Danio rerio

70 known processes

hif1ab

hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b

(Aliases: wu:fb63a10,MGC55405,zgc:55405,fb63a10,hif1a)

hif1ab biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cognition GO:0050890 1 0.846
Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.693
Human Mouse Rat
multi organism process GO:0051704 134 0.662
Rat Fly
positive regulation of cellular process GO:0048522 201 0.658
Human Mouse Rat Fly
organic acid metabolic process GO:0006082 31 0.590
Mouse
neuron differentiation GO:0030182 353 0.572
Zebrafish Mouse
regulation of cell death GO:0010941 103 0.557
Human Zebrafish Mouse Rat Worm
regulation of macromolecule metabolic process GO:0060255 317 0.544
regulation of cell communication GO:0010646 232 0.523
Human Mouse
generation of neurons GO:0048699 385 0.518
Zebrafish Mouse
response to hormone GO:0009725 48 0.505
Rat Fly
single organism metabolic process GO:0044710 217 0.494
Mouse
neuron development GO:0048666 262 0.433
Zebrafish
regulation of cellular component organization GO:0051128 86 0.424
Fly
multicellular organismal reproductive process GO:0048609 35 0.424
Rat Fly
cellular response to hormone stimulus GO:0032870 39 0.418
Rat Fly
regulation of immune system process GO:0002682 34 0.418
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.417
response to abiotic stimulus GO:0009628 122 0.415
pyruvate metabolic process GO:0006090 1 0.413
Mouse
regulation of cellular metabolic process GO:0031323 320 0.405
positive regulation of cellular catabolic process GO:0031331 3 0.399
Fly
regulation of gene expression GO:0010468 265 0.392
organelle organization GO:0006996 227 0.389
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.362
Human Mouse Rat Fly
regulation of anatomical structure size GO:0090066 33 0.360
Rat
regulation of multicellular organismal process GO:0051239 277 0.358
Human Mouse Rat
response to biotic stimulus GO:0009607 97 0.355
Rat
negative regulation of cellular process GO:0048523 283 0.349
Human Mouse Rat Worm Fly
signal transduction GO:0007165 455 0.348
Human Mouse
response to chemical GO:0042221 320 0.344
negative regulation of programmed cell death GO:0043069 58 0.339
Human Mouse Rat Worm
regulation of metabolic process GO:0019222 359 0.338
response to stress GO:0006950 263 0.337
cell motility GO:0048870 244 0.332
Mouse Fly
response to oxygen containing compound GO:1901700 55 0.329
regulation of signal transduction GO:0009966 225 0.324
Human Mouse
regulation of neural precursor cell proliferation GO:2000177 3 0.318
Mouse
macromolecule modification GO:0043412 111 0.316
negative regulation of biological process GO:0048519 304 0.312
Human Mouse Rat Worm Fly
establishment of protein localization to organelle GO:0072594 4 0.310
cellular response to nutrient levels GO:0031669 2 0.308
Worm
heterocycle biosynthetic process GO:0018130 215 0.306
morphogenesis of an epithelium GO:0002009 333 0.306
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.303
Human Mouse Rat Fly
organonitrogen compound metabolic process GO:1901564 74 0.298
cellular response to extracellular stimulus GO:0031668 2 0.285
Worm
microtubule based process GO:0007017 60 0.283
Human
developmental growth GO:0048589 166 0.274
positive regulation of cellular metabolic process GO:0031325 94 0.272
Human Mouse Rat Fly
regulation of biological quality GO:0065008 263 0.272
Human Mouse Rat
oxoacid metabolic process GO:0043436 31 0.270
Mouse
phosphorus metabolic process GO:0006793 109 0.260
locomotion GO:0040011 313 0.247
Zebrafish Mouse Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.243
Mouse
regulation of signaling GO:0023051 235 0.239
Human Mouse
transport GO:0006810 220 0.239
Human Mouse
protein import GO:0017038 3 0.234
neuron projection development GO:0031175 180 0.232
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.226
Human Mouse Rat Fly
regulation of cell differentiation GO:0045595 142 0.224
Mouse
protein targeting to nucleus GO:0044744 3 0.222
positive regulation of signal transduction GO:0009967 56 0.221
Mouse
