Danio rerio

2 known processes

galcb

galactosylceramidase b

(Aliases: zgc:56444,wu:fi04e07,galc)

galcb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
generation of neurons GO:0048699 385 0.305
signal transduction GO:0007165 455 0.236
regulation of signaling GO:0023051 235 0.213
heart development GO:0007507 313 0.131
single organism transport GO:0044765 206 0.126
apoptotic process GO:0006915 116 0.120
cellular protein catabolic process GO:0044257 4 0.112
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.109
gland development GO:0048732 143 0.108
endosomal transport GO:0016197 2 0.098
digestive tract morphogenesis GO:0048546 231 0.094
embryonic organ development GO:0048568 381 0.092
regulation of cell communication GO:0010646 232 0.090
brain development GO:0007420 293 0.088
immune system process GO:0002376 241 0.086
cell motility GO:0048870 244 0.082
hematopoietic or lymphoid organ development GO:0048534 191 0.080
locomotion GO:0040011 313 0.077
negative regulation of cell communication GO:0010648 96 0.075
negative regulation of biological process GO:0048519 304 0.075
regulation of signal transduction GO:0009966 225 0.074
single organism localization GO:1902578 225 0.074
system process GO:0003008 185 0.070
cell projection morphogenesis GO:0048858 244 0.070
embryonic organ morphogenesis GO:0048562 274 0.069
larval development GO:0002164 2 0.065
regulation of cell differentiation GO:0045595 142 0.065
aging GO:0007568 2 0.063
single organism metabolic process GO:0044710 217 0.062
determination of bilateral symmetry GO:0009855 204 0.060
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.060
gastrulation GO:0007369 208 0.059
proteasomal protein catabolic process GO:0010498 2 0.059
head development GO:0060322 303 0.058
tube morphogenesis GO:0035239 349 0.058
cellular response to external stimulus GO:0071496 2 0.058
central nervous system development GO:0007417 387 0.056
cellular component assembly GO:0022607 170 0.055
cell surface receptor signaling pathway GO:0007166 325 0.055
regulation of developmental process GO:0050793 247 0.055
regulation of protein complex assembly GO:0043254 3 0.054
regulation of cell death GO:0010941 103 0.054
cell part morphogenesis GO:0032990 246 0.053
specification of symmetry GO:0009799 204 0.053
spindle assembly GO:0051225 2 0.051
cell projection organization GO:0030030 284 0.049
cell morphogenesis GO:0000902 289 0.048
ubiquitin dependent protein catabolic process GO:0006511 3 0.047
immune system development GO:0002520 191 0.047
cellular component movement GO:0006928 335 0.046
regulation of response to stimulus GO:0048583 269 0.045
neuron differentiation GO:0030182 353 0.045
protein metabolic process GO:0019538 183 0.044
cell morphogenesis involved in differentiation GO:0000904 195 0.044
autophagy GO:0006914 4 0.043
programmed cell death GO:0012501 119 0.043
negative regulation of cellular process GO:0048523 283 0.042
positive regulation of transport GO:0051050 2 0.042
death GO:0016265 121 0.042
cell migration GO:0016477 237 0.041
axon development GO:0061564 166 0.040
cellular protein metabolic process GO:0044267 129 0.039
regulation of protein catabolic process GO:0042176 1 0.039
positive regulation of catabolic process GO:0009896 4 0.039
cellular response to extracellular stimulus GO:0031668 2 0.039
positive regulation of biological process GO:0048518 253 0.039
organonitrogen compound metabolic process GO:1901564 74 0.038
embryo development ending in birth or egg hatching GO:0009792 271 0.038
establishment of localization GO:0051234 244 0.036
positive regulation of apoptotic signaling pathway GO:2001235 1 0.036
negative regulation of response to stimulus GO:0048585 104 0.036
guanosine containing compound catabolic process GO:1901069 2 0.036
modification dependent protein catabolic process GO:0019941 3 0.035
determination of heart left right asymmetry GO:0061371 117 0.035
heart morphogenesis GO:0003007 156 0.035
axonogenesis GO:0007409 152 0.034
skeletal system morphogenesis GO:0048705 102 0.034
digestive system development GO:0055123 289 0.034
cellular response to starvation GO:0009267 1 0.034
regionalization GO:0003002 274 0.033
heterocycle metabolic process GO:0046483 290 0.033
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.033
cellular component morphogenesis GO:0032989 336 0.033
neuron projection development GO:0031175 180 0.033
meiotic nuclear division GO:0007126 4 0.032
positive regulation of secretion by cell GO:1903532 1 0.032
