Danio rerio

0 known processes

eif2c4

eukaryotic translation initiation factor 2C, 4

eif2c4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of neurological system process GO:0031644 2 0.428
response to dsrna GO:0043331 7 0.223
cognition GO:0050890 1 0.204
stem cell maintenance GO:0019827 4 0.183
multicellular organism growth GO:0035264 4 0.174
regulation of multicellular organism growth GO:0040014 4 0.174
periodic partitioning GO:0007365 1 0.173
aging GO:0007568 2 0.161
metal ion transport GO:0030001 58 0.145
brain development GO:0007420 293 0.128
cellular response to dsrna GO:0071359 1 0.125
larval development GO:0002164 2 0.124
germ line stem cell maintenance GO:0030718 2 0.119
system process GO:0003008 185 0.112
regulation of wound healing GO:0061041 2 0.111
single organism localization GO:1902578 225 0.106
cation transmembrane transport GO:0098655 65 0.102
regulation of gene expression GO:0010468 265 0.096
cellular nitrogen compound metabolic process GO:0034641 290 0.095
cation transport GO:0006812 81 0.095
stem cell development GO:0048864 82 0.095
developmental growth GO:0048589 166 0.090
chordate embryonic development GO:0043009 271 0.088
regulation of metabolic process GO:0019222 359 0.087
regionalization GO:0003002 274 0.077
segment polarity determination GO:0007367 1 0.077
chemosensory behavior GO:0007635 1 0.072
regulation of gene expression epigenetic GO:0040029 11 0.065
generation of neurons GO:0048699 385 0.061
organic cyclic compound metabolic process GO:1901360 301 0.059
cellular macromolecule metabolic process GO:0044260 391 0.058
cellular response to organic cyclic compound GO:0071407 38 0.057
heterocycle metabolic process GO:0046483 290 0.057
positive regulation of transport GO:0051050 2 0.055
autophagy GO:0006914 4 0.054
regulation of macromolecule metabolic process GO:0060255 317 0.053
heterocycle biosynthetic process GO:0018130 215 0.053
striated muscle cell differentiation GO:0051146 129 0.053
regulation of establishment of protein localization GO:0070201 4 0.052
rna processing GO:0006396 25 0.052
rna catabolic process GO:0006401 7 0.052
nitrogen compound metabolic process GO:0006807 319 0.050
regulation of behavior GO:0050795 24 0.050
mrna catabolic process GO:0006402 6 0.049
nuclear transport GO:0051169 4 0.046
positive regulation of wound healing GO:0090303 1 0.046
eye development GO:0001654 277 0.045
centrosome organization GO:0051297 1 0.045
response to chemical GO:0042221 320 0.045
maintenance of location GO:0051235 4 0.044
regulation of protein metabolic process GO:0051246 56 0.044
nucleocytoplasmic transport GO:0006913 4 0.044
segmentation GO:0035282 97 0.041
neuromast development GO:0048884 46 0.041
single organism metabolic process GO:0044710 217 0.041
cell migration GO:0016477 237 0.040
dsrna fragmentation GO:0031050 1 0.039
cellular component assembly GO:0022607 170 0.039
cellular response to extracellular stimulus GO:0031668 2 0.039
cellular aromatic compound metabolic process GO:0006725 295 0.039
posttranscriptional gene silencing GO:0016441 3 0.038
cell substrate adhesion GO:0031589 4 0.038
homeostatic process GO:0042592 142 0.038
organic substance biosynthetic process GO:1901576 289 0.038
positive regulation of cell cycle GO:0045787 3 0.037
locomotion GO:0040011 313 0.037
gene expression GO:0010467 252 0.037
skeletal muscle organ development GO:0060538 78 0.037
regulation of rna biosynthetic process GO:2001141 213 0.037
ion transport GO:0006811 114 0.036
transport GO:0006810 220 0.036
mrna cleavage involved in gene silencing by mirna GO:0035279 1 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
protein dephosphorylation GO:0006470 3 0.035
negative regulation of gene expression GO:0010629 65 0.035
gene silencing by mirna GO:0035195 3 0.035
regulation of cytoplasmic transport GO:1903649 4 0.035
positive regulation of developmental process GO:0051094 50 0.034
negative regulation of catabolic process GO:0009895 3 0.033
heart looping GO:0001947 94 0.033
morphogenesis of an epithelium GO:0002009 333 0.033
behavior GO:0007610 74 0.032
regulation of biological quality GO:0065008 263 0.032
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
