Danio rerio

15 known processes

fen1

flap structure-specific endonuclease 1

(Aliases: FEN-1,cb879)

fen1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 3 0.810
Yeast
double strand break repair via homologous recombination GO:0000724 1 0.762
biosynthetic process GO:0009058 294 0.680
Human Yeast Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.641
Human Yeast Mouse Worm
cellular aromatic compound metabolic process GO:0006725 295 0.611
Human Yeast Mouse Worm
embryo development ending in birth or egg hatching GO:0009792 271 0.593
Worm
cellular biosynthetic process GO:0044249 286 0.569
Human Yeast Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.532
Yeast
organic substance biosynthetic process GO:1901576 289 0.456
Human Yeast Mouse
chromosome organization GO:0051276 31 0.407
Yeast
larval development GO:0002164 2 0.376
dna metabolic process GO:0006259 27 0.373
Human Yeast Mouse Worm
nucleic acid metabolic process GO:0090304 244 0.326
Human Yeast Mouse Worm
regulation of metabolic process GO:0019222 359 0.285
nucleobase containing compound metabolic process GO:0006139 274 0.274
Human Yeast Mouse Worm
aromatic compound biosynthetic process GO:0019438 217 0.270
Yeast
response to stress GO:0006950 263 0.270
Yeast Mouse
regulation of primary metabolic process GO:0080090 311 0.262
peptidyl lysine acetylation GO:0018394 2 0.248
nitrogen compound metabolic process GO:0006807 319 0.238
Human Yeast Mouse Worm
recombinational repair GO:0000725 1 0.238
single organism organelle organization GO:1902589 199 0.237
Yeast
gene expression GO:0010467 252 0.226
locomotion GO:0040011 313 0.218
Worm
chromatin modification GO:0016568 21 0.213
cellular response to stress GO:0033554 62 0.211
Yeast Mouse
heterocycle metabolic process GO:0046483 290 0.206
Human Yeast Mouse Worm
protein acetylation GO:0006473 2 0.198
heterocycle biosynthetic process GO:0018130 215 0.186
Yeast
cellular macromolecule metabolic process GO:0044260 391 0.176
Human Yeast Mouse Worm
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.172
nucleoside phosphate biosynthetic process GO:1901293 21 0.170
internal protein amino acid acetylation GO:0006475 2 0.170
programmed cell death GO:0012501 119 0.153
Worm
nucleobase containing compound biosynthetic process GO:0034654 205 0.151
Yeast
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.149
regulation of transcription dna templated GO:0006355 213 0.149
organic cyclic compound metabolic process GO:1901360 301 0.142
Human Yeast Mouse Worm
regulation of nitrogen compound metabolic process GO:0051171 251 0.139
cellular nitrogen compound biosynthetic process GO:0044271 218 0.137
Yeast
macromolecule biosynthetic process GO:0009059 227 0.136
Human Yeast Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.135
regulation of macromolecule metabolic process GO:0060255 317 0.134
cellular response to dna damage stimulus GO:0006974 24 0.128
Yeast Mouse
regulation of cellular metabolic process GO:0031323 320 0.125
rna biosynthetic process GO:0032774 181 0.124
eye development GO:0001654 277 0.121
deoxyribonucleotide biosynthetic process GO:0009263 1 0.119
sensory organ development GO:0007423 393 0.118
regulation of gene expression GO:0010468 265 0.110
negative regulation of biological process GO:0048519 304 0.110
regulation of biosynthetic process GO:0009889 250 0.108
organelle organization GO:0006996 227 0.106
Yeast
negative regulation of gene expression GO:0010629 65 0.103
developmental process involved in reproduction GO:0003006 27 0.101
Yeast Worm
immune system process GO:0002376 241 0.101
rna transport GO:0050658 2 0.094
mitotic dna damage checkpoint GO:0044773 4 0.084
nucleotide biosynthetic process GO:0009165 21 0.082
centrosome organization GO:0051297 1 0.081
immune system development GO:0002520 191 0.081
regulation of rna metabolic process GO:0051252 224 0.081
single fertilization GO:0007338 3 0.079
chromatin organization GO:0006325 22 0.079
establishment of localization GO:0051234 244 0.078
Worm
regulation of rna biosynthetic process GO:2001141 213 0.078
response to abiotic stimulus GO:0009628 122 0.077
negative regulation of metabolic process GO:0009892 86 0.077
dna biosynthetic process GO:0071897 3 0.076
Yeast
internal peptidyl lysine acetylation GO:0018393 2 0.075
single organism biosynthetic process GO:0044711 71 0.074
regulation of programmed cell death GO:0043067 101 0.074
single organism metabolic process GO:0044710 217 0.073
Yeast Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.072
regulation of mitotic cell cycle phase transition GO:1901990 8 0.072
