Danio rerio

60 known processes

her6

hairy-related 6

(Aliases: cb129,HER-6)

her6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of metabolic process GO:0009893 108 0.969
Zebrafish
embryonic organ development GO:0048568 381 0.958
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.952
Zebrafish Fly
regulation of primary metabolic process GO:0080090 311 0.950
Zebrafish Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.945
Zebrafish Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.921
Zebrafish Fly
central nervous system development GO:0007417 387 0.916
embryonic organ morphogenesis GO:0048562 274 0.914
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.892
cell morphogenesis involved in differentiation GO:0000904 195 0.886
Zebrafish Fly
negative regulation of biological process GO:0048519 304 0.872
Zebrafish Worm Fly
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.864
Zebrafish
system process GO:0003008 185 0.861
locomotion GO:0040011 313 0.858
neural precursor cell proliferation GO:0061351 20 0.855
Fly
cellular component morphogenesis GO:0032989 336 0.846
Zebrafish Fly
developmental process involved in reproduction GO:0003006 27 0.830
Worm Fly
positive regulation of neural precursor cell proliferation GO:2000179 1 0.814
Fly
neuroblast proliferation GO:0007405 2 0.813
Fly
positive regulation of stem cell proliferation GO:2000648 1 0.808
Fly
signal transduction GO:0007165 455 0.803
cell morphogenesis GO:0000902 289 0.794
Zebrafish Fly
cellular aromatic compound metabolic process GO:0006725 295 0.791
Zebrafish Fly
regulation of epithelial cell proliferation GO:0050678 3 0.789
head development GO:0060322 303 0.760
regulation of neural precursor cell proliferation GO:2000177 3 0.744
Fly
radial glial cell differentiation GO:0060019 2 0.720
regulation of macromolecule metabolic process GO:0060255 317 0.699
Zebrafish Worm Fly
negative regulation of cellular process GO:0048523 283 0.682
Zebrafish Fly
mesenchymal cell development GO:0014031 78 0.681
nucleic acid metabolic process GO:0090304 244 0.650
Zebrafish Fly
heart development GO:0007507 313 0.645
localization of cell GO:0051674 244 0.643
regulation of developmental process GO:0050793 247 0.629
cell migration GO:0016477 237 0.626
protein modification process GO:0036211 100 0.625
Zebrafish
neuron projection morphogenesis GO:0048812 161 0.620
Zebrafish Fly
cellular component movement GO:0006928 335 0.616
forebrain development GO:0030900 96 0.611
regulation of cell cycle GO:0051726 52 0.598
Zebrafish Fly
neurological system process GO:0050877 62 0.582
positive regulation of notch signaling pathway GO:0045747 3 0.580
axon development GO:0061564 166 0.567
Zebrafish
mesenchymal cell differentiation GO:0048762 87 0.550
cell projection morphogenesis GO:0048858 244 0.534
Zebrafish Fly
skin development GO:0043588 54 0.533
Worm
neuron differentiation GO:0030182 353 0.524
regulation of gene expression GO:0010468 265 0.524
Zebrafish Worm Fly
reproductive process GO:0022414 40 0.519
Worm Fly
positive regulation of biological process GO:0048518 253 0.511
Zebrafish Fly
neuron projection guidance GO:0097485 86 0.510
regulation of cellular metabolic process GO:0031323 320 0.504
Zebrafish Fly
response to wounding GO:0009611 116 0.504
regulation of rna metabolic process GO:0051252 224 0.499
Zebrafish Fly
eye development GO:0001654 277 0.498
Zebrafish
epidermal cell differentiation GO:0009913 36 0.489
Worm
positive regulation of cell cycle GO:0045787 3 0.486
Zebrafish Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.483
Zebrafish Fly
positive regulation of cellular metabolic process GO:0031325 94 0.479
Zebrafish
sexual reproduction GO:0019953 36 0.479
growth GO:0040007 174 0.474
epithelial cell differentiation GO:0030855 116 0.470
Worm
cell fate commitment GO:0045165 99 0.464
Worm
gamete generation GO:0007276 33 0.464
peripheral nervous system development GO:0007422 55 0.463
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.460
