|
|
regulation of multicellular organismal process
|
GO:0051239 |
277 |
0.975
|
Human Zebrafish Mouse Fly |
|
|
signal transduction
|
GO:0007165 |
455 |
0.961
|
|
|
|
vasculature development
|
GO:0001944 |
278 |
0.955
|
|
|
|
regulation of multicellular organismal development
|
GO:2000026 |
223 |
0.940
|
Zebrafish |
|
|
lymph vessel development
|
GO:0001945 |
27 |
0.938
|
|
|
|
regulation of signal transduction
|
GO:0009966 |
225 |
0.910
|
Human Fly |
|
|
negative regulation of cellular process
|
GO:0048523 |
283 |
0.882
|
Human Fly |
|
|
blood vessel morphogenesis
|
GO:0048514 |
216 |
0.797
|
|
|
|
digestive tract development
|
GO:0048565 |
265 |
0.796
|
Fly |
|
|
cell surface receptor signaling pathway
|
GO:0007166 |
325 |
0.793
|
|
|
|
cardiac cell fate commitment
|
GO:0060911 |
1 |
0.763
|
|
|
|
apoptotic process
|
GO:0006915 |
116 |
0.751
|
Human Zebrafish Fly |
|
|
blood vessel development
|
GO:0001568 |
246 |
0.750
|
|
|
|
regulation of developmental process
|
GO:0050793 |
247 |
0.744
|
Zebrafish Mouse Fly |
|
|
regulation of primary metabolic process
|
GO:0080090 |
311 |
0.743
|
Human |
|
|
cellular macromolecule metabolic process
|
GO:0044260 |
391 |
0.742
|
Human Zebrafish Mouse Rat |
|
|
venous endothelial cell migration involved in lymph vessel development
|
GO:0060855 |
4 |
0.676
|
|
|
|
regulation of cellular macromolecule biosynthetic process
|
GO:2000112 |
222 |
0.675
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
130 |
0.664
|
Mouse Fly |
|
|
cellular aromatic compound metabolic process
|
GO:0006725 |
295 |
0.610
|
|
|
|
regulation of signaling
|
GO:0023051 |
235 |
0.604
|
Human Fly |
|
|
sprouting angiogenesis
|
GO:0002040 |
53 |
0.591
|
|
|
|
positive regulation of cellular process
|
GO:0048522 |
201 |
0.568
|
Human Zebrafish Mouse Rat Fly |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
48 |
0.567
|
|
|
|
response to organic substance
|
GO:0010033 |
153 |
0.557
|
Human Mouse Rat Fly |
|
|
regulation of nucleic acid templated transcription
|
GO:1903506 |
213 |
0.537
|
|
|
|
gene expression
|
GO:0010467 |
252 |
0.533
|
|
|
|
lymph vessel morphogenesis
|
GO:0036303 |
25 |
0.518
|
|
|
|
negative regulation of biological process
|
GO:0048519 |
304 |
0.515
|
Human Fly |
|
|
digestive system development
|
GO:0055123 |
289 |
0.497
|
Fly |
|
|
tube morphogenesis
|
GO:0035239 |
349 |
0.491
|
Fly |
|
|
protein metabolic process
|
GO:0019538 |
183 |
0.490
|
Human Zebrafish Mouse Rat |
|
|
regulation of cell death
|
GO:0010941 |
103 |
0.488
|
Human Fly |
|
|
rna metabolic process
|
GO:0016070 |
219 |
0.475
|
|
|
|
gastrulation
|
GO:0007369 |
208 |
0.468
|
|
|
|
regulation of nucleobase containing compound metabolic process
|
GO:0019219 |
250 |
0.467
|
|
|
|
regulation of cellular metabolic process
|
GO:0031323 |
320 |
0.458
|
Human Fly |
|
|
regulation of nitrogen compound metabolic process
|
GO:0051171 |
251 |
0.439
|
|
|
|
regulation of transcription dna templated
|
GO:0006355 |
213 |
0.437
|
|
|
|
heterocycle biosynthetic process
|
GO:0018130 |
215 |
0.436
|
|
|
|
central nervous system development
|
GO:0007417 |
387 |
0.428
|
Zebrafish Fly |
|
|
patterning of blood vessels
|
GO:0001569 |
15 |
0.398
|
|
|
|
heart development
|
GO:0007507 |
313 |
0.394
|
Zebrafish |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
191 |
0.391
|
Zebrafish Fly |
|
|
regulation of retina development in camera type eye
|
GO:1902866 |
2 |
0.388
|
Zebrafish |
|
|
regulation of gene expression
|
GO:0010468 |
265 |
0.387
|
|
|
|
cellular component movement
|
GO:0006928 |
335 |
0.383
|
|
|
|
cell motility
|
GO:0048870 |
244 |
0.379
|
|
|
|
regulation of transcription from rna polymerase ii promoter
|
GO:0006357 |
114 |
0.378
|
|
|
|
intracellular signal transduction
|
GO:0035556 |
85 |
0.371
|
Human Fly |
|
|
artery morphogenesis
|
GO:0048844 |
14 |
0.370
|
Zebrafish |
|
|
phosphorus metabolic process
|
GO:0006793 |
109 |
0.364
|
Human Zebrafish Mouse Rat Fly |
|
|
regulation of cell communication
|
GO:0010646 |
232 |
0.349
|
Human Fly |
|
|
hemopoiesis
|
GO:0030097 |
183 |
0.349
|
Zebrafish Fly |
|
|
biosynthetic process
|
GO:0009058 |
294 |
0.347
|
|
|
|
positive regulation of cellular metabolic process
|
GO:0031325 |
94 |
0.346
|
Human Fly |
|
|
regulation of response to stimulus
|
GO:0048583 |
269 |
0.344
|
Human Zebrafish Fly |
|
|
