Danio rerio

0 known processes

hapln3

hyaluronan and proteoglycan link protein 3

(Aliases: zgc:85609)

hapln3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
angiogenesis GO:0001525 158 0.803
Zebrafish
blood vessel morphogenesis GO:0048514 216 0.725
Zebrafish
inner ear development GO:0048839 126 0.710
vasculature development GO:0001944 278 0.552
Zebrafish
embryonic organ development GO:0048568 381 0.412
embryonic organ morphogenesis GO:0048562 274 0.357
appendage morphogenesis GO:0035107 56 0.355
aging GO:0007568 2 0.353
segmentation GO:0035282 97 0.308
ear development GO:0043583 127 0.282
sensory organ morphogenesis GO:0090596 200 0.268
otic vesicle morphogenesis GO:0071600 34 0.254
synaptic growth at neuromuscular junction GO:0051124 2 0.247
sensory organ development GO:0007423 393 0.242
otic vesicle development GO:0071599 42 0.235
determination of dorsal ventral asymmetry GO:0048262 34 0.220
chordate embryonic development GO:0043009 271 0.211
tube morphogenesis GO:0035239 349 0.187
appendage development GO:0048736 80 0.184
blood vessel development GO:0001568 246 0.175
Zebrafish
fin morphogenesis GO:0033334 53 0.169
cellular component movement GO:0006928 335 0.158
digestive tract morphogenesis GO:0048546 231 0.151
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.143
tissue remodeling GO:0048771 4 0.142
cell migration GO:0016477 237 0.141
somite development GO:0061053 96 0.128
morphogenesis of an epithelium GO:0002009 333 0.125
regulation of biological quality GO:0065008 263 0.124
inner ear morphogenesis GO:0042472 63 0.123
connective tissue development GO:0061448 99 0.122
ear morphogenesis GO:0042471 64 0.120
mesoderm development GO:0007498 88 0.117
patterning of blood vessels GO:0001569 15 0.115
fin development GO:0033333 77 0.115
regulation of synapse organization GO:0050807 3 0.112
cell projection morphogenesis GO:0048858 244 0.112
pectoral fin development GO:0033339 50 0.112
cilium morphogenesis GO:0060271 85 0.109
embryonic heart tube development GO:0035050 133 0.109
regionalization GO:0003002 274 0.108
cartilage development GO:0051216 96 0.107
regulation of synapse assembly GO:0051963 3 0.104
response to external stimulus GO:0009605 264 0.099
branching morphogenesis of an epithelial tube GO:0048754 15 0.096
cellular component biogenesis GO:0044085 178 0.094
developmental growth GO:0048589 166 0.093
stem cell maintenance GO:0019827 4 0.092
dorsal ventral pattern formation GO:0009953 125 0.088
neural tube development GO:0021915 62 0.088
cellular component morphogenesis GO:0032989 336 0.086
oxidative demethylation GO:0070989 1 0.085
heart development GO:0007507 313 0.085
establishment of endothelial barrier GO:0061028 3 0.083
positive regulation of cellular component biogenesis GO:0044089 3 0.082
epithelial tube morphogenesis GO:0060562 148 0.081
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.081
taxis GO:0042330 109 0.080
embryonic skeletal system morphogenesis GO:0048704 93 0.080
oligodendrocyte differentiation GO:0048709 23 0.080
specification of symmetry GO:0009799 204 0.080
cellular respiration GO:0045333 3 0.076
otic vesicle formation GO:0030916 27 0.075
localization of cell GO:0051674 244 0.075
digestive tract development GO:0048565 265 0.075
single organism localization GO:1902578 225 0.074
sensory system development GO:0048880 76 0.074
lateral line development GO:0048882 66 0.073
endosomal transport GO:0016197 2 0.068
embryo development ending in birth or egg hatching GO:0009792 271 0.068
neural tube patterning GO:0021532 33 0.067
cell migration involved in heart development GO:0060973 22 0.066
tube formation GO:0035148 25 0.066
regulation of epidermis development GO:0045682 2 0.063
positive regulation of muscle organ development GO:0048636 1 0.062
embryonic appendage morphogenesis GO:0035113 30 0.061
single organism transport GO:0044765 206 0.061
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.061
cell motility GO:0048870 244 0.060
digestive system development GO:0055123 289 0.058
stem cell division GO:0017145 1 0.058
regulation of endodermal cell differentiation GO:1903224 15 0.057
cell fate specification GO:0001708 68 0.057
neuromuscular junction development GO:0007528 9 0.056
midbrain hindbrain boundary development GO:0030917 23 0.056
mesenchyme development GO:0060485 127 0.055
adult behavior GO:0030534 2 0.054
central nervous system development GO:0007417 387 0.053
skin development GO:0043588 54 0.052
