Danio rerio

18 known processes

eif4e

eukaryotic translation initiation factor 4e

(Aliases: eif4e-1,zgc:86680,eif4e1a)

eif4e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.426
death GO:0016265 121 0.384
establishment of localization GO:0051234 244 0.367
immune system process GO:0002376 241 0.319
apoptotic process GO:0006915 116 0.275
regulation of mrna processing GO:0050684 3 0.243
biosynthetic process GO:0009058 294 0.229
immune system development GO:0002520 191 0.194
hemopoiesis GO:0030097 183 0.193
programmed cell death GO:0012501 119 0.189
positive regulation of metabolic process GO:0009893 108 0.185
regulation of apoptotic process GO:0042981 98 0.180
meiotic chromosome segregation GO:0045132 3 0.179
cellular nitrogen compound metabolic process GO:0034641 290 0.179
regulation of metabolic process GO:0019222 359 0.173
organic substance biosynthetic process GO:1901576 289 0.158
cellular amine metabolic process GO:0044106 2 0.158
cell death GO:0008219 121 0.157
hematopoietic or lymphoid organ development GO:0048534 191 0.153
positive regulation of biological process GO:0048518 253 0.152
nuclear transport GO:0051169 4 0.132
amine metabolic process GO:0009308 2 0.120
regulation of programmed cell death GO:0043067 101 0.117
organonitrogen compound metabolic process GO:1901564 74 0.110
purine nucleoside monophosphate catabolic process GO:0009128 4 0.103
cellular component assembly GO:0022607 170 0.102
embryo development ending in birth or egg hatching GO:0009792 271 0.097
cellular component biogenesis GO:0044085 178 0.097
macromolecule biosynthetic process GO:0009059 227 0.096
regulation of macromolecule metabolic process GO:0060255 317 0.091
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.090
nucleocytoplasmic transport GO:0006913 4 0.088
modification dependent macromolecule catabolic process GO:0043632 3 0.087
cell cycle GO:0007049 93 0.085
alternative mrna splicing via spliceosome GO:0000380 1 0.081
muscle cell differentiation GO:0042692 139 0.080
positive regulation of cellular catabolic process GO:0031331 3 0.079
digestive system development GO:0055123 289 0.077
regulation of cellular biosynthetic process GO:0031326 245 0.077
regulation of cell death GO:0010941 103 0.076
cellular component movement GO:0006928 335 0.074
aging GO:0007568 2 0.073
positive regulation of cellular process GO:0048522 201 0.072
establishment of protein localization to organelle GO:0072594 4 0.071
cellular macromolecule biosynthetic process GO:0034645 224 0.068
hematopoietic progenitor cell differentiation GO:0002244 23 0.067
positive regulation of cellular metabolic process GO:0031325 94 0.067
protein import GO:0017038 3 0.065
single organism localization GO:1902578 225 0.064
myeloid cell differentiation GO:0030099 86 0.064
regulation of cellular metabolic process GO:0031323 320 0.063
ubiquitin dependent protein catabolic process GO:0006511 3 0.063
regulation of reproductive process GO:2000241 4 0.063
transport GO:0006810 220 0.063
regulation of multicellular organism growth GO:0040014 4 0.062
regulation of cell differentiation GO:0045595 142 0.062
regulation of establishment of protein localization GO:0070201 4 0.062
cell motility GO:0048870 244 0.062
morphogenesis of an epithelium GO:0002009 333 0.061
mrna splicing via spliceosome GO:0000398 10 0.061
heterocycle metabolic process GO:0046483 290 0.060
stem cell proliferation GO:0072089 4 0.059
multicellular organism growth GO:0035264 4 0.059
cellular response to dna damage stimulus GO:0006974 24 0.058
guanosine containing compound catabolic process GO:1901069 2 0.058
regionalization GO:0003002 274 0.056
regulation of cell shape GO:0008360 1 0.056
regulation of developmental process GO:0050793 247 0.056
heterocycle biosynthetic process GO:0018130 215 0.056
fertilization GO:0009566 3 0.055
embryonic organ development GO:0048568 381 0.055
mitochondrion organization GO:0007005 4 0.054
regulation of nitrogen compound metabolic process GO:0051171 251 0.054
intracellular signal transduction GO:0035556 85 0.052
regulation of gene expression GO:0010468 265 0.052
cellular macromolecule metabolic process GO:0044260 391 0.051
stem cell maintenance GO:0019827 4 0.050
leukocyte proliferation GO:0070661 1 0.049
cellular biosynthetic process GO:0044249 286 0.047
digestive tract development GO:0048565 265 0.047
gastrulation GO:0007369 208 0.047
regulation of rna biosynthetic process GO:2001141 213 0.047
