Danio rerio

16 known processes

hfe2

hemochromatosis type 2

(Aliases: MGC136698,hjv,id:ibd3464,RGMr,DL-M,zgc:136698,MGC162101,wu:fb38f10,RGMC)

hfe2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular aromatic compound metabolic process GO:0006725 295 0.287
Mouse
neuroblast proliferation GO:0007405 2 0.274
regulation of nitrogen compound metabolic process GO:0051171 251 0.202
Mouse Worm
rna biosynthetic process GO:0032774 181 0.198
Mouse
regulation of biosynthetic process GO:0009889 250 0.198
Mouse Worm
gene expression GO:0010467 252 0.194
Mouse
heart morphogenesis GO:0003007 156 0.185
cellular component morphogenesis GO:0032989 336 0.183
regulation of rna biosynthetic process GO:2001141 213 0.183
Mouse Worm
positive regulation of gene expression GO:0010628 71 0.162
Mouse
cell motility GO:0048870 244 0.149
stem cell proliferation GO:0072089 4 0.143
mesodermal cell migration GO:0008078 12 0.135
blood vessel development GO:0001568 246 0.134
vasculature development GO:0001944 278 0.132
nucleocytoplasmic transport GO:0006913 4 0.128
macromolecule biosynthetic process GO:0009059 227 0.125
Mouse
morphogenesis of an epithelium GO:0002009 333 0.119
biosynthetic process GO:0009058 294 0.118
Mouse
rna metabolic process GO:0016070 219 0.117
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.114
Mouse
cellular component movement GO:0006928 335 0.113
tube morphogenesis GO:0035239 349 0.111
Worm
organic cyclic compound metabolic process GO:1901360 301 0.108
Mouse
skeletal muscle organ development GO:0060538 78 0.104
sensory organ development GO:0007423 393 0.103
localization of cell GO:0051674 244 0.103
regulation of cellular biosynthetic process GO:0031326 245 0.100
Mouse Worm
aromatic compound biosynthetic process GO:0019438 217 0.097
Mouse
regulation of cellular metabolic process GO:0031323 320 0.097
Mouse Worm
embryonic heart tube development GO:0035050 133 0.096
regulation of metabolic process GO:0019222 359 0.095
Mouse Worm
chordate embryonic development GO:0043009 271 0.095
heart development GO:0007507 313 0.095
cellular response to external stimulus GO:0071496 2 0.094
response to nutrient GO:0007584 3 0.093
system process GO:0003008 185 0.088
cell migration GO:0016477 237 0.086
cell migration involved in gastrulation GO:0042074 79 0.086
establishment of protein localization to organelle GO:0072594 4 0.084
embryonic organ development GO:0048568 381 0.081
determination of bilateral symmetry GO:0009855 204 0.080
cellular nitrogen compound metabolic process GO:0034641 290 0.078
Mouse
regulation of protein targeting GO:1903533 2 0.078
sensory perception of chemical stimulus GO:0007606 3 0.076
nuclear transport GO:0051169 4 0.075
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.074
Mouse Worm
ameboidal type cell migration GO:0001667 143 0.073
cellular biosynthetic process GO:0044249 286 0.070
Mouse
organic substance biosynthetic process GO:1901576 289 0.070
Mouse
single organism nuclear import GO:1902593 3 0.069
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.068
nuclear import GO:0051170 3 0.068
nucleic acid metabolic process GO:0090304 244 0.067
Mouse
regulation of protein import into nucleus GO:0042306 2 0.065
heterocycle biosynthetic process GO:0018130 215 0.065
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.065
response to external stimulus GO:0009605 264 0.062
segmentation GO:0035282 97 0.061
aging GO:0007568 2 0.059
cellular macromolecule biosynthetic process GO:0034645 224 0.058
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.057
Mouse Worm
regulation of nucleic acid templated transcription GO:1903506 213 0.056
Mouse Worm
muscle tissue development GO:0060537 110 0.056
regulation of gene expression GO:0010468 265 0.056
Mouse Worm
chemosensory behavior GO:0007635 1 0.055
camera type eye development GO:0043010 222 0.055
regionalization GO:0003002 274 0.055
nucleobase containing compound biosynthetic process GO:0034654 205 0.054
Mouse
neural tube patterning GO:0021532 33 0.053
positive regulation of transcription dna templated GO:0045893 57 0.051
Mouse
protein import into nucleus GO:0006606 3 0.050
peripheral nervous system development GO:0007422 55 0.050
brain development GO:0007420 293 0.050
camera type eye morphogenesis GO:0048593 108 0.050
gastrulation GO:0007369 208 0.050
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.050
Mouse Worm
regulation of stem cell proliferation GO:0072091 2 0.050
locomotion GO:0040011 313 0.049
sprouting angiogenesis GO:0002040 53 0.049
protein import GO:0017038 3 0.049
regulation of macromolecule biosynthetic process GO:0010556 225 0.048
Mouse Worm
regulation of developmental process GO:0050793 247 0.047
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.046
Mouse