reproductive process GO:0022414 40 0.220
Mouse Rat Fly
regulation of intracellular signal transduction GO:1902531 57 0.218
Human Mouse
response to external stimulus GO:0009605 264 0.213
Zebrafish Rat Worm
single organism organelle organization GO:1902589 199 0.212
anatomical structure homeostasis GO:0060249 36 0.205
Mouse
response to organic substance GO:0010033 153 0.200
response to virus GO:0009615 21 0.198
cellular macromolecule metabolic process GO:0044260 391 0.198
intracellular signal transduction GO:0035556 85 0.196
Human Mouse
cellular response to organic substance GO:0071310 105 0.196
Human Mouse Rat Fly
positive regulation of metabolic process GO:0009893 108 0.195
Human Mouse Rat Fly
negative regulation of growth GO:0045926 10 0.195
Mouse Fly
positive regulation of biological process GO:0048518 253 0.191
Human Mouse Rat Fly
regulation of primary metabolic process GO:0080090 311 0.189
protein secretion GO:0009306 1 0.187
positive regulation of cellular component biogenesis GO:0044089 3 0.186
regulation of molecular function GO:0065009 70 0.186
Mouse
axonogenesis GO:0007409 152 0.174
Zebrafish
ras protein signal transduction GO:0007265 7 0.173
positive regulation of catabolic process GO:0009896 4 0.172
Fly
negative regulation of cell communication GO:0010648 96 0.172
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.172
enzyme linked receptor protein signaling pathway GO:0007167 106 0.168
Mouse
growth GO:0040007 174 0.167
Mouse Fly
cell surface receptor signaling pathway GO:0007166 325 0.167
Mouse
single organism localization GO:1902578 225 0.161
Human Mouse
aromatic compound biosynthetic process GO:0019438 217 0.159
carboxylic acid metabolic process GO:0019752 22 0.158
Mouse
small molecule metabolic process GO:0044281 77 0.157
Mouse
nucleic acid metabolic process GO:0090304 244 0.156
response to organic cyclic compound GO:0014070 51 0.149
Rat
cellular protein metabolic process GO:0044267 129 0.149
regulation of rna biosynthetic process GO:2001141 213 0.148
regulation of epithelial cell proliferation GO:0050678 3 0.145
regulation of multicellular organismal development GO:2000026 223 0.145
Mouse
neuron apoptotic process GO:0051402 20 0.143
stem cell proliferation GO:0072089 4 0.141
Mouse
cellular ketone metabolic process GO:0042180 11 0.140
cellular nitrogen compound metabolic process GO:0034641 290 0.140
erk1 and erk2 cascade GO:0070371 4 0.136
negative regulation of response to stimulus GO:0048585 104 0.135
Human Mouse
epithelial tube morphogenesis GO:0060562 148 0.134
Mouse
regulation of stem cell proliferation GO:0072091 2 0.133
Mouse
nitrogen compound metabolic process GO:0006807 319 0.133
rna metabolic process GO:0016070 219 0.132
cell part morphogenesis GO:0032990 246 0.132
Zebrafish
positive regulation of rna biosynthetic process GO:1902680 57 0.130
Human Mouse Rat Fly
regulation of protein localization to nucleus GO:1900180 2 0.130
organic substance transport GO:0071702 58 0.129
Mouse
positive regulation of gene expression GO:0010628 71 0.127
Human Mouse Rat Fly
nucleobase containing compound metabolic process GO:0006139 274 0.126
extrinsic apoptotic signaling pathway GO:0097191 3 0.125
regulation of cytoplasmic transport GO:1903649 4 0.122
response to nitrogen compound GO:1901698 19 0.122
Rat Fly
regulation of response to stimulus GO:0048583 269 0.121
Human Mouse Rat
hepaticobiliary system development GO:0061008 98 0.120
cellular macromolecule biosynthetic process GO:0034645 224 0.119
carbohydrate metabolic process GO:0005975 12 0.118
Mouse
regulation of developmental process GO:0050793 247 0.117
Mouse
neurological system process GO:0050877 62 0.117
Mouse
regulation of neuron apoptotic process GO:0043523 17 0.116
Human Zebrafish Mouse
regulation of erk1 and erk2 cascade GO:0070372 4 0.114
glial cell proliferation GO:0014009 4 0.113
cell projection morphogenesis GO:0048858 244 0.112
Zebrafish
cellular response to peptide hormone stimulus GO:0071375 5 0.111
Rat Fly
single organism nuclear import GO:1902593 3 0.109
regulation of nucleic acid templated transcription GO:1903506 213 0.109
