Danio rerio

27 known processes

fancl

Fanconi anemia, complementation group L

(Aliases: zgc:66144,zgc:76938)

fancl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female sex differentiation GO:0046660 4 0.879
gene expression GO:0010467 252 0.791
negative regulation of dna recombination GO:0045910 2 0.778
synapsis GO:0007129 1 0.670
multicellular organismal reproductive process GO:0048609 35 0.626
oocyte differentiation GO:0009994 14 0.597
sexual reproduction GO:0019953 36 0.572
regulation of cellular metabolic process GO:0031323 320 0.539
development of primary female sexual characteristics GO:0046545 4 0.520
nucleic acid metabolic process GO:0090304 244 0.502
Human
organic cyclic compound metabolic process GO:1901360 301 0.471
Human
gamete generation GO:0007276 33 0.434
pole plasm assembly GO:0007315 4 0.400
reproductive process GO:0022414 40 0.386
regulation of nitrogen compound metabolic process GO:0051171 251 0.347
regulation of primary metabolic process GO:0080090 311 0.345
multicellular organism reproduction GO:0032504 35 0.318
single organism transport GO:0044765 206 0.316
cellular macromolecule metabolic process GO:0044260 391 0.292
Human Mouse
developmental process involved in reproduction GO:0003006 27 0.288
spermatid development GO:0007286 2 0.287
regulation of macromolecule metabolic process GO:0060255 317 0.262
female gonad development GO:0008585 4 0.262
oocyte construction GO:0007308 5 0.261
cellular component assembly GO:0022607 170 0.251
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.244
maternal determination of anterior posterior axis embryo GO:0008358 4 0.237
single organism organelle organization GO:1902589 199 0.232
spermatid differentiation GO:0048515 2 0.232
reproduction GO:0000003 40 0.231
establishment of localization in cell GO:0051649 77 0.224
oocyte axis specification GO:0007309 5 0.219
negative regulation of cellular process GO:0048523 283 0.219
regulation of cellular biosynthetic process GO:0031326 245 0.216
regulation of multicellular organismal development GO:2000026 223 0.212
rna modification GO:0009451 2 0.210
meiotic nuclear division GO:0007126 4 0.204
organelle organization GO:0006996 227 0.201
production of small rna involved in gene silencing by rna GO:0070918 1 0.183
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.180
single organism reproductive process GO:0044702 40 0.175
spermatogenesis GO:0007283 7 0.169
programmed cell death GO:0012501 119 0.168
multi organism process GO:0051704 134 0.165
cellular aromatic compound metabolic process GO:0006725 295 0.165
Human
regulation of developmental process GO:0050793 247 0.164
macromolecule biosynthetic process GO:0009059 227 0.163
negative regulation of developmental process GO:0051093 65 0.160
chromosome organization GO:0051276 31 0.159
regulation of localization GO:0032879 104 0.158
ovulation cycle GO:0042698 2 0.149
nucleobase containing compound metabolic process GO:0006139 274 0.144
Human
regulation of cell differentiation GO:0045595 142 0.139
signal transduction GO:0007165 455 0.139
regulation of mrna catabolic process GO:0061013 3 0.137
rna metabolic process GO:0016070 219 0.134
stem cell division GO:0017145 1 0.133
organic cyclic compound biosynthetic process GO:1901362 223 0.133
cytoplasm organization GO:0007028 4 0.131
intracellular mrna localization GO:0008298 1 0.131
single organism localization GO:1902578 225 0.130
cellular macromolecule biosynthetic process GO:0034645 224 0.128
female gamete generation GO:0007292 14 0.121
male meiosis GO:0007140 2 0.119
nitrogen compound metabolic process GO:0006807 319 0.118
Human
rhythmic process GO:0048511 21 0.116
heterocycle metabolic process GO:0046483 290 0.115
Human
single organism metabolic process GO:0044710 217 0.113
Human
meiosis i GO:0007127 1 0.112
cell cycle GO:0007049 93 0.111
positive regulation of biological process GO:0048518 253 0.111
cellular component biogenesis GO:0044085 178 0.110
regulation of smad protein complex assembly GO:0010990 1 0.110
cellular response to estradiol stimulus GO:0071392 1 0.110
hormone transport GO:0009914 2 0.108
response to dsrna GO:0043331 7 0.101
positive regulation of cell cycle GO:0045787 3 0.098
regulation of metabolic process GO:0019222 359 0.094
germ line stem cell division GO:0042078 1 0.092
ovulation cycle process GO:0022602 2 0.091
positive regulation of mrna metabolic process GO:1903313 2 0.089
rna catabolic process GO:0006401 7 0.089