maintenance of location GO:0051235 4 0.046
eye development GO:0001654 277 0.046
cellular protein catabolic process GO:0044257 4 0.045
heterocycle metabolic process GO:0046483 290 0.044
Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.044
muscle organ development GO:0007517 101 0.044
skeletal muscle tissue development GO:0007519 67 0.044
cell surface receptor signaling pathway GO:0007166 325 0.043
Mouse Worm
positive regulation of transport GO:0051050 2 0.043
regulation of establishment of protein localization GO:0070201 4 0.043
cell proliferation GO:0008283 80 0.042
protein localization to nucleus GO:0034504 3 0.042
cellular response to extracellular stimulus GO:0031668 2 0.042
gland development GO:0048732 143 0.041
regulation of protein transport GO:0051223 3 0.041
convergent extension GO:0060026 118 0.041
skeletal muscle fiber development GO:0048741 35 0.040
myotube differentiation GO:0014902 45 0.040
cell morphogenesis GO:0000902 289 0.040
single organism organelle organization GO:1902589 199 0.040
regulation of protein localization to nucleus GO:1900180 2 0.040
heart process GO:0003015 71 0.040
central nervous system development GO:0007417 387 0.039
striated muscle tissue development GO:0014706 110 0.039
sensory perception of smell GO:0007608 2 0.039
regulation of skeletal muscle fiber development GO:0048742 2 0.038
taxis GO:0042330 109 0.038
regulation of transcription dna templated GO:0006355 213 0.038
Mouse Worm
cellular protein metabolic process GO:0044267 129 0.038
positive regulation of cellular biosynthetic process GO:0031328 68 0.038
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.037
Mouse
regulation of organelle assembly GO:1902115 4 0.037
cell part morphogenesis GO:0032990 246 0.037
cartilage condensation GO:0001502 3 0.036
cell matrix adhesion GO:0007160 4 0.036
response to glucose GO:0009749 3 0.035
larval development GO:0002164 2 0.035
Worm
wnt signaling pathway GO:0016055 80 0.035
biological adhesion GO:0022610 40 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
Worm
digestive tract development GO:0048565 265 0.035
Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.034
Mouse
cell projection morphogenesis GO:0048858 244 0.034
cell projection organization GO:0030030 284 0.033
protein metabolic process GO:0019538 183 0.033
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.033
striated muscle cell differentiation GO:0051146 129 0.033
regulation of anatomical structure morphogenesis GO:0022603 130 0.033
digestive system development GO:0055123 289 0.032
Worm
specification of symmetry GO:0009799 204 0.032
regulation of dna replication GO:0006275 3 0.032
epithelial tube morphogenesis GO:0060562 148 0.032
chemotaxis GO:0006935 104 0.032
epithelial cell migration GO:0010631 25 0.032
blood vessel morphogenesis GO:0048514 216 0.032
organic cyclic compound biosynthetic process GO:1901362 223 0.032
Mouse
response to chemical GO:0042221 320 0.032
embryo development ending in birth or egg hatching GO:0009792 271 0.031
response to hexose GO:0009746 3 0.031
regulation of cell communication GO:0010646 232 0.031
Mouse Worm
digestive tract morphogenesis GO:0048546 231 0.031
Worm
generation of neurons GO:0048699 385 0.031
cellular response to biotic stimulus GO:0071216 3 0.031
signal transduction GO:0007165 455 0.030
Mouse Worm
positive regulation of cellular metabolic process GO:0031325 94 0.030
Mouse
regulation of multicellular organismal process GO:0051239 277 0.030
Worm
axonal fasciculation GO:0007413 11 0.030
myotube cell development GO:0014904 35 0.030
nucleic acid templated transcription GO:0097659 181 0.030
Mouse
response to monosaccharide GO:0034284 3 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.030
negative regulation of biological process GO:0048519 304 0.029
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.029
Mouse Worm
head development GO:0060322 303 0.029
heart looping GO:0001947 94 0.029
response to carbohydrate GO:0009743 3 0.029
positive regulation of cell cycle GO:0045787 3 0.029
regulation of cytokine production GO:0001817 3 0.028
regulation of wound healing GO:0061041 2 0.027
neuron projection development GO:0031175 180 0.027
transcription dna templated GO:0006351 181 0.027
Mouse
response to vitamin GO:0033273 3 0.027
somitogenesis GO:0001756 87 0.027
muscle cell development GO:0055001 115 0.027
adult behavior GO:0030534 2 0.026
regulation of cytoplasmic transport GO:1903649 4 0.026
post embryonic morphogenesis GO:0009886 4 0.026
establishment of localization GO:0051234 244 0.026
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.026
Mouse Worm
positive regulation of metabolic process GO:0009893 108 0.025
Mouse
somite development GO:0061053 96 0.025
programmed cell death GO:0012501 119 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
