Danio rerio

0 known processes

grn1

granulin 1

(Aliases: MGC136318,zgc:136318)

grn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to other organism GO:0051707 97 0.200
immunoglobulin mediated immune response GO:0016064 3 0.168
tyrosine phosphorylation of stat protein GO:0007260 1 0.157
cellular ketone metabolic process GO:0042180 11 0.146
small molecule metabolic process GO:0044281 77 0.107
response to external biotic stimulus GO:0043207 97 0.103
regulation of production of molecular mediator of immune response GO:0002700 1 0.098
single organism metabolic process GO:0044710 217 0.096
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.094
complement activation GO:0006956 3 0.093
larval development GO:0002164 2 0.088
response to external stimulus GO:0009605 264 0.088
nitrogen compound metabolic process GO:0006807 319 0.084
organonitrogen compound metabolic process GO:1901564 74 0.083
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.081
regulation of stem cell proliferation GO:0072091 2 0.081
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.079
regulation of cellular amino acid metabolic process GO:0006521 0 0.079
regulation of signaling GO:0023051 235 0.078
organic substance biosynthetic process GO:1901576 289 0.078
stem cell proliferation GO:0072089 4 0.078
regulation of cellular amine metabolic process GO:0033238 0 0.077
b cell mediated immunity GO:0019724 3 0.077
activation of immune response GO:0002253 9 0.077
oxoacid metabolic process GO:0043436 31 0.074
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.074
regulation of establishment of protein localization GO:0070201 4 0.071
hematopoietic or lymphoid organ development GO:0048534 191 0.069
response to biotic stimulus GO:0009607 97 0.066
maintenance of location GO:0051235 4 0.066
amine metabolic process GO:0009308 2 0.065
immune system process GO:0002376 241 0.062
organic cyclic compound biosynthetic process GO:1901362 223 0.061
cellular nitrogen compound metabolic process GO:0034641 290 0.060
response to drug GO:0042493 3 0.057
protein activation cascade GO:0072376 6 0.056
digestive system development GO:0055123 289 0.054
cellular amine metabolic process GO:0044106 2 0.053
regulation of developmental process GO:0050793 247 0.053
cellular biosynthetic process GO:0044249 286 0.052
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.052
positive regulation of stress activated mapk cascade GO:0032874 3 0.052
cell projection morphogenesis GO:0048858 244 0.051
regulation of cell activation GO:0050865 1 0.050
alcohol biosynthetic process GO:0046165 2 0.049
regulation of synapse organization GO:0050807 3 0.049
regulation of response to stimulus GO:0048583 269 0.048
multicellular organism growth GO:0035264 4 0.048
single organism biosynthetic process GO:0044711 71 0.046
regulation of jak stat cascade GO:0046425 3 0.046
positive regulation of immune effector process GO:0002699 3 0.045
organic cyclic compound metabolic process GO:1901360 301 0.045
positive regulation of cell activation GO:0050867 1 0.045
biosynthetic process GO:0009058 294 0.043
carboxylic acid metabolic process GO:0019752 22 0.043
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.042
complement activation classical pathway GO:0006958 3 0.041
production of molecular mediator of immune response GO:0002440 2 0.041
blood vessel morphogenesis GO:0048514 216 0.041
synaptic growth at neuromuscular junction GO:0051124 2 0.040
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.040
lymphocyte mediated immunity GO:0002449 5 0.040
regulation of signal transduction GO:0009966 225 0.039
positive regulation of striated muscle cell differentiation GO:0051155 1 0.039
cellular amino acid metabolic process GO:0006520 7 0.038
regulation of multicellular organismal process GO:0051239 277 0.037
positive regulation of jnk cascade GO:0046330 3 0.037
organic acid metabolic process GO:0006082 31 0.037
locomotion GO:0040011 313 0.037
regulation of cell communication GO:0010646 232 0.036
angiogenesis GO:0001525 158 0.036
response to stress GO:0006950 263 0.036
positive regulation of secretion by cell GO:1903532 1 0.035
response to virus GO:0009615 21 0.034
regulation of inflammatory response GO:0050727 2 0.034
morphogenesis of an epithelium GO:0002009 333 0.034
aging GO:0007568 2 0.034
ribosome assembly GO:0042255 1 0.033
zymogen activation GO:0031638 3 0.033
leukocyte differentiation GO:0002521 25 0.033
cellular component movement GO:0006928 335 0.033
regulation of cellular ketone metabolic process GO:0010565 7 0.032
regulation of protein import into nucleus GO:0042306 2 0.032
gene expression GO:0010467 252 0.032
long chain fatty acid metabolic process GO:0001676 1 0.031
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.031
i kappab kinase nf kappab signaling GO:0007249 4 0.031