larval development
|
GO:0002164 |
2 |
0.335
|
|
|
|
angiogenesis
|
GO:0001525 |
158 |
0.321
|
|
|
|
rna biosynthetic process
|
GO:0032774 |
181 |
0.320
|
|
|
|
lymphangiogenesis
|
GO:0001946 |
25 |
0.318
|
|
|
|
cellular nitrogen compound biosynthetic process
|
GO:0044271 |
218 |
0.306
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
231 |
0.303
|
Fly |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
7 |
0.302
|
|
|
|
transport
|
GO:0006810 |
220 |
0.299
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
42 |
0.296
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
116 |
0.295
|
Zebrafish Fly |
|
|
xanthophore differentiation
|
GO:0050936 |
3 |
0.292
|
Zebrafish |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
106 |
0.291
|
|
|
|
hypothalamus cell differentiation
|
GO:0021979 |
4 |
0.287
|
|
|
|
nucleobase containing compound biosynthetic process
|
GO:0034654 |
205 |
0.281
|
|
|
|
regulation of metabolic process
|
GO:0019222 |
359 |
0.280
|
Human Fly |
|
|
nucleic acid templated transcription
|
GO:0097659 |
181 |
0.273
|
|
|
|
regulation of rna biosynthetic process
|
GO:2001141 |
213 |
0.263
|
|
|
|
regulation of biological quality
|
GO:0065008 |
263 |
0.261
|
Fly |
|
|
somatic stem cell maintenance
|
GO:0035019 |
1 |
0.258
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
58 |
0.243
|
Human Fly |
|
|
cardioblast migration to the midline involved in heart field formation
|
GO:0060975 |
7 |
0.242
|
|
|
|
positive regulation of signal transduction
|
GO:0009967 |
56 |
0.242
|
Human Fly |
|
|
positive regulation of developmental process
|
GO:0051094 |
50 |
0.239
|
Zebrafish |
|
|
regulation of lymphangiogenesis
|
GO:1901490 |
4 |
0.236
|
|
|
|
transcription dna templated
|
GO:0006351 |
181 |
0.233
|
|
|
|
localization of cell
|
GO:0051674 |
244 |
0.231
|
|
|
|
regulation of macromolecule biosynthetic process
|
GO:0010556 |
225 |
0.224
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
2 |
0.221
|
Human |
|
|
regulation of macromolecule metabolic process
|
GO:0060255 |
317 |
0.218
|
Human |
|
|
endoderm development
|
GO:0007492 |
49 |
0.218
|
|
|
|
nucleobase containing compound metabolic process
|
GO:0006139 |
274 |
0.218
|
|
|
|
positive regulation of biological process
|
GO:0048518 |
253 |
0.216
|
Human Zebrafish Mouse Rat Fly |
|
|
growth
|
GO:0040007 |
174 |
0.214
|
Rat |
|
|
hepaticobiliary system development
|
GO:0061008 |
98 |
0.209
|
|
|
|
positive regulation of gene expression
|
GO:0010628 |
71 |
0.206
|
|
|
|
cell migration
|
GO:0016477 |
237 |
0.204
|
|
|
|
cellular nitrogen compound metabolic process
|
GO:0034641 |
290 |
0.203
|
|
|
|
nitrogen compound metabolic process
|
GO:0006807 |
319 |
0.200
|
|
|
|
mesenchyme development
|
GO:0060485 |
127 |
0.199
|
|
|
|
nuclear transport
|
GO:0051169 |
4 |
0.198
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
0 |
0.198
|
|
|
|
glial cell migration
|
GO:0008347 |
3 |
0.198
|
|
|
|
osteoclast development
|
GO:0036035 |
1 |
0.196
|
Zebrafish |
|
|
gland development
|
GO:0048732 |
143 |
0.195
|
Zebrafish Fly |
|
|
vasculogenesis
|
GO:0001570 |
41 |
0.195
|
Zebrafish |
|
|
cardiac chamber formation
|
GO:0003207 |
4 |
0.191
|
|
|
|
macromolecule modification
|
GO:0043412 |
111 |
0.191
|
Human Zebrafish Mouse Rat |
|
|
regulation of neural retina development
|
GO:0061074 |
2 |
0.189
|
Zebrafish |
|
|
regulation of cell differentiation
|
GO:0045595 |
142 |
0.189
|
Fly |
|
|
response to stress
|
GO:0006950 |
263 |
0.188
|
Human Fly |
|
|
aromatic compound biosynthetic process
|
GO:0019438 |
217 |
0.187
|
|
|
|
positive regulation of response to stimulus
|
GO:0048584 |
80 |
0.185
|
Human Zebrafish Fly |
|
|
muscle organ development
|
GO:0007517 |
101 |
0.183
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
11 |
0.181
|
Human |
|
|
locomotion
|
GO:0040011 |
313 |
0.179
|
|
|
|
organic cyclic compound biosynthetic process
|
GO:1901362 |
223 |
0.173
|
|
|
|
endothelial cell fate commitment
|
GO:0060839 |
3 |
0.172
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
14 |
0.172
|
Human Zebrafish |
|
|
heterocycle metabolic process
|
GO:0046483 |
290 |
0.172
|
|
|
|
myeloid cell development
|
GO:0061515 |
32 |
0.172
|
Zebrafish |
|
|
cell fate specification
|
GO:0001708 |
68 |
0.166
|
|
|
|
regulation of embryonic development
|
GO:0045995 |
47 |
0.164
|
|
|
|