Zebrafish Fly
phosphate containing compound metabolic process GO:0006796 108 0.459
Zebrafish
ectodermal placode morphogenesis GO:0071697 32 0.459
hepaticobiliary system development GO:0061008 98 0.458
chromosome organization GO:0051276 31 0.453
cell proliferation in forebrain GO:0021846 3 0.446
macromolecule biosynthetic process GO:0009059 227 0.445
Zebrafish Fly
brain development GO:0007420 293 0.444
gland development GO:0048732 143 0.443
Fly
generation of neurons GO:0048699 385 0.443
epidermis development GO:0008544 48 0.438
Worm
sex determination GO:0007530 1 0.428
Fly
regulation of biological quality GO:0065008 263 0.427
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.425
inner ear receptor cell fate commitment GO:0060120 4 0.424
single organism metabolic process GO:0044710 217 0.421
mesenchyme development GO:0060485 127 0.398
regulation of metabolic process GO:0019222 359 0.394
Zebrafish Worm Fly
immune system development GO:0002520 191 0.391
regulation of inner ear receptor cell differentiation GO:2000980 1 0.390
single organism organelle organization GO:1902589 199 0.389
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.386
cellular protein metabolic process GO:0044267 129 0.385
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.381
Zebrafish Fly
cell motility GO:0048870 244 0.369
negative regulation of macromolecule metabolic process GO:0010605 76 0.364
Zebrafish Worm Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.364
Zebrafish Fly
axon guidance GO:0007411 86 0.362
regulation of biosynthetic process GO:0009889 250 0.359
Zebrafish Fly
determination of bilateral symmetry GO:0009855 204 0.355
brain morphogenesis GO:0048854 18 0.355
regulation of cell differentiation GO:0045595 142 0.354
auditory receptor cell fate commitment GO:0009912 4 0.346
stem cell development GO:0048864 82 0.342
keratinocyte differentiation GO:0030216 0 0.339
regulation of neurogenesis GO:0050767 87 0.337
astrocyte differentiation GO:0048708 1 0.317
stem cell proliferation GO:0072089 4 0.306
Fly
sensory organ morphogenesis GO:0090596 200 0.304
biosynthetic process GO:0009058 294 0.303
Zebrafish Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.299
Zebrafish Fly
single organism reproductive process GO:0044702 40 0.292
cell proliferation GO:0008283 80 0.292
Fly
female gamete generation GO:0007292 14 0.288
regulation of transcription dna templated GO:0006355 213 0.288
Zebrafish Fly
regulation of signaling GO:0023051 235 0.283
developmental growth GO:0048589 166 0.280
morphogenesis of an epithelium GO:0002009 333 0.279
positive regulation of cell proliferation GO:0008284 15 0.279
Fly
mitotic nuclear division GO:0007067 18 0.274
Fly
rna biosynthetic process GO:0032774 181 0.269
Zebrafish Fly
photoreceptor cell differentiation GO:0046530 55 0.268
lateral inhibition GO:0046331 1 0.267
transcription dna templated GO:0006351 181 0.267
Zebrafish Fly
bmp signaling pathway GO:0030509 52 0.267
positive regulation of macromolecule metabolic process GO:0010604 93 0.265
Zebrafish
nucleic acid templated transcription GO:0097659 181 0.261
Zebrafish Fly
epithelial tube morphogenesis GO:0060562 148 0.258
regulation of response to stimulus GO:0048583 269 0.257
axonogenesis GO:0007409 152 0.254
Zebrafish
spinal cord radial glial cell differentiation GO:0021531 2 0.252
neural crest cell differentiation GO:0014033 72 0.251
aromatic compound biosynthetic process GO:0019438 217 0.249
Zebrafish Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.245
Zebrafish Fly
regulation of cellular component organization GO:0051128 86 0.241
Fly
negative regulation of epithelial cell migration GO:0010633 1 0.239
regulation of cellular biosynthetic process GO:0031326 245 0.238
Zebrafish Fly
auditory receptor cell differentiation GO:0042491 15 0.235
regulation of apoptotic process GO:0042981 98 0.234
positive regulation of cell communication GO:0010647 56 0.234
nucleobase containing compound metabolic process GO:0006139 274 0.224
Zebrafish Fly
