Danio rerio

0 known processes

fmnl2a

formin-like 2a

(Aliases: fmnl2,si:ch211-279a7.1)

fmnl2a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
specification of symmetry GO:0009799 204 0.307
regulation of biological quality GO:0065008 263 0.188
cell part morphogenesis GO:0032990 246 0.170
cellular component assembly GO:0022607 170 0.166
regulation of cell shape GO:0008360 1 0.152
heart development GO:0007507 313 0.137
guanosine containing compound metabolic process GO:1901068 4 0.133
regulation of cell matrix adhesion GO:0001952 1 0.123
regulation of signaling GO:0023051 235 0.120
regulation of cellular component organization GO:0051128 86 0.120
modification dependent protein catabolic process GO:0019941 3 0.120
regulation of cellular metabolic process GO:0031323 320 0.113
positive regulation of biological process GO:0048518 253 0.110
heart looping GO:0001947 94 0.102
cell surface receptor signaling pathway GO:0007166 325 0.099
positive regulation of phospholipase c activity GO:0010863 1 0.098
axon guidance GO:0007411 86 0.097
sequestering of metal ion GO:0051238 3 0.094
regulation of localization GO:0032879 104 0.093
adherens junction organization GO:0034332 4 0.091
regulation of cell communication GO:0010646 232 0.082
extrinsic apoptotic signaling pathway GO:0097191 3 0.081
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.081
actin cytoskeleton organization GO:0030036 63 0.080
macrophage chemotaxis GO:0048246 3 0.080
regulation of cell substrate adhesion GO:0010810 1 0.079
protein complex subunit organization GO:0071822 46 0.078
convergent extension GO:0060026 118 0.076
determination of left right symmetry GO:0007368 179 0.074
neural crest cell differentiation GO:0014033 72 0.074
cellular aromatic compound metabolic process GO:0006725 295 0.072
skeletal muscle organ development GO:0060538 78 0.072
taxis GO:0042330 109 0.070
smooth muscle contraction GO:0006939 2 0.070
cell morphogenesis involved in differentiation GO:0000904 195 0.069
inner ear receptor stereocilium organization GO:0060122 8 0.069
epithelial tube morphogenesis GO:0060562 148 0.067
central nervous system development GO:0007417 387 0.066
eye development GO:0001654 277 0.065
regulation of multicellular organismal development GO:2000026 223 0.065
negative regulation of cellular process GO:0048523 283 0.065
macromolecular complex subunit organization GO:0043933 74 0.065
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.064
positive regulation of cellular component biogenesis GO:0044089 3 0.064
blood vessel morphogenesis GO:0048514 216 0.064
convergent extension involved in gastrulation GO:0060027 71 0.062
regulation of signal transduction GO:0009966 225 0.061
cell matrix adhesion GO:0007160 4 0.059
regulation of embryonic development GO:0045995 47 0.058
mesenchymal cell development GO:0014031 78 0.058
cellular component movement GO:0006928 335 0.058
single organismal cell cell adhesion GO:0016337 29 0.057
ameboidal type cell migration GO:0001667 143 0.056
neuron development GO:0048666 262 0.056
angiogenesis GO:0001525 158 0.055
cell death GO:0008219 121 0.054
lipid storage GO:0019915 1 0.054
inorganic ion transmembrane transport GO:0098660 57 0.053
generation of neurons GO:0048699 385 0.052
blood vessel development GO:0001568 246 0.052
chordate embryonic development GO:0043009 271 0.051
response to stress GO:0006950 263 0.050
regulation of heart contraction GO:0008016 32 0.049
embryonic viscerocranium morphogenesis GO:0048703 52 0.048
tube morphogenesis GO:0035239 349 0.046
synaptic vesicle localization GO:0097479 1 0.045
adult behavior GO:0030534 2 0.044
regulation of anatomical structure morphogenesis GO:0022603 130 0.044
heart morphogenesis GO:0003007 156 0.044
mitotic dna integrity checkpoint GO:0044774 4 0.044
venous blood vessel development GO:0060841 9 0.043
gastrulation GO:0007369 208 0.043
brain development GO:0007420 293 0.042
somite development GO:0061053 96 0.042
negative regulation of signal transduction GO:0009968 94 0.042
cell migration GO:0016477 237 0.042
embryonic heart tube morphogenesis GO:0003143 108 0.041
cell projection morphogenesis GO:0048858 244 0.040
death GO:0016265 121 0.040
cellular component morphogenesis GO:0032989 336 0.040
mesenchyme development GO:0060485 127 0.040
cellular component biogenesis GO:0044085 178 0.040
axon development GO:0061564 166 0.040
larval development GO:0002164 2 0.039
biosynthetic process GO:0009058 294 0.039
muscle organ development GO:0007517 101 0.039
intracellular signal transduction GO:0035556 85 0.038
muscle structure development GO:0061061 196 0.038