regulation of cellular biosynthetic process
|
GO:0031326 |
245 |
0.163
|
|
|
|
response to chemical
|
GO:0042221 |
320 |
0.162
|
Human Zebrafish Mouse Rat Fly |
|
|
venous blood vessel morphogenesis
|
GO:0048845 |
3 |
0.162
|
|
|
|
stem cell proliferation
|
GO:0072089 |
4 |
0.162
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
12 |
0.159
|
|
|
|
cellular response to chemical stimulus
|
GO:0070887 |
157 |
0.157
|
Human Zebrafish Mouse Rat Fly |
|
|
protein targeting to nucleus
|
GO:0044744 |
3 |
0.155
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
69 |
0.154
|
|
|
|
negative regulation of rna metabolic process
|
GO:0051253 |
48 |
0.153
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
195 |
0.152
|
|
|
|
positive regulation of signaling
|
GO:0023056 |
56 |
0.150
|
Human Fly |
|
|
regulation of biosynthetic process
|
GO:0009889 |
250 |
0.148
|
|
|
|
positive regulation of axon guidance
|
GO:1902669 |
1 |
0.147
|
|
|
|
transcription from rna polymerase ii promoter
|
GO:0006366 |
80 |
0.145
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
0 |
0.144
|
|
|
|
organic substance biosynthetic process
|
GO:1901576 |
289 |
0.144
|
|
|
|
positive regulation of macromolecule metabolic process
|
GO:0010604 |
93 |
0.143
|
Human |
|
|
macrophage chemotaxis
|
GO:0048246 |
3 |
0.139
|
Zebrafish |
|
|
regulation of cell proliferation
|
GO:0042127 |
37 |
0.139
|
Human Mouse |
|
|
endodermal cell fate determination
|
GO:0007493 |
2 |
0.139
|
|
|
|
nucleic acid metabolic process
|
GO:0090304 |
244 |
0.139
|
|
|
|
negative regulation of gene expression
|
GO:0010629 |
65 |
0.138
|
|
|
|
generation of neurons
|
GO:0048699 |
385 |
0.138
|
|
|
|
macrophage differentiation
|
GO:0030225 |
7 |
0.137
|
Zebrafish |
|
|
carboxylic acid metabolic process
|
GO:0019752 |
22 |
0.137
|
|
|
|
immune system process
|
GO:0002376 |
241 |
0.136
|
Zebrafish Fly |
|
|
dorsal aorta morphogenesis
|
GO:0035912 |
3 |
0.131
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
3 |
0.128
|
|
|
|
regionalization
|
GO:0003002 |
274 |
0.128
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
87 |
0.128
|
|
|
|
notch signaling pathway
|
GO:0007219 |
35 |
0.126
|
|
|
|
positive regulation of nitrogen compound metabolic process
|
GO:0051173 |
69 |
0.125
|
|
|
|
camera type eye development
|
GO:0043010 |
222 |
0.125
|
Zebrafish |
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
2 |
0.124
|
|
|
|
cell migration to the midline involved in heart development
|
GO:0003318 |
12 |
0.124
|
|
|
|
single organism metabolic process
|
GO:0044710 |
217 |
0.122
|
Human Fly |
|
|
regulation of cell fate commitment
|
GO:0010453 |
22 |
0.121
|
|
|
|
cellular protein metabolic process
|
GO:0044267 |
129 |
0.119
|
Human Zebrafish Mouse Rat |
|
|
regulation of rna metabolic process
|
GO:0051252 |
224 |
0.119
|
|
|
|
regulation of cellular component organization
|
GO:0051128 |
86 |
0.118
|
Rat Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
3 |
0.118
|
|
|
|
cell death
|
GO:0008219 |
121 |
0.117
|
Human Zebrafish Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
15 |
0.115
|
Human Mouse |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
3 |
0.115
|
|
|
|
positive regulation of metabolic process
|
GO:0009893 |
108 |
0.113
|
Human Fly |
|
|
negative regulation of cellular biosynthetic process
|
GO:0031327 |
55 |
0.113
|
|
|
|
positive regulation of transport
|
GO:0051050 |
2 |
0.112
|
|
|
|
regulation of apoptotic process
|
GO:0042981 |
98 |
0.111
|
Human Fly |
|
|
cellular localization
|
GO:0051641 |
97 |
0.111
|
|
|
|
embryonic organ development
|
GO:0048568 |
381 |
0.111
|
Zebrafish Fly |
|
|
regulation of chemotaxis
|
GO:0050920 |
18 |
0.111
|
Zebrafish |
|
|
cardiac atrium morphogenesis
|
GO:0003209 |
2 |
0.108
|
|
|
|
muscle tissue development
|
GO:0060537 |
110 |
0.107
|
|
|
|
venous blood vessel development
|
GO:0060841 |
9 |
0.107
|
|
|
|
cellular biosynthetic process
|
GO:0044249 |
286 |
0.106
|
|
|
|
amine metabolic process
|
GO:0009308 |
2 |
0.105
|
|
|
|
endocrine system development
|
GO:0035270 |
65 |
0.105
|
Zebrafish |
|
|
cardiogenic plate morphogenesis
|
GO:0003142 |
1 |
0.105
|
|
|
|
positive regulation of transcription dna templated
|
GO:0045893 |
57 |
0.104
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
0 |
0.103
|
|
|
|
establishment of localization
|
GO:0051234 |
