Danio rerio

42 known processes

fxr1

fragile X mental retardation, autosomal homolog 1

(Aliases: zgc:66226,wu:fd18c10,wu:fb16f11)

fxr1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
striated muscle cell development GO:0055002 108 0.423
axonogenesis GO:0007409 152 0.420
Fly
generation of neurons GO:0048699 385 0.403
Zebrafish Fly
nucleic acid metabolic process GO:0090304 244 0.376
Fly
axon development GO:0061564 166 0.363
Fly
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.336
muscle cell differentiation GO:0042692 139 0.294
neuron projection development GO:0031175 180 0.274
Zebrafish Fly
cellular component morphogenesis GO:0032989 336 0.218
Zebrafish Fly
sarcomere organization GO:0045214 26 0.190
neuron development GO:0048666 262 0.186
Zebrafish Fly
striated muscle cell differentiation GO:0051146 129 0.176
nitrogen compound metabolic process GO:0006807 319 0.164
Fly
neuron differentiation GO:0030182 353 0.162
Zebrafish Fly
striated muscle tissue development GO:0014706 110 0.160
determination of bilateral symmetry GO:0009855 204 0.159
muscle tissue development GO:0060537 110 0.155
cell projection morphogenesis GO:0048858 244 0.152
Zebrafish Fly
organelle assembly GO:0070925 110 0.141
Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.135
Fly
heart development GO:0007507 313 0.133
myofibril assembly GO:0030239 48 0.129
neuron projection morphogenesis GO:0048812 161 0.129
Zebrafish Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.126
Zebrafish Fly
nucleobase containing compound metabolic process GO:0006139 274 0.119
Fly
regulation of biological quality GO:0065008 263 0.118
Fly
neurological system process GO:0050877 62 0.114
Zebrafish Fly
macromolecule biosynthetic process GO:0009059 227 0.114
Mouse Fly
heterocycle metabolic process GO:0046483 290 0.107
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.103
aging GO:0007568 2 0.102
heart morphogenesis GO:0003007 156 0.102
locomotion GO:0040011 313 0.102
Fly
larval development GO:0002164 2 0.101
embryonic heart tube morphogenesis GO:0003143 108 0.098
muscle cell development GO:0055001 115 0.096
cytoskeleton organization GO:0007010 96 0.096
Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.091
modification dependent protein catabolic process GO:0019941 3 0.090
heart process GO:0003015 71 0.089
heart contraction GO:0060047 71 0.087
circulatory system process GO:0003013 87 0.079
response to abiotic stimulus GO:0009628 122 0.076
Fly
cell surface receptor signaling pathway GO:0007166 325 0.076
Fly
cellular respiration GO:0045333 3 0.074
actomyosin structure organization GO:0031032 53 0.072
establishment of protein localization to organelle GO:0072594 4 0.072
system process GO:0003008 185 0.070
Zebrafish Fly
cardiac muscle cell development GO:0055013 20 0.070
cardiac muscle tissue development GO:0048738 48 0.068
aromatic compound biosynthetic process GO:0019438 217 0.067
regulation of stem cell proliferation GO:0072091 2 0.065
Fly
morphogenesis of an epithelium GO:0002009 333 0.064
meiotic nuclear division GO:0007126 4 0.064
cellular aromatic compound metabolic process GO:0006725 295 0.063
Fly
muscle structure development GO:0061061 196 0.063
cognition GO:0050890 1 0.063
Zebrafish Fly
cellular macromolecule metabolic process GO:0044260 391 0.062
Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.062
Mouse Fly
cellular component assembly involved in morphogenesis GO:0010927 107 0.061
Fly
homeostatic process GO:0042592 142 0.060
cardiac muscle cell differentiation GO:0055007 30 0.059
cardiac cell development GO:0055006 21 0.058
response to light stimulus GO:0009416 46 0.058
i kappab kinase nf kappab signaling GO:0007249 4 0.057
cell projection organization GO:0030030 284 0.057
Zebrafish Fly
muscle system process GO:0003012 20 0.057
ubiquitin dependent protein catabolic process GO:0006511 3 0.056
rna localization GO:0006403 4 0.055
Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.053
chemotaxis GO:0006935 104 0.053
Fly
camera type eye development GO:0043010 222 0.052
convergent extension involved in gastrulation GO:0060027 71 0.052
meiotic cell cycle process GO:1903046 3 0.052
single organism organelle organization GO:1902589 199 0.050
Fly
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.050
blood circulation GO:0008015 87 0.050
specification of symmetry GO:0009799 204 0.048
spermatid differentiation GO:0048515 2 0.047
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.047