head development GO:0060322 303 0.052
cell projection organization GO:0030030 284 0.052
multicellular organism growth GO:0035264 4 0.051
regulation of cell shape GO:0008360 1 0.050
regulation of cellular response to growth factor stimulus GO:0090287 35 0.050
negative regulation of cell fate commitment GO:0010454 13 0.050
kupffer s vesicle development GO:0070121 50 0.049
cell part morphogenesis GO:0032990 246 0.049
negative regulation of multicellular organismal process GO:0051241 69 0.047
endodermal cell fate commitment GO:0001711 18 0.047
embryonic viscerocranium morphogenesis GO:0048703 52 0.047
regulation of glial cell differentiation GO:0045685 4 0.046
system process GO:0003008 185 0.045
rostrocaudal neural tube patterning GO:0021903 29 0.044
regulation of bone remodeling GO:0046850 2 0.043
synapse assembly GO:0007416 9 0.043
posterior lateral line development GO:0048916 38 0.043
endoderm formation GO:0001706 29 0.042
cell morphogenesis GO:0000902 289 0.042
brain development GO:0007420 293 0.042
notochord development GO:0030903 54 0.042
growth GO:0040007 174 0.041
sensory perception of light stimulus GO:0050953 19 0.041
otolith development GO:0048840 32 0.041
locomotion GO:0040011 313 0.040
regulation of blood vessel size GO:0050880 2 0.040
positive regulation of skeletal muscle tissue development GO:0048643 1 0.040
regulation of sodium ion transport GO:0002028 2 0.039
positive regulation of transport GO:0051050 2 0.039
eye development GO:0001654 277 0.039
morphogenesis of a branching epithelium GO:0061138 16 0.038
meiotic cell cycle process GO:1903046 3 0.038
apoptotic process involved in development GO:1902742 2 0.038
ribonucleoside monophosphate catabolic process GO:0009158 4 0.038
heart looping GO:0001947 94 0.038
neuron projection morphogenesis GO:0048812 161 0.037
odontogenesis of dentin containing tooth GO:0042475 1 0.037
regulation of cell fate specification GO:0042659 20 0.037
determination of left right symmetry GO:0007368 179 0.037
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.036
anterior posterior pattern specification GO:0009952 152 0.036
monovalent inorganic cation transport GO:0015672 42 0.036
response to antibiotic GO:0046677 1 0.035
regulation of skeletal muscle tissue development GO:0048641 4 0.035
mechanoreceptor differentiation GO:0042490 37 0.034
cardiocyte differentiation GO:0035051 44 0.034
pectoral fin morphogenesis GO:0035138 29 0.034
extracellular structure organization GO:0043062 27 0.034
meiotic nuclear division GO:0007126 4 0.033
skeletal system morphogenesis GO:0048705 102 0.033
formation of primary germ layer GO:0001704 62 0.033
negative regulation of angiogenesis GO:0016525 7 0.032
endodermal cell fate specification GO:0001714 17 0.032
detection of visible light GO:0009584 12 0.031
embryonic cranial skeleton morphogenesis GO:0048701 90 0.031
chemotaxis GO:0006935 104 0.031
epithelial cell differentiation GO:0030855 116 0.031
positive regulation of striated muscle tissue development GO:0045844 1 0.031
positive regulation of synapse assembly GO:0051965 1 0.031
organelle organization GO:0006996 227 0.030
regulation of cell substrate adhesion GO:0010810 1 0.030
cellular component assembly GO:0022607 170 0.030
mechanosensory lateral line system development GO:0048881 49 0.030
generation of neurons GO:0048699 385 0.030
regulation of tissue remodeling GO:0034103 2 0.030
gamete generation GO:0007276 33 0.029
positive regulation of biological process GO:0048518 253 0.029
neuromast development GO:0048884 46 0.029
response to chemical GO:0042221 320 0.029
embryonic limb morphogenesis GO:0030326 2 0.029
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.028
establishment of localization GO:0051234 244 0.027
mesoderm formation GO:0001707 43 0.027
regulation of multicellular organismal process GO:0051239 277 0.027
ion transport GO:0006811 114 0.027
regulation of gastrulation GO:0010470 24 0.027
developmental process involved in reproduction GO:0003006 27 0.027
swim bladder inflation GO:0048798 5 0.027
embryonic heart tube morphogenesis GO:0003143 108 0.027
stem cell proliferation GO:0072089 4 0.027
regulation of multicellular organismal development GO:2000026 223 0.027
actin mediated cell contraction GO:0070252 1 0.027
posterior lateral line system development GO:0048915 46 0.026
basement membrane assembly GO:0070831 3 0.026
response to oxygen levels GO:0070482 25 0.026
