Danio rerio

0 known processes

hps1

Hermansky-Pudlak syndrome 1

(Aliases: MGC123240,im:7143944,zgc:123240)

hps1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to stress GO:0006950 263 0.075
Mouse
cellular biosynthetic process GO:0044249 286 0.071
response to external stimulus GO:0009605 264 0.071
response to drug GO:0042493 3 0.069
response to chemical GO:0042221 320 0.067
cellular aromatic compound metabolic process GO:0006725 295 0.067
nucleobase containing compound metabolic process GO:0006139 274 0.064
biosynthetic process GO:0009058 294 0.062
organic substance biosynthetic process GO:1901576 289 0.058
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.057
aromatic compound biosynthetic process GO:0019438 217 0.056
cellular nitrogen compound metabolic process GO:0034641 290 0.052
chordate embryonic development GO:0043009 271 0.051
heterocycle metabolic process GO:0046483 290 0.050
organic cyclic compound metabolic process GO:1901360 301 0.049
nucleic acid metabolic process GO:0090304 244 0.049
nitrogen compound metabolic process GO:0006807 319 0.049
cellular macromolecule metabolic process GO:0044260 391 0.047
neuron differentiation GO:0030182 353 0.046
positive regulation of transport GO:0051050 2 0.045
cellular response to external stimulus GO:0071496 2 0.045
single organism metabolic process GO:0044710 217 0.042
determination of left right symmetry GO:0007368 179 0.040
negative regulation of cellular process GO:0048523 283 0.040
organic cyclic compound biosynthetic process GO:1901362 223 0.040
regulation of synapse organization GO:0050807 3 0.037
immune system process GO:0002376 241 0.037
Mouse
apoptotic process GO:0006915 116 0.037
tube morphogenesis GO:0035239 349 0.037
brain development GO:0007420 293 0.035
rna metabolic process GO:0016070 219 0.035
regulation of synaptic plasticity GO:0048167 1 0.035
amine metabolic process GO:0009308 2 0.035
mitochondrion organization GO:0007005 4 0.035
negative regulation of biological process GO:0048519 304 0.034
small molecule metabolic process GO:0044281 77 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.034
regulation of multicellular organism growth GO:0040014 4 0.034
adult behavior GO:0030534 2 0.033
determination of bilateral symmetry GO:0009855 204 0.033
single organism nuclear import GO:1902593 3 0.033
heterocycle biosynthetic process GO:0018130 215 0.033
digestive system development GO:0055123 289 0.032
aging GO:0007568 2 0.032
protein targeting to nucleus GO:0044744 3 0.032
cellular nitrogen compound biosynthetic process GO:0044271 218 0.032
negative regulation of kinase activity GO:0033673 4 0.032
regulation of gene expression GO:0010468 265 0.032
gtp metabolic process GO:0046039 4 0.031
autophagy GO:0006914 4 0.031
maintenance of location GO:0051235 4 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.031
fat soluble vitamin metabolic process GO:0006775 4 0.031
response to organic substance GO:0010033 153 0.030
rna biosynthetic process GO:0032774 181 0.030
carboxylic acid metabolic process GO:0019752 22 0.030
multicellular organism growth GO:0035264 4 0.030
signal transduction GO:0007165 455 0.030
response to nutrient GO:0007584 3 0.029
central nervous system development GO:0007417 387 0.029
eye development GO:0001654 277 0.029
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.029
cellular component morphogenesis GO:0032989 336 0.029
cellular response to nutrient levels GO:0031669 2 0.029
neuron development GO:0048666 262 0.028
nuclear transport GO:0051169 4 0.028
phosphorus metabolic process GO:0006793 109 0.028
larval development GO:0002164 2 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
regulation of biological quality GO:0065008 263 0.027
Mouse
gene expression GO:0010467 252 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
vitamin a metabolic process GO:0006776 1 0.027
embryonic organ development GO:0048568 381 0.027
positive regulation of catabolic process GO:0009896 4 0.027
system process GO:0003008 185 0.027
digestive tract development GO:0048565 265 0.027
pancreas development GO:0031016 84 0.027
cellular response to extracellular stimulus GO:0031668 2 0.027
regulation of autophagy GO:0010506 3 0.027
cognition GO:0050890 1 0.027
cellular response to radiation GO:0071478 4 0.027
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.026
regulation of inflammatory response GO:0050727 2 0.026
guanosine containing compound catabolic process GO:1901069 2 0.026
alpha amino acid metabolic process GO:1901605 3 0.026
positive regulation of cell cycle GO:0045787 3 0.026
nucleic acid templated transcription GO:0097659 181 0.026
lipid storage GO:0019915 1 0.025
cellular protein catabolic process GO:0044257 4 0.025
regulation of signaling GO:0023051 235 0.025
regulation of response to stimulus GO:0048583 269 0.025
cellular amino acid metabolic process GO:0006520 7 0.025