protein localization to nucleus GO:0034504 3 0.032
cellular macromolecule catabolic process GO:0044265 12 0.032
embryonic pattern specification GO:0009880 44 0.031
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.031
catabolic process GO:0009056 32 0.031
rna metabolic process GO:0016070 219 0.030
cellular protein metabolic process GO:0044267 129 0.030
single organism transport GO:0044765 206 0.030
response to organic cyclic compound GO:0014070 51 0.030
cellular response to nutrient levels GO:0031669 2 0.029
small gtpase mediated signal transduction GO:0007264 8 0.029
organic substance catabolic process GO:1901575 28 0.029
mrna cleavage GO:0006379 1 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
cellular component biogenesis GO:0044085 178 0.029
adult behavior GO:0030534 2 0.029
regulation of response to stimulus GO:0048583 269 0.029
monovalent inorganic cation transport GO:0015672 42 0.028
transcription dna templated GO:0006351 181 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
nucleobase containing compound catabolic process GO:0034655 15 0.028
negative regulation of kinase activity GO:0033673 4 0.028
cellular response to chemical stimulus GO:0070887 157 0.027
protein import GO:0017038 3 0.027
carbon dioxide transport GO:0015670 3 0.027
negative regulation of macromolecule metabolic process GO:0010605 76 0.027
nuclear migration GO:0007097 3 0.027
multi organism process GO:0051704 134 0.027
cellular amine metabolic process GO:0044106 2 0.027
negative regulation of nucleic acid templated transcription GO:1903507 45 0.027
regulation of autophagy GO:0010506 3 0.026
regulation of protein transport GO:0051223 3 0.026
nitric oxide biosynthetic process GO:0006809 2 0.026
muscle structure development GO:0061061 196 0.026
embryonic heart tube development GO:0035050 133 0.026
negative regulation of translation GO:0017148 1 0.026
cellular macromolecule biosynthetic process GO:0034645 224 0.025
muscle cell development GO:0055001 115 0.025
amine metabolic process GO:0009308 2 0.025
regulation of transcription dna templated GO:0006355 213 0.025
protein metabolic process GO:0019538 183 0.025
cellular extravasation GO:0045123 1 0.025
microtubule organizing center organization GO:0031023 1 0.025
head development GO:0060322 303 0.024
response to nutrient GO:0007584 3 0.024
embryonic heart tube morphogenesis GO:0003143 108 0.024
signal transduction GO:0007165 455 0.024
cell projection organization GO:0030030 284 0.024
cellular response to organic substance GO:0071310 105 0.024
striated muscle tissue development GO:0014706 110 0.024
rna biosynthetic process GO:0032774 181 0.024
nuclear import GO:0051170 3 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
cellular biosynthetic process GO:0044249 286 0.024
embryo development ending in birth or egg hatching GO:0009792 271 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.023
mrna processing GO:0006397 14 0.023
nucleic acid templated transcription GO:0097659 181 0.023
establishment of localization GO:0051234 244 0.023
cell morphogenesis GO:0000902 289 0.023
nucleic acid metabolic process GO:0090304 244 0.022
hemopoiesis GO:0030097 183 0.022
aromatic compound biosynthetic process GO:0019438 217 0.022
peptide transport GO:0015833 1 0.022
regulation of metal ion transport GO:0010959 4 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
cellular response to external stimulus GO:0071496 2 0.022
positive regulation of ras protein signal transduction GO:0046579 1 0.021
cellular carbohydrate metabolic process GO:0044262 4 0.021
digestive system development GO:0055123 289 0.021
negative regulation of protein phosphorylation GO:0001933 4 0.021
heart development GO:0007507 313 0.021
ameboidal type cell migration GO:0001667 143 0.021
gtp catabolic process GO:0006184 2 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
regulation of calcium ion transport GO:0051924 2 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
guanosine containing compound catabolic process GO:1901069 2 0.020
stem cell differentiation GO:0048863 117 0.020
single organism behavior GO:0044708 24 0.020
cortical actin cytoskeleton organization GO:0030866 1 0.020