negative regulation of programmed cell death GO:0043069 58 0.047
regulation of rna metabolic process GO:0051252 224 0.046
nitrogen compound metabolic process GO:0006807 319 0.046
regulation of primary metabolic process GO:0080090 311 0.045
regulation of multicellular organismal development GO:2000026 223 0.045
organic cyclic compound metabolic process GO:1901360 301 0.044
regulation of cytoplasmic transport GO:1903649 4 0.044
organonitrogen compound biosynthetic process GO:1901566 47 0.044
nuclear import GO:0051170 3 0.043
guanosine containing compound metabolic process GO:1901068 4 0.043
positive regulation of transport GO:0051050 2 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.042
cell migration GO:0016477 237 0.041
negative regulation of cellular process GO:0048523 283 0.041
protein targeting to nucleus GO:0044744 3 0.041
regulation of signal transduction GO:0009966 225 0.040
dna catabolic process GO:0006308 1 0.040
regulation of multicellular organismal process GO:0051239 277 0.040
b cell differentiation GO:0030183 1 0.039
embryonic organ morphogenesis GO:0048562 274 0.039
protein localization to nucleus GO:0034504 3 0.039
embryonic limb morphogenesis GO:0030326 2 0.038
localization of cell GO:0051674 244 0.038
cell morphogenesis GO:0000902 289 0.038
generation of neurons GO:0048699 385 0.038
rna metabolic process GO:0016070 219 0.037
single organism transport GO:0044765 206 0.036
cellular aromatic compound metabolic process GO:0006725 295 0.036
cellular response to chemical stimulus GO:0070887 157 0.036
cell proliferation GO:0008283 80 0.036
b cell activation GO:0042113 2 0.036
regulation of cellular amine metabolic process GO:0033238 0 0.036
regulation of mitochondrion organization GO:0010821 1 0.036
digestive tract morphogenesis GO:0048546 231 0.035
single organism metabolic process GO:0044710 217 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.035
blood vessel development GO:0001568 246 0.035
positive regulation of catalytic activity GO:0043085 25 0.034
cellular protein metabolic process GO:0044267 129 0.034
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.034
mononuclear cell proliferation GO:0032943 1 0.034
organelle assembly GO:0070925 110 0.034
establishment of localization in cell GO:0051649 77 0.034
spindle assembly GO:0051225 2 0.033
regulation of catalytic activity GO:0050790 55 0.033
cytoskeleton organization GO:0007010 96 0.032
signal transduction GO:0007165 455 0.032
positive regulation of response to stimulus GO:0048584 80 0.031
regulation of skeletal muscle tissue development GO:0048641 4 0.031
cellular macromolecular complex assembly GO:0034622 24 0.030
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.030
taxis GO:0042330 109 0.029
embryonic pattern specification GO:0009880 44 0.029
meiotic cell cycle process GO:1903046 3 0.029
single organism nuclear import GO:1902593 3 0.029
phosphorus metabolic process GO:0006793 109 0.029
rna biosynthetic process GO:0032774 181 0.028
negative regulation of cell death GO:0060548 60 0.028
response to monosaccharide GO:0034284 3 0.028
regulation of protein ubiquitination GO:0031396 3 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
neuron differentiation GO:0030182 353 0.027
cellular ketone metabolic process GO:0042180 11 0.027
cellular localization GO:0051641 97 0.027
oxoacid metabolic process GO:0043436 31 0.027
tube morphogenesis GO:0035239 349 0.027
atp catabolic process GO:0006200 4 0.027
positive regulation of catabolic process GO:0009896 4 0.027
positive regulation of dna metabolic process GO:0051054 1 0.026
positive regulation of cell cycle GO:0045787 3 0.026
vasculature development GO:0001944 278 0.026
rna splicing GO:0008380 16 0.026
regulation of intracellular protein transport GO:0033157 3 0.026
ribonucleoside monophosphate catabolic process GO:0009158 4 0.026
microtubule organizing center organization GO:0031023 1 0.025
negative regulation of apoptotic process GO:0043066 55 0.025
regulation of neuron differentiation GO:0045664 56 0.025
nucleic acid metabolic process GO:0090304 244 0.024
nucleic acid templated transcription GO:0097659 181 0.024
single fertilization GO:0007338 3 0.024
small molecule metabolic process GO:0044281 77 0.024
regulation of response to stimulus GO:0048583 269 0.024
nuclear export GO:0051168 1 0.024
cytokinesis GO:0000910 3 0.023
regulation of nucleoside metabolic process GO:0009118 2 0.023
cellular protein catabolic process GO:0044257 4 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.023