244 |
0.102
|
|
|
|
negative regulation of cellular macromolecule biosynthetic process
|
GO:2000113 |
48 |
0.101
|
|
|
|
female sex differentiation
|
GO:0046660 |
4 |
0.100
|
|
|
|
regulation of mesenchymal cell proliferation
|
GO:0010464 |
1 |
0.100
|
|
|
|
eye development
|
GO:0001654 |
277 |
0.099
|
Zebrafish |
|
|
regulation of synapse organization
|
GO:0050807 |
3 |
0.099
|
|
|
|
response to external stimulus
|
GO:0009605 |
264 |
0.098
|
Zebrafish Fly |
|
|
programmed cell death
|
GO:0012501 |
119 |
0.097
|
Human Zebrafish Fly |
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
1 |
0.097
|
Human |
|
|
regulation of protein catabolic process
|
GO:0042176 |
1 |
0.096
|
|
|
|
regulation of molecular function
|
GO:0065009 |
70 |
0.096
|
|
|
|
positive regulation of multicellular organismal process
|
GO:0051240 |
52 |
0.096
|
Human Zebrafish |
|
|
single organism localization
|
GO:1902578 |
225 |
0.094
|
|
|
|
primitive hemopoiesis
|
GO:0060215 |
27 |
0.094
|
|
|
|
positive regulation of macrophage chemotaxis
|
GO:0010759 |
1 |
0.094
|
Zebrafish |
|
|
phosphate containing compound metabolic process
|
GO:0006796 |
108 |
0.094
|
Human Zebrafish Mouse Rat Fly |
|
|
negative regulation of macromolecule biosynthetic process
|
GO:0010558 |
48 |
0.094
|
|
|
|
positive regulation of muscle tissue development
|
GO:1901863 |
1 |
0.093
|
|
|
|
regulation of neuron migration
|
GO:2001222 |
2 |
0.093
|
|
|
|
cellular macromolecule biosynthetic process
|
GO:0034645 |
224 |
0.092
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
55 |
0.092
|
Human Fly |
|
|
cellular response to stress
|
GO:0033554 |
62 |
0.090
|
Human Fly |
|
|
regulation of mononuclear cell migration
|
GO:0071675 |
1 |
0.089
|
Zebrafish |
|
|
positive regulation of neural retina development
|
GO:0061075 |
1 |
0.088
|
Zebrafish |
|
|
wound healing
|
GO:0042060 |
90 |
0.088
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
60 |
0.088
|
Human Fly |
|
|
negative regulation of developmental process
|
GO:0051093 |
65 |
0.087
|
|
|
|
ectodermal placode morphogenesis
|
GO:0071697 |
32 |
0.087
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
2 |
0.087
|
|
|
|
negative regulation of angiogenesis
|
GO:0016525 |
7 |
0.085
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
55 |
0.085
|
Fly |
|
|
lymphatic endothelial cell differentiation
|
GO:0060836 |
1 |
0.085
|
|
|
|
regulation of binding
|
GO:0051098 |
3 |
0.084
|
|
|
|
lateral line development
|
GO:0048882 |
66 |
0.082
|
|
|
|
inner ear receptor cell development
|
GO:0060119 |
20 |
0.082
|
|
|
|
liver development
|
GO:0001889 |
96 |
0.081
|
|
|
|
oxoacid metabolic process
|
GO:0043436 |
31 |
0.081
|
|
|
|
regulation of vasculogenesis
|
GO:2001212 |
1 |
0.079
|
|
|
|
organic cyclic compound metabolic process
|
GO:1901360 |
301 |
0.079
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
2 |
0.079
|
|
|
|
regulation of programmed cell death
|
GO:0043067 |
101 |
0.078
|
Human Fly |
|
|
immune system development
|
GO:0002520 |
191 |
0.078
|
Zebrafish Fly |
|
|
neuron projection morphogenesis
|
GO:0048812 |
161 |
0.078
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
0 |
0.077
|
|
|
|
trabecula morphogenesis
|
GO:0061383 |
2 |
0.077
|
|
|
|
sensory organ development
|
GO:0007423 |
393 |
0.076
|
Zebrafish |
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
4 |
0.076
|
|
|
|
organic acid metabolic process
|
GO:0006082 |
31 |
0.076
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
4 |
0.075
|
|
|
|
system process
|
GO:0003008 |
185 |
0.074
|
Zebrafish |
|
|
mesenchymal cell proliferation
|
GO:0010463 |
1 |
0.074
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
38 |
0.073
|
|
|
|
negative regulation of metabolic process
|
GO:0009892 |
86 |
0.073
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
20 |
0.072
|
|
|
|
neuroepithelial cell differentiation
|
GO:0060563 |
26 |
0.072
|
Zebrafish |
|
|
axon guidance
|
GO:0007411 |
86 |
0.071
|
|
|
|
regeneration
|
GO:0031099 |
91 |
0.071
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
2 |
0.069
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
336 |
0.069
|
Fly |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
3 |
0.068
|
|
|
|
regulation of cellular protein metabolic process
|
GO:0032268 |
52 |
0.068
|
Human |
|
|
protein secretion
|
GO:0009306 |
1 |