stem cell division GO:0017145 1 0.020
response to vitamin GO:0033273 3 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
posttranscriptional regulation of gene expression GO:0010608 14 0.020
sensory organ development GO:0007423 393 0.020
cell matrix adhesion GO:0007160 4 0.020
cellular nitrogen compound biosynthetic process GO:0044271 218 0.020
regulation of developmental process GO:0050793 247 0.020
gene silencing GO:0016458 4 0.019
muscle tissue development GO:0060537 110 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
cortical cytoskeleton organization GO:0030865 1 0.019
cranial nerve development GO:0021545 42 0.019
establishment of localization in cell GO:0051649 77 0.019
somatic muscle development GO:0007525 4 0.019
striated muscle cell development GO:0055002 108 0.019
digestive tract development GO:0048565 265 0.019
gtp metabolic process GO:0046039 4 0.018
compound eye development GO:0048749 2 0.018
cell aging GO:0007569 2 0.018
central nervous system development GO:0007417 387 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
adherens junction assembly GO:0034333 1 0.018
protein targeting to nucleus GO:0044744 3 0.018
photoreceptor cell outer segment organization GO:0035845 9 0.018
ribonucleoprotein complex biogenesis GO:0022613 13 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
cellular ketone metabolic process GO:0042180 11 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.018
single organism nuclear import GO:1902593 3 0.018
ribosomal small subunit biogenesis GO:0042274 2 0.018
apical junction assembly GO:0043297 1 0.018
ribonucleoprotein complex subunit organization GO:0071826 8 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
zinc ion homeostasis GO:0055069 1 0.017
neuron differentiation GO:0030182 353 0.017
negative regulation of biosynthetic process GO:0009890 55 0.017
myotube cell development GO:0014904 35 0.017
superoxide metabolic process GO:0006801 2 0.017
lipid metabolic process GO:0006629 52 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
mrna metabolic process GO:0016071 20 0.017
negative regulation of cellular catabolic process GO:0031330 3 0.017
regulation of growth rate GO:0040009 1 0.017
negative regulation of cellular process GO:0048523 283 0.017
muscle fiber development GO:0048747 52 0.017
ph reduction GO:0045851 1 0.017
regulation of system process GO:0044057 40 0.017
negative regulation of ras protein signal transduction GO:0046580 1 0.017
muscle organ development GO:0007517 101 0.017
zinc ion transmembrane transport GO:0071577 1 0.017
regulation of ph GO:0006885 3 0.017
ras protein signal transduction GO:0007265 7 0.016
response to glucocorticoid GO:0051384 1 0.016
positive regulation of dna metabolic process GO:0051054 1 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
fatty acid transport GO:0015908 1 0.016
adherens junction organization GO:0034332 4 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
regulation of protein catabolic process GO:0042176 1 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
regulation of transporter activity GO:0032409 2 0.016
lipid storage GO:0019915 1 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
negative regulation of metabolic process GO:0009892 86 0.016
regulation of rna metabolic process GO:0051252 224 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
heart contraction GO:0060047 71 0.016
single organism membrane fusion GO:0044801 2 0.016
g1 s transition of mitotic cell cycle GO:0000082 1 0.016
organelle organization GO:0006996 227 0.016
positive regulation of secretion GO:0051047 1 0.016
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.016
organic cyclic compound catabolic process GO:1901361 15 0.016
regulation of intracellular signal transduction GO:1902531 57 0.016
somitogenesis GO:0001756 87 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
sodium ion import GO:0097369 3 0.015
forebrain cell migration GO:0021885 1 0.015
negative regulation of autophagy GO:0010507 1 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
positive regulation of biological process GO:0048518 253 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