regulation of cell communication GO:0010646 232 0.222
gastrulation GO:0007369 208 0.222
midbrain hindbrain boundary development GO:0030917 23 0.221
Zebrafish
positive regulation of cell fate specification GO:0042660 1 0.218
cell cycle process GO:0022402 53 0.216
Fly
regulation of multicellular organismal process GO:0051239 277 0.212
gliogenesis GO:0042063 45 0.203
Zebrafish
regulation of rna biosynthetic process GO:2001141 213 0.202
Zebrafish Fly
organic cyclic compound metabolic process GO:1901360 301 0.199
Zebrafish Fly
regulation of catenin import into nucleus GO:0035412 2 0.199
chordate embryonic development GO:0043009 271 0.193
sensory organ development GO:0007423 393 0.188
Zebrafish
liver development GO:0001889 96 0.187
regulation of stem cell proliferation GO:0072091 2 0.187
Fly
regulation of organelle organization GO:0033043 29 0.185
Fly
intracellular signal transduction GO:0035556 85 0.183
embryo development ending in birth or egg hatching GO:0009792 271 0.181
developmental cell growth GO:0048588 52 0.180
regulation of protein transport GO:0051223 3 0.179
multi organism reproductive process GO:0044703 36 0.179
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.178
negative regulation of cell differentiation GO:0045596 46 0.178
Zebrafish
notch signaling pathway GO:0007219 35 0.174
response to growth factor GO:0070848 39 0.172
nitrogen compound metabolic process GO:0006807 319 0.170
Zebrafish Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.167
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.167
Zebrafish Fly
regulation of skeletal muscle tissue development GO:0048641 4 0.167
enzyme linked receptor protein signaling pathway GO:0007167 106 0.166
mitotic cell cycle process GO:1903047 48 0.165
Fly
cellular protein modification process GO:0006464 100 0.162
Zebrafish
response to chemical GO:0042221 320 0.161
positive regulation of gene expression GO:0010628 71 0.160
cell death GO:0008219 121 0.159
response to organic substance GO:0010033 153 0.158
somite specification GO:0001757 12 0.157
renal tubule morphogenesis GO:0061333 1 0.157
positive regulation of cellular process GO:0048522 201 0.156
Zebrafish Fly
positive regulation of cell fate commitment GO:0010455 1 0.155
regulation of signal transduction GO:0009966 225 0.155
multicellular organism growth GO:0035264 4 0.153
epithelial cell development GO:0002064 42 0.153
peripheral nervous system neuron differentiation GO:0048934 28 0.152
Zebrafish
negative regulation of metabolic process GO:0009892 86 0.148
Zebrafish Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.148
Zebrafish Fly
regulation of protein metabolic process GO:0051246 56 0.146
Zebrafish
neuron development GO:0048666 262 0.146
Zebrafish Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.145
Fly
glial cell migration GO:0008347 3 0.145
compound eye development GO:0048749 2 0.144
regulation of protein import into nucleus GO:0042306 2 0.142
cognition GO:0050890 1 0.142
negative regulation of multicellular organismal process GO:0051241 69 0.141
Zebrafish
regulation of oligodendrocyte differentiation GO:0048713 1 0.139
regulation of phosphorus metabolic process GO:0051174 43 0.139
Zebrafish
lens development in camera type eye GO:0002088 22 0.137
cilium morphogenesis GO:0060271 85 0.136
neural crest cell development GO:0014032 62 0.133
positive regulation of cellular protein metabolic process GO:0032270 22 0.132
Zebrafish
heart looping GO:0001947 94 0.131
leukocyte differentiation GO:0002521 25 0.130
regulation of cell development GO:0060284 100 0.128
epithelial cell proliferation GO:0050673 17 0.127
cell part morphogenesis GO:0032990 246 0.126
Zebrafish Fly
cell projection organization GO:0030030 284 0.126
Zebrafish Fly
immune system process GO:0002376 241 0.125
negative regulation of endothelial cell migration GO:0010596 1 0.125
macromolecule modification GO:0043412 111 0.125
Zebrafish
negative regulation of neurogenesis GO:0050768 20 0.124
Zebrafish