gliogenesis GO:0042063 45 0.026
midbrain development GO:0030901 28 0.026
establishment of blood brain barrier GO:0060856 2 0.026
oxidation reduction process GO:0055114 41 0.026
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.026
response to abiotic stimulus GO:0009628 122 0.025
membrane repolarization GO:0086009 2 0.025
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.025
transport GO:0006810 220 0.025
signal transduction GO:0007165 455 0.025
trigeminal nerve development GO:0021559 3 0.024
response to fibroblast growth factor GO:0071774 22 0.024
regulation of anatomical structure morphogenesis GO:0022603 130 0.024
nucleoside monophosphate catabolic process GO:0009125 4 0.024
cell projection assembly GO:0030031 64 0.024
cell substrate adhesion GO:0031589 4 0.024
outflow tract morphogenesis GO:0003151 1 0.024
embryonic pectoral fin morphogenesis GO:0035118 24 0.024
basement membrane organization GO:0071711 5 0.023
wound healing GO:0042060 90 0.023
regulation of erk1 and erk2 cascade GO:0070372 4 0.023
cognition GO:0050890 1 0.023
neuron projection extension GO:1990138 45 0.023
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.023
positive regulation of cell adhesion GO:0045785 1 0.023
developmental programmed cell death GO:0010623 4 0.023
stem cell differentiation GO:0048863 117 0.023
swim bladder maturation GO:0048796 5 0.023
visual perception GO:0007601 17 0.023
hepaticobiliary system development GO:0061008 98 0.023
regulation of guanylate cyclase activity GO:0031282 6 0.023
limb bud formation GO:0060174 2 0.023
regulation of epithelial cell proliferation GO:0050678 3 0.023
regulation of vasculogenesis GO:2001212 1 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.022
formation of anatomical boundary GO:0048859 14 0.022
endodermal cell differentiation GO:0035987 19 0.022
cellular response to light stimulus GO:0071482 4 0.022
negative regulation of cell differentiation GO:0045596 46 0.022
negative regulation of epithelial cell proliferation GO:0050680 1 0.022
microtubule based process GO:0007017 60 0.022
regulation of dna replication GO:0006275 3 0.022
metal ion transport GO:0030001 58 0.022
regulation of signaling GO:0023051 235 0.022
hepatocyte differentiation GO:0070365 1 0.022
semicircular canal formation GO:0060876 4 0.021
skeletal system development GO:0001501 181 0.021
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.021
single organism metabolic process GO:0044710 217 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.021
regulation of receptor mediated endocytosis GO:0048259 4 0.021
axonogenesis GO:0007409 152 0.021
embryonic skeletal system development GO:0048706 97 0.021
cytokinesis GO:0000910 3 0.021
amine metabolic process GO:0009308 2 0.021
hindbrain formation GO:0021576 3 0.021
regulation of organ growth GO:0046620 3 0.020
larval development GO:0002164 2 0.020
neuroblast fate determination GO:0007400 1 0.020
chemosensory behavior GO:0007635 1 0.020
regulation of cell communication GO:0010646 232 0.020
ras protein signal transduction GO:0007265 7 0.020
proepicardium development GO:0003342 4 0.020
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.020
carbohydrate biosynthetic process GO:0016051 1 0.020
neuron projection development GO:0031175 180 0.020
cellular response to endogenous stimulus GO:0071495 68 0.020
epidermis development GO:0008544 48 0.020
negative regulation of nervous system development GO:0051961 22 0.020
regulation of cell migration GO:0030334 40 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
septum transversum development GO:0003343 4 0.019
glial cell differentiation GO:0010001 42 0.019
ectodermal placode formation GO:0060788 26 0.019
regulation of tube size GO:0035150 2 0.019
regulation of mesenchymal cell proliferation GO:0010464 1 0.019
chondrocyte development GO:0002063 4 0.019
cellular sodium ion homeostasis GO:0006883 1 0.019
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.019
startle response GO:0001964 4 0.019
regulation of cell motility GO:2000145 46 0.019
medial fin morphogenesis GO:0035141 14 0.019
positive regulation of multicellular organismal process GO:0051240 52 0.019
medial fin development GO:0033338 16 0.019
biological adhesion GO:0022610 40 0.018
small molecule metabolic process GO:0044281 77 0.018
neuron development GO:0048666 262 0.018
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.018
cardiac chamber development GO:0003205 19 0.018