cell growth GO:0016049 57 0.108
Fly
tissue homeostasis GO:0001894 25 0.108
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.107
positive regulation of cell death GO:0010942 29 0.106
Rat
regulation of phosphate metabolic process GO:0019220 43 0.105
cell proliferation GO:0008283 80 0.104
Mouse Rat
regulation of phosphorus metabolic process GO:0051174 43 0.103
mapk cascade GO:0000165 18 0.103
carbohydrate derivative metabolic process GO:1901135 61 0.101
Mouse
response to endogenous stimulus GO:0009719 83 0.098
Rat Fly
negative regulation of cell growth GO:0030308 7 0.098
Fly
adherens junction organization GO:0034332 4 0.095
regulation of cell projection organization GO:0031344 44 0.095
response to oxidative stress GO:0006979 11 0.093
Human Mouse Rat
aging GO:0007568 2 0.091
Worm
hypothalamus cell differentiation GO:0021979 4 0.091
Zebrafish
locomotor rhythm GO:0045475 3 0.091
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.090
Rat
retina development in camera type eye GO:0060041 146 0.089
Mouse
protein kinase b signaling GO:0043491 9 0.088
canonical wnt signaling pathway GO:0060070 48 0.086
axon development GO:0061564 166 0.086
Zebrafish
signal transduction by phosphorylation GO:0023014 18 0.085
regulation of mapk cascade GO:0043408 14 0.085
nucleic acid templated transcription GO:0097659 181 0.084
regulation of phosphorylation GO:0042325 26 0.083
cellular protein modification process GO:0006464 100 0.083
mitotic cell cycle GO:0000278 64 0.082
protein import into nucleus GO:0006606 3 0.082
establishment of localization GO:0051234 244 0.082
Human Mouse
gland development GO:0048732 143 0.082
Mouse
neuron death GO:0070997 21 0.081
embryonic organ morphogenesis GO:0048562 274 0.080
Mouse
negative regulation of neural precursor cell proliferation GO:2000178 1 0.079
positive regulation of cell matrix adhesion GO:0001954 1 0.079
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.078
Human Mouse Rat Fly
regulation of cell growth GO:0001558 29 0.078
Fly
cellular component biogenesis GO:0044085 178 0.078
response to external biotic stimulus GO:0043207 97 0.077
Rat
regulation of cellular amino acid metabolic process GO:0006521 0 0.077
regulation of dna templated transcription in response to stress GO:0043620 0 0.076
Human Mouse Rat
negative regulation of signal transduction GO:0009968 94 0.076
Human Mouse
regulation of neuron projection development GO:0010975 40 0.076
cellular amino acid metabolic process GO:0006520 7 0.075
regulation of purine nucleotide catabolic process GO:0033121 2 0.075
behavior GO:0007610 74 0.075
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.074
Mouse
tube morphogenesis GO:0035239 349 0.074
Mouse
cellular response to endogenous stimulus GO:0071495 68 0.073
Rat Fly
biosynthetic process GO:0009058 294 0.073
regulation of apoptotic process GO:0042981 98 0.071
Human Zebrafish Mouse Rat Worm
urogenital system development GO:0001655 97 0.071
cell morphogenesis GO:0000902 289 0.070
Zebrafish Mouse
nuclear import GO:0051170 3 0.070
gene expression GO:0010467 252 0.070
regulation of protein targeting GO:1903533 2 0.070
positive regulation of protein kinase b signaling GO:0051897 1 0.070
taxis GO:0042330 109 0.069
Zebrafish
cellular amine metabolic process GO:0044106 2 0.069
multicellular organism reproduction GO:0032504 35 0.069
Rat Fly
response to temperature stimulus GO:0009266 15 0.068
Worm
guanosine containing compound catabolic process GO:1901069 2 0.068
response to corticosteroid GO:0031960 1 0.068
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.068
cell morphogenesis involved in differentiation GO:0000904 195 0.068
Zebrafish Mouse
regulation of oligodendrocyte differentiation GO:0048713 1 0.067
kidney development GO:0001822 92 0.067
cellular component assembly GO:0022607 170 0.066
regulation of intracellular protein transport GO:0033157 3 0.066
cell substrate adhesion GO:0031589 4 0.064
negative regulation of multicellular organismal process GO:0051241 69 0.064
Mouse Rat
response to oxygen levels GO:0070482 25 0.064