heart looping GO:0001947 94 0.046
muscle contraction GO:0006936 18 0.046
cell death in response to oxidative stress GO:0036473 2 0.046
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.044
determination of heart left right asymmetry GO:0061371 117 0.044
regulation of rna biosynthetic process GO:2001141 213 0.043
nucleocytoplasmic transport GO:0006913 4 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.042
cell migration GO:0016477 237 0.042
vasculature development GO:0001944 278 0.041
single organism metabolic process GO:0044710 217 0.040
cell proliferation GO:0008283 80 0.039
Fly
modification dependent macromolecule catabolic process GO:0043632 3 0.039
regulation of rna metabolic process GO:0051252 224 0.038
regulation of binding GO:0051098 3 0.038
axon guidance GO:0007411 86 0.037
Fly
regulation of cellular response to oxidative stress GO:1900407 2 0.037
directional locomotion GO:0033058 1 0.037
nuclear transport GO:0051169 4 0.037
regulation of mrna splicing via spliceosome GO:0048024 3 0.037
chemical homeostasis GO:0048878 49 0.037
positive regulation of transport GO:0051050 2 0.036
regulation of macromolecule metabolic process GO:0060255 317 0.036
Mouse Fly
cellular protein catabolic process GO:0044257 4 0.036
protein import into nucleus GO:0006606 3 0.036
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.035
axonal fasciculation GO:0007413 11 0.035
Fly
cell morphogenesis GO:0000902 289 0.034
Zebrafish Fly
determination of left right symmetry GO:0007368 179 0.034
nucleic acid templated transcription GO:0097659 181 0.033
cellular component assembly GO:0022607 170 0.033
Fly
heterocycle biosynthetic process GO:0018130 215 0.033
positive regulation of cell cycle GO:0045787 3 0.032
regulation of gene expression GO:0010468 265 0.032
Mouse Fly
central nervous system development GO:0007417 387 0.032
Zebrafish Fly
gastrulation GO:0007369 208 0.031
response to chemical GO:0042221 320 0.031
Fly
actin cytoskeleton organization GO:0030036 63 0.031
neuron neuron synaptic transmission GO:0007270 1 0.031
cellular component movement GO:0006928 335 0.031
Fly
digestive system development GO:0055123 289 0.030
transport GO:0006810 220 0.030
Fly
regulation of transcription dna templated GO:0006355 213 0.030
gene expression GO:0010467 252 0.030
Mouse Fly
cardiocyte differentiation GO:0035051 44 0.030
regulation of protein binding GO:0043393 3 0.029
anatomical structure homeostasis GO:0060249 36 0.029
proteasomal protein catabolic process GO:0010498 2 0.029
protein localization to nucleus GO:0034504 3 0.029
cellular macromolecule biosynthetic process GO:0034645 224 0.028
Mouse Fly
cellular component disassembly GO:0022411 1 0.028
single organism transport GO:0044765 206 0.028
Fly
actin filament based process GO:0030029 64 0.028
synaptic growth at neuromuscular junction GO:0051124 2 0.027
Fly
cardiac myofibril assembly GO:0055003 9 0.027
stem cell differentiation GO:0048863 117 0.027
Zebrafish
transmission of nerve impulse GO:0019226 19 0.027
convergent extension GO:0060026 118 0.026
nuclear import GO:0051170 3 0.026
digestive tract morphogenesis GO:0048546 231 0.026
cell death GO:0008219 121 0.026
regulation of response to oxidative stress GO:1902882 2 0.026
multi organism reproductive process GO:0044703 36 0.026
Fly
biosynthetic process GO:0009058 294 0.026
Mouse Fly
actin filament based movement GO:0030048 1 0.026
protein import GO:0017038 3 0.025
regulation of macromolecule biosynthetic process GO:0010556 225 0.025
Mouse Fly
regulation of neural precursor cell proliferation GO:2000177 3 0.024
Fly
stem cell proliferation GO:0072089 4 0.024
Fly
cellular biosynthetic process GO:0044249 286 0.024
Mouse Fly
regulation of signaling GO:0023051 235 0.024
Fly
muscle organ development GO:0007517 101 0.024
macromolecule localization GO:0033036 54 0.024
Fly
head development GO:0060322 303 0.024
Zebrafish Fly
protein targeting to nucleus GO:0044744 3 0.024
alternative mrna splicing via spliceosome GO:0000380 1 0.023
regulation of synapse assembly GO:0051963 3 0.023
Fly
cell cycle g1 s phase transition GO:0044843 1 0.023
response to external stimulus GO:0009605 264 0.023
Fly
stem cell maintenance GO:0019827 4 0.023
regulation of nucleoside metabolic process GO:0009118 2 0.022
organic cyclic compound metabolic process GO:1901360 301 0.022
Fly
tube morphogenesis GO:0035239 349 0.022
gamete generation GO:0007276 33 0.022