nuclear transcribed mrna catabolic process GO:0000956 4 0.084
oogenesis GO:0048477 14 0.084
oocyte development GO:0048599 14 0.083
transport GO:0006810 220 0.083
apoptotic process GO:0006915 116 0.083
regulation of biosynthetic process GO:0009889 250 0.083
stem cell maintenance GO:0019827 4 0.081
regulation of rna metabolic process GO:0051252 224 0.076
cell migration GO:0016477 237 0.075
chromosome organization involved in meiosis GO:0070192 1 0.075
cellular nitrogen compound metabolic process GO:0034641 290 0.074
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.073
heterocycle biosynthetic process GO:0018130 215 0.073
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.071
germ line stem cell maintenance GO:0030718 2 0.071
reciprocal meiotic recombination GO:0007131 1 0.071
cellular localization GO:0051641 97 0.069
cell cycle process GO:0022402 53 0.067
protein metabolic process GO:0019538 183 0.066
Human Mouse
mrna 3 end processing GO:0031124 2 0.065
regionalization GO:0003002 274 0.064
catabolic process GO:0009056 32 0.064
cellular biosynthetic process GO:0044249 286 0.062
cellular component movement GO:0006928 335 0.062
sex determination GO:0007530 1 0.062
establishment of localization GO:0051234 244 0.062
guanosine containing compound metabolic process GO:1901068 4 0.061
regulation of macromolecule biosynthetic process GO:0010556 225 0.060
osteoclast development GO:0036035 1 0.060
anterior posterior pattern specification GO:0009952 152 0.057
cellular nitrogen compound biosynthetic process GO:0044271 218 0.057
meiotic chromosome segregation GO:0045132 3 0.057
nucleobase containing compound biosynthetic process GO:0034654 205 0.057
transcription dna templated GO:0006351 181 0.055
meiotic cell cycle process GO:1903046 3 0.054
aging GO:0007568 2 0.053
regulation of mrna processing GO:0050684 3 0.052
regulation of gene expression GO:0010468 265 0.052
dna templated transcription initiation GO:0006352 1 0.050
cellular protein modification process GO:0006464 100 0.050
Human Mouse
rna localization GO:0006403 4 0.049
regulation of cell communication GO:0010646 232 0.049
regulation of rna biosynthetic process GO:2001141 213 0.048
cell motility GO:0048870 244 0.048
vasculature development GO:0001944 278 0.046
nucleobase containing compound catabolic process GO:0034655 15 0.046
guanosine containing compound catabolic process GO:1901069 2 0.046
cell aging GO:0007569 2 0.045
immune system process GO:0002376 241 0.044
regulation of nucleic acid templated transcription GO:1903506 213 0.044
regulation of reproductive process GO:2000241 4 0.044
regulation of transcription dna templated GO:0006355 213 0.044
blastoderm segmentation GO:0007350 6 0.042
cellular response to dsrna GO:0071359 1 0.042
morphogenesis of follicular epithelium GO:0016333 1 0.042
negative regulation of hormone secretion GO:0046888 2 0.042
meiotic cell cycle GO:0051321 5 0.041
microtubule cytoskeleton organization GO:0000226 33 0.040
negative regulation of cellular metabolic process GO:0031324 77 0.039
centrosome duplication GO:0051298 1 0.039
meiosis ii GO:0007135 1 0.038
organic substance transport GO:0071702 58 0.037
aromatic compound biosynthetic process GO:0019438 217 0.037
regulation of dna recombination GO:0000018 2 0.036
male gamete generation GO:0048232 7 0.036
alternative mrna splicing via spliceosome GO:0000380 1 0.035
hormone secretion GO:0046879 2 0.035
ovarian follicle development GO:0001541 2 0.033
spindle assembly GO:0051225 2 0.033
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.032
cell death GO:0008219 121 0.032
somitogenesis GO:0001756 87 0.032
positive regulation of catabolic process GO:0009896 4 0.032
small gtpase mediated signal transduction GO:0007264 8 0.032
cell maturation GO:0048469 23 0.032
rna 3 end processing GO:0031123 2 0.032
developmental maturation GO:0021700 34 0.031
cellular macromolecule catabolic process GO:0044265 12 0.031
biosynthetic process GO:0009058 294 0.031
enzyme linked receptor protein signaling pathway GO:0007167 106 0.031
negative regulation of biological process GO:0048519 304 0.030
axis specification GO:0009798 43 0.030
regulation of cellular protein metabolic process GO:0032268 52 0.030
oocyte anterior posterior axis specification GO:0007314 4 0.030
cell substrate adhesion GO:0031589 4 0.029
dna biosynthetic process GO:0071897 3 0.029
oocyte maturation GO:0001556 4 0.029
reciprocal dna recombination GO:0035825 1 0.029