regulation of cell size GO:0008361 29 0.063
Rat
regulation of cellular biosynthetic process GO:0031326 245 0.063
protein metabolic process GO:0019538 183 0.062
Mouse
notch signaling pathway GO:0007219 35 0.062
cellular response to external stimulus GO:0071496 2 0.061
Rat Worm
regulation of hydrolase activity GO:0051336 28 0.061
blood vessel morphogenesis GO:0048514 216 0.060
Mouse
regulation of protein complex assembly GO:0043254 3 0.060
cellular response to chemical stimulus GO:0070887 157 0.060
Human Mouse Rat Fly
positive regulation of cell communication GO:0010647 56 0.060
Mouse
reproduction GO:0000003 40 0.060
Rat Fly
negative regulation of signaling GO:0023057 96 0.059
Human Mouse
negative regulation of cell differentiation GO:0045596 46 0.059
neuron projection morphogenesis GO:0048812 161 0.059
Zebrafish
transition metal ion homeostasis GO:0055076 5 0.057
Mouse
establishment or maintenance of cell polarity GO:0007163 29 0.057
macrophage chemotaxis GO:0048246 3 0.057
regulation of multicellular organism growth GO:0040014 4 0.057
cardiac cell fate commitment GO:0060911 1 0.057
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.057
multi organism reproductive process GO:0044703 36 0.057
Rat Fly
macromolecule biosynthetic process GO:0009059 227 0.056
cell cycle process GO:0022402 53 0.056
cell cycle GO:0007049 93 0.056
Fly
negative regulation of secretion GO:0051048 2 0.056
protein modification process GO:0036211 100 0.056
phosphate containing compound metabolic process GO:0006796 108 0.055
wnt signaling pathway GO:0016055 80 0.055
heterocycle metabolic process GO:0046483 290 0.055
regulation of protein kinase b signaling GO:0051896 8 0.054
positive regulation of protein complex assembly GO:0031334 2 0.054
single organism transport GO:0044765 206 0.054
Human Mouse
larval development GO:0002164 2 0.054
amine metabolic process GO:0009308 2 0.054
regulation of cell development GO:0060284 100 0.053
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.052
Human Mouse Rat Fly
apoptotic process GO:0006915 116 0.052
organic substance biosynthetic process GO:1901576 289 0.052
convergent extension GO:0060026 118 0.052
mesenchyme development GO:0060485 127 0.051
Mouse
renal system development GO:0072001 94 0.051
vesicle mediated transport GO:0016192 22 0.051
maintenance of location GO:0051235 4 0.051
regulation of rac protein signal transduction GO:0035020 1 0.050
protein localization GO:0008104 40 0.050
spindle assembly involved in meiosis GO:0090306 1 0.050
cellular aromatic compound metabolic process GO:0006725 295 0.050
cellular response to organonitrogen compound GO:0071417 5 0.050
Rat Fly
regulation of neuron differentiation GO:0045664 56 0.049
axon guidance GO:0007411 86 0.049
Zebrafish
cell migration GO:0016477 237 0.049
Mouse Fly
regulation of nucleocytoplasmic transport GO:0046822 2 0.049
protein localization to nucleus GO:0034504 3 0.049
positive regulation of signaling GO:0023056 56 0.048
Mouse
regulation of cellular protein metabolic process GO:0032268 52 0.048
response to steroid hormone GO:0048545 35 0.048
Rat
cellular response to nitrogen compound GO:1901699 6 0.048
Rat Fly
liver development GO:0001889 96 0.047
peptidyl serine modification GO:0018209 2 0.047
regulation of cellular amine metabolic process GO:0033238 0 0.047
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.047
regulation of protein transport GO:0051223 3 0.046
metal ion homeostasis GO:0055065 26 0.046
Mouse
system process GO:0003008 185 0.046
Mouse Rat
negative regulation of protein kinase activity GO:0006469 4 0.046
microtubule organizing center organization GO:0031023 1 0.046
positive regulation of epithelial cell proliferation GO:0050679 1 0.045
regulation of purine nucleotide metabolic process GO:1900542 17 0.045
response to inorganic substance GO:0010035 38 0.045
Rat
odontogenesis of dentin containing tooth GO:0042475 1 0.045
chemical homeostasis GO:0048878 49 0.045
Human Mouse Rat
negative regulation of macromolecule metabolic process GO:0010605 76 0.044
Rat
segmentation GO:0035282 97 0.044