single organism biosynthetic process GO:0044711 71 0.025
regulation of cell communication GO:0010646 232 0.025
organonitrogen compound metabolic process GO:1901564 74 0.024
blood circulation GO:0008015 87 0.024
negative regulation of catabolic process GO:0009895 3 0.024
response to glucocorticoid GO:0051384 1 0.024
response to corticosteroid GO:0031960 1 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.023
transcription dna templated GO:0006351 181 0.023
neurotransmitter transport GO:0006836 2 0.023
regulation of primary metabolic process GO:0080090 311 0.023
regulation of cellular metabolic process GO:0031323 320 0.023
cellular response to chemical stimulus GO:0070887 157 0.023
response to external biotic stimulus GO:0043207 97 0.023
nuclear import GO:0051170 3 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.023
embryo development ending in birth or egg hatching GO:0009792 271 0.023
generation of neurons GO:0048699 385 0.023
digestive tract morphogenesis GO:0048546 231 0.022
response to lipid GO:0033993 60 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
guanosine containing compound metabolic process GO:1901068 4 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
regulation of nucleoside metabolic process GO:0009118 2 0.022
regulation of reproductive process GO:2000241 4 0.022
organic acid metabolic process GO:0006082 31 0.022
negative regulation of cellular catabolic process GO:0031330 3 0.021
response to light stimulus GO:0009416 46 0.021
head development GO:0060322 303 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.021
response to hydrogen peroxide GO:0042542 3 0.021
phototransduction GO:0007602 2 0.021
multi organism process GO:0051704 134 0.021
response to uv GO:0009411 3 0.021
meiotic cell cycle process GO:1903046 3 0.021
neuroblast proliferation GO:0007405 2 0.021
oxoacid metabolic process GO:0043436 31 0.021
regulation of apoptotic process GO:0042981 98 0.021
membrane fusion GO:0061025 2 0.021
death GO:0016265 121 0.020
specification of symmetry GO:0009799 204 0.020
negative regulation of sequestering of calcium ion GO:0051283 4 0.020
regulation of protein catabolic process GO:0042176 1 0.020
morphogenesis of an epithelium GO:0002009 333 0.020
regulation of nucleotide catabolic process GO:0030811 2 0.020
regulation of blood pressure GO:0008217 1 0.020
locomotion GO:0040011 313 0.020
cellular component movement GO:0006928 335 0.020
protein import into nucleus GO:0006606 3 0.019
regulation of cell activation GO:0050865 1 0.019
Mouse
embryonic heart tube development GO:0035050 133 0.019
cellular response to oxygen levels GO:0071453 1 0.019
transport GO:0006810 220 0.019
Mouse
intracellular receptor signaling pathway GO:0030522 30 0.019
cellular response to starvation GO:0009267 1 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
neurotransmitter secretion GO:0007269 2 0.019
regulation of signal transduction GO:0009966 225 0.018
cellular amine metabolic process GO:0044106 2 0.018
phosphate containing compound metabolic process GO:0006796 108 0.018
response to biotic stimulus GO:0009607 97 0.018
circulatory system process GO:0003013 87 0.018
neuron neuron synaptic transmission GO:0007270 1 0.018
stem cell proliferation GO:0072089 4 0.018
cellular aldehyde metabolic process GO:0006081 4 0.018
gtp catabolic process GO:0006184 2 0.018
response to vitamin GO:0033273 3 0.017
meiotic nuclear division GO:0007126 4 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
response to organic cyclic compound GO:0014070 51 0.017
regulation of tube size GO:0035150 2 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
cellular hormone metabolic process GO:0034754 19 0.017
synaptic vesicle transport GO:0048489 1 0.017
cell part morphogenesis GO:0032990 246 0.017
macroautophagy GO:0016236 1 0.017
sensory perception of pain GO:0019233 1 0.017
positive regulation of biological process GO:0048518 253 0.017
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
cellular response to organic substance GO:0071310 105 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
regulation of transcription dna templated GO:0006355 213 0.017
phagocytosis GO:0006909 3 0.017
regulation of response to extracellular stimulus GO:0032104 1 0.017
peptide transport GO:0015833 1 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.016
cell cycle g1 s phase transition GO:0044843 1 0.016
regulation of gtpase activity GO:0043087 2 0.016
cellular response to stress GO:0033554 62 0.016
cellular ketone metabolic process GO:0042180 11 0.016
multicellular organismal response to stress GO:0033555 2 0.016
regulation of dendrite development GO:0050773 3 0.016
protein metabolic process GO:0019538 183 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
regulation of blood vessel size GO:0050880 2 0.016
tissue remodeling GO:0048771 4 0.016