positive regulation of cytokine production GO:0001819 2 0.030
regulation of blood pressure GO:0008217 1 0.030
regulation of cytokine production GO:0001817 3 0.030
immune response GO:0006955 28 0.029
positive regulation of dna metabolic process GO:0051054 1 0.029
defense response to bacterium GO:0042742 22 0.029
secondary metabolic process GO:0019748 3 0.029
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.029
response to bacterium GO:0009617 58 0.028
nuclear transport GO:0051169 4 0.028
interspecies interaction between organisms GO:0044419 4 0.028
regulation of multicellular organism growth GO:0040014 4 0.028
response to nutrient GO:0007584 3 0.028
phosphorus metabolic process GO:0006793 109 0.027
regulation of multicellular organismal development GO:2000026 223 0.027
regulation of protein transport GO:0051223 3 0.027
regulation of metabolic process GO:0019222 359 0.027
immune system development GO:0002520 191 0.027
sensory perception of chemical stimulus GO:0007606 3 0.027
cell migration GO:0016477 237 0.026
regulation of cytoplasmic transport GO:1903649 4 0.026
leukocyte proliferation GO:0070661 1 0.026
striated muscle tissue development GO:0014706 110 0.026
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.026
regulation of biological quality GO:0065008 263 0.026
membrane fusion GO:0061025 2 0.026
cellular amide metabolic process GO:0043603 4 0.025
camera type eye development GO:0043010 222 0.025
nucleocytoplasmic transport GO:0006913 4 0.025
cell motility GO:0048870 244 0.025
digestive tract development GO:0048565 265 0.024
b cell activation GO:0042113 2 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
hydrogen peroxide metabolic process GO:0042743 2 0.023
brain development GO:0007420 293 0.023
immune effector process GO:0002252 23 0.023
regulation of tube size GO:0035150 2 0.023
regulation of metal ion transport GO:0010959 4 0.023
positive regulation of transport GO:0051050 2 0.023
nuclear import GO:0051170 3 0.023
regulation of epithelial cell proliferation GO:0050678 3 0.022
positive regulation of biological process GO:0048518 253 0.022
multi organism process GO:0051704 134 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
heterocycle metabolic process GO:0046483 290 0.022
positive regulation of multicellular organismal process GO:0051240 52 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.022
viral process GO:0016032 1 0.022
immunoglobulin production GO:0002377 1 0.022
cellular response to chemical stimulus GO:0070887 157 0.022
positive regulation of multi organism process GO:0043902 3 0.022
regulation of phospholipase activity GO:0010517 2 0.021
positive regulation of metabolic process GO:0009893 108 0.021
response to corticosteroid GO:0031960 1 0.021
organelle fusion GO:0048284 3 0.021
localization of cell GO:0051674 244 0.021
energy homeostasis GO:0097009 3 0.021
regulation of response to cytokine stimulus GO:0060759 3 0.021
hemopoiesis GO:0030097 183 0.021
gastrulation GO:0007369 208 0.021
signal transduction GO:0007165 455 0.021
endosomal transport GO:0016197 2 0.020
apoptotic process involved in development GO:1902742 2 0.020
collagen metabolic process GO:0032963 2 0.020
nucleobase containing compound metabolic process GO:0006139 274 0.020
lipid storage GO:0019915 1 0.020
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.020
gland development GO:0048732 143 0.020
positive regulation of leukocyte differentiation GO:1902107 1 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
regulation of immune system process GO:0002682 34 0.020
type i interferon production GO:0032606 2 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
very long chain fatty acid biosynthetic process GO:0042761 4 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
positive regulation of jak stat cascade GO:0046427 2 0.019
steroid biosynthetic process GO:0006694 5 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
protein targeting to nucleus GO:0044744 3 0.019
response to wounding GO:0009611 116 0.019
programmed cell death GO:0012501 119 0.019
positive regulation of stem cell proliferation GO:2000648 1 0.019
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.019
immune response activating signal transduction GO:0002757 5 0.019
somatic cell dna recombination GO:0016444 1 0.019
adaptive immune response GO:0002250 5 0.019
regulation of protein complex assembly GO:0043254 3 0.018
single organism membrane fusion GO:0044801 2 0.018
intracellular signal transduction GO:0035556 85 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
glucocorticoid metabolic process GO:0008211 2 0.018
negative regulation of chemotaxis GO:0050922 4 0.018
lymphocyte proliferation GO:0046651 1 0.018
regulation of programmed cell death GO:0043067 101 0.018
b cell differentiation GO:0030183 1 0.018
mononuclear cell proliferation GO:0032943 1 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