regulation of cellular ketone metabolic process GO:0010565 7 0.044
negative regulation of cell death GO:0060548 60 0.044
Human Mouse Rat Worm
regulation of gtpase activity GO:0043087 2 0.044
oxidation reduction process GO:0055114 41 0.043
neurotransmitter secretion GO:0007269 2 0.042
membrane organization GO:0061024 21 0.042
iron ion homeostasis GO:0055072 4 0.042
Mouse
regulation of catalytic activity GO:0050790 55 0.042
Mouse
regulation of nucleoside metabolic process GO:0009118 2 0.042
actin filament based process GO:0030029 64 0.041
modification dependent protein catabolic process GO:0019941 3 0.041
amino acid transport GO:0006865 2 0.041
positive regulation of nucleic acid templated transcription GO:1903508 57 0.041
Human Mouse Rat Fly
regulation of protein import into nucleus GO:0042306 2 0.041
homeostatic process GO:0042592 142 0.041
Human Mouse Rat
cellular biosynthetic process GO:0044249 286 0.041
osteoclast differentiation GO:0030316 1 0.041
small gtpase mediated signal transduction GO:0007264 8 0.041
mesenchymal cell development GO:0014031 78 0.040
Mouse
sexual reproduction GO:0019953 36 0.040
Fly
negative regulation of apoptotic signaling pathway GO:2001234 10 0.040
Human
cytoskeleton organization GO:0007010 96 0.040
oocyte development GO:0048599 14 0.039
detection of temperature stimulus GO:0016048 0 0.039
nucleocytoplasmic transport GO:0006913 4 0.039
brain development GO:0007420 293 0.039
Zebrafish Mouse
regulation of cellular component size GO:0032535 30 0.038
Rat
morphogenesis of a branching structure GO:0001763 21 0.038
phagocytosis GO:0006909 3 0.038
peptidyl serine phosphorylation GO:0018105 1 0.038
regulation of photoreceptor cell differentiation GO:0046532 2 0.037
response to extracellular stimulus GO:0009991 10 0.037
Worm
vasculogenesis GO:0001570 41 0.037
cellular localization GO:0051641 97 0.037
Human Mouse
positive regulation of molecular function GO:0044093 33 0.037
autophagy GO:0006914 4 0.036
Fly
tissue remodeling GO:0048771 4 0.036
Mouse
regulation of synaptic plasticity GO:0048167 1 0.036
regulation of autophagy GO:0010506 3 0.036
Fly
regulation of rna metabolic process GO:0051252 224 0.036
muscle structure development GO:0061061 196 0.035
regulation of gtp catabolic process GO:0033124 2 0.035
regulation of dendrite development GO:0050773 3 0.035
single organism reproductive process GO:0044702 40 0.034
Mouse Rat Fly
positive regulation of stress activated mapk cascade GO:0032874 3 0.034
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.034
Zebrafish
regulation of nucleotide catabolic process GO:0030811 2 0.034
ubiquitin dependent protein catabolic process GO:0006511 3 0.034
neuron neuron synaptic transmission GO:0007270 1 0.034
cellular catabolic process GO:0044248 27 0.034
Mouse Fly
establishment of synaptic vesicle localization GO:0097480 1 0.034
hormone metabolic process GO:0042445 19 0.033
Human
interspecies interaction between organisms GO:0044419 4 0.033
monocarboxylic acid metabolic process GO:0032787 17 0.033
Mouse
skeletal muscle organ development GO:0060538 78 0.033
establishment of localization in cell GO:0051649 77 0.033
Human Mouse
phosphorylation GO:0016310 69 0.033
negative regulation of cellular metabolic process GO:0031324 77 0.033
Rat
response to nutrient GO:0007584 3 0.033
vasculature development GO:0001944 278 0.032
Mouse
embryonic organ development GO:0048568 381 0.032
Mouse
nephron tubule morphogenesis GO:0072078 1 0.032
regulation of growth GO:0040008 42 0.032
Mouse Fly
regulation of nervous system development GO:0051960 90 0.032
Mouse
multicellular organismal homeostasis GO:0048871 29 0.032
regulation of neurogenesis GO:0050767 87 0.032
Mouse
cell cell signaling GO:0007267 52 0.031
Mouse
response to decreased oxygen levels GO:0036293 25 0.031
chordate embryonic development GO:0043009 271 0.031
Mouse
blood vessel development GO:0001568 246 0.031
Mouse
positive regulation of multicellular organismal process GO:0051240 52 0.031
Human Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.031