0.067
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
1 |
0.067
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
2 |
0.066
|
|
|
|
macromolecule biosynthetic process
|
GO:0009059 |
227 |
0.064
|
|
|
|
regulation of locomotion
|
GO:0040012 |
55 |
0.064
|
Human Zebrafish |
|
|
positive regulation of rna metabolic process
|
GO:0051254 |
59 |
0.064
|
|
|
|
heart morphogenesis
|
GO:0003007 |
156 |
0.063
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
33 |
0.063
|
|
|
|
aorta development
|
GO:0035904 |
4 |
0.063
|
|
|
|
response to oxygen levels
|
GO:0070482 |
25 |
0.062
|
|
|
|
negative regulation of macromolecule metabolic process
|
GO:0010605 |
76 |
0.062
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
29 |
0.062
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
17 |
0.061
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
35 |
0.060
|
|
|
|
pigmentation
|
GO:0043473 |
85 |
0.060
|
Zebrafish |
|
|
regulation of protein binding
|
GO:0043393 |
3 |
0.060
|
|
|
|
neuron differentiation
|
GO:0030182 |
353 |
0.059
|
|
|
|
pancreas development
|
GO:0031016 |
84 |
0.059
|
|
|
|
regulation of heart growth
|
GO:0060420 |
2 |
0.058
|
|
|
|
regulation of stem cell proliferation
|
GO:0072091 |
2 |
0.058
|
|
|
|
response to wounding
|
GO:0009611 |
116 |
0.058
|
|
|
|
response to lipid
|
GO:0033993 |
60 |
0.058
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
39 |
0.058
|
Human Mouse Rat |
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
3 |
0.058
|
Human |
|
|
positive regulation of nucleic acid templated transcription
|
GO:1903508 |
57 |
0.057
|
|
|
|
epithelial cell migration
|
GO:0010631 |
25 |
0.057
|
|
|
|
ectodermal placode development
|
GO:0071696 |
37 |
0.056
|
|
|
|
positive regulation of stem cell proliferation
|
GO:2000648 |
1 |
0.056
|
|
|
|
homeostatic process
|
GO:0042592 |
142 |
0.055
|
Fly |
|
|
regulation of organ morphogenesis
|
GO:2000027 |
35 |
0.055
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
1 |
0.055
|
|
|
|
ventricular cardiac muscle tissue morphogenesis
|
GO:0055010 |
2 |
0.055
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
4 |
0.054
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
3 |
0.054
|
Human |
|
|
phagocytosis
|
GO:0006909 |
3 |
0.054
|
|
|
|
axonal defasciculation
|
GO:0007414 |
2 |
0.054
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
46 |
0.053
|
|
|
|
epithelial cell development
|
GO:0002064 |
42 |
0.053
|
Fly |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
3 |
0.053
|
|
|
|
maintenance of location
|
GO:0051235 |
4 |
0.052
|
|
|
|
female gonad development
|
GO:0008585 |
4 |
0.052
|
|
|
|
neuron development
|
GO:0048666 |
262 |
0.052
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
333 |
0.051
|
Fly |
|
|
innervation
|
GO:0060384 |
3 |
0.051
|
|
|
|
anterior posterior pattern specification
|
GO:0009952 |
152 |
0.051
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
11 |
0.051
|
Human Zebrafish |
|
|
endodermal cell fate specification
|
GO:0001714 |
17 |
0.050
|
|
|
|
trabecula formation
|
GO:0060343 |
2 |
0.050
|
|
|
|
glial cell differentiation
|
GO:0010001 |
42 |
0.050
|
Zebrafish |
|
|
positive regulation of rna biosynthetic process
|
GO:1902680 |
57 |
0.049
|
|
|
|
phosphorylation
|
GO:0016310 |
69 |
0.049
|
Human Zebrafish Mouse Rat Fly |
|
|
cardiac muscle tissue development
|
GO:0048738 |
48 |
0.049
|
|
|
|
negative regulation of rna biosynthetic process
|
GO:1902679 |
45 |
0.049
|
|
|
|
post embryonic morphogenesis
|
GO:0009886 |
4 |
0.049
|
Fly |
|
|
gastrulation with mouth forming second
|
GO:0001702 |
44 |
0.047
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
25 |
0.047
|
|
|
|
protein phosphorylation
|
GO:0006468 |
47 |
0.047
|
Human Zebrafish Mouse Rat |
|
|
vesicle mediated transport
|
GO:0016192 |
22 |
0.047
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
2 |
0.047
|
|
|
|
protein import
|
GO:0017038 |
3 |
0.047
|
|
|
|
neuron projection extension involved in neuron projection guidance
|
GO:1902284 |
10 |
0.046
|
|
|
|
lateral line system development
|
GO:0048925 |
76 |
0.046
|
|
|
|
response to retinoic acid
|
GO:0032526 |
6 |
0.046
|
|
|
|
facial nerve development
|
GO:0021561 |
3 |
0.046
|
|
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
1 |
0.046
|
|
|
|
skeletal system development
|
GO:0001501 |
181 |