response to stress GO:0006950 263 0.022
macromolecular complex assembly GO:0065003 35 0.022
cellular component morphogenesis GO:0032989 336 0.022
aromatic compound biosynthetic process GO:0019438 217 0.022
lymphocyte proliferation GO:0046651 1 0.022
embryonic digestive tract development GO:0048566 4 0.022
catecholamine metabolic process GO:0006584 2 0.022
axis specification GO:0009798 43 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
neuron projection morphogenesis GO:0048812 161 0.022
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.022
regulation of anatomical structure morphogenesis GO:0022603 130 0.022
axon development GO:0061564 166 0.021
single organism cellular localization GO:1902580 46 0.021
centrosome cycle GO:0007098 1 0.021
gene expression GO:0010467 252 0.021
organic acid metabolic process GO:0006082 31 0.021
regulation of cell development GO:0060284 100 0.021
regulation of nucleocytoplasmic transport GO:0046822 2 0.021
phagocytosis GO:0006909 3 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
protein import into nucleus GO:0006606 3 0.021
negative regulation of cytoplasmic transport GO:1903650 2 0.021
protein metabolic process GO:0019538 183 0.021
protein polyubiquitination GO:0000209 4 0.021
heart development GO:0007507 313 0.021
nucleobase containing compound catabolic process GO:0034655 15 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
proteasomal protein catabolic process GO:0010498 2 0.020
gtp catabolic process GO:0006184 2 0.020
positive regulation of macromolecule metabolic process GO:0010604 93 0.020
maintenance of location GO:0051235 4 0.020
negative regulation of autophagy GO:0010507 1 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
dorsal ventral pattern formation GO:0009953 125 0.020
regulation of growth GO:0040008 42 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
regulation of neurogenesis GO:0050767 87 0.019
anterior posterior pattern specification GO:0009952 152 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.019
single organism organelle organization GO:1902589 199 0.019
chordate embryonic development GO:0043009 271 0.019
translational initiation GO:0006413 3 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.019
reproduction GO:0000003 40 0.019
regulation of mitotic cell cycle GO:0007346 25 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
stem cell differentiation GO:0048863 117 0.018
response to chemical GO:0042221 320 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
stem cell fate commitment GO:0048865 1 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.018
gland development GO:0048732 143 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
segmentation GO:0035282 97 0.018
response to external stimulus GO:0009605 264 0.017
negative regulation of biological process GO:0048519 304 0.017
double strand break repair GO:0006302 3 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
regulation of biological quality GO:0065008 263 0.017
gtp metabolic process GO:0046039 4 0.017
regulation of synapse organization GO:0050807 3 0.016
vitamin biosynthetic process GO:0009110 2 0.016
stem cell division GO:0017145 1 0.016
striated muscle cell differentiation GO:0051146 129 0.016
regulation of rna splicing GO:0043484 8 0.016
somitogenesis GO:0001756 87 0.016
spermatid differentiation GO:0048515 2 0.016
neuron development GO:0048666 262 0.016
protein complex assembly GO:0006461 30 0.016
protein complex biogenesis GO:0070271 30 0.016
negative regulation of developmental process GO:0051093 65 0.016
response to uv GO:0009411 3 0.016
neuroblast proliferation GO:0007405 2 0.016
regulation of mrna splicing via spliceosome GO:0048024 3 0.016
pronuclear migration GO:0035046 1 0.016
regulation of binding GO:0051098 3 0.016
somite development GO:0061053 96 0.016
regulation of cell activation GO:0050865 1 0.016
regulation of biosynthetic process GO:0009889 250 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
establishment of organelle localization GO:0051656 45 0.015
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.015
regulation of organelle assembly GO:1902115 4 0.015
actin filament polymerization GO:0030041 2 0.015
macromolecule localization GO:0033036 54 0.015
transcription dna templated GO:0006351 181 0.015
regulation of cellular response to stress GO:0080135 20 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.015
cell projection morphogenesis GO:0048858 244 0.015
