Danio rerio

7 known processes

hsd11b2

hydroxysteroid 11-beta dehydrogenase 2

(Aliases: wu:fi31d01)

hsd11b2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell surface receptor signaling pathway GO:0007166 325 0.220
negative regulation of biological process GO:0048519 304 0.198
signal transduction GO:0007165 455 0.152
muscle tissue development GO:0060537 110 0.128
nitrogen compound metabolic process GO:0006807 319 0.122
g protein coupled receptor signaling pathway GO:0007186 74 0.095
g1 s transition of mitotic cell cycle GO:0000082 1 0.087
regulation of response to stimulus GO:0048583 269 0.086
otic vesicle formation GO:0030916 27 0.081
cellular biosynthetic process GO:0044249 286 0.081
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.072
Zebrafish
positive regulation of biological process GO:0048518 253 0.072
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.068
regulation of programmed cell death GO:0043067 101 0.066
mitochondrion organization GO:0007005 4 0.062
multicellular organism growth GO:0035264 4 0.060
cellular response to extracellular stimulus GO:0031668 2 0.060
organic cyclic compound metabolic process GO:1901360 301 0.059
Rat
cellular response to external stimulus GO:0071496 2 0.059
negative regulation of response to stimulus GO:0048585 104 0.058
regulation of macromolecule metabolic process GO:0060255 317 0.055
positive regulation of cellular component biogenesis GO:0044089 3 0.054
skeletal muscle organ development GO:0060538 78 0.053
response to abiotic stimulus GO:0009628 122 0.052
Rat
cellular nitrogen compound metabolic process GO:0034641 290 0.052
cell cycle g1 s phase transition GO:0044843 1 0.052
positive regulation of cellular catabolic process GO:0031331 3 0.052
regulation of signaling GO:0023051 235 0.052
small molecule metabolic process GO:0044281 77 0.051
Zebrafish
nucleobase containing compound metabolic process GO:0006139 274 0.051
developmental growth GO:0048589 166 0.050
blood vessel morphogenesis GO:0048514 216 0.049
gtp catabolic process GO:0006184 2 0.047
chordate embryonic development GO:0043009 271 0.047
head development GO:0060322 303 0.047
negative regulation of multicellular organismal process GO:0051241 69 0.046
regulation of cell communication GO:0010646 232 0.045
cellular response to nutrient levels GO:0031669 2 0.045
membrane fusion GO:0061025 2 0.044
single organism biosynthetic process GO:0044711 71 0.043
Zebrafish
stem cell maintenance GO:0019827 4 0.042
otic vesicle development GO:0071599 42 0.041
morphogenesis of an epithelium GO:0002009 333 0.041
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.040
vasculature development GO:0001944 278 0.040
specification of symmetry GO:0009799 204 0.040
Zebrafish
organic cyclic compound biosynthetic process GO:1901362 223 0.040
negative regulation of signaling GO:0023057 96 0.039
larval development GO:0002164 2 0.039
aging GO:0007568 2 0.039
heterocycle biosynthetic process GO:0018130 215 0.039
regulation of cell death GO:0010941 103 0.038
programmed cell death GO:0012501 119 0.038
establishment of protein localization to plasma membrane GO:0090002 1 0.038
endocrine system development GO:0035270 65 0.038
Zebrafish
central nervous system development GO:0007417 387 0.038
lateral inhibition GO:0046331 1 0.037
aromatic compound biosynthetic process GO:0019438 217 0.037
muscle structure development GO:0061061 196 0.036
blood vessel development GO:0001568 246 0.036
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.036
establishment of localization GO:0051234 244 0.036
guanosine containing compound catabolic process GO:1901069 2 0.036
multicellular organismal metabolic process GO:0044236 2 0.036
gtp metabolic process GO:0046039 4 0.036
cellular aromatic compound metabolic process GO:0006725 295 0.036
transcription dna templated GO:0006351 181 0.036
response to carbohydrate GO:0009743 3 0.036
regulation of binding GO:0051098 3 0.035
adult behavior GO:0030534 2 0.035
negative regulation of developmental process GO:0051093 65 0.034
glucose homeostasis GO:0042593 1 0.034
regulation of cellular metabolic process GO:0031323 320 0.034
regulation of signal transduction GO:0009966 225 0.033
response to chemical GO:0042221 320 0.033
