
formation of primary germ layer GO:0001704 62 0.041
cellular nitrogen compound metabolic process GO:0034641 290 0.041
primary neural tube formation GO:0014020 1 0.040
rna metabolic process GO:0016070 219 0.040
regulation of cellular component organization GO:0051128 86 0.040
establishment of localization in cell GO:0051649 77 0.040
organic cyclic compound metabolic process GO:1901360 301 0.039
compound eye development GO:0048749 2 0.038
regulation of reproductive process GO:2000241 4 0.038
negative regulation of biological process GO:0048519 304 0.037
regulation of cell differentiation GO:0045595 142 0.036
regulation of stem cell differentiation GO:2000736 4 0.035
single organism nuclear import GO:1902593 3 0.035
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.035
gastrulation GO:0007369 208 0.034
protein import GO:0017038 3 0.034
cell projection organization GO:0030030 284 0.033
protein metabolic process GO:0019538 183 0.033
death GO:0016265 121 0.033
extracellular matrix organization GO:0030198 27 0.033
regulation of protein transport GO:0051223 3 0.033
notch signaling pathway GO:0007219 35 0.033
regulation of multicellular organismal process GO:0051239 277 0.033
heterocycle biosynthetic process GO:0018130 215 0.032
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
developmental growth GO:0048589 166 0.032
mesoderm formation GO:0001707 43 0.031
nucleobase containing compound biosynthetic process GO:0034654 205 0.031
generation of neurons GO:0048699 385 0.031
organic acid metabolic process GO:0006082 31 0.031
regulation of synapse assembly GO:0051963 3 0.031
digestive tract development GO:0048565 265 0.031
maintenance of location GO:0051235 4 0.031
digestive system development GO:0055123 289 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.030
macromolecule biosynthetic process GO:0009059 227 0.030
single organism organelle organization GO:1902589 199 0.030
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.030
regulation of cell morphogenesis GO:0022604 42 0.029
multicellular organism growth GO:0035264 4 0.029
positive regulation of cellular biosynthetic process GO:0031328 68 0.029
negative regulation of mapk cascade GO:0043409 4 0.029
secondary metabolic process GO:0019748 3 0.029
tube closure GO:0060606 1 0.029
positive regulation of nucleic acid templated transcription GO:1903508 57 0.028
cell morphogenesis GO:0000902 289 0.028
immune system process GO:0002376 241 0.028
cellular response to external stimulus GO:0071496 2 0.027
response to vitamin GO:0033273 3 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
cellular localization GO:0051641 97 0.026
positive regulation of neuron apoptotic process GO:0043525 1 0.026
negative regulation of multicellular organismal process GO:0051241 69 0.026
positive regulation of transcription dna templated GO:0045893 57 0.025
amine metabolic process GO:0009308 2 0.025
regulation of biosynthetic process GO:0009889 250 0.025
mitotic cell cycle process GO:1903047 48 0.025
positive regulation of cytoskeleton organization GO:0051495 3 0.025
gene expression GO:0010467 252 0.025
chondrocyte development GO:0002063 4 0.025
regulation of erk1 and erk2 cascade GO:0070372 4 0.025
regulation of locomotion GO:0040012 55 0.024
regulation of protein metabolic process GO:0051246 56 0.024
skeletal system morphogenesis GO:0048705 102 0.024
protein import into nucleus GO:0006606 3 0.024
digestive tract morphogenesis GO:0048546 231 0.023
regulation of cell shape GO:0008360 1 0.023
single organism localization GO:1902578 225 0.023
phosphorus metabolic process GO:0006793 109 0.023
positive regulation of cell cycle GO:0045787 3 0.023
cellular component morphogenesis GO:0032989 336 0.023
actomyosin structure organization GO:0031032 53 0.022
regulation of stem cell proliferation GO:0072091 2 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
sarcomere organization GO:0045214 26 0.022
macromolecular complex subunit organization GO:0043933 74 0.022
brain development GO:0007420 293 0.022
cellular protein modification process GO:0006464 100 0.022
trabecula formation GO:0060343 2 0.022
adult behavior GO:0030534 2 0.022
mesenchymal cell development GO:0014031 78 0.022
actin filament based process GO:0030029 64 0.022
angiogenesis GO:0001525 158 0.022
embryonic organ development GO:0048568 381 0.021
negative regulation of cellular process GO:0048523 283 0.021
negative regulation of cell projection organization GO:0031345 9 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
negative regulation of programmed cell death GO:0043069 58 0.021
response to amino acid GO:0043200 2 0.021
transcription dna templated GO:0006351 181 0.021
regulation of gastrulation GO:0010470 24 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
sympathetic ganglion development GO:0061549 2 0.021
sensory organ morphogenesis GO:0090596 200 0.021
actin cytoskeleton organization GO:0030036 63 0.021
nuclear import GO:0051170 3 0.021
protein secretion GO:0009306 1 0.021
intracellular estrogen receptor signaling pathway GO:0030520 3 0.021
atp catabolic process GO:0006200 4 0.021