Worm
neurological system process GO:0050877 62 0.025
positive regulation of cellular process GO:0048522 201 0.025
Mouse
stem cell division GO:0017145 1 0.025
nitrogen compound metabolic process GO:0006807 319 0.025
Mouse
negative regulation of protein phosphorylation GO:0001933 4 0.024
cell cycle GO:0007049 93 0.024
determination of heart left right asymmetry GO:0061371 117 0.023
response to stress GO:0006950 263 0.023
protein targeting to nucleus GO:0044744 3 0.023
regulation of intracellular protein transport GO:0033157 3 0.022
phosphate containing compound metabolic process GO:0006796 108 0.022
determination of left right symmetry GO:0007368 179 0.022
notochord development GO:0030903 54 0.022
positive regulation of biological process GO:0048518 253 0.022
Mouse
response to abiotic stimulus GO:0009628 122 0.022
skin development GO:0043588 54 0.021
regulation of skeletal muscle tissue development GO:0048641 4 0.021
circulatory system process GO:0003013 87 0.021
transcription from rna polymerase ii promoter GO:0006366 80 0.021
Mouse
single organism localization GO:1902578 225 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
Mouse Worm
anterior posterior pattern specification GO:0009952 152 0.021
growth GO:0040007 174 0.021
Worm
cell differentiation in spinal cord GO:0021515 40 0.020
positive regulation of cell activation GO:0050867 1 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.020
sensory organ morphogenesis GO:0090596 200 0.020
positive regulation of developmental process GO:0051094 50 0.020
tissue remodeling GO:0048771 4 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
negative regulation of cytoplasmic transport GO:1903650 2 0.020
detection of chemical stimulus GO:0009593 4 0.020
cellular response to lipopolysaccharide GO:0071222 3 0.020
neuron projection morphogenesis GO:0048812 161 0.019
muscle cell differentiation GO:0042692 139 0.019
cell fate commitment GO:0045165 99 0.019
Worm
positive regulation of cell division GO:0051781 2 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.019
hemopoiesis GO:0030097 183 0.019
single organism metabolic process GO:0044710 217 0.019
epithelium migration GO:0090132 25 0.019
positive regulation of muscle cell differentiation GO:0051149 1 0.018
regulation of cell cycle GO:0051726 52 0.018
angiogenesis GO:0001525 158 0.018
defense response to fungus GO:0050832 2 0.018
regulation of primary metabolic process GO:0080090 311 0.018
Mouse Worm
apoptotic process GO:0006915 116 0.018
bmp signaling pathway GO:0030509 52 0.018
Mouse Worm
regulation of biological quality GO:0065008 263 0.018
Mouse
formation of anatomical boundary GO:0048859 14 0.018
leukocyte migration GO:0050900 15 0.018
hormone transport GO:0009914 2 0.017
positive regulation of biosynthetic process GO:0009891 68 0.017
Mouse
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 4 0.017
diencephalon development GO:0021536 58 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.016
axon guidance GO:0007411 86 0.016
positive regulation of secretion GO:0051047 1 0.016
cellular amine metabolic process GO:0044106 2 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
Mouse
multicellular organism growth GO:0035264 4 0.016
Worm
negative regulation of protein transport GO:0051224 3 0.016
skeletal system development GO:0001501 181 0.016
mitotic cell cycle process GO:1903047 48 0.016
positive regulation of cell adhesion GO:0045785 1 0.015
regulation of bmp signaling pathway GO:0030510 39 0.015
Mouse Worm
protein acetylation GO:0006473 2 0.015
transport GO:0006810 220 0.015
epithelial cell differentiation GO:0030855 116 0.015
protein modification process GO:0036211 100 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.015
organelle organization GO:0006996 227 0.015
alcohol biosynthetic process GO:0046165 2 0.015
endothelial cell fate commitment GO:0060839 3 0.015
defense response to other organism GO:0098542 33 0.015
tissue migration GO:0090130 37 0.015
phosphorylation GO:0016310 69 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
response to growth factor GO:0070848 39 0.015
regulation of cell activation GO:0050865 1 0.015
zymogen activation GO:0031638 3 0.015
regulation of response to stimulus GO:0048583 269 0.015
Mouse Worm
skeletal muscle thin filament assembly GO:0030240 4 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
neuron differentiation GO:0030182 353 0.014
cellular component assembly GO:0022607 170 0.014
immune system process GO:0002376 241 0.014
defense response to bacterium GO:0042742 22 0.014
regulation of protein catabolic process GO:0042176 1 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
cell substrate adhesion GO:0031589 4 0.014
response to corticosteroid GO:0031960 1 0.014