gastrulation GO:0007369 208 0.015
nucleobase containing compound transport GO:0015931 2 0.015
meiosis i GO:0007127 1 0.015
peptidyl serine phosphorylation GO:0018105 1 0.015
regulation of primary metabolic process GO:0080090 311 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
death GO:0016265 121 0.015
regulation of gtpase activity GO:0043087 2 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
fertilization GO:0009566 3 0.014
regulation of mrna processing GO:0050684 3 0.014
digestive tract morphogenesis GO:0048546 231 0.014
actin filament based movement GO:0030048 1 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
regulation of dna replication GO:0006275 3 0.014
regulation of developmental growth GO:0048638 38 0.014
positive regulation of protein kinase b signaling GO:0051897 1 0.014
negative regulation of biological process GO:0048519 304 0.014
cellular nitrogen compound catabolic process GO:0044270 15 0.014
stem cell proliferation GO:0072089 4 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
mitochondrion organization GO:0007005 4 0.014
anterior posterior pattern specification GO:0009952 152 0.014
b cell activation GO:0042113 2 0.014
regulation of signal transduction GO:0009966 225 0.014
immune system development GO:0002520 191 0.014
meiotic cell cycle process GO:1903046 3 0.014
lateral line system development GO:0048925 76 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
regulation of dna templated transcription in response to stress GO:0043620 0 0.014
gene silencing by rna GO:0031047 4 0.014
determination of bilateral symmetry GO:0009855 204 0.014
divalent inorganic cation homeostasis GO:0072507 22 0.013
positive regulation of catabolic process GO:0009896 4 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
response to transition metal nanoparticle GO:1990267 28 0.013
regulation of cellular ph GO:0030641 1 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
response to uv GO:0009411 3 0.013
protein modification process GO:0036211 100 0.013
meiotic nuclear division GO:0007126 4 0.013
oxoacid metabolic process GO:0043436 31 0.013
vacuolar transport GO:0007034 2 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
zinc ion transport GO:0006829 2 0.013
sensory system development GO:0048880 76 0.013
protein polymerization GO:0051258 4 0.013
water homeostasis GO:0030104 4 0.013
cellular localization GO:0051641 97 0.013
cellular potassium ion transport GO:0071804 10 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
cellular response to xenobiotic stimulus GO:0071466 35 0.013
tube morphogenesis GO:0035239 349 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
ribonucleoprotein complex assembly GO:0022618 5 0.013
cellular response to light stimulus GO:0071482 4 0.013
neurological system process GO:0050877 62 0.013
regulation of binding GO:0051098 3 0.013
establishment of rna localization GO:0051236 3 0.013
regulation of cell differentiation GO:0045595 142 0.012
cellular response to oxygen levels GO:0071453 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
rna localization GO:0006403 4 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of dendrite development GO:0050773 3 0.012
regulation of transmembrane transport GO:0034762 18 0.012
regulation of synapse organization GO:0050807 3 0.012
cellular response to nitrogen compound GO:1901699 6 0.012
nitric oxide metabolic process GO:0046209 2 0.012
gamete generation GO:0007276 33 0.012
production of small rna involved in gene silencing by rna GO:0070918 1 0.012
organelle fusion GO:0048284 3 0.012
protein import into nucleus GO:0006606 3 0.012
membrane fusion GO:0061025 2 0.012
specification of symmetry GO:0009799 204 0.012
post embryonic organ development GO:0048569 4 0.012
somite development GO:0061053 96 0.012
regulation of biosynthetic process GO:0009889 250 0.012
cellular aldehyde metabolic process GO:0006081 4 0.012
protein complex localization GO:0031503 1 0.012
biosynthetic process GO:0009058 294 0.012
nuclear export GO:0051168 1 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
cell part morphogenesis GO:0032990 246 0.012
aromatic compound catabolic process GO:0019439 15 0.012