Rat
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.033
positive regulation of response to stimulus GO:0048584 80 0.032
heterocycle metabolic process GO:0046483 290 0.032
energy reserve metabolic process GO:0006112 2 0.032
regulation of metabolic process GO:0019222 359 0.032
positive regulation of catabolic process GO:0009896 4 0.032
organonitrogen compound metabolic process GO:1901564 74 0.031
regulation of reproductive process GO:2000241 4 0.031
regulation of protein complex assembly GO:0043254 3 0.031
germ line stem cell maintenance GO:0030718 2 0.030
response to light stimulus GO:0009416 46 0.030
digestive system development GO:0055123 289 0.030
Zebrafish
mesenchyme development GO:0060485 127 0.030
Zebrafish
gland development GO:0048732 143 0.029
organic acid metabolic process GO:0006082 31 0.029
positive regulation of transport GO:0051050 2 0.029
regulation of developmental process GO:0050793 247 0.028
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
negative regulation of cellular process GO:0048523 283 0.028
growth GO:0040007 174 0.028
regulation of neuron migration GO:2001222 2 0.028
positive regulation of secretion by cell GO:1903532 1 0.028
guanosine containing compound metabolic process GO:1901068 4 0.028
hemopoiesis GO:0030097 183 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.027
hormone transport GO:0009914 2 0.027
cell growth GO:0016049 57 0.027
regulation of rna metabolic process GO:0051252 224 0.027
cellular response to chemical stimulus GO:0070887 157 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.027
cellular response to starvation GO:0009267 1 0.027
heart development GO:0007507 313 0.027
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.026
Zebrafish
cell part morphogenesis GO:0032990 246 0.026
cell fate commitment GO:0045165 99 0.026
cell morphogenesis GO:0000902 289 0.026
rna biosynthetic process GO:0032774 181 0.026
regulation of cell cycle GO:0051726 52 0.026
regulation of cell activation GO:0050865 1 0.026
cellular component morphogenesis GO:0032989 336 0.026
regulation of blood pressure GO:0008217 1 0.025
Rat
camera type eye development GO:0043010 222 0.025
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.025
immune system process GO:0002376 241 0.025
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.025
regulation of rna biosynthetic process GO:2001141 213 0.025
negative regulation of cellular biosynthetic process GO:0031327 55 0.025
regulation of response to nutrient levels GO:0032107 1 0.025
regionalization GO:0003002 274 0.025
regulation of apoptotic process GO:0042981 98 0.025
regulation of muscle contraction GO:0006937 3 0.024
regulation of cell shape GO:0008360 1 0.024
positive regulation of cell cycle GO:0045787 3 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
response to biotic stimulus GO:0009607 97 0.024
carbohydrate homeostasis GO:0033500 1 0.024
muscle organ development GO:0007517 101 0.024
positive regulation of gtp catabolic process GO:0033126 1 0.024
digestive tract development GO:0048565 265 0.024
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.024
regulation of gtp catabolic process GO:0033124 2 0.024
nucleic acid templated transcription GO:0097659 181 0.024
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
cell proliferation GO:0008283 80 0.023
single organism metabolic process GO:0044710 217 0.023
Zebrafish Rat
regulation of multicellular organismal metabolic process GO:0044246 2 0.023
neuron differentiation GO:0030182 353 0.023
Zebrafish
cardiac atrium development GO:0003230 4 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.023
oxoacid metabolic process GO:0043436 31 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
sensory perception of pain GO:0019233 1 0.023
hormone secretion GO:0046879 2 0.023
regulation of biological quality GO:0065008 263 0.023
Zebrafish Rat
negative regulation of signal transduction GO:0009968 94 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.022
protein secretion GO:0009306 1 0.022
brain development GO:0007420 293 0.022
single organism membrane fusion GO:0044801 2 0.022
collagen metabolic process GO:0032963 2 0.021
cellular amine metabolic process GO:0044106 2 0.021