0.046
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
7 |
0.046
|
|
|
|
retina development in camera type eye
|
GO:0060041 |
146 |
0.045
|
Zebrafish |
|
|
striated muscle tissue development
|
GO:0014706 |
110 |
0.045
|
|
|
|
epiboly involved in gastrulation with mouth forming second
|
GO:0055113 |
35 |
0.045
|
|
|
|
negative regulation of nitrogen compound metabolic process
|
GO:0051172 |
59 |
0.045
|
|
|
|
cellular modified amino acid metabolic process
|
GO:0006575 |
3 |
0.045
|
|
|
|
dorsal ventral pattern formation
|
GO:0009953 |
125 |
0.045
|
|
|
|
regulation of protein metabolic process
|
GO:0051246 |
56 |
0.045
|
Human |
|
|
signal transduction in absence of ligand
|
GO:0038034 |
1 |
0.045
|
|
|
|
smooth muscle contraction
|
GO:0006939 |
2 |
0.044
|
Zebrafish |
|
|
positive regulation of mesenchymal cell proliferation
|
GO:0002053 |
1 |
0.044
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
3 |
0.044
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
86 |
0.044
|
Zebrafish |
|
|
stem cell differentiation
|
GO:0048863 |
117 |
0.044
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
4 |
0.044
|
|
|
|
tissue migration
|
GO:0090130 |
37 |
0.043
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
1 |
0.043
|
|
|
|
outflow tract morphogenesis
|
GO:0003151 |
1 |
0.043
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
1 |
0.043
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
4 |
0.043
|
|
|
|
gliogenesis
|
GO:0042063 |
45 |
0.043
|
Zebrafish |
|
|
response to estrogen
|
GO:0043627 |
27 |
0.042
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter
|
GO:0045944 |
22 |
0.042
|
|
|
|
positive regulation of lymphangiogenesis
|
GO:1901492 |
3 |
0.042
|
|
|
|
cardiac chamber development
|
GO:0003205 |
19 |
0.041
|
|
|
|
pharyngeal muscle development
|
GO:0043282 |
4 |
0.041
|
|
|
|
death
|
GO:0016265 |
121 |
0.041
|
Human Zebrafish Fly |
|
|
peripheral nervous system development
|
GO:0007422 |
55 |
0.041
|
|
|
|
determination of heart left right asymmetry
|
GO:0061371 |
117 |
0.041
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
53 |
0.041
|
|
|
|
single organism transport
|
GO:0044765 |
206 |
0.041
|
|
|
|
inner ear receptor cell differentiation
|
GO:0060113 |
29 |
0.041
|
|
|
|
ectodermal placode formation
|
GO:0060788 |
26 |
0.040
|
|
|
|
cell migration involved in heart formation
|
GO:0060974 |
10 |
0.040
|
|
|
|
artery development
|
GO:0060840 |
22 |
0.040
|
Zebrafish |
|
|
dorsal aorta development
|
GO:0035907 |
4 |
0.040
|
|
|
|
regulation of immune system process
|
GO:0002682 |
34 |
0.040
|
Zebrafish Fly |
|
|
organ regeneration
|
GO:0031100 |
1 |
0.039
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
3 |
0.039
|
|
|
|
behavior
|
GO:0007610 |
74 |
0.038
|
Zebrafish |
|
|
aorta morphogenesis
|
GO:0035909 |
3 |
0.038
|
|
|
|
megakaryocyte development
|
GO:0035855 |
1 |
0.038
|
|
|
|
negative regulation of transcription dna templated
|
GO:0045892 |
45 |
0.038
|
|
|
|
positive regulation of cellular biosynthetic process
|
GO:0031328 |
68 |
0.038
|
|
|
|
cell adhesion
|
GO:0007155 |
40 |
0.038
|
|
|
|
positive regulation of cell communication
|
GO:0010647 |
56 |
0.037
|
Human Fly |
|
|
sensory organ morphogenesis
|
GO:0090596 |
200 |
0.037
|
|
|
|
positive regulation of cell substrate adhesion
|
GO:0010811 |
1 |
0.037
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
108 |
0.037
|
|
|
|
regulation of cell development
|
GO:0060284 |
100 |
0.037
|
|
|
|
regulation of cell shape
|
GO:0008360 |
1 |
0.037
|
Fly |
|
|
oligodendrocyte differentiation
|
GO:0048709 |
23 |
0.036
|
|
|
|
regulation of reproductive process
|
GO:2000241 |
4 |
0.036
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
36 |
0.036
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
1 |
0.036
|
|
|
|
regulation of erythrocyte differentiation
|
GO:0045646 |
2 |
0.036
|
|
|
|
cellular protein modification process
|
GO:0006464 |
100 |
0.035
|
Human Zebrafish Mouse Rat |
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
2 |
0.035
|
|
|
|
wnt signaling pathway planar cell polarity pathway
|
GO:0060071 |
4 |
0.035
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
5 |
0.035
|
Human |
|
|
endothelial cell migration
|
GO:0043542 |
19 |
0.034
|
|
|
|
renal system development
|
GO:0072001 |
94 |
0.034
|
Fly |
|
|
