Danio rerio

0 known processes

hint2

histidine triad nucleotide binding protein 2

(Aliases: MGC163082,si:dkey-87i10.2,zgc:163082)

hint2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
inner ear development GO:0048839 126 0.287
transmembrane transport GO:0055085 120 0.235
ear development GO:0043583 127 0.218
sensory organ development GO:0007423 393 0.166
response to external stimulus GO:0009605 264 0.164
semicircular canal development GO:0060872 24 0.125
cytosolic calcium ion transport GO:0060401 3 0.083
regulation of cell projection assembly GO:0060491 4 0.079
larval development GO:0002164 2 0.076
organelle organization GO:0006996 227 0.074
vasculature development GO:0001944 278 0.072
mitochondrion organization GO:0007005 4 0.071
positive regulation of transport GO:0051050 2 0.068
positive regulation of secretion GO:0051047 1 0.067
actin polymerization or depolymerization GO:0008154 2 0.064
regulation of reactive oxygen species metabolic process GO:2000377 2 0.064
positive regulation of biological process GO:0048518 253 0.063
regulation of synaptic plasticity GO:0048167 1 0.061
aging GO:0007568 2 0.058
angiogenesis GO:0001525 158 0.056
regulation of guanylate cyclase activity GO:0031282 6 0.055
central nervous system development GO:0007417 387 0.055
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.055
cellular response to toxic substance GO:0097237 1 0.052
hydrogen peroxide metabolic process GO:0042743 2 0.050
positive regulation of protein polymerization GO:0032273 2 0.050
cell projection organization GO:0030030 284 0.049
maintenance of location GO:0051235 4 0.048
biosynthetic process GO:0009058 294 0.047
multicellular organism growth GO:0035264 4 0.047
amine metabolic process GO:0009308 2 0.047
positive regulation of cgmp biosynthetic process GO:0030828 6 0.046
establishment of localization GO:0051234 244 0.046
regulation of protein ubiquitination GO:0031396 3 0.043
somite development GO:0061053 96 0.043
cellular transition metal ion homeostasis GO:0046916 3 0.043
regulation of multicellular organism growth GO:0040014 4 0.043
taste bud formation GO:0061195 3 0.042
single organism transport GO:0044765 206 0.041
g protein coupled receptor signaling pathway GO:0007186 74 0.041
cognition GO:0050890 1 0.040
sensory organ morphogenesis GO:0090596 200 0.039
regulation of reproductive process GO:2000241 4 0.039
single organism localization GO:1902578 225 0.039
skeletal muscle organ development GO:0060538 78 0.039
embryonic organ development GO:0048568 381 0.039
phototransduction visible light GO:0007603 2 0.039
negative regulation of kinase activity GO:0033673 4 0.039
negative regulation of biological process GO:0048519 304 0.038
head development GO:0060322 303 0.038
regulation of cellular amino acid metabolic process GO:0006521 0 0.037
positive regulation of muscle tissue development GO:1901863 1 0.037
developmental programmed cell death GO:0010623 4 0.036
regulation of response to oxidative stress GO:1902882 2 0.036
regulation of cgmp biosynthetic process GO:0030826 6 0.035
cellular amino acid metabolic process GO:0006520 7 0.035
oocyte maturation GO:0001556 4 0.034
regulation of cellular amine metabolic process GO:0033238 0 0.034
cellular response to light stimulus GO:0071482 4 0.034
heart morphogenesis GO:0003007 156 0.033
positive regulation of striated muscle tissue development GO:0045844 1 0.032
heart development GO:0007507 313 0.032
positive regulation of blood circulation GO:1903524 2 0.032
organic acid metabolic process GO:0006082 31 0.032
cellular ketone metabolic process GO:0042180 11 0.032
embryonic heart tube morphogenesis GO:0003143 108 0.032
rhodopsin mediated signaling pathway GO:0016056 1 0.032
positive regulation of muscle organ development GO:0048636 1 0.032
tube morphogenesis GO:0035239 349 0.031
cellular component movement GO:0006928 335 0.031
single organism metabolic process GO:0044710 217 0.030
regulation of protein complex assembly GO:0043254 3 0.030
cellular macromolecule metabolic process GO:0044260 391 0.030
actin filament polymerization GO:0030041 2 0.030
intramembranous ossification GO:0001957 3 0.030
cellular localization GO:0051641 97 0.030
carboxylic acid metabolic process GO:0019752 22 0.030
positive regulation of cellular amine metabolic process GO:0033240 0 0.030
locomotion GO:0040011 313 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
regulation of muscle contraction GO:0006937 3 0.029
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
phototransduction GO:0007602 2 0.029
monoamine transport GO:0015844 1 0.029