cardiac cell fate commitment GO:0060911 1 0.018
somitogenesis GO:0001756 87 0.018
positive regulation of catabolic process GO:0009896 4 0.018
pharyngeal system development GO:0060037 18 0.018
single organism organelle organization GO:1902589 199 0.018
bone remodeling GO:0046849 2 0.018
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.018
cellular response to organic substance GO:0071310 105 0.018
toxin metabolic process GO:0009404 1 0.018
cellular response to xenobiotic stimulus GO:0071466 35 0.018
regulation of cellular component movement GO:0051270 55 0.017
heart morphogenesis GO:0003007 156 0.017
protein localization to nucleus GO:0034504 3 0.017
regulation of cell fate commitment GO:0010453 22 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
negative regulation of chemotaxis GO:0050922 4 0.017
purine nucleoside monophosphate catabolic process GO:0009128 4 0.017
glomerulus vasculature development GO:0072012 2 0.017
positive regulation of developmental process GO:0051094 50 0.017
axon development GO:0061564 166 0.016
response to organic substance GO:0010033 153 0.016
embryonic pattern specification GO:0009880 44 0.016
mesenchymal cell proliferation GO:0010463 1 0.016
cellular response to radiation GO:0071478 4 0.016
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.016
erk1 and erk2 cascade GO:0070371 4 0.016
semicircular canal development GO:0060872 24 0.016
calcium mediated signaling GO:0019722 2 0.016
cardiac atrium morphogenesis GO:0003209 2 0.016
inner ear receptor cell fate commitment GO:0060120 4 0.016
cell adhesion GO:0007155 40 0.016
cellular response to external stimulus GO:0071496 2 0.016
cardiac atrium development GO:0003230 4 0.016
epiboly GO:0090504 41 0.016
cellular localization GO:0051641 97 0.016
organic cyclic compound metabolic process GO:1901360 301 0.015
caudal fin morphogenesis GO:0035143 7 0.015
establishment of organelle localization GO:0051656 45 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.015
negative regulation of heart contraction GO:0045822 2 0.015
diterpenoid metabolic process GO:0016101 15 0.015
response to stress GO:0006950 263 0.015
organ formation GO:0048645 17 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
cell matrix adhesion GO:0007160 4 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
cytokinetic process GO:0032506 2 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
tissue homeostasis GO:0001894 25 0.015
regulation of reproductive process GO:2000241 4 0.014
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.014
ectodermal placode development GO:0071696 37 0.014
synapse organization GO:0050808 21 0.014
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.014
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.014
multi organism reproductive process GO:0044703 36 0.014
hydrogen peroxide metabolic process GO:0042743 2 0.014
regulation of endodermal cell fate specification GO:0042663 15 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.014
rhombomere 5 development GO:0021571 4 0.014
response to growth factor GO:0070848 39 0.013
positive regulation of cgmp biosynthetic process GO:0030828 6 0.013
regulation of cell adhesion GO:0030155 15 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
actin filament based movement GO:0030048 1 0.013
liver development GO:0001889 96 0.013
lateral line system development GO:0048925 76 0.013
cellular response to growth factor stimulus GO:0071363 39 0.013
morphogenesis of an epithelial sheet GO:0002011 49 0.013
xenobiotic metabolic process GO:0006805 4 0.013
trabecula morphogenesis GO:0061383 2 0.013
cellular macromolecule metabolic process GO:0044260 391 0.013
otic placode formation GO:0043049 23 0.013
regulation of circadian rhythm GO:0042752 4 0.013
reproduction GO:0000003 40 0.013
regulation of protein complex assembly GO:0043254 3 0.013
cell death GO:0008219 121 0.013
epidermal cell fate specification GO:0009957 4 0.013
peptide transport GO:0015833 1 0.013
hydrogen peroxide biosynthetic process GO:0050665 1 0.012
water homeostasis GO:0030104 4 0.012
endoderm development GO:0007492 49 0.012
pancreas development GO:0031016 84 0.012
regulation of dendrite development GO:0050773 3 0.012
regulation of cell proliferation GO:0042127 37 0.012
negative regulation of blood circulation GO:1903523 2 0.012
calcium ion dependent exocytosis GO:0017156 1 0.012
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.012