regulation of cysteine type endopeptidase activity GO:2000116 21 0.017
regulation of reproductive process GO:2000241 4 0.017
cellular modified amino acid metabolic process GO:0006575 3 0.017
cellular transition metal ion homeostasis GO:0046916 3 0.016
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.016
cell morphogenesis GO:0000902 289 0.016
blood circulation GO:0008015 87 0.016
regulation of binding GO:0051098 3 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
single organism nuclear import GO:1902593 3 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
liver development GO:0001889 96 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.016
positive regulation of muscle cell differentiation GO:0051149 1 0.016
negative regulation of defense response GO:0031348 2 0.016
protein localization to nucleus GO:0034504 3 0.015
digestive tract morphogenesis GO:0048546 231 0.015
spermatid development GO:0007286 2 0.015
antimicrobial humoral response GO:0019730 2 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
gtp metabolic process GO:0046039 4 0.015
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.015
cell aging GO:0007569 2 0.015
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
response to vitamin GO:0033273 3 0.015
lymphangiogenesis GO:0001946 25 0.015
lipid metabolic process GO:0006629 52 0.015
regulation of protein metabolic process GO:0051246 56 0.015
developmental programmed cell death GO:0010623 4 0.015
lateral inhibition GO:0046331 1 0.015
response to unfolded protein GO:0006986 2 0.015
centrosome organization GO:0051297 1 0.015
multicellular organismal metabolic process GO:0044236 2 0.014
type i interferon biosynthetic process GO:0045351 1 0.014
cellular response to prostaglandin stimulus GO:0071379 3 0.014
response to oxygen radical GO:0000305 2 0.014
regulation of synapse assembly GO:0051963 3 0.014
regulation of response to extracellular stimulus GO:0032104 1 0.014
multi organism cellular process GO:0044764 2 0.014
positive regulation of developmental process GO:0051094 50 0.014
gtp catabolic process GO:0006184 2 0.014
negative regulation of response to cytokine stimulus GO:0060761 2 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
protein import into nucleus GO:0006606 3 0.014
positive regulation of myeloid cell differentiation GO:0045639 2 0.014
developmental growth GO:0048589 166 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
neuroblast proliferation GO:0007405 2 0.014
response to ketone GO:1901654 1 0.014
humoral immune response GO:0006959 5 0.014
regulation of cytokine mediated signaling pathway GO:0001959 3 0.014
positive regulation of production of molecular mediator of immune response GO:0002702 1 0.014
fatty acid biosynthetic process GO:0006633 4 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
response to chemical GO:0042221 320 0.014
negative regulation of protein import into nucleus GO:0042308 2 0.014
cytoskeleton dependent cytokinesis GO:0061640 3 0.014
positive regulation of camp biosynthetic process GO:0030819 2 0.014
energy reserve metabolic process GO:0006112 2 0.014
cell projection organization GO:0030030 284 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
long chain fatty acid transport GO:0015909 1 0.013
embryonic skeletal system morphogenesis GO:0048704 93 0.013
fatty acid elongation GO:0030497 1 0.013
cellular protein catabolic process GO:0044257 4 0.013
defense response to other organism GO:0098542 33 0.013
regulation of neuronal synaptic plasticity GO:0048168 1 0.013
cellular component morphogenesis GO:0032989 336 0.013
cellular response to unfolded protein GO:0034620 2 0.013
leukocyte mediated cytotoxicity GO:0001909 1 0.013
photoreceptor cell fate specification GO:0043704 1 0.013
response to organic substance GO:0010033 153 0.013
organ regeneration GO:0031100 1 0.013
response to alkaloid GO:0043279 2 0.013
positive regulation of protein polymerization GO:0032273 2 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
cerebellar granular layer development GO:0021681 3 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
regulation of gene expression GO:0010468 265 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
rna stabilization GO:0043489 4 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
regulation of gtpase activity GO:0043087 2 0.013
growth GO:0040007 174 0.013
neuron development GO:0048666 262 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
astrocyte differentiation GO:0048708 1 0.012
actin filament polymerization GO:0030041 2 0.012
muscle structure development GO:0061061 196 0.012
lymph vessel development GO:0001945 27 0.012
regulation of protein catabolic process GO:0042176 1 0.012
cognition GO:0050890 1 0.012
response to topologically incorrect protein GO:0035966 2 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