chordate embryonic development GO:0043009 271 0.032
cell death GO:0008219 121 0.031
gene expression GO:0010467 252 0.031
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.031
enzyme linked receptor protein signaling pathway GO:0007167 106 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.031
neuron development GO:0048666 262 0.030
regulation of erk1 and erk2 cascade GO:0070372 4 0.030
single organism organelle organization GO:1902589 199 0.030
cellular response to nutrient levels GO:0031669 2 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
negative regulation of cell death GO:0060548 60 0.030
regulation of multicellular organismal process GO:0051239 277 0.030
transport GO:0006810 220 0.029
negative regulation of signaling GO:0023057 96 0.029
cytoskeleton dependent cytokinesis GO:0061640 3 0.029
localization of cell GO:0051674 244 0.029
phosphate containing compound metabolic process GO:0006796 108 0.029
digestive tract development GO:0048565 265 0.029
homeostatic process GO:0042592 142 0.028
cellular ion homeostasis GO:0006873 17 0.028
guanosine containing compound metabolic process GO:1901068 4 0.028
organelle fusion GO:0048284 3 0.028
macroautophagy GO:0016236 1 0.028
skeletal system development GO:0001501 181 0.027
response to drug GO:0042493 3 0.027
cytokinesis GO:0000910 3 0.027
regulation of multicellular organismal development GO:2000026 223 0.027
regulation of transcription dna templated GO:0006355 213 0.027
regulation of cellular protein catabolic process GO:1903362 1 0.026
positive regulation of cellular amine metabolic process GO:0033240 0 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.025
cellular response to chemical stimulus GO:0070887 157 0.025
response to chemical GO:0042221 320 0.025
ribonucleoside monophosphate catabolic process GO:0009158 4 0.025
regulation of primary metabolic process GO:0080090 311 0.025
sensory organ development GO:0007423 393 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.025
positive regulation of protein complex assembly GO:0031334 2 0.024
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 20 0.024
regulation of metabolic process GO:0019222 359 0.024
erk1 and erk2 cascade GO:0070371 4 0.023
morphogenesis of an epithelium GO:0002009 333 0.023
nitrogen compound metabolic process GO:0006807 319 0.023
hormone transport GO:0009914 2 0.023
synaptic growth at neuromuscular junction GO:0051124 2 0.023
protein targeting to nucleus GO:0044744 3 0.023
regulation of biological quality GO:0065008 263 0.023
b cell differentiation GO:0030183 1 0.023
establishment of localization in cell GO:0051649 77 0.022
blood vessel morphogenesis GO:0048514 216 0.022
regulation of nucleotide catabolic process GO:0030811 2 0.022
response to external stimulus GO:0009605 264 0.022
gtp metabolic process GO:0046039 4 0.022
cellular aromatic compound metabolic process GO:0006725 295 0.022
neuron projection morphogenesis GO:0048812 161 0.022
meiotic cell cycle process GO:1903046 3 0.022
multicellular organism growth GO:0035264 4 0.022
protein localization to nucleus GO:0034504 3 0.022
intracellular signal transduction GO:0035556 85 0.022
cellular macromolecule metabolic process GO:0044260 391 0.021
response to endogenous stimulus GO:0009719 83 0.021
epithelial tube morphogenesis GO:0060562 148 0.021
vasculature development GO:0001944 278 0.021
determination of left right symmetry GO:0007368 179 0.020
exocytosis GO:0006887 1 0.020
macromolecular complex subunit organization GO:0043933 74 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
nuclear import GO:0051170 3 0.020
regulation of organ growth GO:0046620 3 0.020
regulation of intracellular signal transduction GO:1902531 57 0.020
lipid storage GO:0019915 1 0.020
regulation of purine nucleotide catabolic process GO:0033121 2 0.020
regulation of synapse assembly GO:0051963 3 0.020
myeloid cell differentiation GO:0030099 86 0.020
peptidyl serine modification GO:0018209 2 0.019
nuclear transport GO:0051169 4 0.019
gtp catabolic process GO:0006184 2 0.019
purine nucleoside monophosphate catabolic process GO:0009128 4 0.019
centrosome cycle GO:0007098 1 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
regulation of synapse organization GO:0050807 3 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.019
carbohydrate derivative metabolic process GO:1901135 61 0.019
positive regulation of secretion GO:0051047 1 0.019
macromolecular complex assembly GO:0065003 35 0.018
regulation of stem cell proliferation GO:0072091 2 0.018
