Danio rerio

0 known processes

hsd17b12a

hydroxysteroid (17-beta) dehydrogenase 12a

(Aliases: zgc:55589,zgc:77599,fi06g11,wu:fi06g11)

hsd17b12a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
very long chain fatty acid biosynthetic process GO:0042761 4 0.855
Yeast
sensory system development GO:0048880 76 0.753
lateral line system development GO:0048925 76 0.747
larval development GO:0002164 2 0.620
Worm
fatty acid elongation GO:0030497 1 0.481
Yeast
homeostatic process GO:0042592 142 0.455
organic cyclic compound biosynthetic process GO:1901362 223 0.419
Zebrafish Worm
biosynthetic process GO:0009058 294 0.399
Yeast Zebrafish Worm
androgen biosynthetic process GO:0006702 1 0.361
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.348
Worm
long chain fatty acid biosynthetic process GO:0042759 1 0.347
Worm
long chain fatty acid metabolic process GO:0001676 1 0.322
Worm
cellular biosynthetic process GO:0044249 286 0.295
Yeast Zebrafish Worm
s adenosylmethionine metabolic process GO:0046500 1 0.277
single organism metabolic process GO:0044710 217 0.243
Yeast Zebrafish Worm
aging GO:0007568 2 0.215
Worm
negative regulation of cellular process GO:0048523 283 0.207
neuron projection morphogenesis GO:0048812 161 0.199
rna biosynthetic process GO:0032774 181 0.190
cellular aromatic compound metabolic process GO:0006725 295 0.171
negative regulation of biological process GO:0048519 304 0.163
organic substance biosynthetic process GO:1901576 289 0.163
Yeast Zebrafish Worm
cellular macromolecule metabolic process GO:0044260 391 0.154
nitrogen compound metabolic process GO:0006807 319 0.152
Yeast
cellular macromolecule biosynthetic process GO:0034645 224 0.139
cellular nitrogen compound biosynthetic process GO:0044271 218 0.138
locomotion GO:0040011 313 0.128
Worm
organic cyclic compound metabolic process GO:1901360 301 0.126
Zebrafish Worm
regulation of rna metabolic process GO:0051252 224 0.124
macromolecule biosynthetic process GO:0009059 227 0.123
positive regulation of cellular process GO:0048522 201 0.121
Mouse
regulation of biological quality GO:0065008 263 0.120
Zebrafish Worm
androgen metabolic process GO:0008209 2 0.110
Zebrafish Worm
fatty acid biosynthetic process GO:0006633 4 0.108
Yeast Worm
gastrulation GO:0007369 208 0.107
positive regulation of cell adhesion GO:0045785 1 0.106
Mouse
transport GO:0006810 220 0.100
response to stress GO:0006950 263 0.099
Zebrafish
membrane lipid biosynthetic process GO:0046467 2 0.099
Yeast
negative regulation of multicellular organismal process GO:0051241 69 0.094
positive regulation of biological process GO:0048518 253 0.093
Mouse
single organism transport GO:0044765 206 0.091
cellular response to nutrient levels GO:0031669 2 0.091
hormone biosynthetic process GO:0042446 3 0.089
Zebrafish
aromatic compound biosynthetic process GO:0019438 217 0.089
regionalization GO:0003002 274 0.088
heterocycle biosynthetic process GO:0018130 215 0.088
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.086
cell morphogenesis GO:0000902 289 0.086
nucleic acid metabolic process GO:0090304 244 0.085
sexual reproduction GO:0019953 36 0.084
reproduction GO:0000003 40 0.084
Worm
cell death GO:0008219 121 0.084
regulation of cell death GO:0010941 103 0.082
very long chain fatty acid metabolic process GO:0000038 4 0.080
Yeast
nucleobase containing compound metabolic process GO:0006139 274 0.079
nucleobase containing compound biosynthetic process GO:0034654 205 0.078
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.076
positive regulation of macromolecule metabolic process GO:0010604 93 0.073
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.072
gamete generation GO:0007276 33 0.072
regulation of cellular metabolic process GO:0031323 320 0.072
gene expression GO:0010467 252 0.070
nucleic acid templated transcription GO:0097659 181 0.069
cellular response to starvation GO:0009267 1 0.069
organonitrogen compound metabolic process GO:1901564 74 0.068
Yeast
muscle contraction GO:0006936 18 0.067
response to external stimulus GO:0009605 264 0.066
regulation of dna templated transcription in response to stress GO:0043620 0 0.066
response to chemical GO:0042221 320 0.065
cellular response to extracellular stimulus GO:0031668 2 0.064
meiosis i GO:0007127 1 0.064
cellular response to external stimulus GO:0071496 2 0.064
multi organism reproductive process GO:0044703 36 0.063
carboxylic acid metabolic process GO:0019752 22 0.063