response to glucose GO:0009749 3 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
determination of bilateral symmetry GO:0009855 204 0.021
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.021
regulation of collagen metabolic process GO:0010712 2 0.021
regulation of primary metabolic process GO:0080090 311 0.020
biosynthetic process GO:0009058 294 0.020
Zebrafish
positive regulation of blood circulation GO:1903524 2 0.020
carbohydrate biosynthetic process GO:0016051 1 0.020
striated muscle tissue development GO:0014706 110 0.020
peptide transport GO:0015833 1 0.020
regulation of response to extracellular stimulus GO:0032104 1 0.020
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.020
positive regulation of secretion GO:0051047 1 0.020
hindbrain development GO:0030902 91 0.020
immune system development GO:0002520 191 0.020
regulation of cell development GO:0060284 100 0.020
positive regulation of muscle organ development GO:0048636 1 0.020
regulation of protein transport GO:0051223 3 0.020
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.020
regulation of reactive oxygen species metabolic process GO:2000377 2 0.020
negative regulation of cell communication GO:0010648 96 0.020
negative regulation of biosynthetic process GO:0009890 55 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
regulation of mitochondrion organization GO:0010821 1 0.019
gene expression GO:0010467 252 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
transport GO:0006810 220 0.019
regulation of establishment of protein localization GO:0070201 4 0.019
cellular ketone metabolic process GO:0042180 11 0.019
regulation of heart growth GO:0060420 2 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
cell matrix adhesion GO:0007160 4 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
cell projection morphogenesis GO:0048858 244 0.019
regulation of organ growth GO:0046620 3 0.019
maintenance of location GO:0051235 4 0.019
death GO:0016265 121 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.018
regulation of cellular component organization GO:0051128 86 0.018
regulation of epithelial cell proliferation GO:0050678 3 0.018
multicellular organismal response to stress GO:0033555 2 0.018
regulation of transcription dna templated GO:0006355 213 0.018
neuron projection morphogenesis GO:0048812 161 0.018
regulation of gtpase activity GO:0043087 2 0.018
hematopoietic or lymphoid organ development GO:0048534 191 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
regulation of metal ion transport GO:0010959 4 0.018
regulation of phosphorus metabolic process GO:0051174 43 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.018
regulation of ion transmembrane transporter activity GO:0032412 2 0.018
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
protein localization to plasma membrane GO:0072659 1 0.017
pancreas development GO:0031016 84 0.017
Zebrafish
pericardium development GO:0060039 1 0.017
angiogenesis GO:0001525 158 0.017
cell morphogenesis involved in differentiation GO:0000904 195 0.017
cell migration GO:0016477 237 0.017
hormone biosynthetic process GO:0042446 3 0.017
apoptotic process GO:0006915 116 0.017
regulation of biosynthetic process GO:0009889 250 0.017
response to vitamin GO:0033273 3 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
ventricular cardiac muscle tissue development GO:0003229 3 0.017
cell cycle arrest GO:0007050 1 0.017
stem cell differentiation GO:0048863 117 0.017
Zebrafish
cognition GO:0050890 1 0.017
response to hexose GO:0009746 3 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
regulation of cytokine production GO:0001817 3 0.016
axon ensheathment in central nervous system GO:0032291 2 0.016
cellular carbohydrate metabolic process GO:0044262 4 0.016
axon development GO:0061564 166 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
neurotransmitter secretion GO:0007269 2 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.016
cell death GO:0008219 121 0.016
cell fate specification GO:0001708 68 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
cardiac atrium morphogenesis GO:0003209 2 0.016
response to external stimulus GO:0009605 264 0.016
Rat
regulation of endothelial cell proliferation GO:0001936 1 0.016