regulation of nuclear division GO:0051783 9 0.124
Fly
transcription from rna polymerase ii promoter GO:0006366 80 0.123
Fly
regulation of notch signaling pathway GO:0008593 16 0.122
regulation of catalytic activity GO:0050790 55 0.121
Zebrafish
gene expression GO:0010467 252 0.120
Zebrafish Worm Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.119
forebrain anterior posterior pattern specification GO:0021797 3 0.118
positive regulation of cell differentiation GO:0045597 30 0.117
Fly
negative regulation of immune system process GO:0002683 7 0.116
neuron projection development GO:0031175 180 0.116
Zebrafish Fly
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.116
rna metabolic process GO:0016070 219 0.116
Zebrafish Fly
regulation of mitotic cell cycle GO:0007346 25 0.115
Fly
regulation of binding GO:0051098 3 0.115
embryonic skeletal system morphogenesis GO:0048704 93 0.114
regulation of programmed cell death GO:0043067 101 0.114
cellular biosynthetic process GO:0044249 286 0.113
Zebrafish Fly
startle response GO:0001964 4 0.112
response to estrogen GO:0043627 27 0.112
determination of left right symmetry GO:0007368 179 0.111
protein import into nucleus GO:0006606 3 0.110
regulation of reproductive process GO:2000241 4 0.107
ear morphogenesis GO:0042471 64 0.107
inner ear development GO:0048839 126 0.107
single organism localization GO:1902578 225 0.106
myeloid leukocyte differentiation GO:0002573 15 0.106
cranial nerve development GO:0021545 42 0.104
cellular response to chemical stimulus GO:0070887 157 0.104
mesodermal cell fate specification GO:0007501 12 0.104
positive regulation of cell division GO:0051781 2 0.103
Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.103
Zebrafish Fly
regulation of glial cell differentiation GO:0045685 4 0.101
response to stress GO:0006950 263 0.101
Fly
thalamus development GO:0021794 6 0.101
cell projection assembly GO:0030031 64 0.097
blood vessel morphogenesis GO:0048514 216 0.095
forebrain neuron fate commitment GO:0021877 1 0.094
negative regulation of developmental process GO:0051093 65 0.094
Zebrafish
oocyte maturation GO:0001556 4 0.094
regulation of cell division GO:0051302 12 0.093
Fly
multi organism process GO:0051704 134 0.093
positive regulation of mesodermal cell fate specification GO:0048337 1 0.092
peripheral nervous system neuron development GO:0048935 22 0.092
Zebrafish
digestive tract morphogenesis GO:0048546 231 0.091
nephron epithelium morphogenesis GO:0072088 1 0.089
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.088
Zebrafish Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.088
Zebrafish Fly
mitotic cell cycle GO:0000278 64 0.088
Fly
rhombomere development GO:0021546 19 0.087
negative regulation of myeloid cell differentiation GO:0045638 1 0.087
tube morphogenesis GO:0035239 349 0.086
Fly
cell fate specification GO:0001708 68 0.085
Worm
regulation of cellular protein metabolic process GO:0032268 52 0.085
Zebrafish
phosphorylation GO:0016310 69 0.085
Zebrafish
phosphorus metabolic process GO:0006793 109 0.084
Zebrafish
negative regulation of epithelial cell proliferation GO:0050680 1 0.084
erythrocyte differentiation GO:0030218 54 0.084
cell migration involved in gastrulation GO:0042074 79 0.083
positive regulation of neurogenesis GO:0050769 24 0.083
Fly
arterial endothelial cell differentiation GO:0060842 2 0.083
ameboidal type cell migration GO:0001667 143 0.081
wnt signaling pathway GO:0016055 80 0.081
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.080
regulation of bmp signaling pathway GO:0030510 39 0.078
organic substance biosynthetic process GO:1901576 289 0.078
Zebrafish Fly
positive regulation of biosynthetic process GO:0009891 68 0.078
oligodendrocyte differentiation GO:0048709 23 0.078
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.078
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.077
regulation of multicellular organismal development GO:2000026 223 0.077
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.076