positive regulation of translation GO:0045727 1 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
sensory perception of chemical stimulus GO:0007606 3 0.015
negative regulation of intracellular transport GO:0032387 3 0.014
single organism reproductive process GO:0044702 40 0.014
oocyte anterior posterior axis specification GO:0007314 4 0.014
cell cycle process GO:0022402 53 0.014
regulation of protein metabolic process GO:0051246 56 0.014
convergent extension GO:0060026 118 0.014
cell projection organization GO:0030030 284 0.014
muscle structure development GO:0061061 196 0.014
organelle fusion GO:0048284 3 0.014
positive regulation of jnk cascade GO:0046330 3 0.014
regulation of signal transduction by p53 class mediator GO:1901796 9 0.014
axonogenesis GO:0007409 152 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
regulation of signaling GO:0023051 235 0.014
cellular response to light stimulus GO:0071482 4 0.014
positive regulation of developmental process GO:0051094 50 0.013
positive regulation of cell activation GO:0050867 1 0.013
insulin like growth factor receptor signaling pathway GO:0048009 4 0.013
regulation of cell communication GO:0010646 232 0.013
morphogenesis of an epithelial sheet GO:0002011 49 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
response to carbohydrate GO:0009743 3 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
positive regulation of cellular component biogenesis GO:0044089 3 0.013
regulation of translational initiation GO:0006446 1 0.013
centrosome organization GO:0051297 1 0.013
apoptotic signaling pathway GO:0097190 23 0.012
photoreceptor cell morphogenesis GO:0008594 1 0.012
regulation of molecular function GO:0065009 70 0.012
negative regulation of signaling GO:0023057 96 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
response to amphetamine GO:0001975 1 0.012
organic substance catabolic process GO:1901575 28 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
cell cycle g1 s phase transition GO:0044843 1 0.012
cellular response to stress GO:0033554 62 0.012
cell fate specification GO:0001708 68 0.012
reproductive process GO:0022414 40 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
double strand break repair via homologous recombination GO:0000724 1 0.012
mitochondrial transport GO:0006839 2 0.012
determination of bilateral symmetry GO:0009855 204 0.012
negative regulation of protein transport GO:0051224 3 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
cellular amide metabolic process GO:0043603 4 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
regulation of tube size GO:0035150 2 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
negative regulation of signal transduction GO:0009968 94 0.011
mechanosensory behavior GO:0007638 2 0.011
cell growth GO:0016049 57 0.011
positive regulation of signal transduction GO:0009967 56 0.011
regulation of protein catabolic process GO:0042176 1 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
organelle organization GO:0006996 227 0.011
fat soluble vitamin metabolic process GO:0006775 4 0.011
signal transduction by p53 class mediator GO:0072331 13 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
neuron projection development GO:0031175 180 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
regulation of cellular component size GO:0032535 30 0.011
muscle tissue development GO:0060537 110 0.011
regulation of protein transport GO:0051223 3 0.011
microtubule based process GO:0007017 60 0.011
recombinational repair GO:0000725 1 0.011
cytoplasmic transport GO:0016482 11 0.011
developmental growth GO:0048589 166 0.010
cytoplasm organization GO:0007028 4 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.010
ion transport GO:0006811 114 0.010
oocyte maturation GO:0001556 4 0.010
response to organic substance GO:0010033 153 0.010
mitotic dna integrity checkpoint GO:0044774 4 0.010
specification of symmetry GO:0009799 204 0.010
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.010
protein complex subunit organization GO:0071822 46 0.010
positive regulation of cell differentiation GO:0045597 30 0.010
positive regulation of multi organism process GO:0043902 3 0.010
macromolecule modification GO:0043412 111 0.010
dopamine metabolic process GO:0042417 2 0.010
regulation of oocyte development GO:0060281 3 0.010
response to glucose GO:0009749 3 0.010

eif4e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018