blood vessel morphogenesis GO:0048514 216 0.029
organism emergence from protective structure GO:0071684 4 0.028
regulation of cell proliferation GO:0042127 37 0.028
Mouse
regulation of signal transduction GO:0009966 225 0.028
sister chromatid cohesion GO:0007062 2 0.027
rna processing GO:0006396 25 0.027
centrosome organization GO:0051297 1 0.027
female germ line stem cell maintenance GO:0036099 1 0.026
response to chemical GO:0042221 320 0.026
regulation of gene silencing by rna GO:0060966 1 0.026
response to stress GO:0006950 263 0.026
Human
ribonucleoprotein complex subunit organization GO:0071826 8 0.025
regulation of stem cell differentiation GO:2000736 4 0.024
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.024
regulation of cytokine production GO:0001817 3 0.024
locomotion GO:0040011 313 0.024
positive regulation of cellular process GO:0048522 201 0.024
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.024
regulation of protein complex assembly GO:0043254 3 0.024
organic substance biosynthetic process GO:1901576 289 0.023
phosphorus metabolic process GO:0006793 109 0.023
dna repair GO:0006281 6 0.023
Human
nucleic acid templated transcription GO:0097659 181 0.023
death GO:0016265 121 0.022
protein n linked glycosylation GO:0006487 1 0.022
cellular nitrogen compound catabolic process GO:0044270 15 0.022
cell projection assembly GO:0030031 64 0.022
regulation of cell death GO:0010941 103 0.022
ncrna metabolic process GO:0034660 12 0.022
gtp metabolic process GO:0046039 4 0.021
reproductive structure development GO:0048608 5 0.021
segmentation GO:0035282 97 0.021
cellular response to oxygen radical GO:0071450 2 0.021
regulation of response to stimulus GO:0048583 269 0.021
organelle fission GO:0048285 23 0.021
regulation of signaling GO:0023051 235 0.021
macromolecule localization GO:0033036 54 0.020
protein modification process GO:0036211 100 0.020
Human Mouse
growth GO:0040007 174 0.020
mrna metabolic process GO:0016071 20 0.020
anterior posterior axis specification embryo GO:0008595 5 0.019
multi organism reproductive process GO:0044703 36 0.019
positive regulation of cellular component biogenesis GO:0044089 3 0.019
regulation of autophagy GO:0010506 3 0.019
endosomal transport GO:0016197 2 0.019
chromosome segregation GO:0007059 12 0.019
regulation of cell maturation GO:1903429 1 0.019
cellular protein catabolic process GO:0044257 4 0.019
rna stabilization GO:0043489 4 0.019
mitotic cell cycle process GO:1903047 48 0.019
regulation of hormone secretion GO:0046883 2 0.019
indole containing compound metabolic process GO:0042430 2 0.019
female meiotic division GO:0007143 2 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
angiogenesis GO:0001525 158 0.019
maintenance of gastrointestinal epithelium GO:0030277 7 0.018
trabecula formation GO:0060343 2 0.018
regulation of stem cell proliferation GO:0072091 2 0.018
smad protein complex assembly GO:0007183 1 0.018
rna biosynthetic process GO:0032774 181 0.018
multicellular organism growth GO:0035264 4 0.018
positive regulation of transport GO:0051050 2 0.017
blood vessel development GO:0001568 246 0.017
fatty acid biosynthetic process GO:0006633 4 0.017
response to drug GO:0042493 3 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
positive regulation of stem cell proliferation GO:2000648 1 0.017
zymogen activation GO:0031638 3 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.016
trabecula morphogenesis GO:0061383 2 0.016
positive regulation of cellular biosynthetic process GO:0031328 68 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
negative regulation of gene expression GO:0010629 65 0.016
development of primary sexual characteristics GO:0045137 5 0.016
cellular macromolecular complex assembly GO:0034622 24 0.016
opioid receptor signaling pathway GO:0038003 3 0.016
protein complex biogenesis GO:0070271 30 0.016
organic substance catabolic process GO:1901575 28 0.016
protein complex subunit organization GO:0071822 46 0.016
embryonic organ development GO:0048568 381 0.015
endodermal cell fate determination GO:0007493 2 0.015
cognition GO:0050890 1 0.015
gtp catabolic process GO:0006184 2 0.015
positive regulation of mrna processing GO:0050685 1 0.015
regulation of cell cycle GO:0051726 52 0.015
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.015
negative regulation of cell communication GO:0010648 96 0.015
response to estrogen GO:0043627 27 0.015