immune system development GO:0002520 191 0.016
stem cell maintenance GO:0019827 4 0.016
protein import GO:0017038 3 0.016
regulation of programmed cell death GO:0043067 101 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
regulation of metal ion transport GO:0010959 4 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
regulation of cytokine production GO:0001817 3 0.016
cortical cytoskeleton organization GO:0030865 1 0.016
organelle organization GO:0006996 227 0.016
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
positive regulation of secretion GO:0051047 1 0.016
diterpenoid metabolic process GO:0016101 15 0.016
chemosensory behavior GO:0007635 1 0.016
positive regulation of inflammatory response GO:0050729 1 0.016
cortical actin cytoskeleton organization GO:0030866 1 0.016
regulation of biosynthetic process GO:0009889 250 0.016
response to alkaloid GO:0043279 2 0.016
cell projection organization GO:0030030 284 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regulation of synapse assembly GO:0051963 3 0.016
mesenchyme development GO:0060485 127 0.016
synaptic vesicle localization GO:0097479 1 0.015
single organism transport GO:0044765 206 0.015
Mouse
regulation of metabolic process GO:0019222 359 0.015
organelle fusion GO:0048284 3 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
response to carbohydrate GO:0009743 3 0.015
cytoskeleton dependent cytokinesis GO:0061640 3 0.015
locomotor rhythm GO:0045475 3 0.015
homeostatic process GO:0042592 142 0.015
heart development GO:0007507 313 0.015
post golgi vesicle mediated transport GO:0006892 1 0.015
positive regulation of cell activation GO:0050867 1 0.015
Mouse
sensory organ development GO:0007423 393 0.015
Mouse
cellular modified amino acid metabolic process GO:0006575 3 0.015
programmed cell death GO:0012501 119 0.015
sensory perception of chemical stimulus GO:0007606 3 0.015
cellular response to light stimulus GO:0071482 4 0.015
hindbrain development GO:0030902 91 0.015
response to radiation GO:0009314 51 0.015
anterior posterior pattern specification GO:0009952 152 0.015
double strand break repair GO:0006302 3 0.015
axon ensheathment in central nervous system GO:0032291 2 0.015
localization of cell GO:0051674 244 0.015
regulation of binding GO:0051098 3 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
response to abiotic stimulus GO:0009628 122 0.015
single organism organelle organization GO:1902589 199 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
heart contraction GO:0060047 71 0.014
response to other organism GO:0051707 97 0.014
alcohol biosynthetic process GO:0046165 2 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
spermatid development GO:0007286 2 0.014
hemopoiesis GO:0030097 183 0.014
regulation of calcium ion transport GO:0051924 2 0.014
eye morphogenesis GO:0048592 144 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
regulation of protein transport GO:0051223 3 0.014
cell morphogenesis GO:0000902 289 0.014
response to endogenous stimulus GO:0009719 83 0.014
photoreceptor cell differentiation GO:0046530 55 0.014
response to inorganic substance GO:0010035 38 0.014
terpenoid metabolic process GO:0006721 15 0.014
regulation of nervous system development GO:0051960 90 0.014
melanin metabolic process GO:0006582 2 0.014
regulation of cell death GO:0010941 103 0.014
positive regulation of synapse assembly GO:0051965 1 0.014
hormone secretion GO:0046879 2 0.014
macromolecule modification GO:0043412 111 0.014
regulation of response to nutrient levels GO:0032107 1 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
regulation of developmental process GO:0050793 247 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
axon development GO:0061564 166 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
regulation of muscle contraction GO:0006937 3 0.013
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.013
response to monosaccharide GO:0034284 3 0.013
cellular protein metabolic process GO:0044267 129 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
lipid oxidation GO:0034440 1 0.013
lipid metabolic process GO:0006629 52 0.013
spermatid differentiation GO:0048515 2 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
response to wounding GO:0009611 116 0.013
Mouse
stem cell division GO:0017145 1 0.013
regulation of cell differentiation GO:0045595 142 0.013
protein modification process GO:0036211 100 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
protein localization to nucleus GO:0034504 3 0.013
myeloid cell differentiation GO:0030099 86 0.013
camera type eye development GO:0043010 222 0.013
Mouse
regulation of establishment of protein localization GO:0070201 4 0.013
wound healing GO:0042060 90 0.013
Mouse
regulation of protein complex assembly GO:0043254 3 0.013
positive regulation of cellular process GO:0048522 201 0.013