regulation of localization GO:0032879 104 0.012
centrosome duplication GO:0051298 1 0.012
regulation of cell activation GO:0050865 1 0.012
blastoderm segmentation GO:0007350 6 0.012
response to external stimulus GO:0009605 264 0.012
xenobiotic metabolic process GO:0006805 4 0.012
intracellular signal transduction GO:0035556 85 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
camera type eye development GO:0043010 222 0.012
mitochondrion morphogenesis GO:0070584 2 0.012
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.011
immune system process GO:0002376 241 0.011
regulation of translational initiation GO:0006446 1 0.011
centrosome cycle GO:0007098 1 0.011
cell projection morphogenesis GO:0048858 244 0.011
secondary metabolic process GO:0019748 3 0.011
androgen metabolic process GO:0008209 2 0.011
swimming behavior GO:0036269 8 0.011
organic acid metabolic process GO:0006082 31 0.011
phagocytosis engulfment GO:0006911 1 0.011
regulation of signaling GO:0023051 235 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
single fertilization GO:0007338 3 0.011
response to corticosteroid GO:0031960 1 0.011
sensory organ morphogenesis GO:0090596 200 0.011
regulation of intracellular ph GO:0051453 1 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
gas transport GO:0015669 3 0.011
chromosome organization involved in meiosis GO:0070192 1 0.011
protein acetylation GO:0006473 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
response to ketone GO:1901654 1 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
negative regulation of signaling GO:0023057 96 0.011
rna 3 end processing GO:0031123 2 0.011
stem cell fate commitment GO:0048865 1 0.011
female germ line stem cell maintenance GO:0036099 1 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
cell motility GO:0048870 244 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
macromolecule modification GO:0043412 111 0.011
cellular component movement GO:0006928 335 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
heart morphogenesis GO:0003007 156 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
regulation of protein binding GO:0043393 3 0.011
hindbrain formation GO:0021576 3 0.011
endosomal transport GO:0016197 2 0.011
exocytosis GO:0006887 1 0.011
transmembrane transport GO:0055085 120 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.011
regulation of blood vessel size GO:0050880 2 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.011
response to organic substance GO:0010033 153 0.011
nucleic acid transport GO:0050657 2 0.010
growth GO:0040007 174 0.010
positive regulation of neuron death GO:1901216 1 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
alpha amino acid metabolic process GO:1901605 3 0.010
development of primary female sexual characteristics GO:0046545 4 0.010
spermatid differentiation GO:0048515 2 0.010
membrane invagination GO:0010324 1 0.010
estrogen metabolic process GO:0008210 2 0.010
production of mirnas involved in gene silencing by mirna GO:0035196 1 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
sarcomere organization GO:0045214 26 0.010
epithelial tube morphogenesis GO:0060562 148 0.010
startle response GO:0001964 4 0.010
positive regulation of cell activation GO:0050867 1 0.010
fat soluble vitamin metabolic process GO:0006775 4 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
cellular component maintenance GO:0043954 3 0.010
actin cytoskeleton organization GO:0030036 63 0.010
rho protein signal transduction GO:0007266 5 0.010
inorganic ion transmembrane transport GO:0098660 57 0.010

eif2c4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
muscular disease DOID:0080000 0 0.023
muscle tissue disease DOID:66 0 0.023
myopathy DOID:423 0 0.023
musculoskeletal system disease DOID:17 0 0.023
bone marrow disease DOID:4961 0 0.022
immune system disease DOID:2914 0 0.022
hematopoietic system disease DOID:74 0 0.022
anemia DOID:2355 0 0.020
aplastic anemia DOID:12449 0 0.020
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.016
connective tissue disease DOID:65 0 0.015
nervous system disease DOID:863 0 0.015
organ system cancer DOID:0050686 0 0.014
bone disease DOID:0080001 0 0.013