regulation of response to biotic stimulus GO:0002831 2 0.012
regulation of immunoglobulin production GO:0002637 1 0.012
negative regulation of immune response GO:0050777 2 0.012
regulation of wound healing GO:0061041 2 0.012
stem cell differentiation GO:0048863 117 0.012
phagocytosis GO:0006909 3 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
protein import GO:0017038 3 0.012
regulation of transcription dna templated GO:0006355 213 0.012
peptide transport GO:0015833 1 0.012
sensory perception of smell GO:0007608 2 0.012
chemosensory behavior GO:0007635 1 0.012
xenobiotic metabolic process GO:0006805 4 0.012
peptide metabolic process GO:0006518 1 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
endoplasmic reticulum unfolded protein response GO:0030968 2 0.012
rna metabolic process GO:0016070 219 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
positive regulation of cell killing GO:0031343 2 0.012
atp catabolic process GO:0006200 4 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
modification of morphology or physiology of other organism GO:0035821 4 0.012
steroid metabolic process GO:0008202 7 0.012
positive regulation of immune response GO:0050778 11 0.011
cytokinesis GO:0000910 3 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
cellular protein metabolic process GO:0044267 129 0.011
sensory system development GO:0048880 76 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
cell part morphogenesis GO:0032990 246 0.011
alpha amino acid metabolic process GO:1901605 3 0.011
nephron tubule morphogenesis GO:0072078 1 0.011
nik nf kappab signaling GO:0038061 1 0.011
mrna stabilization GO:0048255 4 0.011
regulation of primary metabolic process GO:0080090 311 0.011
ameboidal type cell migration GO:0001667 143 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
oxidation reduction process GO:0055114 41 0.011
response to cold GO:0009409 4 0.011
negative regulation of biological process GO:0048519 304 0.011
cellular response to xenobiotic stimulus GO:0071466 35 0.011
response to abiotic stimulus GO:0009628 122 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
regulation of developmental growth GO:0048638 38 0.011
nucleic acid metabolic process GO:0090304 244 0.011
neuron projection development GO:0031175 180 0.011
regulation of autophagy GO:0010506 3 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.011
cell killing GO:0001906 2 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
lymph vessel morphogenesis GO:0036303 25 0.011
gastrulation with mouth forming second GO:0001702 44 0.011
dna biosynthetic process GO:0071897 3 0.011
cellular response to external stimulus GO:0071496 2 0.011
regulation of organ growth GO:0046620 3 0.011
sprouting angiogenesis GO:0002040 53 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
tube morphogenesis GO:0035239 349 0.011
protein secretion GO:0009306 1 0.011
central nervous system development GO:0007417 387 0.011
regulation of heart growth GO:0060420 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
neuron differentiation GO:0030182 353 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
sleep GO:0030431 1 0.011
positive regulation of wound healing GO:0090303 1 0.011
positive regulation of signal transduction GO:0009967 56 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
negative regulation of cellular process GO:0048523 283 0.010
endothelial cell differentiation GO:0045446 20 0.010
endocrine process GO:0050886 2 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
positive regulation of immune system process GO:0002684 17 0.010
positive regulation of reproductive process GO:2000243 2 0.010
mitochondrion organization GO:0007005 4 0.010
organism emergence from protective structure GO:0071684 4 0.010
defense response to fungus GO:0050832 2 0.010
regulation of intracellular protein transport GO:0033157 3 0.010
regulation of blood vessel size GO:0050880 2 0.010
er nucleus signaling pathway GO:0006984 2 0.010
axon development GO:0061564 166 0.010
regulation of cellular protein metabolic process GO:0032268 52 0.010
macroautophagy GO:0016236 1 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010
neuron neuron synaptic transmission GO:0007270 1 0.010
regulation of rna biosynthetic process GO:2001141 213 0.010
rna biosynthetic process GO:0032774 181 0.010
protein acetylation GO:0006473 2 0.010
system process GO:0003008 185 0.010
negative regulation of leukocyte chemotaxis GO:0002689 3 0.010

grn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.026
disease of metabolism DOID:0014667 0 0.021
inherited metabolic disorder DOID:655 0 0.016
lipid storage disease DOID:9455 0 0.014
lysosomal storage disease DOID:3211 0 0.014
retinal disease DOID:5679 0 0.012
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012