Yeast Worm
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.060
chordate embryonic development GO:0043009 271 0.060
single organism biosynthetic process GO:0044711 71 0.059
Yeast Zebrafish Worm
regulation of protein transport GO:0051223 3 0.059
developmental process involved in reproduction GO:0003006 27 0.057
Worm
skeletal system development GO:0001501 181 0.057
regulation of biosynthetic process GO:0009889 250 0.057
regulation of gene expression GO:0010468 265 0.056
organic acid metabolic process GO:0006082 31 0.055
Yeast Worm
transcription from rna polymerase ii promoter GO:0006366 80 0.054
lipid biosynthetic process GO:0008610 22 0.053
Yeast Zebrafish Worm
response to organic substance GO:0010033 153 0.053
regulation of multicellular organismal process GO:0051239 277 0.052
water homeostasis GO:0030104 4 0.052
cellular response to chemical stimulus GO:0070887 157 0.051
somite development GO:0061053 96 0.051
regulation of epithelial cell proliferation GO:0050678 3 0.049
regulation of photoreceptor cell differentiation GO:0046532 2 0.048
lateral line development GO:0048882 66 0.048
regulation of rna biosynthetic process GO:2001141 213 0.047
regulation of multicellular organism growth GO:0040014 4 0.047
ion transmembrane transport GO:0034220 91 0.046
meiotic nuclear division GO:0007126 4 0.045
alpha amino acid metabolic process GO:1901605 3 0.045
sodium ion transmembrane transport GO:0035725 21 0.044
multicellular organismal reproductive process GO:0048609 35 0.044
muscle structure development GO:0061061 196 0.043
cellular nitrogen compound metabolic process GO:0034641 290 0.043
regulation of macromolecule metabolic process GO:0060255 317 0.043
response to other organism GO:0051707 97 0.043
multi organism process GO:0051704 134 0.043
transcription dna templated GO:0006351 181 0.043
response to drug GO:0042493 3 0.042
embryonic organ morphogenesis GO:0048562 274 0.041
regulation of nitrogen compound metabolic process GO:0051171 251 0.041
regulation of blood pressure GO:0008217 1 0.040
cellular response to stress GO:0033554 62 0.040
cellular component movement GO:0006928 335 0.040
regulation of multicellular organismal development GO:2000026 223 0.039
neuron development GO:0048666 262 0.039
protein import GO:0017038 3 0.039
carbohydrate metabolic process GO:0005975 12 0.039
determination of bilateral symmetry GO:0009855 204 0.038
sodium ion transport GO:0006814 24 0.038
regulation of protein metabolic process GO:0051246 56 0.038
immune system process GO:0002376 241 0.038
muscle cell differentiation GO:0042692 139 0.037
system process GO:0003008 185 0.037
small molecule metabolic process GO:0044281 77 0.036
Yeast Worm
regulation of metabolic process GO:0019222 359 0.036
Worm
establishment of localization GO:0051234 244 0.036
negative regulation of mapk cascade GO:0043409 4 0.036
nuclear transport GO:0051169 4 0.036
regulation of transcription dna templated GO:0006355 213 0.036
negative regulation of developmental process GO:0051093 65 0.035
regulation of cytokine production GO:0001817 3 0.035
cardiac cell development GO:0055006 21 0.035
neurological system process GO:0050877 62 0.035
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.034
programmed cell death GO:0012501 119 0.034
oxidation reduction process GO:0055114 41 0.033
Yeast Zebrafish Worm
segmentation GO:0035282 97 0.033
apoptotic process GO:0006915 116 0.033
rna metabolic process GO:0016070 219 0.033
multicellular organism reproduction GO:0032504 35 0.033
meiotic cell cycle process GO:1903046 3 0.033
single organism carbohydrate metabolic process GO:0044723 12 0.032
cell part morphogenesis GO:0032990 246 0.032
cardiac muscle cell differentiation GO:0055007 30 0.032
digestive tract development GO:0048565 265 0.032
appendage development GO:0048736 80 0.032
negative regulation of cell communication GO:0010648 96 0.031
organic substance transport GO:0071702 58 0.031
transmembrane transport GO:0055085 120 0.031
pigmentation GO:0043473 85 0.031
response to endogenous stimulus GO:0009719 83 0.031
positive regulation of defense response to virus by host GO:0002230 0 0.031
heterocycle metabolic process GO:0046483 290 0.031
zymogen activation GO:0031638 3 0.031
multicellular organism growth GO:0035264 4 0.031
smooth muscle contraction GO:0006939 2 0.030
response to topologically incorrect protein GO:0035966 2 0.029
response to nutrient GO:0007584 3 0.029
regulation of protein complex assembly GO:0043254 3 0.029