Fly
rna biosynthetic process GO:0032774 181 0.022
electron transport chain GO:0022900 2 0.022
regulation of membrane potential GO:0042391 23 0.022
brain development GO:0007420 293 0.022
Zebrafish Fly
eye development GO:0001654 277 0.022
detection of abiotic stimulus GO:0009582 24 0.022
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.022
embryonic organ morphogenesis GO:0048562 274 0.021
cell migration involved in gastrulation GO:0042074 79 0.021
nitric oxide metabolic process GO:0046209 2 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
digestive tract development GO:0048565 265 0.021
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.021
regulation of oxidative stress induced cell death GO:1903201 2 0.021
ameboidal type cell migration GO:0001667 143 0.021
regulation of protein complex assembly GO:0043254 3 0.020
somite development GO:0061053 96 0.020
lipid homeostasis GO:0055088 3 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
adult behavior GO:0030534 2 0.020
maintenance of location GO:0051235 4 0.020
positive regulation of catabolic process GO:0009896 4 0.020
phagocytosis GO:0006909 3 0.020
cellular response to oxygen levels GO:0071453 1 0.020
neuron projection guidance GO:0097485 86 0.020
Fly
regulation of mrna processing GO:0050684 3 0.020
endocardial cushion formation GO:0003272 2 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
neurotransmitter secretion GO:0007269 2 0.019
Fly
regulation of heart contraction GO:0008016 32 0.019
mesenchymal cell differentiation GO:0048762 87 0.019
Zebrafish
apoptotic process GO:0006915 116 0.019
sensory organ development GO:0007423 393 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.019
positive regulation of blood circulation GO:1903524 2 0.019
germ line stem cell maintenance GO:0030718 2 0.019
embryonic organ development GO:0048568 381 0.019
organelle organization GO:0006996 227 0.019
Fly
mitotic cell cycle GO:0000278 64 0.019
Fly
meiotic chromosome segregation GO:0045132 3 0.018
angiogenesis GO:0001525 158 0.018
regulation of primary metabolic process GO:0080090 311 0.018
Mouse Fly
regulation of response to stimulus GO:0048583 269 0.018
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.018
Fly
epithelial tube morphogenesis GO:0060562 148 0.018
cell part morphogenesis GO:0032990 246 0.018
Zebrafish Fly
death GO:0016265 121 0.018
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.018
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
Mouse Fly
regulation of cell differentiation GO:0045595 142 0.017
Fly
actin filament polymerization GO:0030041 2 0.017
single organism localization GO:1902578 225 0.017
Fly
cellular response to hypoxia GO:0071456 1 0.017
embryonic heart tube development GO:0035050 133 0.017
localization of cell GO:0051674 244 0.016
nitric oxide biosynthetic process GO:0006809 2 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
somitogenesis GO:0001756 87 0.016
anterior posterior pattern specification GO:0009952 152 0.016
regulation of nervous system development GO:0051960 90 0.016
Fly
ras protein signal transduction GO:0007265 7 0.016
actin polymerization or depolymerization GO:0008154 2 0.016
regulation of synaptic plasticity GO:0048167 1 0.016
macromolecular complex disassembly GO:0032984 1 0.016
positive regulation of heart contraction GO:0045823 2 0.016
cellular component biogenesis GO:0044085 178 0.016
Fly
regulation of muscle contraction GO:0006937 3 0.016
multicellular organism reproduction GO:0032504 35 0.016
Fly
post embryonic morphogenesis GO:0009886 4 0.016
membrane repolarization GO:0086009 2 0.015
regulation of system process GO:0044057 40 0.015
Fly
cardiac muscle cell contraction GO:0086003 1 0.015
rna metabolic process GO:0016070 219 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
Mouse Fly
multicellular organismal signaling GO:0035637 22 0.015
transmembrane transport GO:0055085 120 0.015
organic acid metabolic process GO:0006082 31 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
action potential GO:0001508 19 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
Mouse Fly
spermatid development GO:0007286 2 0.014
Fly
regulation of intracellular protein transport GO:0033157 3 0.014
retina development in camera type eye GO:0060041 146 0.014
cellular response to hormone stimulus GO:0032870 39 0.014
Fly
regulation of mitotic cell cycle embryonic GO:0009794 2 0.014
Fly
carbohydrate derivative metabolic process GO:1901135 61 0.014