positive regulation of cellular process GO:0048522 201 0.018
lipid catabolic process GO:0016042 4 0.018
negative regulation of catabolic process GO:0009895 3 0.018
negative regulation of secretion by cell GO:1903531 2 0.018
cellular response to organic substance GO:0071310 105 0.018
response to antibiotic GO:0046677 1 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.018
cellular protein modification process GO:0006464 100 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.018
muscle structure development GO:0061061 196 0.018
organic cyclic compound metabolic process GO:1901360 301 0.017
ion homeostasis GO:0050801 41 0.017
embryonic heart tube morphogenesis GO:0003143 108 0.017
hepaticobiliary system development GO:0061008 98 0.017
regulation of apoptotic process GO:0042981 98 0.017
positive regulation of signal transduction GO:0009967 56 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.017
small molecule metabolic process GO:0044281 77 0.017
regulation of protein transport GO:0051223 3 0.017
atp catabolic process GO:0006200 4 0.017
regulation of binding GO:0051098 3 0.017
regulation of hormone secretion GO:0046883 2 0.017
peptidyl serine phosphorylation GO:0018105 1 0.016
neurotransmitter transport GO:0006836 2 0.016
membrane fusion GO:0061025 2 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
negative regulation of cellular catabolic process GO:0031330 3 0.016
phosphorylation GO:0016310 69 0.016
negative regulation of signal transduction GO:0009968 94 0.016
regulation of programmed cell death GO:0043067 101 0.016
developmental growth GO:0048589 166 0.016
adult behavior GO:0030534 2 0.016
neural tube patterning GO:0021532 33 0.016
protein complex biogenesis GO:0070271 30 0.016
protein localization to plasma membrane GO:0072659 1 0.016
protein import into nucleus GO:0006606 3 0.015
circulatory system process GO:0003013 87 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
regulation of gtp catabolic process GO:0033124 2 0.015
cognition GO:0050890 1 0.015
nucleobase containing compound metabolic process GO:0006139 274 0.015
regulation of blood pressure GO:0008217 1 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
secondary metabolic process GO:0019748 3 0.015
cellular nitrogen compound metabolic process GO:0034641 290 0.015
protein import GO:0017038 3 0.015
positive regulation of signaling GO:0023056 56 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
cellular transition metal ion homeostasis GO:0046916 3 0.015
viral process GO:0016032 1 0.015
response to hexose GO:0009746 3 0.015
rna localization GO:0006403 4 0.015
response to glucose GO:0009749 3 0.015
regulation of tube size GO:0035150 2 0.015
cilium assembly GO:0042384 58 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.015
phagocytosis GO:0006909 3 0.015
regulation of cardiac muscle tissue development GO:0055024 1 0.015
pigment cell differentiation GO:0050931 38 0.015
regulation of cell activation GO:0050865 1 0.014
retina development in camera type eye GO:0060041 146 0.014
response to organic substance GO:0010033 153 0.014
protein modification process GO:0036211 100 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
regulation of gene expression GO:0010468 265 0.014
proteolysis GO:0006508 38 0.014
oxoacid metabolic process GO:0043436 31 0.014
camera type eye development GO:0043010 222 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
regulation of proteolysis GO:0030162 24 0.014
embryonic skeletal system development GO:0048706 97 0.014
response to abiotic stimulus GO:0009628 122 0.014
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.014
protein polymerization GO:0051258 4 0.014
regulation of protein targeting GO:1903533 2 0.014
regulation of neurogenesis GO:0050767 87 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
negative regulation of protein transport GO:0051224 3 0.013
cellular response to toxic substance GO:0097237 1 0.013
regulation of blood vessel size GO:0050880 2 0.013
regulation of cell development GO:0060284 100 0.013
regulation of reproductive process GO:2000241 4 0.013
small molecule catabolic process GO:0044282 3 0.013
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.013
neuromuscular synaptic transmission GO:0007274 2 0.013
organic substance biosynthetic process GO:1901576 289 0.013
mitochondrion organization GO:0007005 4 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
cellular amine metabolic process GO:0044106 2 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