regulation of rna metabolic process GO:0051252 224 0.021
multicellular organismal reproductive process GO:0048609 35 0.020
multicellular organismal water homeostasis GO:0050891 1 0.020
positive regulation of rna biosynthetic process GO:1902680 57 0.020
regulation of neurogenesis GO:0050767 87 0.020
phagocytosis GO:0006909 3 0.020
regulation of phosphate metabolic process GO:0019220 43 0.020
negative regulation of epithelial cell migration GO:0010633 1 0.020
cellular macromolecule localization GO:0070727 21 0.020
blood circulation GO:0008015 87 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.020
regulation of sodium ion transport GO:0002028 2 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
negative regulation of response to stimulus GO:0048585 104 0.020
negative regulation of biosynthetic process GO:0009890 55 0.019
neuroblast proliferation GO:0007405 2 0.019
ossification GO:0001503 23 0.019
cell death GO:0008219 121 0.019
wnt signaling pathway GO:0016055 80 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
extracellular structure organization GO:0043062 27 0.019
cellular amide metabolic process GO:0043603 4 0.019
ear development GO:0043583 127 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
single organism membrane organization GO:0044802 20 0.018
negative regulation of protein kinase activity GO:0006469 4 0.018
neuron projection morphogenesis GO:0048812 161 0.018
mesenchymal cell differentiation GO:0048762 87 0.018
enzyme linked receptor protein signaling pathway GO:0007167 106 0.018
embryonic skeletal system development GO:0048706 97 0.018
striated muscle cell development GO:0055002 108 0.018
nuclear transport GO:0051169 4 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
nucleic acid templated transcription GO:0097659 181 0.018
signal transduction by phosphorylation GO:0023014 18 0.018
neural keel formation GO:0014025 1 0.017
regulation of cell development GO:0060284 100 0.017
actin mediated cell contraction GO:0070252 1 0.017
heart development GO:0007507 313 0.017
regulation of rna biosynthetic process GO:2001141 213 0.017
growth plate cartilage development GO:0003417 2 0.017
neuron differentiation GO:0030182 353 0.017
basement membrane assembly GO:0070831 3 0.017
erk1 and erk2 cascade GO:0070371 4 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.017
negative regulation of developmental process GO:0051093 65 0.016
sympathetic nervous system development GO:0048485 3 0.016
regulation of primary metabolic process GO:0080090 311 0.016
eye development GO:0001654 277 0.016
protein complex subunit organization GO:0071822 46 0.016
head development GO:0060322 303 0.016
organelle organization GO:0006996 227 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
positive regulation of response to stimulus GO:0048584 80 0.016
circulatory system process GO:0003013 87 0.015
cell substrate adhesion GO:0031589 4 0.015
positive regulation of transport GO:0051050 2 0.015
cellular component movement GO:0006928 335 0.015
stem cell development GO:0048864 82 0.015
rna biosynthetic process GO:0032774 181 0.015
cell migration involved in gastrulation GO:0042074 79 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
lateral line development GO:0048882 66 0.015
macromolecule modification GO:0043412 111 0.015
negative regulation of neuron differentiation GO:0045665 10 0.015
positive regulation of neuron death GO:1901216 1 0.015
positive regulation of protein kinase b signaling GO:0051897 1 0.015
regeneration GO:0031099 91 0.015
establishment of localization GO:0051234 244 0.015
positive regulation of neural precursor cell proliferation GO:2000179 1 0.015
monoamine transport GO:0015844 1 0.015
regulation of tube size GO:0035150 2 0.015
cell fate commitment GO:0045165 99 0.015
cellular protein metabolic process GO:0044267 129 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
negative regulation of embryonic development GO:0045992 11 0.015
nucleic acid metabolic process GO:0090304 244 0.015
non canonical wnt signaling pathway GO:0035567 13 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.014
negative regulation of stem cell differentiation GO:2000737 2 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.014
regulation of intracellular signal transduction GO:1902531 57 0.014
glucose homeostasis GO:0042593 1 0.014
negative regulation of metabolic process GO:0009892 86 0.014
multicellular organism reproduction GO:0032504 35 0.014
otolith development GO:0048840 32 0.014
g1 s transition of mitotic cell cycle GO:0000082 1 0.014
response to oxygen containing compound GO:1901700 55 0.014
response to nutrient GO:0007584 3 0.014
protein targeting to nucleus GO:0044744 3 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
regulation of molecular function GO:0065009 70 0.014
embryonic viscerocranium morphogenesis GO:0048703 52 0.013
axonogenesis GO:0007409 152 0.013
mesodermal cell fate specification GO:0007501 12 0.013
positive regulation of notch signaling pathway GO:0045747 3 0.013
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 1 0.013
post embryonic organ development GO:0048569 4 0.013