negative regulation of kinase activity GO:0033673 4 0.030
lipid storage GO:0019915 1 0.030
muscle tissue development GO:0060537 110 0.030
pigmentation GO:0043473 85 0.030
compound eye development GO:0048749 2 0.030
eye development GO:0001654 277 0.030
Mouse
positive regulation of notch signaling pathway GO:0045747 3 0.030
rna biosynthetic process GO:0032774 181 0.030
regulation of cellular component biogenesis GO:0044087 12 0.029
protein acetylation GO:0006473 2 0.029
positive regulation of phosphate metabolic process GO:0045937 21 0.029
cellular response to oxygen levels GO:0071453 1 0.029
Human Mouse Rat Fly
regulation of cell motility GO:2000145 46 0.029
Mouse Fly
cell type specific apoptotic process GO:0097285 22 0.029
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
myotube differentiation GO:0014902 45 0.028
cellular response to stress GO:0033554 62 0.028
Human Mouse Rat Worm Fly
regulation of reproductive process GO:2000241 4 0.028
response to acid chemical GO:0001101 17 0.028
Rat
cell matrix adhesion GO:0007160 4 0.028
regulation of rho protein signal transduction GO:0035023 2 0.028
protein phosphorylation GO:0006468 47 0.028
mitochondrion organization GO:0007005 4 0.028
modulation by virus of host morphology or physiology GO:0019048 1 0.028
dicarboxylic acid transport GO:0006835 1 0.028
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.027
regulation of protein catabolic process GO:0042176 1 0.027
macromolecular complex assembly GO:0065003 35 0.027
positive regulation of nucleoside metabolic process GO:0045979 1 0.027
dna catabolic process GO:0006308 1 0.027
neuron migration GO:0001764 22 0.027
lateral line system development GO:0048925 76 0.027
protein complex localization GO:0031503 1 0.027
exocrine system development GO:0035272 28 0.027
muscle cell differentiation GO:0042692 139 0.027
multicellular organism growth GO:0035264 4 0.027
localization of cell GO:0051674 244 0.027
Mouse Fly
regulation of protein metabolic process GO:0051246 56 0.027
organic cyclic compound biosynthetic process GO:1901362 223 0.027
neural crest cell development GO:0014032 62 0.027
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.026
mitotic cell cycle process GO:1903047 48 0.026
apoptotic signaling pathway GO:0097190 23 0.026
Human
negative regulation of apoptotic process GO:0043066 55 0.026
Human Mouse Rat Worm
response to light stimulus GO:0009416 46 0.026
Mouse Rat
developmental process involved in reproduction GO:0003006 27 0.026
Mouse Fly
cellular response to organic cyclic compound GO:0071407 38 0.026
Rat
head development GO:0060322 303 0.026
Zebrafish Mouse
peripheral nervous system development GO:0007422 55 0.025
regulation of cell migration GO:0030334 40 0.025
Mouse Fly
lymph vessel development GO:0001945 27 0.025
regulation of glial cell proliferation GO:0060251 4 0.025
muscle organ development GO:0007517 101 0.025
regulation of tube size GO:0035150 2 0.025
Rat
synaptic target recognition GO:0008039 1 0.025
regulation of hormone levels GO:0010817 21 0.025
Human Mouse
protein complex biogenesis GO:0070271 30 0.024
epithelial cell differentiation GO:0030855 116 0.024
Mouse
positive regulation of programmed cell death GO:0043068 29 0.024
Rat
posterior lateral line neuromast development GO:0048919 20 0.024
lipid metabolic process GO:0006629 52 0.023
regulation of cell proliferation GO:0042127 37 0.023
Mouse Rat
hematopoietic or lymphoid organ development GO:0048534 191 0.023
Mouse
negative regulation of response to cytokine stimulus GO:0060761 2 0.023
membrane invagination GO:0010324 1 0.023
skeletal muscle tissue development GO:0007519 67 0.023
regulation of protein phosphorylation GO:0001932 18 0.023
cell aging GO:0007569 2 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
macromolecule localization GO:0033036 54 0.022
striated muscle tissue development GO:0014706 110 0.022
phagocytosis engulfment GO:0006911 1 0.022
regulation of protein modification process GO:0031399 29 0.022
energy reserve metabolic process GO:0006112 2 0.022
somitogenesis GO:0001756 87 0.022