Fly
rhombomere morphogenesis GO:0021593 17 0.076
neuroblast fate commitment GO:0014017 1 0.076
multicellular organismal reproductive process GO:0048609 35 0.075
positive regulation of protein metabolic process GO:0051247 23 0.073
Zebrafish
neural crest cell migration GO:0001755 42 0.073
camera type eye development GO:0043010 222 0.073
negative regulation of nervous system development GO:0051961 22 0.073
Zebrafish
neural tube development GO:0021915 62 0.073
Zebrafish
hemopoiesis GO:0030097 183 0.072
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.072
heart morphogenesis GO:0003007 156 0.072
anterior posterior pattern specification GO:0009952 152 0.072
regulation of skeletal muscle fiber development GO:0048742 2 0.071
nephron development GO:0072006 31 0.071
embryonic heart tube development GO:0035050 133 0.070
regeneration GO:0031099 91 0.070
digestive system development GO:0055123 289 0.070
cell migration involved in heart development GO:0060973 22 0.069
cell cycle GO:0007049 93 0.068
Zebrafish Fly
determination of heart left right asymmetry GO:0061371 117 0.068
glial cell differentiation GO:0010001 42 0.068
multicellular organism reproduction GO:0032504 35 0.067
germ cell development GO:0007281 22 0.067
posterior lateral line system development GO:0048915 46 0.066
regulation of cellular component movement GO:0051270 55 0.066
cellular amine metabolic process GO:0044106 2 0.066
muscle tissue development GO:0060537 110 0.066
positive regulation of striated muscle tissue development GO:0045844 1 0.066
specification of organ identity GO:0010092 2 0.066
myeloid cell development GO:0061515 32 0.065
regulation of multicellular organism growth GO:0040014 4 0.065
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.065
Zebrafish Fly
digestive tract development GO:0048565 265 0.065
positive regulation of signal transduction GO:0009967 56 0.065
forebrain dorsal ventral pattern formation GO:0021798 1 0.065
regulation of cell cycle process GO:0010564 20 0.064
Fly
regulation of immune system process GO:0002682 34 0.064
mesodermal cell differentiation GO:0048333 21 0.064
regulation of cell death GO:0010941 103 0.063
negative regulation of protein phosphorylation GO:0001933 4 0.063
eye morphogenesis GO:0048592 144 0.063
blood vessel development GO:0001568 246 0.062
meiotic nuclear division GO:0007126 4 0.062
forebrain regionalization GO:0021871 4 0.062
olfactory placode morphogenesis GO:0071699 7 0.061
angiogenesis GO:0001525 158 0.061
detection of external stimulus GO:0009581 24 0.061
notochord development GO:0030903 54 0.060
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 1 0.060
Zebrafish
regulation of response to stress GO:0080134 36 0.059
somitogenesis GO:0001756 87 0.059
larval development GO:0002164 2 0.058
regulation of cell activation GO:0050865 1 0.058
positive regulation of response to stimulus GO:0048584 80 0.058
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.058
mechanoreceptor differentiation GO:0042490 37 0.057
mononuclear cell proliferation GO:0032943 1 0.057
protein phosphorylation GO:0006468 47 0.057
Zebrafish
neuroblast differentiation GO:0014016 1 0.057
positive regulation of cellular biosynthetic process GO:0031328 68 0.056
regulation of wnt signaling pathway GO:0030111 53 0.056
hindbrain development GO:0030902 91 0.055
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.055
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.054
Zebrafish Fly
exocrine system development GO:0035272 28 0.054
Fly
cellular response to biotic stimulus GO:0071216 3 0.054
paraxial mesoderm development GO:0048339 8 0.054
lipid storage GO:0019915 1 0.054
positive regulation of mesoderm development GO:2000382 1 0.054
nephron tubule morphogenesis GO:0072078 1 0.053
skeletal system development GO:0001501 181 0.053
cytoskeleton organization GO:0007010 96 0.053
positive regulation of gliogenesis GO:0014015 2 0.053
smoothened signaling pathway GO:0007224 30 0.052