membrane repolarization GO:0086009 2 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
determination of bilateral symmetry GO:0009855 204 0.013
cell migration GO:0016477 237 0.013
appendage morphogenesis GO:0035107 56 0.013
neuron projection development GO:0031175 180 0.013
basement membrane organization GO:0071711 5 0.013
sensory perception of smell GO:0007608 2 0.013
small gtpase mediated signal transduction GO:0007264 8 0.012
inner ear development GO:0048839 126 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
regulation of neuron projection development GO:0010975 40 0.012
regulation of protein complex assembly GO:0043254 3 0.012
dendrite guidance GO:0070983 0 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
mesodermal cell fate commitment GO:0001710 14 0.012
cellular response to organic substance GO:0071310 105 0.012
regulation of hydrolase activity GO:0051336 28 0.012
regulation of cell proliferation GO:0042127 37 0.012
body morphogenesis GO:0010171 16 0.012
mesoderm morphogenesis GO:0048332 51 0.012
positive regulation of multicellular organismal process GO:0051240 52 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
transport GO:0006810 220 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
gland development GO:0048732 143 0.012
lens fiber cell development GO:0070307 3 0.012
regulation of cellular response to growth factor stimulus GO:0090287 35 0.012
membrane organization GO:0061024 21 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
regulation of cellular amine metabolic process GO:0033238 0 0.012
carboxylic acid catabolic process GO:0046395 3 0.012
camera type eye morphogenesis GO:0048593 108 0.012
regulation of epithelial to mesenchymal transition GO:0010717 3 0.012
negative regulation of endothelial cell migration GO:0010596 1 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
peptide metabolic process GO:0006518 1 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
negative regulation of mitosis GO:0045839 3 0.011
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.011
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.011
protein stabilization GO:0050821 2 0.011
cell migration involved in vasculogenesis GO:0035441 1 0.011
fin regeneration GO:0031101 51 0.011
homeostatic process GO:0042592 142 0.011
actin filament based movement GO:0030048 1 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
positive regulation of signaling GO:0023056 56 0.011
negative regulation of signaling GO:0023057 96 0.011
mesoderm development GO:0007498 88 0.011
phosphorylation GO:0016310 69 0.011
regulation of synapse structure and activity GO:0050803 5 0.011
positive regulation of secretion GO:0051047 1 0.011
protein trimerization GO:0070206 4 0.011
multi organism reproductive process GO:0044703 36 0.011
cytoskeleton organization GO:0007010 96 0.011
muscle fiber development GO:0048747 52 0.011
negative regulation of intracellular signal transduction GO:1902532 22 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
branching morphogenesis of a nerve GO:0048755 4 0.011
cell projection morphogenesis GO:0048858 244 0.011
mapk cascade GO:0000165 18 0.011
regulation of behavior GO:0050795 24 0.011
organelle assembly GO:0070925 110 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
regulation of axonogenesis GO:0050770 32 0.011
muscle cell development GO:0055001 115 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.011
apoptotic process GO:0006915 116 0.011
regulation of cytokine production GO:0001817 3 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
olfactory placode development GO:0071698 12 0.010
segmentation GO:0035282 97 0.010
determination of left right symmetry GO:0007368 179 0.010
eye morphogenesis GO:0048592 144 0.010
cell proliferation GO:0008283 80 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
regulation of catalytic activity GO:0050790 55 0.010
regulation of blood vessel size GO:0050880 2 0.010
regulation of mapk cascade GO:0043408 14 0.010
cell part morphogenesis GO:0032990 246 0.010
programmed cell death GO:0012501 119 0.010
neuron development GO:0048666 262 0.010
regulation of positive chemotaxis GO:0050926 4 0.010
embryonic digestive tract development GO:0048566 4 0.010

egfl6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.217
bone disease DOID:0080001 0 0.066
musculoskeletal system disease DOID:17 0 0.066
connective tissue disease DOID:65 0 0.066
charcot marie tooth disease type 4 DOID:0050541 0 0.044
neuropathy DOID:870 0 0.044
nervous system disease DOID:863 0 0.044
charcot marie tooth disease DOID:10595 0 0.044
neuromuscular disease DOID:440 0 0.044
bone development disease DOID:0080006 0 0.028
intestinal cancer DOID:10155 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
colorectal cancer DOID:9256 0 0.011
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011
large intestine cancer DOID:5672 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011
colon cancer DOID:219 0 0.011
colon carcinoma DOID:1520 0 0.011
osteochondrodysplasia DOID:2256 0 0.011
cardiovascular system disease DOID:1287 0 0.010