reactive oxygen species biosynthetic process GO:1903409 1 0.029
positive regulation of protein complex assembly GO:0031334 2 0.029
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.029
peptide metabolic process GO:0006518 1 0.028
regulation of cell differentiation GO:0045595 142 0.028
signal transduction GO:0007165 455 0.028
cellular amino acid metabolic process GO:0006520 7 0.028
death GO:0016265 121 0.028
reproductive process GO:0022414 40 0.028
Worm
establishment of endothelial barrier GO:0061028 3 0.028
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.028
reciprocal meiotic recombination GO:0007131 1 0.027
developmental growth GO:0048589 166 0.027
monovalent inorganic cation transport GO:0015672 42 0.027
neuromast development GO:0048884 46 0.027
cellular localization GO:0051641 97 0.026
regulation of circadian rhythm GO:0042752 4 0.026
cellular component disassembly GO:0022411 1 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
mesenchymal cell differentiation GO:0048762 87 0.026
oxoacid metabolic process GO:0043436 31 0.025
Yeast Worm
embryonic skeletal system development GO:0048706 97 0.025
axonogenesis GO:0007409 152 0.025
extracellular matrix organization GO:0030198 27 0.025
Mouse
single organism organelle organization GO:1902589 199 0.025
regulation of nucleic acid templated transcription GO:1903506 213 0.025
dna templated transcription elongation GO:0006354 3 0.025
cellular response to organic substance GO:0071310 105 0.025
response to abiotic stimulus GO:0009628 122 0.025
carbohydrate derivative biosynthetic process GO:1901137 43 0.025
nucleocytoplasmic transport GO:0006913 4 0.024
somitogenesis GO:0001756 87 0.024
embryonic skeletal system morphogenesis GO:0048704 93 0.024
cellular component biogenesis GO:0044085 178 0.024
negative regulation of ras protein signal transduction GO:0046580 1 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.024
autophagy GO:0006914 4 0.024
endocrine process GO:0050886 2 0.023
regulation of developmental process GO:0050793 247 0.023
protein metabolic process GO:0019538 183 0.023
lipid storage GO:0019915 1 0.023
regulation of response to oxidative stress GO:1902882 2 0.023
liver development GO:0001889 96 0.023
muscle tissue development GO:0060537 110 0.023
multicellular organismal water homeostasis GO:0050891 1 0.023
negative regulation of cellular metabolic process GO:0031324 77 0.023
sensory organ development GO:0007423 393 0.023
biological adhesion GO:0022610 40 0.023
Mouse
regulation of primary metabolic process GO:0080090 311 0.023
cranial nerve development GO:0021545 42 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.022
steroid biosynthetic process GO:0006694 5 0.022
Zebrafish Worm
response to alkaloid GO:0043279 2 0.022
cell motility GO:0048870 244 0.022
lipid metabolic process GO:0006629 52 0.022
Yeast Zebrafish Worm
cell morphogenesis involved in differentiation GO:0000904 195 0.022
hepaticobiliary system development GO:0061008 98 0.022
regulation of glial cell differentiation GO:0045685 4 0.022
production of molecular mediator of immune response GO:0002440 2 0.021
protein complex localization GO:0031503 1 0.021
neuron differentiation GO:0030182 353 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
epiboly GO:0090504 41 0.021
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.020
neural crest cell development GO:0014032 62 0.020
female sex differentiation GO:0046660 4 0.020
Worm
carbohydrate homeostasis GO:0033500 1 0.020
regulation of embryonic development GO:0045995 47 0.020
positive regulation of immune effector process GO:0002699 3 0.020
maintenance of location GO:0051235 4 0.020
regulation of striated muscle contraction GO:0006942 2 0.019
regulation of membrane potential GO:0042391 23 0.019
cellular protein metabolic process GO:0044267 129 0.019
estrogen metabolic process GO:0008210 2 0.019
Worm
regulation of apoptotic process GO:0042981 98 0.019
response to carbohydrate GO:0009743 3 0.019
response to virus GO:0009615 21 0.019
stem cell maintenance GO:0019827 4 0.019
b cell activation GO:0042113 2 0.019
blood circulation GO:0008015 87 0.018
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
establishment of localization in cell GO:0051649 77 0.018
positive regulation of catabolic process GO:0009896 4 0.018
anterior posterior pattern specification GO:0009952 152 0.018
embryonic cranial skeleton morphogenesis GO:0048701 90 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.018