signal transduction GO:0007165 455 0.028
system process GO:0003008 185 0.028
regulation of metal ion transport GO:0010959 4 0.027
chordate embryonic development GO:0043009 271 0.027
protein polymerization GO:0051258 4 0.027
cellular protein catabolic process GO:0044257 4 0.027
striated muscle cell differentiation GO:0051146 129 0.027
cellular response to decreased oxygen levels GO:0036294 1 0.027
cellular component biogenesis GO:0044085 178 0.027
transport GO:0006810 220 0.027
cellular response to radiation GO:0071478 4 0.027
blood vessel morphogenesis GO:0048514 216 0.026
cellular component morphogenesis GO:0032989 336 0.026
single organism organelle organization GO:1902589 199 0.026
blood vessel development GO:0001568 246 0.026
regulation of protein polymerization GO:0032271 2 0.026
adult behavior GO:0030534 2 0.026
determination of bilateral symmetry GO:0009855 204 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
locus ceruleus development GO:0021703 3 0.025
erk1 and erk2 cascade GO:0070371 4 0.025
organic substance biosynthetic process GO:1901576 289 0.025
heart process GO:0003015 71 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.024
regulation of filopodium assembly GO:0051489 2 0.024
long chain fatty acid transport GO:0015909 1 0.024
ion transport GO:0006811 114 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.024
positive regulation of cellular process GO:0048522 201 0.024
direct ossification GO:0036072 3 0.024
regulation of sodium ion transport GO:0002028 2 0.023
cell death in response to oxidative stress GO:0036473 2 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
regulation of blood pressure GO:0008217 1 0.023
regulation of localization GO:0032879 104 0.022
sequestering of metal ion GO:0051238 3 0.022
regulation of cellular response to oxidative stress GO:1900407 2 0.022
cgmp metabolic process GO:0046068 7 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
heart contraction GO:0060047 71 0.022
hindbrain formation GO:0021576 3 0.022
cation transmembrane transport GO:0098655 65 0.022
autophagy GO:0006914 4 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
small molecule metabolic process GO:0044281 77 0.021
macromolecular complex subunit organization GO:0043933 74 0.021
regulation of blood vessel size GO:0050880 2 0.021
brain development GO:0007420 293 0.021
response to drug GO:0042493 3 0.021
positive regulation of secretion by cell GO:1903532 1 0.021
establishment of localization in cell GO:0051649 77 0.021
limb bud formation GO:0060174 2 0.021
calcium ion transmembrane transport GO:0070588 13 0.021
inner ear morphogenesis GO:0042472 63 0.021
circulatory system process GO:0003013 87 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
regulation of receptor mediated endocytosis GO:0048259 4 0.020
regulation of signaling GO:0023051 235 0.020
cellular response to external stimulus GO:0071496 2 0.020
regulation of gene expression GO:0010468 265 0.020
establishment of synaptic vesicle localization GO:0097480 1 0.020
protein complex biogenesis GO:0070271 30 0.020
intracellular signal transduction GO:0035556 85 0.019
specification of symmetry GO:0009799 204 0.019
determination of left right symmetry GO:0007368 179 0.019
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.019
neurotransmitter transport GO:0006836 2 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
negative regulation of developmental process GO:0051093 65 0.019
cellular respiration GO:0045333 3 0.019
neuron neuron synaptic transmission GO:0007270 1 0.018
heart looping GO:0001947 94 0.018
regulation of transporter activity GO:0032409 2 0.018
regulation of ion transmembrane transporter activity GO:0032412 2 0.018
positive regulation of protein complex assembly GO:0031334 2 0.018
oxidation reduction process GO:0055114 41 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
smooth muscle contraction GO:0006939 2 0.018
porphyrin containing compound metabolic process GO:0006778 10 0.017
actin filament based movement GO:0030048 1 0.017
stem cell maintenance GO:0019827 4 0.017
cardiac muscle cell differentiation GO:0055007 30 0.017
regulation of hydrogen peroxide metabolic process GO:0010310 1 0.017
negative regulation of cellular process GO:0048523 283 0.017
regulation of oxidative stress induced cell death GO:1903201 2 0.017
cellular component disassembly GO:0022411 1 0.017
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.017
protein heterooligomerization GO:0051291 1 0.017
regulation of neurotransmitter secretion GO:0046928 1 0.016
rhombomere 6 development GO:0021572 4 0.016