pigmentation GO:0043473 85 0.012
renal system vasculature development GO:0061437 2 0.012
negative regulation of embryonic development GO:0045992 11 0.012
positive regulation of muscle cell differentiation GO:0051149 1 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
regulation of neurogenesis GO:0050767 87 0.012
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.012
cellular protein catabolic process GO:0044257 4 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
regulation of metabolic process GO:0019222 359 0.012
taste bud formation GO:0061195 3 0.012
intramembranous ossification GO:0001957 3 0.012
Zebrafish
axon extension involved in axon guidance GO:0048846 10 0.012
positive regulation of epithelial cell migration GO:0010634 2 0.012
regulation of cell differentiation GO:0045595 142 0.012
glucocorticoid biosynthetic process GO:0006704 1 0.012
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
regulation of cell activation GO:0050865 1 0.011
oogenesis GO:0048477 14 0.011
nephron morphogenesis GO:0072028 2 0.011
behavior GO:0007610 74 0.011
hemostasis GO:0007599 13 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.011
negative regulation of gastrulation GO:2000542 11 0.011
positive regulation of bmp signaling pathway GO:0030513 10 0.011
reactive oxygen species biosynthetic process GO:1903409 1 0.011
anion transport GO:0006820 38 0.011
hormone metabolic process GO:0042445 19 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
atp catabolic process GO:0006200 4 0.011
positive regulation of blood circulation GO:1903524 2 0.011
cranial suture morphogenesis GO:0060363 1 0.011
germ line stem cell division GO:0042078 1 0.011
mitotic cell cycle GO:0000278 64 0.011
endochondral bone morphogenesis GO:0060350 8 0.011
cellular response to oxygen levels GO:0071453 1 0.011
ribose phosphate biosynthetic process GO:0046390 20 0.011
bmp signaling pathway GO:0030509 52 0.011
neurotransmitter secretion GO:0007269 2 0.011
cellular response to nutrient levels GO:0031669 2 0.011
regulation of developmental process GO:0050793 247 0.011
response to endogenous stimulus GO:0009719 83 0.011
cell migration involved in heart formation GO:0060974 10 0.011
negative regulation of cellular process GO:0048523 283 0.011
regulation of organelle assembly GO:1902115 4 0.011
positive regulation of cell division GO:0051781 2 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
developmental cell growth GO:0048588 52 0.011
axis specification GO:0009798 43 0.011
negative regulation of immune response GO:0050777 2 0.011
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.011
skeletal muscle organ development GO:0060538 78 0.011
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.011
neuron fate commitment GO:0048663 26 0.011
glucocorticoid metabolic process GO:0008211 2 0.011
protein metabolic process GO:0019538 183 0.011
endothelial cell migration GO:0043542 19 0.011
regulation of synapse structure and activity GO:0050803 5 0.011
notochord cell differentiation GO:0060034 18 0.011
regulation of angiogenesis GO:0045765 26 0.011
immune system process GO:0002376 241 0.011
somatic stem cell maintenance GO:0035019 1 0.011
cellular amine metabolic process GO:0044106 2 0.010
single organismal cell cell adhesion GO:0016337 29 0.010
cell proliferation GO:0008283 80 0.010
camera type eye development GO:0043010 222 0.010
regulation of blood pressure GO:0008217 1 0.010
regulation of stem cell proliferation GO:0072091 2 0.010
gland development GO:0048732 143 0.010
regulation of body fluid levels GO:0050878 16 0.010
maintenance of location GO:0051235 4 0.010
regulation of calcium ion transport GO:0051924 2 0.010
positive regulation of heart contraction GO:0045823 2 0.010
protein localization to plasma membrane GO:0072659 1 0.010
determination of ventral identity GO:0048264 21 0.010
negative regulation of cell fate specification GO:0009996 11 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
semicircular canal morphogenesis GO:0048752 18 0.010
regulation of protein ubiquitination GO:0031396 3 0.010
actin filament polymerization GO:0030041 2 0.010
organic substance biosynthetic process GO:1901576 289 0.010
direct ossification GO:0036072 3 0.010
Zebrafish

hapln3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.025
lysosomal storage disease DOID:3211 0 0.019
inherited metabolic disorder DOID:655 0 0.019
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019