regulation of glial cell differentiation GO:0045685 4 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
positive regulation of programmed cell death GO:0043068 29 0.015
purine containing compound biosynthetic process GO:0072522 20 0.015
cellular response to radiation GO:0071478 4 0.015
nuclear transport GO:0051169 4 0.015
positive regulation of striated muscle tissue development GO:0045844 1 0.015
response to nutrient GO:0007584 3 0.015
response to radiation GO:0009314 51 0.015
embryonic organ development GO:0048568 381 0.015
Zebrafish
alpha amino acid metabolic process GO:1901605 3 0.015
membrane hyperpolarization GO:0060081 1 0.015
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.015
response to food GO:0032094 1 0.015
Rat
regulation of cell projection assembly GO:0060491 4 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
response to uv GO:0009411 3 0.015
regulation of gene expression GO:0010468 265 0.015
negative regulation of metabolic process GO:0009892 86 0.014
cellular response to oxygen levels GO:0071453 1 0.014
pigmentation GO:0043473 85 0.014
amine metabolic process GO:0009308 2 0.014
cell substrate adhesion GO:0031589 4 0.014
erythrocyte differentiation GO:0030218 54 0.014
regulation of protein binding GO:0043393 3 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
regulation of bmp signaling pathway GO:0030510 39 0.014
response to topologically incorrect protein GO:0035966 2 0.014
protein targeting to nucleus GO:0044744 3 0.014
photoreceptor cell fate commitment GO:0046552 1 0.014
endocrine process GO:0050886 2 0.014
Rat
regulation of cell migration GO:0030334 40 0.014
sensory organ development GO:0007423 393 0.014
Zebrafish
regulation of carbohydrate biosynthetic process GO:0043255 1 0.014
circulatory system process GO:0003013 87 0.014
Zebrafish Rat
ossification GO:0001503 23 0.014
localization of cell GO:0051674 244 0.014
response to ketone GO:1901654 1 0.014
regulation of cell differentiation GO:0045595 142 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
neurological system process GO:0050877 62 0.014
tube morphogenesis GO:0035239 349 0.014
Zebrafish
water homeostasis GO:0030104 4 0.013
single organism transport GO:0044765 206 0.013
exocrine system development GO:0035272 28 0.013
Zebrafish
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
protein metabolic process GO:0019538 183 0.013
response to stress GO:0006950 263 0.013
response to organic substance GO:0010033 153 0.013
Rat
regulation of skeletal muscle tissue development GO:0048641 4 0.013
mesoderm development GO:0007498 88 0.013
cellular component movement GO:0006928 335 0.013
homeostatic process GO:0042592 142 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
lymphocyte proliferation GO:0046651 1 0.013
eye development GO:0001654 277 0.013
Zebrafish
regulation of cellular amine metabolic process GO:0033238 0 0.013
response to drug GO:0042493 3 0.013
Rat
cellular response to stress GO:0033554 62 0.013
glucocorticoid metabolic process GO:0008211 2 0.013
Rat
regulation of carbohydrate metabolic process GO:0006109 4 0.013
apoptotic process involved in development GO:1902742 2 0.013
positive regulation of myeloid cell differentiation GO:0045639 2 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
small molecule biosynthetic process GO:0044283 16 0.013
Zebrafish
gastrulation GO:0007369 208 0.013
meiotic cell cycle process GO:1903046 3 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.013
mitotic dna damage checkpoint GO:0044773 4 0.013
regulation of hormone levels GO:0010817 21 0.013
Zebrafish
intracellular signal transduction GO:0035556 85 0.013
cytosolic calcium ion transport GO:0060401 3 0.013
otic vesicle morphogenesis GO:0071600 34 0.013
cell adhesion mediated by integrin GO:0033627 1 0.013
regulation of synaptic plasticity GO:0048167 1 0.013
energy homeostasis GO:0097009 3 0.013
single organism nuclear import GO:1902593 3 0.012
skeletal muscle tissue development GO:0007519 67 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
response to hormone GO:0009725 48 0.012
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
sequestering of metal ion GO:0051238 3 0.012