urogenital system development GO:0001655 97 0.015
embryonic axis specification GO:0000578 12 0.015
cell cycle g2 m phase transition GO:0044839 4 0.015
long chain fatty acid biosynthetic process GO:0042759 1 0.015
response to glucocorticoid GO:0051384 1 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
intracellular signal transduction GO:0035556 85 0.015
nuclear import GO:0051170 3 0.015
autophagy GO:0006914 4 0.015
negative regulation of cell differentiation GO:0045596 46 0.015
regulation of cellular component organization GO:0051128 86 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.014
homeostatic process GO:0042592 142 0.014
defense response to other organism GO:0098542 33 0.014
macromolecular complex subunit organization GO:0043933 74 0.014
regulation of wound healing GO:0061041 2 0.014
germ cell development GO:0007281 22 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.014
cellular component morphogenesis GO:0032989 336 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
cellular catabolic process GO:0044248 27 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
cell division GO:0051301 20 0.014
negative regulation of secretion GO:0051048 2 0.014
skeletal muscle tissue development GO:0007519 67 0.014
positive regulation of wound healing GO:0090303 1 0.013
cytoskeleton organization GO:0007010 96 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
positive regulation of translation GO:0045727 1 0.013
actin cytoskeleton organization GO:0030036 63 0.013
regulation of transferase activity GO:0051338 16 0.013
g2 m transition of mitotic cell cycle GO:0000086 4 0.013
long chain fatty acid metabolic process GO:0001676 1 0.013
positive regulation of response to stimulus GO:0048584 80 0.013
chordate embryonic development GO:0043009 271 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
negative regulation of translation GO:0017148 1 0.013
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.013
pancreas development GO:0031016 84 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.012
protein acetylation GO:0006473 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
response to organic substance GO:0010033 153 0.012
double strand break repair GO:0006302 3 0.012
regulation of cellular localization GO:0060341 12 0.012
myeloid cell development GO:0061515 32 0.012
regulation of protein catabolic process GO:0042176 1 0.012
regulation of dna templated transcription in response to stress GO:0043620 0 0.012
larval development GO:0002164 2 0.012
segment polarity determination GO:0007367 1 0.012
positive regulation of gene expression GO:0010628 71 0.012
notochord development GO:0030903 54 0.012
b cell activation GO:0042113 2 0.012
negative regulation of response to cytokine stimulus GO:0060761 2 0.011
positive regulation of molecular function GO:0044093 33 0.011
positive regulation of cell division GO:0051781 2 0.011
positive regulation of lipase activity GO:0060193 1 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
stem cell proliferation GO:0072089 4 0.011
maintenance of location GO:0051235 4 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
cellular amine metabolic process GO:0044106 2 0.011
macromolecule modification GO:0043412 111 0.011
Human Mouse
regulation of cell activation GO:0050865 1 0.011
aromatic compound catabolic process GO:0019439 15 0.011
regulation of cell projection assembly GO:0060491 4 0.011
positive regulation of protein metabolic process GO:0051247 23 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
regulation of oocyte development GO:0060281 3 0.011
ameboidal type cell migration GO:0001667 143 0.011
positive regulation of signal transduction GO:0009967 56 0.011
macromolecular complex assembly GO:0065003 35 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.010
cellular response to organic substance GO:0071310 105 0.010
bone remodeling GO:0046849 2 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010
cell part morphogenesis GO:0032990 246 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
regulation of behavior GO:0050795 24 0.010
regulation of apoptotic process GO:0042981 98 0.010
sex differentiation GO:0007548 5 0.010
regulation of locomotion GO:0040012 55 0.010
wound healing GO:0042060 90 0.010

fancl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.025
Human
disease of anatomical entity DOID:7 0 0.025
Human
hematopoietic system disease DOID:74 0 0.025
Human
endocrine system disease DOID:28 0 0.017