Mouse
hormone transport GO:0009914 2 0.013
organophosphate biosynthetic process GO:0090407 23 0.013
pigmentation GO:0043473 85 0.013
Mouse
cell projection morphogenesis GO:0048858 244 0.012
lipid homeostasis GO:0055088 3 0.012
macromolecule biosynthetic process GO:0009059 227 0.012
cytokinesis GO:0000910 3 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
response to hexose GO:0009746 3 0.012
membrane invagination GO:0010324 1 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
cell migration GO:0016477 237 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
oxidation reduction process GO:0055114 41 0.012
response to ketone GO:1901654 1 0.012
regulation of protein binding GO:0043393 3 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
organophosphate metabolic process GO:0019637 37 0.012
response to oxygen levels GO:0070482 25 0.012
rna localization GO:0006403 4 0.012
retinoid metabolic process GO:0001523 15 0.012
single fertilization GO:0007338 3 0.012
regulation of organ growth GO:0046620 3 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
small molecule catabolic process GO:0044282 3 0.012
response to glucose GO:0009749 3 0.012
exocytosis GO:0006887 1 0.012
phototransduction visible light GO:0007603 2 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
regulation of cell projection assembly GO:0060491 4 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
central nervous system myelination GO:0022010 2 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
b cell activation GO:0042113 2 0.011
regulation of localization GO:0032879 104 0.011
heart process GO:0003015 71 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
action potential GO:0001508 19 0.011
actin mediated cell contraction GO:0070252 1 0.011
monoamine transport GO:0015844 1 0.011
fat soluble vitamin biosynthetic process GO:0042362 2 0.011
intracellular signal transduction GO:0035556 85 0.011
growth GO:0040007 174 0.011
regeneration GO:0031099 91 0.011
cell substrate adhesion GO:0031589 4 0.011
blood vessel morphogenesis GO:0048514 216 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
regulation of molecular function GO:0065009 70 0.011
behavior GO:0007610 74 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
axonogenesis GO:0007409 152 0.011
cellular amino acid biosynthetic process GO:0008652 2 0.011
positive regulation of immune effector process GO:0002699 3 0.011
response to amino acid GO:0043200 2 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
cellular protein modification process GO:0006464 100 0.011
alcohol metabolic process GO:0006066 11 0.011
muscle cell development GO:0055001 115 0.011
carbohydrate homeostasis GO:0033500 1 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
mononuclear cell proliferation GO:0032943 1 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
cellular component assembly GO:0022607 170 0.011
cytosolic calcium ion transport GO:0060401 3 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
positive regulation of blood circulation GO:1903524 2 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
regulation of circadian rhythm GO:0042752 4 0.011
heart looping GO:0001947 94 0.011
regulation of multicellular organismal metabolic process GO:0044246 2 0.011
organic substance transport GO:0071702 58 0.011
Mouse
striated muscle cell development GO:0055002 108 0.010
cell death GO:0008219 121 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
fertilization GO:0009566 3 0.010
cell proliferation GO:0008283 80 0.010
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
response to hormone GO:0009725 48 0.010
protein polymerization GO:0051258 4 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010
protein localization to plasma membrane GO:0072659 1 0.010
tissue regeneration GO:0042246 74 0.010
cellular lipid catabolic process GO:0044242 3 0.010
carboxylic acid catabolic process GO:0046395 3 0.010
negative regulation of cell communication GO:0010648 96 0.010
macromolecular complex disassembly GO:0032984 1 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
organelle assembly GO:0070925 110 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.010
retina development in camera type eye GO:0060041 146 0.010
Mouse

hps1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
nervous system disease DOID:863 0 0.026
eye and adnexa disease DOID:1492 0 0.026
sensory system disease DOID:0050155 0 0.026
eye disease DOID:5614 0 0.026
disease of metabolism DOID:0014667 0 0.021
musculoskeletal system disease DOID:17 0 0.020
retinitis pigmentosa DOID:10584 0 0.015
retinal degeneration DOID:8466 0 0.015
retinal disease DOID:5679 0 0.015
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
cancer DOID:162 0 0.013
connective tissue disease DOID:65 0 0.012
bone disease DOID:0080001 0 0.012
inherited metabolic disorder DOID:655 0 0.011