negative regulation of protein transport GO:0051224 3 0.022
regulation of cell substrate adhesion GO:0010810 1 0.022
single organism biosynthetic process GO:0044711 71 0.022
immune system development GO:0002520 191 0.022
Mouse
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.022
positive regulation of cell substrate adhesion GO:0010811 1 0.021
regulation of ras gtpase activity GO:0032318 2 0.021
synaptic vesicle transport GO:0048489 1 0.021
organic substance catabolic process GO:1901575 28 0.021
Mouse
negative regulation of protein phosphorylation GO:0001933 4 0.021
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.021
positive regulation of biosynthetic process GO:0009891 68 0.021
Human Mouse Rat Fly
regionalization GO:0003002 274 0.021
regulation of localization GO:0032879 104 0.021
Mouse Fly
death GO:0016265 121 0.020
developmental cell growth GO:0048588 52 0.020
transcription dna templated GO:0006351 181 0.020
response to growth factor GO:0070848 39 0.020
Mouse
negative regulation of secretion by cell GO:1903531 2 0.020
cell recognition GO:0008037 19 0.020
skeletal system morphogenesis GO:0048705 102 0.020
neuron recognition GO:0008038 18 0.020
neural crest cell migration GO:0001755 42 0.020
Mouse
negative regulation of neurogenesis GO:0050768 20 0.020
single organism behavior GO:0044708 24 0.020
Mouse
central nervous system development GO:0007417 387 0.020
Zebrafish Mouse
negative regulation of gene expression GO:0010629 65 0.020
Rat
tor signaling GO:0031929 7 0.019
Mouse
developmental growth involved in morphogenesis GO:0060560 86 0.019
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.019
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.019
ovarian follicle development GO:0001541 2 0.019
cell projection organization GO:0030030 284 0.019
Zebrafish
response to other organism GO:0051707 97 0.019
Rat
regulation of establishment of protein localization GO:0070201 4 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.019
Rat
negative regulation of protein import into nucleus GO:0042308 2 0.018
cytokinesis GO:0000910 3 0.018
cellular hormone metabolic process GO:0034754 19 0.018
response to drug GO:0042493 3 0.018
Rat
response to bacterium GO:0009617 58 0.018
Rat
regulation of protein binding GO:0043393 3 0.018
synaptic vesicle localization GO:0097479 1 0.018
positive regulation of developmental process GO:0051094 50 0.018
Mouse
single organism carbohydrate metabolic process GO:0044723 12 0.018
Mouse
signal transduction in absence of ligand GO:0038034 1 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
lateral line development GO:0048882 66 0.017
response to lipid GO:0033993 60 0.017
Rat
peptidyl amino acid modification GO:0018193 16 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
positive regulation of histone modification GO:0031058 1 0.017
positive regulation of cellular protein metabolic process GO:0032270 22 0.017
regulation of organelle organization GO:0033043 29 0.017
cellular response to dna damage stimulus GO:0006974 24 0.017
Fly
organelle localization GO:0051640 49 0.017
negative regulation of developmental process GO:0051093 65 0.017
Mouse
stem cell fate commitment GO:0048865 1 0.017
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.017
negative regulation of protein complex assembly GO:0031333 1 0.017
positive regulation of nervous system development GO:0051962 25 0.017
Mouse
cell fate commitment GO:0045165 99 0.017
positive regulation of glial cell proliferation GO:0060252 1 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017

hif1ab disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.085
disease of cellular proliferation DOID:14566 0 0.085
organ system cancer DOID:0050686 0 0.085
central nervous system disease DOID:331 0 0.072
disease of anatomical entity DOID:7 0 0.072
tauopathy DOID:680 0 0.072
neurodegenerative disease DOID:1289 0 0.072
nervous system disease DOID:863 0 0.072
cardiovascular system disease DOID:1287 0 0.019
dementia DOID:1307 0 0.018
disease of mental health DOID:150 0 0.018
cognitive disorder DOID:1561 0 0.018