synaptic vesicle transport GO:0048489 1 0.016
response to vitamin GO:0033273 3 0.016
regulation of skeletal muscle tissue development GO:0048641 4 0.016
regulation of calcium ion transport GO:0051924 2 0.016
cell morphogenesis GO:0000902 289 0.016
regulation of receptor internalization GO:0002090 2 0.016
anterior posterior pattern specification GO:0009952 152 0.016
skeletal muscle tissue development GO:0007519 67 0.016
negative regulation of map kinase activity GO:0043407 2 0.016
regulation of fatty acid metabolic process GO:0019217 1 0.016
organelle fusion GO:0048284 3 0.016
negative regulation of mapk cascade GO:0043409 4 0.016
negative regulation of epithelial cell proliferation GO:0050680 1 0.016
lipid homeostasis GO:0055088 3 0.016
generation of neurons GO:0048699 385 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
semicircular canal formation GO:0060876 4 0.016
microtubule depolymerization GO:0007019 1 0.016
peptidyl serine phosphorylation GO:0018105 1 0.015
inorganic cation transmembrane transport GO:0098662 50 0.015
tissue remodeling GO:0048771 4 0.015
regulation of biological quality GO:0065008 263 0.015
specification of axis polarity GO:0065001 4 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
response to carbohydrate GO:0009743 3 0.015
regulation of endothelial cell proliferation GO:0001936 1 0.015
sensory perception GO:0007600 39 0.015
regulation of cell communication GO:0010646 232 0.015
muscle contraction GO:0006936 18 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
response to monosaccharide GO:0034284 3 0.015
regulation of binding GO:0051098 3 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
meiotic chromosome segregation GO:0045132 3 0.015
positive regulation of skeletal muscle tissue development GO:0048643 1 0.015
astrocyte differentiation GO:0048708 1 0.015
positive regulation of exocytosis GO:0045921 1 0.015
neurotransmitter secretion GO:0007269 2 0.015
small molecule catabolic process GO:0044282 3 0.015
kupffer s vesicle development GO:0070121 50 0.014
regulation of release of sequestered calcium ion into cytosol GO:0051279 1 0.014
spermatid development GO:0007286 2 0.014
regulation of tube size GO:0035150 2 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
cellular component assembly GO:0022607 170 0.014
protein import GO:0017038 3 0.014
organic cyclic compound metabolic process GO:1901360 301 0.014
olfactory lobe development GO:0021988 4 0.014
renal system process GO:0003014 14 0.014
meiotic cell cycle process GO:1903046 3 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
protein metabolic process GO:0019538 183 0.014
regulation of metabolic process GO:0019222 359 0.014
mitotic dna integrity checkpoint GO:0044774 4 0.014
positive regulation of cell cycle GO:0045787 3 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
growth GO:0040007 174 0.014
spermatid differentiation GO:0048515 2 0.014
receptor internalization GO:0031623 2 0.014
multi organism process GO:0051704 134 0.014
regulation of nucleotide biosynthetic process GO:0030808 15 0.013
response to food GO:0032094 1 0.013
regulation of bone remodeling GO:0046850 2 0.013
homeostasis of number of cells within a tissue GO:0048873 4 0.013
cellular amine metabolic process GO:0044106 2 0.013
meiotic nuclear division GO:0007126 4 0.013
compound eye development GO:0048749 2 0.013
regulation of neurotransmitter transport GO:0051588 1 0.013
regulation of developmental process GO:0050793 247 0.013
reactive oxygen species metabolic process GO:0072593 6 0.013
regulation of organelle assembly GO:1902115 4 0.013
mitochondrial transport GO:0006839 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
response to nutrient GO:0007584 3 0.013
reproduction GO:0000003 40 0.013
positive regulation of heart contraction GO:0045823 2 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
cell projection morphogenesis GO:0048858 244 0.013
membrane hyperpolarization GO:0060081 1 0.013
light induced release of internally sequestered calcium ion GO:0008377 1 0.013
response to abiotic stimulus GO:0009628 122 0.013
insulin like growth factor receptor signaling pathway GO:0048009 4 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
response to hexose GO:0009746 3 0.013
response to antibiotic GO:0046677 1 0.013
modification dependent protein catabolic process GO:0019941 3 0.013
regulation of protein transport GO:0051223 3 0.013
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.013
heterocycle metabolic process GO:0046483 290 0.013
regulation of cyclase activity GO:0031279 12 0.012