regulation of filopodium assembly GO:0051489 2 0.013
fertilization GO:0009566 3 0.013
b cell activation GO:0042113 2 0.013
positive regulation of cell activation GO:0050867 1 0.013
spindle assembly involved in meiosis GO:0090306 1 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
macromolecule modification GO:0043412 111 0.013
embryonic heart tube development GO:0035050 133 0.013
multi organism cellular process GO:0044764 2 0.012
maintenance of location GO:0051235 4 0.012
ameboidal type cell migration GO:0001667 143 0.012
response to carbohydrate GO:0009743 3 0.012
cell proliferation GO:0008283 80 0.012
neuron projection guidance GO:0097485 86 0.012
positive regulation of multi organism process GO:0043902 3 0.012
response to monosaccharide GO:0034284 3 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
response to alkaloid GO:0043279 2 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
regulation of gtpase activity GO:0043087 2 0.012
organic acid metabolic process GO:0006082 31 0.012
pancreas development GO:0031016 84 0.012
neuron apoptotic process GO:0051402 20 0.012
cation homeostasis GO:0055080 33 0.012
hemopoiesis GO:0030097 183 0.012
positive regulation of cell communication GO:0010647 56 0.012
response to stress GO:0006950 263 0.012
regulation of autophagy GO:0010506 3 0.012
multi organism process GO:0051704 134 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
synaptic vesicle transport GO:0048489 1 0.012
membrane invagination GO:0010324 1 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
phagocytosis engulfment GO:0006911 1 0.012
regulation of protein polymerization GO:0032271 2 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
regulation of protein metabolic process GO:0051246 56 0.012
negative regulation of developmental process GO:0051093 65 0.012
convergent extension GO:0060026 118 0.011
blood vessel development GO:0001568 246 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
cellular component biogenesis GO:0044085 178 0.011
catecholamine metabolic process GO:0006584 2 0.011
amine metabolic process GO:0009308 2 0.011
cell aging GO:0007569 2 0.011
response to glucocorticoid GO:0051384 1 0.011
sphingolipid biosynthetic process GO:0030148 2 0.011
protein dephosphorylation GO:0006470 3 0.011
microtubule polymerization GO:0046785 2 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
lytic vacuole organization GO:0080171 1 0.011
regulation of photoreceptor cell differentiation GO:0046532 2 0.011
organelle assembly GO:0070925 110 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
heart contraction GO:0060047 71 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
single organism nuclear import GO:1902593 3 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
macromolecule localization GO:0033036 54 0.011
stem cell differentiation GO:0048863 117 0.011
protein secretion GO:0009306 1 0.011
cellular homeostasis GO:0019725 26 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.010
anterior posterior pattern specification GO:0009952 152 0.010
regulation of cytokine production GO:0001817 3 0.010
regulation of receptor mediated endocytosis GO:0048259 4 0.010
interspecies interaction between organisms GO:0044419 4 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.010
rna biosynthetic process GO:0032774 181 0.010
negative regulation of kinase activity GO:0033673 4 0.010
cellular nitrogen compound biosynthetic process GO:0044271 218 0.010
meiotic spindle organization GO:0000212 1 0.010
developmental pigmentation GO:0048066 48 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.010
negative regulation of mapk cascade GO:0043409 4 0.010
protein stabilization GO:0050821 2 0.010
blood circulation GO:0008015 87 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
cellular component disassembly GO:0022411 1 0.010
cell fate specification GO:0001708 68 0.010
neurological system process GO:0050877 62 0.010
regulation of response to oxidative stress GO:1902882 2 0.010
nucleic acid templated transcription GO:0097659 181 0.010

galcb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.087
nervous system disease DOID:863 0 0.065
disease of metabolism DOID:0014667 0 0.032
inherited metabolic disorder DOID:655 0 0.032
lysosomal storage disease DOID:3211 0 0.024
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.020
cardiovascular system disease DOID:1287 0 0.017
motor neuron disease DOID:231 0 0.013
amyotrophic lateral sclerosis DOID:332 0 0.013
disease of cellular proliferation DOID:14566 0 0.012