positive regulation of biosynthetic process
|
GO:0009891 |
68 |
0.034
|
|
|
|
positive regulation of muscle organ development
|
GO:0048636 |
1 |
0.034
|
|
|
|
negative regulation of signal transduction
|
GO:0009968 |
94 |
0.034
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
62 |
0.033
|
|
|
|
axon development
|
GO:0061564 |
166 |
0.033
|
|
|
|
negative regulation of nucleobase containing compound metabolic process
|
GO:0045934 |
59 |
0.033
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
1 |
0.033
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
2 |
0.033
|
|
|
|
regulation of organ growth
|
GO:0046620 |
3 |
0.033
|
|
|
|
otic vesicle morphogenesis
|
GO:0071600 |
34 |
0.033
|
|
|
|
cardiac ventricle morphogenesis
|
GO:0003208 |
7 |
0.033
|
|
|
|
otic placode formation
|
GO:0043049 |
23 |
0.032
|
|
|
|
single organism nuclear import
|
GO:1902593 |
3 |
0.032
|
|
|
|
determination of bilateral symmetry
|
GO:0009855 |
204 |
0.032
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
30 |
0.032
|
|
|
|
hepatocyte differentiation
|
GO:0070365 |
1 |
0.032
|
|
|
|
protein import into nucleus
|
GO:0006606 |
3 |
0.032
|
|
|
|
epiboly
|
GO:0090504 |
41 |
0.032
|
|
|
|
epithelium migration
|
GO:0090132 |
25 |
0.031
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
26 |
0.031
|
|
|
|
regulation of heart morphogenesis
|
GO:2000826 |
17 |
0.031
|
|
|
|
specification of organ identity
|
GO:0010092 |
2 |
0.031
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
1 |
0.031
|
|
|
|
cellular response to vascular endothelial growth factor stimulus
|
GO:0035924 |
3 |
0.031
|
Human Mouse Rat |
|
|
regulation of cell fate specification
|
GO:0042659 |
20 |
0.031
|
|
|
|
regulation of systemic arterial blood pressure
|
GO:0003073 |
1 |
0.031
|
|
|
|
mesenchymal cell differentiation
|
GO:0048762 |
87 |
0.031
|
|
|
|
biological adhesion
|
GO:0022610 |
40 |
0.031
|
|
|
|
chemotaxis
|
GO:0006935 |
104 |
0.031
|
Zebrafish |
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
1 |
0.031
|
|
|
|
heart growth
|
GO:0060419 |
7 |
0.031
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
2 |
0.030
|
|
|
|
negative regulation of biosynthetic process
|
GO:0009890 |
55 |
0.030
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
1 |
0.030
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
1 |
0.030
|
|
|
|
positive regulation of cellular protein metabolic process
|
GO:0032270 |
22 |
0.030
|
Human |
|
|
positive regulation of cellular component movement
|
GO:0051272 |
11 |
0.030
|
Human Zebrafish |
|
|
synaptic target recognition
|
GO:0008039 |
1 |
0.030
|
|
|
|
eye morphogenesis
|
GO:0048592 |
144 |
0.030
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
1 |
0.029
|
|
|
|
regulation of phosphorylation
|
GO:0042325 |
26 |
0.029
|
Human Fly |
|
|
regulation of dna templated transcription elongation
|
GO:0032784 |
3 |
0.029
|
|
|
|
organ formation
|
GO:0048645 |
17 |
0.029
|
|
|
|
heart valve formation
|
GO:0003188 |
4 |
0.029
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
2 |
0.029
|
|
|
|
cardiac atrium development
|
GO:0003230 |
4 |
0.029
|
|
|
|
positive regulation of macromolecule biosynthetic process
|
GO:0010557 |
59 |
0.029
|
|
|
|
positive regulation of striated muscle cell differentiation
|
GO:0051155 |
1 |
0.028
|
|
|
|
regulation of endodermal cell fate specification
|
GO:0042663 |
15 |
0.028
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
15 |
0.028
|
|
|
|
b cell activation
|
GO:0042113 |
2 |
0.028
|
|
|
|
negative regulation of nucleic acid templated transcription
|
GO:1903507 |
45 |
0.028
|
|
|
|
regulation of gastrulation
|
GO:0010470 |
24 |
0.027
|
|
|
|
positive regulation of reproductive process
|
GO:2000243 |
2 |
0.027
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
9 |
0.027
|
|
|
|
epithelial cell fate commitment
|
GO:0072148 |
11 |
0.027
|
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
4 |
0.027
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
2 |
0.027
|
|
|
|
megakaryocyte differentiation
|
GO:0030219 |
1 |
0.026
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
2 |
0.026
|
Human |
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
38 |
0.026
|
|
|
|
central nervous system neuron differentiation
|
GO:0021953 |
74 |
0.026
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
2 |
0.026
|
|
|
|