cellular response to nutrient levels GO:0031669 2 0.014
cell recognition GO:0008037 19 0.014
regulation of reactive oxygen species metabolic process GO:2000377 2 0.014
sensory perception of touch GO:0050975 2 0.013
autophagy GO:0006914 4 0.013
amine metabolic process GO:0009308 2 0.013
regulation of cell shape GO:0008360 1 0.013
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.013
Worm
regulation of myotube differentiation GO:0010830 2 0.013
regulation of body fluid levels GO:0050878 16 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
cell chemotaxis GO:0060326 17 0.013
response to other organism GO:0051707 97 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
neuron migration GO:0001764 22 0.013
mesoderm morphogenesis GO:0048332 51 0.013
Worm
keratinocyte differentiation GO:0030216 0 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
regulation of organ growth GO:0046620 3 0.013
negative regulation of cell death GO:0060548 60 0.013
centrosome duplication GO:0051298 1 0.012
oxoacid metabolic process GO:0043436 31 0.012
forebrain development GO:0030900 96 0.012
peptide transport GO:0015833 1 0.012
positive regulation of catabolic process GO:0009896 4 0.012
regulation of cell differentiation GO:0045595 142 0.012
developmental growth GO:0048589 166 0.012
Worm
regulation of metal ion transport GO:0010959 4 0.012
regulation of localization GO:0032879 104 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of endodermal cell fate specification GO:0042663 15 0.012
regulation of programmed cell death GO:0043067 101 0.012
regulation of binding GO:0051098 3 0.012
bone remodeling GO:0046849 2 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
Mouse
urogenital system development GO:0001655 97 0.012
blood vessel endothelial cell migration GO:0043534 18 0.012
positive regulation of immune effector process GO:0002699 3 0.012
lipid storage GO:0019915 1 0.012
female sex differentiation GO:0046660 4 0.012
odontogenesis of dentin containing tooth GO:0042475 1 0.012
negative regulation of catabolic process GO:0009895 3 0.011
gtp catabolic process GO:0006184 2 0.011
protein complex localization GO:0031503 1 0.011
regulation of rna metabolic process GO:0051252 224 0.011
Mouse Worm
production of molecular mediator of immune response GO:0002440 2 0.011
heart contraction GO:0060047 71 0.011
single organism intracellular transport GO:1902582 25 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
cell proliferation involved in heart morphogenesis GO:0061323 2 0.011
neural precursor cell proliferation GO:0061351 20 0.011
positive regulation of striated muscle cell differentiation GO:0051155 1 0.011
protein acylation GO:0043543 3 0.011
cytokine metabolic process GO:0042107 1 0.011
behavior GO:0007610 74 0.011
regulation of cytokine biosynthetic process GO:0042035 1 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
wound healing GO:0042060 90 0.011
positive regulation of cytokine production GO:0001819 2 0.011
mitotic cell cycle GO:0000278 64 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
connective tissue development GO:0061448 99 0.011
primary neural tube formation GO:0014020 1 0.011
retina development in camera type eye GO:0060041 146 0.011
response to glucocorticoid GO:0051384 1 0.011
death GO:0016265 121 0.011
macromolecule modification GO:0043412 111 0.011
embryonic digestive tract development GO:0048566 4 0.011
regulation of cellular component organization GO:0051128 86 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
cytoskeleton organization GO:0007010 96 0.011
cartilage development GO:0051216 96 0.011
inner ear receptor cell differentiation GO:0060113 29 0.011
response to biotic stimulus GO:0009607 97 0.011
sequestering of metal ion GO:0051238 3 0.011
defense response GO:0006952 47 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
regulation of cardiac muscle tissue development GO:0055024 1 0.010
regulation of reproductive process GO:2000241 4 0.010
organic acid metabolic process GO:0006082 31 0.010
compound eye development GO:0048749 2 0.010
neuron development GO:0048666 262 0.010
peripheral nervous system neuron differentiation GO:0048934 28 0.010
positive regulation of response to external stimulus GO:0032103 9 0.010
regulation of synapse organization GO:0050807 3 0.010
membrane invagination GO:0010324 1 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
regulation of circadian rhythm GO:0042752 4 0.010
canonical wnt signaling pathway GO:0060070 48 0.010

hfe2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
nervous system disease DOID:863 0 0.026
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.011
musculoskeletal system disease DOID:17 0 0.011
disease of metabolism DOID:0014667 0 0.010