mitotic recombination GO:0006312 2 0.071
Yeast
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.071
cell cycle g1 s phase transition GO:0044843 1 0.070
negative regulation of rna metabolic process GO:0051253 48 0.070
regulation of proteolysis GO:0030162 24 0.069
single organism localization GO:1902578 225 0.067
rna metabolic process GO:0016070 219 0.066
Human Yeast
meiotic cell cycle process GO:1903046 3 0.064
signal transduction GO:0007165 455 0.063
dna recombination GO:0006310 5 0.063
Yeast
camera type eye development GO:0043010 222 0.063
modification dependent protein catabolic process GO:0019941 3 0.063
centrosome cycle GO:0007098 1 0.062
hemopoiesis GO:0030097 183 0.061
aging GO:0007568 2 0.061
Yeast
non recombinational repair GO:0000726 2 0.060
Yeast
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.060
protein metabolic process GO:0019538 183 0.059
regulation of dna templated transcription elongation GO:0032784 3 0.059
protein acylation GO:0043543 3 0.059
cellular component assembly GO:0022607 170 0.057
double strand break repair via nonhomologous end joining GO:0006303 1 0.057
Yeast
negative regulation of macromolecule metabolic process GO:0010605 76 0.056
dna repair GO:0006281 6 0.056
Yeast Mouse
regulation of apoptotic process GO:0042981 98 0.054
macromolecular complex subunit organization GO:0043933 74 0.054
cell migration GO:0016477 237 0.054
dna catabolic process GO:0006308 1 0.053
Human Yeast Mouse Worm
g1 s transition of mitotic cell cycle GO:0000082 1 0.053
mitotic dna integrity checkpoint GO:0044774 4 0.053
negative regulation of cellular process GO:0048523 283 0.052
regulation of cellular biosynthetic process GO:0031326 245 0.052
positive regulation of cellular process GO:0048522 201 0.052
gene silencing GO:0016458 4 0.051
cellular protein modification process GO:0006464 100 0.051
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.049
cellular macromolecule biosynthetic process GO:0034645 224 0.049
Human Yeast Mouse
transport GO:0006810 220 0.048
Worm
retina development in camera type eye GO:0060041 146 0.047
regulation of multicellular organismal process GO:0051239 277 0.047
regulation of response to stimulus GO:0048583 269 0.046
muscle structure development GO:0061061 196 0.046
regulation of cell death GO:0010941 103 0.046
mitotic cell cycle checkpoint GO:0007093 5 0.046
apoptotic process GO:0006915 116 0.045
Worm
reproductive process GO:0022414 40 0.045
Yeast Worm
cellular component biogenesis GO:0044085 178 0.044
hematopoietic or lymphoid organ development GO:0048534 191 0.044
dna templated transcription elongation GO:0006354 3 0.043
multi organism process GO:0051704 134 0.042
cell death GO:0008219 121 0.042
Worm
negative regulation of chromosome organization GO:2001251 1 0.041
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.041
negative regulation of cellular metabolic process GO:0031324 77 0.040
positive regulation of chromatin modification GO:1903310 1 0.039
microtubule based process GO:0007017 60 0.038
cell cycle checkpoint GO:0000075 7 0.037
regulation of binding GO:0051098 3 0.037
fertilization GO:0009566 3 0.036
cell motility GO:0048870 244 0.036
catabolic process GO:0009056 32 0.036
Human Yeast Mouse Worm
cellular ketone metabolic process GO:0042180 11 0.036
intra s dna damage checkpoint GO:0031573 1 0.035
transcription dna templated GO:0006351 181 0.035
regulation of catalytic activity GO:0050790 55 0.035
multicellular organism growth GO:0035264 4 0.034
digestive system development GO:0055123 289 0.034
nucleic acid templated transcription GO:0097659 181 0.034
organonitrogen compound metabolic process GO:1901564 74 0.034
regulation of dna recombination GO:0000018 2 0.033
positive regulation of cellular catabolic process GO:0031331 3 0.033
cell proliferation GO:0008283 80 0.033
protein modification process GO:0036211 100 0.033
cellular amine metabolic process GO:0044106 2 0.033
pronuclear migration GO:0035046 1 0.033
mitotic metaphase plate congression GO:0007080 1 0.033
cellular component movement GO:0006928 335 0.032
amine metabolic process GO:0009308 2 0.032
regulation of developmental process GO:0050793 247 0.032
response to light stimulus GO:0009416 46 0.032
negative regulation of nucleic acid templated transcription GO:1903507 45 0.031
telomere organization GO:0032200 1 0.031
meiosis i GO:0007127 1 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.031
organelle localization GO:0051640 49 0.031
regulation of cellular amine metabolic process GO:0033238 0 0.031
response to drug GO:0042493 3 0.031