single organism reproductive process
|
GO:0044702 |
40 |
0.026
|
Fly |
|
|
ovulation cycle
|
GO:0042698 |
2 |
0.025
|
|
|
|
specification of symmetry
|
GO:0009799 |
204 |
0.025
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
4 |
0.025
|
|
|
|
lipid metabolic process
|
GO:0006629 |
52 |
0.025
|
|
|
|
response to hypoxia
|
GO:0001666 |
25 |
0.025
|
|
|
|
negative regulation of cellular metabolic process
|
GO:0031324 |
77 |
0.025
|
|
|
|
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
|
GO:0002043 |
4 |
0.025
|
|
|
|
muscle cell migration
|
GO:0014812 |
4 |
0.025
|
|
|
|
negative regulation of response to stimulus
|
GO:0048585 |
104 |
0.025
|
|
|
|
regulation of localization
|
GO:0032879 |
104 |
0.025
|
Human Zebrafish |
|
|
vestibular receptor cell differentiation
|
GO:0060114 |
3 |
0.025
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
1 |
0.025
|
|
|
|
positive regulation of chemotaxis
|
GO:0050921 |
5 |
0.025
|
Zebrafish |
|
|
axonogenesis
|
GO:0007409 |
152 |
0.025
|
|
|
|
small molecule metabolic process
|
GO:0044281 |
77 |
0.025
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
4 |
0.025
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
80 |
0.024
|
|
|
|
regulation of intracellular signal transduction
|
GO:1902531 |
57 |
0.024
|
Human Fly |
|
|
single organism membrane fusion
|
GO:0044801 |
2 |
0.024
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
2 |
0.024
|
|
|
|
negative regulation of reproductive process
|
GO:2000242 |
3 |
0.024
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
18 |
0.024
|
|
|
|
negative regulation of mesodermal cell fate specification
|
GO:0042662 |
3 |
0.024
|
|
|
|
ventricular cardiac muscle cell development
|
GO:0055015 |
5 |
0.024
|
|
|
|
cellular response to organic substance
|
GO:0071310 |
105 |
0.024
|
Human Mouse Rat Fly |
|
|
ear morphogenesis
|
GO:0042471 |
64 |
0.024
|
|
|
|
otic vesicle development
|
GO:0071599 |
42 |
0.024
|
|
|
|
homeostasis of number of cells within a tissue
|
GO:0048873 |
4 |
0.024
|
|
|
|
head development
|
GO:0060322 |
303 |
0.023
|
|
|
|
regulation of behavior
|
GO:0050795 |
24 |
0.023
|
Zebrafish |
|
|
response to organic cyclic compound
|
GO:0014070 |
51 |
0.023
|
|
|
|
positive regulation of neuron migration
|
GO:2001224 |
2 |
0.023
|
|
|
|
response to endogenous stimulus
|
GO:0009719 |
83 |
0.023
|
Fly |
|
|
regulation of phosphate metabolic process
|
GO:0019220 |
43 |
0.023
|
Human Fly |
|
|
regulation of growth rate
|
GO:0040009 |
1 |
0.023
|
|
|
|
nuclear import
|
GO:0051170 |
3 |
0.023
|
|
|
|
endothelium development
|
GO:0003158 |
25 |
0.023
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
26 |
0.023
|
|
|
|
sensory system development
|
GO:0048880 |
76 |
0.023
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
1 |
0.023
|
|
|
|
regulation of transcription elongation from rna polymerase ii promoter
|
GO:0034243 |
3 |
0.022
|
|
|
|
ovulation cycle process
|
GO:0022602 |
2 |
0.022
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
274 |
0.022
|
|
|
|
organonitrogen compound metabolic process
|
GO:1901564 |
74 |
0.022
|
|
|
|
negative regulation of blood circulation
|
GO:1903523 |
2 |
0.022
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
55 |
0.022
|
Human Zebrafish |
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
6 |
0.022
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
15 |
0.022
|
Zebrafish |
|
|
positive regulation of striated muscle tissue development
|
GO:0045844 |
1 |
0.022
|
|
|
|
cell substrate junction assembly
|
GO:0007044 |
2 |
0.021
|
|
|
|
gas transport
|
GO:0015669 |
3 |
0.021
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
97 |
0.021
|
Fly |
|
|
lens fiber cell development
|
GO:0070307 |
3 |
0.021
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
16 |
0.021
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
11 |
0.021
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
3 |
0.021
|
|
|
|
cell migration involved in sprouting angiogenesis
|
GO:0002042 |
8 |
0.021
|
|
|
|
regulation of endodermal cell differentiation
|
GO:1903224 |
15 |
0.021
|
|
|
|
negative regulation of cell communication
|
GO:0010648 |
96 |
0.021
|
|
|
|
response to drug
|
GO:0042493 |
3 |
0.021
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
3 |
0.021
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
79 |
0.020
|
|