regulation of apoptotic process GO:0042981 98 0.038
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.038
cell junction organization GO:0034330 11 0.038
skeletal system morphogenesis GO:0048705 102 0.038
regulation of cell differentiation GO:0045595 142 0.037
regulation of growth GO:0040008 42 0.036
embryonic organ morphogenesis GO:0048562 274 0.036
regulation of nucleotide catabolic process GO:0030811 2 0.036
regionalization GO:0003002 274 0.036
single organism cell adhesion GO:0098602 29 0.036
immune system development GO:0002520 191 0.036
sprouting angiogenesis GO:0002040 53 0.035
oocyte maturation GO:0001556 4 0.034
determination of bilateral symmetry GO:0009855 204 0.034
signal transduction GO:0007165 455 0.034
somitogenesis GO:0001756 87 0.034
regulation of retina development in camera type eye GO:1902866 2 0.034
cytoskeleton organization GO:0007010 96 0.033
digestive tract development GO:0048565 265 0.033
aging GO:0007568 2 0.033
cell substrate adhesion GO:0031589 4 0.033
endothelial cell proliferation GO:0001935 11 0.033
single organism organelle organization GO:1902589 199 0.032
blood vessel endothelial cell migration GO:0043534 18 0.032
cell substrate adherens junction assembly GO:0007045 1 0.032
regulation of phospholipase c activity GO:1900274 1 0.032
regulation of cell motility GO:2000145 46 0.032
negative regulation of signaling GO:0023057 96 0.032
neuron projection morphogenesis GO:0048812 161 0.032
regulation of phosphate metabolic process GO:0019220 43 0.032
neuron projection guidance GO:0097485 86 0.032
single organism transport GO:0044765 206 0.031
reproductive process GO:0022414 40 0.031
cell morphogenesis GO:0000902 289 0.031
regulation of blood vessel size GO:0050880 2 0.031
regulation of multicellular organismal process GO:0051239 277 0.030
cell motility GO:0048870 244 0.030
morphogenesis of an epithelium GO:0002009 333 0.029
inorganic cation transmembrane transport GO:0098662 50 0.029
outflow tract morphogenesis GO:0003151 1 0.029
regulation of cellular component movement GO:0051270 55 0.029
regulation of response to stimulus GO:0048583 269 0.029
regulation of macromolecule metabolic process GO:0060255 317 0.028
cell projection assembly GO:0030031 64 0.028
regulation of synapse organization GO:0050807 3 0.028
regulation of neuron migration GO:2001222 2 0.028
phosphatidylinositol mediated signaling GO:0048015 2 0.028
cytosolic calcium ion transport GO:0060401 3 0.028
regulation of epithelial cell proliferation GO:0050678 3 0.028
mesenchymal cell proliferation GO:0010463 1 0.028
regulation of programmed cell death GO:0043067 101 0.028
organic substance biosynthetic process GO:1901576 289 0.028
single organism reproductive process GO:0044702 40 0.027
embryonic skeletal system morphogenesis GO:0048704 93 0.027
synaptic growth at neuromuscular junction GO:0051124 2 0.027
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.027
epithelial cell proliferation GO:0050673 17 0.027
regulation of cell morphogenesis GO:0022604 42 0.027
regulation of developmental process GO:0050793 247 0.026
regulation of synapse assembly GO:0051963 3 0.026
axonal defasciculation GO:0007414 2 0.026
cellular protein modification process GO:0006464 100 0.026
regulation of purine nucleotide catabolic process GO:0033121 2 0.026
positive regulation of signaling GO:0023056 56 0.026
negative regulation of biological process GO:0048519 304 0.026
proteasomal protein catabolic process GO:0010498 2 0.026
female sex differentiation GO:0046660 4 0.026
cell substrate junction assembly GO:0007044 2 0.025
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.025
regulation of cell death GO:0010941 103 0.025
regulation of tube size GO:0035150 2 0.025
localization of cell GO:0051674 244 0.025
regulation of locomotion GO:0040012 55 0.025
neuromast deposition GO:0048885 9 0.025
ovarian follicle development GO:0001541 2 0.025
auditory receptor cell development GO:0060117 8 0.024
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.024
small molecule metabolic process GO:0044281 77 0.024
adherens junction assembly GO:0034333 1 0.024
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.023
regulation of primary metabolic process GO:0080090 311 0.023
cellular biosynthetic process GO:0044249 286 0.023
regulation of wnt signaling pathway GO:0030111 53 0.023
determination of heart left right asymmetry GO:0061371 117 0.023
dorsal convergence GO:0060030 14 0.023
developmental growth GO:0048589 166 0.023
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
positive regulation of leukocyte chemotaxis GO:0002690 1 0.023