olfactory lobe development GO:0021988 4 0.051
regulation of anatomical structure size GO:0090066 33 0.050
establishment of protein localization to organelle GO:0072594 4 0.050
trigeminal nerve development GO:0021559 3 0.050
stem cell differentiation GO:0048863 117 0.050
odontogenesis of dentin containing tooth GO:0042475 1 0.049
reproduction GO:0000003 40 0.049
negative regulation of neural precursor cell proliferation GO:2000178 1 0.049
positive regulation of epithelial cell proliferation GO:0050679 1 0.048
positive regulation of glial cell differentiation GO:0045687 1 0.048
regulation of erk1 and erk2 cascade GO:0070372 4 0.047
organelle organization GO:0006996 227 0.047
Fly
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.047
patterning of lymph vessels GO:0060854 1 0.047
regulation of transferase activity GO:0051338 16 0.047
Zebrafish
apoptotic process GO:0006915 116 0.046
lymphocyte proliferation GO:0046651 1 0.046
forebrain midbrain boundary formation GO:0021905 1 0.046
patterning of blood vessels GO:0001569 15 0.045
organelle fission GO:0048285 23 0.045
Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.045
regulation of intracellular protein transport GO:0033157 3 0.045
negative regulation of gliogenesis GO:0014014 1 0.045
lens morphogenesis in camera type eye GO:0002089 7 0.044
secondary metabolic process GO:0019748 3 0.044
regulation of nervous system development GO:0051960 90 0.043
cellular response to stress GO:0033554 62 0.043
myeloid cell differentiation GO:0030099 86 0.043
endodermal cell fate determination GO:0007493 2 0.043
positive regulation of multicellular organismal process GO:0051240 52 0.043
Fly
negative regulation of cell migration GO:0030336 17 0.042
neuronal stem cell maintenance GO:0097150 2 0.042
cellular component biogenesis GO:0044085 178 0.042
response to acid chemical GO:0001101 17 0.041
positive regulation of translation GO:0045727 1 0.041
positive regulation of skeletal muscle tissue development GO:0048643 1 0.041
regulation of stem cell differentiation GO:2000736 4 0.041
embryonic eye morphogenesis GO:0048048 30 0.040
stem cell fate determination GO:0048867 1 0.040
protein metabolic process GO:0019538 183 0.040
Zebrafish
skeletal system morphogenesis GO:0048705 102 0.040
camera type eye morphogenesis GO:0048593 108 0.040
dorsal ventral axis specification GO:0009950 14 0.040
kidney epithelium development GO:0072073 23 0.039
death GO:0016265 121 0.039
response to vitamin GO:0033273 3 0.039
sensory perception GO:0007600 39 0.039
regulation of phospholipase activity GO:0010517 2 0.039
regulation of phosphate metabolic process GO:0019220 43 0.039
Zebrafish
response to endogenous stimulus GO:0009719 83 0.039
regulation of developmental growth GO:0048638 38 0.038
sprouting angiogenesis GO:0002040 53 0.038
regulation of phosphorylation GO:0042325 26 0.038
Zebrafish
response to hypoxia GO:0001666 25 0.038
Fly
positive regulation of molecular function GO:0044093 33 0.038
Zebrafish
development of primary female sexual characteristics GO:0046545 4 0.037
positive regulation of signaling GO:0023056 56 0.037
endoderm development GO:0007492 49 0.037
Zebrafish
cell cell signaling GO:0007267 52 0.036
mesoderm development GO:0007498 88 0.036
regulation of cell proliferation GO:0042127 37 0.036
Fly
programmed cell death GO:0012501 119 0.035
diencephalon development GO:0021536 58 0.035
cilium assembly GO:0042384 58 0.035
negative regulation of collateral sprouting GO:0048671 2 0.035
photoreceptor cell fate commitment GO:0046552 1 0.035
inner ear receptor cell differentiation GO:0060113 29 0.035
negative regulation of transcription dna templated GO:0045892 45 0.035
Zebrafish Fly
cellular protein catabolic process GO:0044257 4 0.035
phagocytosis GO:0006909 3 0.035
dorsal ventral pattern formation GO:0009953 125 0.035
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.035
regulation of mitotic cell cycle phase transition GO:1901990 8 0.035
embryonic heart tube morphogenesis GO:0003143 108 0.035