meiotic nuclear division GO:0007126 4 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
response to chemical GO:0042221 320 0.030
regulation of deoxyribonuclease activity GO:0032070 1 0.030
regulation of molecular function GO:0065009 70 0.029
macromolecular complex assembly GO:0065003 35 0.029
protein heterooligomerization GO:0051291 1 0.029
lipid catabolic process GO:0016042 4 0.029
small molecule metabolic process GO:0044281 77 0.029
deoxyribonucleotide metabolic process GO:0009262 1 0.028
pyrimidine containing compound biosynthetic process GO:0072528 2 0.028
protein complex biogenesis GO:0070271 30 0.028
regulation of cellular component organization GO:0051128 86 0.028
covalent chromatin modification GO:0016569 20 0.028
cellular response to external stimulus GO:0071496 2 0.028
peptidyl serine phosphorylation GO:0018105 1 0.028
regulation of hydrolase activity GO:0051336 28 0.028
regulation of establishment of protein localization GO:0070201 4 0.028
leukocyte proliferation GO:0070661 1 0.028
neuron projection development GO:0031175 180 0.028
regulation of lipid catabolic process GO:0050994 2 0.027
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.027
rna localization GO:0006403 4 0.027
proteolysis GO:0006508 38 0.027
single organism reproductive process GO:0044702 40 0.027
Yeast Worm
nuclear transport GO:0051169 4 0.027
cellular response to chemical stimulus GO:0070887 157 0.026
proteasomal protein catabolic process GO:0010498 2 0.026
response to inorganic substance GO:0010035 38 0.026
response to external stimulus GO:0009605 264 0.026
death GO:0016265 121 0.025
Worm
regulation of mitotic cell cycle GO:0007346 25 0.025
intracellular signal transduction GO:0035556 85 0.025
mitotic cell cycle process GO:1903047 48 0.025
phosphorus metabolic process GO:0006793 109 0.025
Yeast
regulation of protein metabolic process GO:0051246 56 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.025
positive regulation of catabolic process GO:0009896 4 0.025
synaptic growth at neuromuscular junction GO:0051124 2 0.024
negative regulation of cell cycle process GO:0010948 9 0.024
response to uv GO:0009411 3 0.024
microtubule polymerization GO:0046785 2 0.024
reproduction GO:0000003 40 0.023
Yeast Worm
negative regulation of programmed cell death GO:0043069 58 0.023
digestive tract development GO:0048565 265 0.023
positive regulation of cellular metabolic process GO:0031325 94 0.022
rna 3 end processing GO:0031123 2 0.022
heterocycle catabolic process GO:0046700 15 0.022
Human Yeast Mouse Worm
protein complex assembly GO:0006461 30 0.021
negative regulation of biosynthetic process GO:0009890 55 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
negative regulation of cellular component organization GO:0051129 16 0.021
organic substance transport GO:0071702 58 0.021
establishment of rna localization GO:0051236 3 0.020
nucleobase containing compound transport GO:0015931 2 0.020
meiotic chromosome segregation GO:0045132 3 0.020
cell morphogenesis GO:0000902 289 0.020
negative regulation of apoptotic process GO:0043066 55 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
cell cycle GO:0007049 93 0.019
growth GO:0040007 174 0.019
maintenance of location GO:0051235 4 0.019
peptidyl amino acid modification GO:0018193 16 0.019
cytokinesis GO:0000910 3 0.019
nuclear division GO:0000280 23 0.019
histone modification GO:0016570 20 0.018
regulation of biological quality GO:0065008 263 0.018
protein complex disassembly GO:0043241 1 0.018
cellular protein metabolic process GO:0044267 129 0.018
negative regulation of cell death GO:0060548 60 0.018
spindle assembly GO:0051225 2 0.018
organic substance catabolic process GO:1901575 28 0.018
Human Yeast Mouse Worm
regulation of cell cycle GO:0051726 52 0.017
regulation of protein catabolic process GO:0042176 1 0.017
regulation of protein transport GO:0051223 3 0.017
protein polyubiquitination GO:0000209 4 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.017
positive regulation of cell cycle GO:0045787 3 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
pyrimidine containing compound metabolic process GO:0072527 3 0.017
nucleic acid transport GO:0050657 2 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
response to external biotic stimulus GO:0043207 97 0.017
organophosphate biosynthetic process GO:0090407 23 0.016
cellular component morphogenesis GO:0032989 336 0.016
reciprocal meiotic recombination GO:0007131 1 0.016
brain development GO:0007420 293 0.016
macromolecule modification GO:0043412 111 0.016