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.023
signal transduction in absence of ligand GO:0038034 1 0.023
locomotion GO:0040011 313 0.023
muscle cell differentiation GO:0042692 139 0.022
multi organism process GO:0051704 134 0.022
neural tube development GO:0021915 62 0.022
embryonic cranial skeleton morphogenesis GO:0048701 90 0.022
positive regulation of map kinase activity GO:0043406 3 0.022
regulation of metabolic process GO:0019222 359 0.022
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.022
organelle organization GO:0006996 227 0.022
inner ear development GO:0048839 126 0.022
calcium ion transport into cytosol GO:0060402 3 0.021
antimicrobial humoral response GO:0019730 2 0.021
positive regulation of apoptotic signaling pathway GO:2001235 1 0.021
sensory organ development GO:0007423 393 0.021
dorsal ventral pattern formation GO:0009953 125 0.021
positive regulation of stress activated mapk cascade GO:0032874 3 0.021
regulation of protein catabolic process GO:0042176 1 0.021
neuron recognition GO:0008038 18 0.021
positive regulation of cell communication GO:0010647 56 0.020
growth GO:0040007 174 0.020
cellular protein catabolic process GO:0044257 4 0.020
water homeostasis GO:0030104 4 0.020
response to external stimulus GO:0009605 264 0.020
macromolecule modification GO:0043412 111 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
g1 s transition of mitotic cell cycle GO:0000082 1 0.020
regulation of rho protein signal transduction GO:0035023 2 0.020
embryonic organ development GO:0048568 381 0.020
mitotic g2 m transition checkpoint GO:0044818 3 0.020
cellular macromolecule metabolic process GO:0044260 391 0.019
positive regulation of catabolic process GO:0009896 4 0.019
regulation of establishment of planar polarity GO:0090175 4 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.019
cellular macromolecule biosynthetic process GO:0034645 224 0.019
regulation of phosphorus metabolic process GO:0051174 43 0.019
epithelial cell development GO:0002064 42 0.019
organonitrogen compound metabolic process GO:1901564 74 0.019
positive regulation of cell adhesion GO:0045785 1 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
otolith development GO:0048840 32 0.019
female gonad development GO:0008585 4 0.018
multicellular organism growth GO:0035264 4 0.018
homeostatic process GO:0042592 142 0.018
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.018
nitrogen compound metabolic process GO:0006807 319 0.018
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 10 0.018
anterior posterior pattern specification GO:0009952 152 0.018
regulation of neural retina development GO:0061074 2 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.018
cellular protein metabolic process GO:0044267 129 0.018
phosphorus metabolic process GO:0006793 109 0.018
auditory receptor cell morphogenesis GO:0002093 4 0.018
programmed cell death GO:0012501 119 0.017
lens fiber cell development GO:0070307 3 0.017
cellular nitrogen compound metabolic process GO:0034641 290 0.017
circulatory system process GO:0003013 87 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
amine metabolic process GO:0009308 2 0.017
epithelial cell migration GO:0010631 25 0.017
single organism nuclear import GO:1902593 3 0.017
organic cyclic compound metabolic process GO:1901360 301 0.016
tube closure GO:0060606 1 0.016
organic acid metabolic process GO:0006082 31 0.016
melanocyte migration GO:0097324 4 0.016
regulation of cell migration GO:0030334 40 0.016
protein dephosphorylation GO:0006470 3 0.016
single organism metabolic process GO:0044710 217 0.016
g2 dna damage checkpoint GO:0031572 3 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
behavior GO:0007610 74 0.016
embryonic heart tube development GO:0035050 133 0.015
gtp catabolic process GO:0006184 2 0.015
positive regulation of signal transduction GO:0009967 56 0.015
response to wounding GO:0009611 116 0.015
myotome development GO:0061055 1 0.015
regulation of reproductive process GO:2000241 4 0.015
transport GO:0006810 220 0.015
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.015
stem cell differentiation GO:0048863 117 0.015
actomyosin structure organization GO:0031032 53 0.015
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.014
maintenance of location GO:0051235 4 0.014
embryonic skeletal system development GO:0048706 97 0.014
regulation of intracellular signal transduction GO:1902531 57 0.014
skeletal system development GO:0001501 181 0.014
regulation of mesenchymal cell proliferation GO:0010464 1 0.014
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.014