response to glucose GO:0009749 3 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
tetrapyrrole metabolic process GO:0033013 10 0.012
ion transmembrane transport GO:0034220 91 0.012
inner ear receptor cell differentiation GO:0060113 29 0.012
cellular biosynthetic process GO:0044249 286 0.012
synaptic vesicle localization GO:0097479 1 0.012
macromolecule modification GO:0043412 111 0.012
ear morphogenesis GO:0042471 64 0.012
negative regulation of blood circulation GO:1903523 2 0.012
photoreceptor cell fate specification GO:0043704 1 0.012
organonitrogen compound biosynthetic process GO:1901566 47 0.012
response to stress GO:0006950 263 0.012
cellular nitrogen compound metabolic process GO:0034641 290 0.012
cell aging GO:0007569 2 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
neurological system process GO:0050877 62 0.012
cgmp biosynthetic process GO:0006182 7 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
embryonic skeletal joint development GO:0072498 3 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
developmental growth GO:0048589 166 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
mesenchyme development GO:0060485 127 0.012
striated muscle cell development GO:0055002 108 0.012
lipid catabolic process GO:0016042 4 0.012
negative regulation of catabolic process GO:0009895 3 0.012
organelle localization GO:0051640 49 0.012
cell projection assembly GO:0030031 64 0.011
neuron differentiation GO:0030182 353 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
chemosensory behavior GO:0007635 1 0.011
cell proliferation GO:0008283 80 0.011
death GO:0016265 121 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
neuron projection development GO:0031175 180 0.011
muscle structure development GO:0061061 196 0.011
protein stabilization GO:0050821 2 0.011
carbon dioxide transport GO:0015670 3 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
sequestering of calcium ion GO:0051208 3 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
localization of cell GO:0051674 244 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
striated muscle tissue development GO:0014706 110 0.011
protein complex disassembly GO:0043241 1 0.011
single organism membrane fusion GO:0044801 2 0.011
chromosome organization involved in meiosis GO:0070192 1 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.011
regulation of lyase activity GO:0051339 12 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
cyclic nucleotide biosynthetic process GO:0009190 18 0.011
respiratory electron transport chain GO:0022904 2 0.011
cellular aldehyde metabolic process GO:0006081 4 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
nuclear transport GO:0051169 4 0.011
ventricular cardiac muscle tissue development GO:0003229 3 0.011
cell part morphogenesis GO:0032990 246 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
actin filament based process GO:0030029 64 0.010
regulation of gastrulation GO:0010470 24 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
regulation of mitochondrion organization GO:0010821 1 0.010
regulation of blood circulation GO:1903522 32 0.010
regulation of carbohydrate biosynthetic process GO:0043255 1 0.010
single organism nuclear import GO:1902593 3 0.010
locomotor rhythm GO:0045475 3 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
fat soluble vitamin metabolic process GO:0006775 4 0.010
release of sequestered calcium ion into cytosol GO:0051209 3 0.010
muscle cell differentiation GO:0042692 139 0.010
morphogenesis of an epithelium GO:0002009 333 0.010
blood circulation GO:0008015 87 0.010
detection of external stimulus GO:0009581 24 0.010
negative regulation of signaling GO:0023057 96 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
cell cell signaling GO:0007267 52 0.010
cellular response to hypoxia GO:0071456 1 0.010
sleep GO:0030431 1 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
regulation of tissue remodeling GO:0034103 2 0.010
development of primary female sexual characteristics GO:0046545 4 0.010

hint2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.094
neurodegenerative disease DOID:1289 0 0.094
parkinson s disease DOID:14330 0 0.094
disease of anatomical entity DOID:7 0 0.094
central nervous system disease DOID:331 0 0.094
synucleinopathy DOID:0050890 0 0.094
disease of metabolism DOID:0014667 0 0.051
inherited metabolic disorder DOID:655 0 0.051
muscle tissue disease DOID:66 0 0.013
muscular disease DOID:0080000 0 0.013
myopathy DOID:423 0 0.013
musculoskeletal system disease DOID:17 0 0.013