maintenance of dna repeat elements GO:0043570 2 0.016
Yeast
negative regulation of mitotic cell cycle GO:0045930 11 0.016
cellular lipid catabolic process GO:0044242 3 0.016
purine nucleoside monophosphate catabolic process GO:0009128 4 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
regulation of cell differentiation GO:0045595 142 0.016
regulation of response to stress GO:0080134 36 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
macromolecule localization GO:0033036 54 0.016
carbohydrate derivative metabolic process GO:1901135 61 0.015
regulation of peptidase activity GO:0052547 23 0.015
adult behavior GO:0030534 2 0.015
cellular protein catabolic process GO:0044257 4 0.015
mitotic cell cycle GO:0000278 64 0.015
establishment of localization in cell GO:0051649 77 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
regulation of cellular protein metabolic process GO:0032268 52 0.015
regulation of dna replication GO:0006275 3 0.015
regulation of gene silencing GO:0060968 1 0.014
positive regulation of histone modification GO:0031058 1 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
Yeast
response to alkaloid GO:0043279 2 0.014
embryonic digestive tract morphogenesis GO:0048557 3 0.014
mrna transport GO:0051028 2 0.014
microtubule cytoskeleton organization GO:0000226 33 0.014
organic acid metabolic process GO:0006082 31 0.014
positive regulation of transport GO:0051050 2 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
mrna metabolic process GO:0016071 20 0.013
establishment of organelle localization GO:0051656 45 0.013
dna integrity checkpoint GO:0031570 6 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.013
nucleotide metabolic process GO:0009117 28 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
negative regulation of nuclear division GO:0051784 3 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
heart development GO:0007507 313 0.013
regulation of gene expression epigenetic GO:0040029 11 0.013
cytoskeleton organization GO:0007010 96 0.013
macromolecular complex disassembly GO:0032984 1 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
establishment of mitotic spindle orientation GO:0000132 10 0.013
carbohydrate derivative biosynthetic process GO:1901137 43 0.013
negative regulation of cell cycle phase transition GO:1901988 5 0.012
response to metal ion GO:0010038 34 0.012
negative regulation of mitosis GO:0045839 3 0.012
cellular nitrogen compound catabolic process GO:0044270 15 0.012
Human Yeast Mouse Worm
histone phosphorylation GO:0016572 2 0.012
regulation of signal transduction GO:0009966 225 0.012
protein targeting to nucleus GO:0044744 3 0.012
microtubule organizing center organization GO:0031023 1 0.012
negative regulation of transcription dna templated GO:0045892 45 0.012
reciprocal dna recombination GO:0035825 1 0.012
developmental growth GO:0048589 166 0.012
nucleoside phosphate metabolic process GO:0006753 28 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
response to radiation GO:0009314 51 0.012
striated muscle cell differentiation GO:0051146 129 0.011
positive regulation of nuclease activity GO:0032075 1 0.011
localization of cell GO:0051674 244 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
mrna processing GO:0006397 14 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
intestinal cholesterol absorption GO:0030299 2 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.011
atp catabolic process GO:0006200 4 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
response to organic substance GO:0010033 153 0.011
macromolecule catabolic process GO:0009057 15 0.011
Human Yeast Mouse Worm
embryonic organ development GO:0048568 381 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
regulation of signaling GO:0023051 235 0.011
positive regulation of biological process GO:0048518 253 0.011
apoptotic signaling pathway GO:0097190 23 0.011
negative regulation of intracellular transport GO:0032387 3 0.010
cellular localization GO:0051641 97 0.010
cell cycle process GO:0022402 53 0.010
oxoacid metabolic process GO:0043436 31 0.010
cellular catabolic process GO:0044248 27 0.010
Human Yeast Mouse Worm
sex differentiation GO:0007548 5 0.010
Worm
cellular macromolecular complex assembly GO:0034622 24 0.010
negative regulation of cell cycle GO:0045786 14 0.010
cellular response to organic substance GO:0071310 105 0.010
epithelial cell differentiation GO:0030855 116 0.010
immunoglobulin mediated immune response GO:0016064 3 0.010

fen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016