regulation of hormone secretion GO:0046883 2 0.012
regulation of autophagy GO:0010506 3 0.012
heart morphogenesis GO:0003007 156 0.012
Zebrafish
hepaticobiliary system development GO:0061008 98 0.012
regulation of calcium ion transport GO:0051924 2 0.012
rna metabolic process GO:0016070 219 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
muscle hypertrophy GO:0014896 2 0.012
skeletal system development GO:0001501 181 0.012
Zebrafish
negative regulation of cell death GO:0060548 60 0.012
regulation of neuron differentiation GO:0045664 56 0.012
neural tube development GO:0021915 62 0.012
axonogenesis GO:0007409 152 0.012
cell projection organization GO:0030030 284 0.012
neuron development GO:0048666 262 0.012
response to monosaccharide GO:0034284 3 0.012
positive regulation of muscle tissue development GO:1901863 1 0.012
lymph vessel development GO:0001945 27 0.012
positive regulation of apoptotic process GO:0043065 29 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
positive regulation of muscle cell differentiation GO:0051149 1 0.012
negative regulation of bmp signaling pathway GO:0030514 13 0.012
positive regulation of epithelial cell migration GO:0010634 2 0.012
cell aging GO:0007569 2 0.012
ear development GO:0043583 127 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
protein import GO:0017038 3 0.011
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.011
intracellular mrna localization GO:0008298 1 0.011
cyclic purine nucleotide metabolic process GO:0052652 18 0.011
peptide metabolic process GO:0006518 1 0.011
positive regulation of carbohydrate metabolic process GO:0045913 1 0.011
regulation of cardiac muscle tissue development GO:0055024 1 0.011
reactive oxygen species metabolic process GO:0072593 6 0.011
nuclear import GO:0051170 3 0.011
multi organism process GO:0051704 134 0.011
Mouse Rat
spermatid differentiation GO:0048515 2 0.011
positive regulation of cellular process GO:0048522 201 0.011
cell motility GO:0048870 244 0.011
regulation of transporter activity GO:0032409 2 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
peripheral nervous system development GO:0007422 55 0.011
macroautophagy GO:0016236 1 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
nucleic acid metabolic process GO:0090304 244 0.011
eye morphogenesis GO:0048592 144 0.011
Zebrafish
sensory organ morphogenesis GO:0090596 200 0.011
Zebrafish
female sex differentiation GO:0046660 4 0.011
ribose phosphate biosynthetic process GO:0046390 20 0.011
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.011
hatching gland development GO:0048785 3 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
negative regulation of ras protein signal transduction GO:0046580 1 0.011
regulation of blood vessel size GO:0050880 2 0.011
protein polymerization GO:0051258 4 0.011
multicellular organismal macromolecule metabolic process GO:0044259 2 0.011
mesenchymal cell differentiation GO:0048762 87 0.011
Zebrafish
regulation of dna replication GO:0006275 3 0.011
positive regulation of heart contraction GO:0045823 2 0.011
response to corticosteroid GO:0031960 1 0.010
Rat
ras protein signal transduction GO:0007265 7 0.010
negative regulation of kinase activity GO:0033673 4 0.010
positive regulation of cell activation GO:0050867 1 0.010
cyclic nucleotide biosynthetic process GO:0009190 18 0.010
positive regulation of metabolic process GO:0009893 108 0.010
negative regulation of feeding behavior GO:2000252 2 0.010
regulation of dendrite development GO:0050773 3 0.010
sleep GO:0030431 1 0.010
single organism localization GO:1902578 225 0.010
stem cell proliferation GO:0072089 4 0.010
central nervous system myelination GO:0022010 2 0.010
skeletal system morphogenesis GO:0048705 102 0.010
epithelial tube morphogenesis GO:0060562 148 0.010
Zebrafish
endocrine pancreas development GO:0031018 27 0.010
Zebrafish
autophagy GO:0006914 4 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010
sprouting angiogenesis GO:0002040 53 0.010

hsd11b2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.012
disease of anatomical entity DOID:7 0 0.012
muscular disease DOID:0080000 0 0.011
musculoskeletal system disease DOID:17 0 0.011
muscle tissue disease DOID:66 0 0.011