cellular response to growth factor stimulus GO:0071363 39 0.035
modification dependent macromolecule catabolic process GO:0043632 3 0.034
proteasomal protein catabolic process GO:0010498 2 0.034
heterocycle metabolic process GO:0046483 290 0.034
Zebrafish Fly
positive regulation of transport GO:0051050 2 0.034
positive regulation of endothelial cell differentiation GO:0045603 2 0.034
negative regulation of phosphate metabolic process GO:0045936 13 0.034
multicellular organismal signaling GO:0035637 22 0.033
rhombomere formation GO:0021594 12 0.033
regulation of protein targeting GO:1903533 2 0.033
tissue remodeling GO:0048771 4 0.033
olfactory placode development GO:0071698 12 0.032
cellular component assembly involved in morphogenesis GO:0010927 107 0.032
peripheral nervous system neuron axonogenesis GO:0048936 13 0.032
Zebrafish
protein targeting to nucleus GO:0044744 3 0.032
regulation of cellular amine metabolic process GO:0033238 0 0.032
specification of symmetry GO:0009799 204 0.032
nuclear transport GO:0051169 4 0.032
spermatid development GO:0007286 2 0.032
homeostasis of number of cells GO:0048872 62 0.032
cellular response to estradiol stimulus GO:0071392 1 0.031
nephron epithelium development GO:0072009 16 0.031
positive regulation of programmed cell death GO:0043068 29 0.031
regulation of neuron differentiation GO:0045664 56 0.030
regulation of filopodium assembly GO:0051489 2 0.030
regulation of extent of cell growth GO:0061387 29 0.030
embryonic skeletal joint development GO:0072498 3 0.030
macromolecule localization GO:0033036 54 0.030
regulation of establishment of protein localization GO:0070201 4 0.030
neuron fate commitment GO:0048663 26 0.030
regulation of mechanoreceptor differentiation GO:0045631 1 0.030
negative regulation of biosynthetic process GO:0009890 55 0.030
Zebrafish Fly
regulation of protein localization to nucleus GO:1900180 2 0.030
negative regulation of nucleic acid templated transcription GO:1903507 45 0.030
Zebrafish Fly
protein localization to nucleus GO:0034504 3 0.030
endocrine system development GO:0035270 65 0.029
positive regulation of muscle tissue development GO:1901863 1 0.029
amine metabolic process GO:0009308 2 0.029
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.029
cellular response to dna damage stimulus GO:0006974 24 0.028
positive regulation of histone modification GO:0031058 1 0.028
motor neuron axon guidance GO:0008045 23 0.028
regulation of collateral sprouting GO:0048670 7 0.028
negative regulation of neutrophil chemotaxis GO:0090024 3 0.028
response to nutrient GO:0007584 3 0.028
fin development GO:0033333 77 0.028
pronephros development GO:0048793 69 0.027
fin regeneration GO:0031101 51 0.027
macromolecular complex subunit organization GO:0043933 74 0.027
negative regulation of response to stimulus GO:0048585 104 0.027
negative regulation of rna biosynthetic process GO:1902679 45 0.027
Zebrafish Fly
tissue migration GO:0090130 37 0.027
ventral spinal cord interneuron specification GO:0021521 3 0.027
wound healing GO:0042060 90 0.026
protein acetylation GO:0006473 2 0.026
negative regulation of histone modification GO:0031057 1 0.026
positive regulation of chromatin modification GO:1903310 1 0.026

her6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.111
connective tissue disease DOID:65 0 0.049
bone disease DOID:0080001 0 0.049
musculoskeletal system disease DOID:17 0 0.049
bone development disease DOID:0080006 0 0.049
dysostosis DOID:1934 0 0.049
nervous system disease DOID:863 0 0.042
gastrointestinal system cancer DOID:3119 0 0.040
organ system cancer DOID:0050686 0 0.040
cancer DOID:162 0 0.040
disease of cellular proliferation DOID:14566 0 0.040
intestinal cancer DOID:10155 0 0.035
large intestine cancer DOID:5672 0 0.035
colorectal cancer DOID:9256 0 0.035
colon cancer DOID:219 0 0.035
colon carcinoma DOID:1520 0 0.035
sensory system disease DOID:0050155 0 0.029
eye and adnexa disease DOID:1492 0 0.029