guanosine containing compound catabolic process GO:1901069 2 0.014
neural retina development GO:0003407 49 0.014
positive regulation of epithelial cell migration GO:0010634 2 0.014
digestive system development GO:0055123 289 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
defense response GO:0006952 47 0.014
protein modification process GO:0036211 100 0.014
neural crest cell development GO:0014032 62 0.014
ribosomal small subunit biogenesis GO:0042274 2 0.014
positive regulation of leukocyte migration GO:0002687 2 0.014
vasculature development GO:0001944 278 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.013
muscle contraction GO:0006936 18 0.013
neural crest cell migration GO:0001755 42 0.013
chondrocyte development GO:0002063 4 0.013
positive regulation of developmental process GO:0051094 50 0.013
regulation of organ morphogenesis GO:2000027 35 0.013
positive regulation of transport GO:0051050 2 0.013
embryonic eye morphogenesis GO:0048048 30 0.013
nuclear import GO:0051170 3 0.013
positive regulation of cellular process GO:0048522 201 0.013
ovulation cycle process GO:0022602 2 0.013
positive regulation of immune effector process GO:0002699 3 0.013
blood circulation GO:0008015 87 0.013
tissue migration GO:0090130 37 0.013
autophagy GO:0006914 4 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
reactive oxygen species metabolic process GO:0072593 6 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
collagen metabolic process GO:0032963 2 0.013
negative regulation of cell migration GO:0030336 17 0.012
tor signaling GO:0031929 7 0.012
cell projection organization GO:0030030 284 0.012
regulation of endothelial cell proliferation GO:0001936 1 0.012
lateral line system development GO:0048925 76 0.012
synaptic target recognition GO:0008039 1 0.012
locomotor rhythm GO:0045475 3 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
cell death in response to oxidative stress GO:0036473 2 0.012
camera type eye development GO:0043010 222 0.012
regulation of cell adhesion GO:0030155 15 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
heart valve formation GO:0003188 4 0.012
epithelium migration GO:0090132 25 0.012
heterocycle metabolic process GO:0046483 290 0.012
protein metabolic process GO:0019538 183 0.012
oxoacid metabolic process GO:0043436 31 0.012
gtp metabolic process GO:0046039 4 0.012
transcription dna templated GO:0006351 181 0.012
interspecies interaction between organisms GO:0044419 4 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
phagocytosis engulfment GO:0006911 1 0.012
cell maturation GO:0048469 23 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
positive regulation of positive chemotaxis GO:0050927 4 0.012
regulation of rho gtpase activity GO:0032319 1 0.012
negative regulation of programmed cell death GO:0043069 58 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
neuromuscular process controlling balance GO:0050885 3 0.011
mitotic g2 dna damage checkpoint GO:0007095 3 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.011
startle response GO:0001964 4 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
tissue regeneration GO:0042246 74 0.011
positive regulation of ras gtpase activity GO:0032320 1 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.011
regulation of cellular response to oxidative stress GO:1900407 2 0.011
collagen fibril organization GO:0030199 1 0.011
telomere organization GO:0032200 1 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
actin filament organization GO:0007015 15 0.011
head development GO:0060322 303 0.011
meiotic cell cycle process GO:1903046 3 0.011
regulation of catalytic activity GO:0050790 55 0.011
patterning of blood vessels GO:0001569 15 0.011
cell cell junction organization GO:0045216 10 0.011
pigmentation GO:0043473 85 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
phosphate containing compound metabolic process GO:0006796 108 0.010
regulation of mononuclear cell migration GO:0071675 1 0.010
nerve development GO:0021675 45 0.010
cellular amine metabolic process GO:0044106 2 0.010
protein targeting to nucleus GO:0044744 3 0.010
system process GO:0003008 185 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
regulation of ras gtpase activity GO:0032318 2 0.010
regulation of nervous system development GO:0051960 90 0.010
wnt signaling pathway GO:0016055 80 0.010

fmnl2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
musculoskeletal system disease DOID:17 0 0.042
nervous system disease DOID:863 0 0.019
disease of cellular proliferation DOID:14566 0 0.013