neurotransmitter transport GO:0006836 2 0.014
Fly
regulation of skeletal muscle tissue development GO:0048641 4 0.014
regionalization GO:0003002 274 0.014
protein metabolic process GO:0019538 183 0.014
Mouse Fly
regulation of circadian rhythm GO:0042752 4 0.014
neural tube patterning GO:0021532 33 0.014
Zebrafish
female meiosis chromosome segregation GO:0016321 1 0.013
spermatogenesis GO:0007283 7 0.013
Fly
regulation of epithelial cell proliferation GO:0050678 3 0.013
microtubule based process GO:0007017 60 0.013
Fly
multi organism process GO:0051704 134 0.013
Fly
regulation of protein polymerization GO:0032271 2 0.013
cation transport GO:0006812 81 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
blood vessel morphogenesis GO:0048514 216 0.013
cellular aldehyde metabolic process GO:0006081 4 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
response to hydrogen peroxide GO:0042542 3 0.013
programmed cell death GO:0012501 119 0.013
ovulation cycle GO:0042698 2 0.013
regulation of metabolic process GO:0019222 359 0.013
Mouse Fly
developmental growth involved in morphogenesis GO:0060560 86 0.013
regulation of epidermis development GO:0045682 2 0.013
regulation of signal transduction GO:0009966 225 0.012
Fly
female meiotic division GO:0007143 2 0.012
epithelial cell differentiation GO:0030855 116 0.012
protein homooligomerization GO:0051260 3 0.012
small molecule metabolic process GO:0044281 77 0.012
mitochondrion organization GO:0007005 4 0.012
chromosome organization GO:0051276 31 0.012
Fly
cell projection assembly GO:0030031 64 0.012
Fly
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.012
Fly
ion transport GO:0006811 114 0.012
skeletal muscle organ development GO:0060538 78 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
Fly
somatic muscle development GO:0007525 4 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
regulation of organelle assembly GO:1902115 4 0.012
sensory perception GO:0007600 39 0.012
Fly
mesenchymal cell development GO:0014031 78 0.012
Zebrafish
negative regulation of synapse assembly GO:0051964 2 0.012
Fly
regulation of dna templated transcription in response to stress GO:0043620 0 0.012
tissue remodeling GO:0048771 4 0.012
signal transduction GO:0007165 455 0.012
Fly
regulation of blood circulation GO:1903522 32 0.011
eye morphogenesis GO:0048592 144 0.011
cellular response to decreased oxygen levels GO:0036294 1 0.011
nuclear export GO:0051168 1 0.011
regulation of myotube differentiation GO:0010830 2 0.011
protein localization GO:0008104 40 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
Fly
neural retina development GO:0003407 49 0.011
endocardial cushion morphogenesis GO:0003203 3 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
cell matrix adhesion GO:0007160 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
positive regulation of neural precursor cell proliferation GO:2000179 1 0.011
Fly
intracellular mrna localization GO:0008298 1 0.011
single organism nuclear import GO:1902593 3 0.011
larval behavior GO:0030537 5 0.011
Fly
carboxylic acid metabolic process GO:0019752 22 0.011
cellular localization GO:0051641 97 0.011
Fly
neural precursor cell proliferation GO:0061351 20 0.011
Fly
cellular homeostasis GO:0019725 26 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
cellular response to starvation GO:0009267 1 0.010
purine nucleotide metabolic process GO:0006163 27 0.010
regulation of notch signaling pathway GO:0008593 16 0.010
establishment of localization GO:0051234 244 0.010
Fly
sleep GO:0030431 1 0.010
Fly
multicellular organismal reproductive process GO:0048609 35 0.010
Fly
nucleic acid transport GO:0050657 2 0.010
Fly
response to drug GO:0042493 3 0.010
regulation of cell communication GO:0010646 232 0.010
Fly
blood vessel development GO:0001568 246 0.010

fxr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.064
musculoskeletal system disease DOID:17 0 0.053
muscular disease DOID:0080000 0 0.053
muscle tissue disease DOID:66 0 0.052
myopathy DOID:423 0 0.028
limb girdle muscular dystrophy DOID:11724 0 0.025
muscular dystrophy DOID:9884 0 0.025
heart disease DOID:114 0 0.022
cardiomyopathy DOID:0050700 0 0.022
cardiovascular system disease DOID:1287 0 0.022
neurodegenerative disease DOID:1289 0 0.020
central nervous system disease DOID:331 0 0.020
nervous system disease DOID:863 0 0.020
intrinsic cardiomyopathy DOID:0060036 0 0.015