positive regulation of cellular metabolic process GO:0031325 94 0.018
taxis GO:0042330 109 0.018
cellular carbohydrate metabolic process GO:0044262 4 0.018
regulation of cardiac muscle contraction GO:0055117 2 0.018
skeletal system morphogenesis GO:0048705 102 0.018
response to organic cyclic compound GO:0014070 51 0.018
regulation of anatomical structure size GO:0090066 33 0.018
protein targeting to nucleus GO:0044744 3 0.017
digestive tract morphogenesis GO:0048546 231 0.017
regulation of sodium ion transport GO:0002028 2 0.017
positive regulation of transcription dna templated GO:0045893 57 0.017
germ cell development GO:0007281 22 0.017
ion transport GO:0006811 114 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.016
bone mineralization GO:0030282 9 0.016
single organism nuclear import GO:1902593 3 0.016
vasculature development GO:0001944 278 0.016
regulation of protein ubiquitination GO:0031396 3 0.016
skeletal muscle organ development GO:0060538 78 0.016
regulation of muscle contraction GO:0006937 3 0.016
hatching GO:0035188 4 0.016
mechanosensory lateral line system development GO:0048881 49 0.016
regulation of protein import into nucleus GO:0042306 2 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.015
neural crest cell differentiation GO:0014033 72 0.015
mesenchymal cell development GO:0014031 78 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
cellular hormone metabolic process GO:0034754 19 0.015
Zebrafish Worm
positive regulation of cytoskeleton organization GO:0051495 3 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of locomotion GO:0040012 55 0.015
gland development GO:0048732 143 0.015
regulation of system process GO:0044057 40 0.015
protein complex disassembly GO:0043241 1 0.015
energy reserve metabolic process GO:0006112 2 0.015
regulation of dendrite development GO:0050773 3 0.015
growth GO:0040007 174 0.015
positive regulation of cytokine production GO:0001819 2 0.015
reciprocal dna recombination GO:0035825 1 0.015
regulation of cell communication GO:0010646 232 0.015
carboxylic acid biosynthetic process GO:0046394 12 0.014
Yeast Worm
positive regulation of cell cycle GO:0045787 3 0.014
regulation of hormone levels GO:0010817 21 0.014
Zebrafish Worm
cytoskeleton organization GO:0007010 96 0.014
epithelial cell morphogenesis GO:0003382 2 0.014
toll like receptor signaling pathway GO:0002224 4 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
protein polymerization GO:0051258 4 0.014
striated muscle contraction GO:0006941 12 0.014
hormone secretion GO:0046879 2 0.014
kupffer s vesicle development GO:0070121 50 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
regulation of programmed cell death GO:0043067 101 0.014
cell proliferation GO:0008283 80 0.014
axon development GO:0061564 166 0.014
organelle organization GO:0006996 227 0.014
muscle system process GO:0003012 20 0.013
regulation of cellular component movement GO:0051270 55 0.013
hydrogen peroxide metabolic process GO:0042743 2 0.013
organic acid biosynthetic process GO:0016053 12 0.013
Yeast Worm
stem cell differentiation GO:0048863 117 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
metal ion homeostasis GO:0055065 26 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
connective tissue development GO:0061448 99 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
response to glucocorticoid GO:0051384 1 0.013
mitochondrion organization GO:0007005 4 0.013
tube morphogenesis GO:0035239 349 0.013
nuclear import GO:0051170 3 0.013
single organism localization GO:1902578 225 0.012
positive regulation of blood circulation GO:1903524 2 0.012
apical junction assembly GO:0043297 1 0.012
regulation of response to biotic stimulus GO:0002831 2 0.012
regulation of localization GO:0032879 104 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
regulation of organ growth GO:0046620 3 0.012
cognition GO:0050890 1 0.012
spindle assembly GO:0051225 2 0.012
protein modification process GO:0036211 100 0.012
specification of symmetry GO:0009799 204 0.012
cell surface receptor signaling pathway GO:0007166 325 0.012
positive regulation of metabolic process GO:0009893 108 0.012
cardiac conduction GO:0061337 3 0.011
smooth muscle tissue development GO:0048745 1 0.011
cardiac muscle cell development GO:0055013 20 0.011
localization of cell GO:0051674 244 0.011
cellular response to hypoxia GO:0071456 1 0.011
response to glucose GO:0009749 3 0.011
regulation of cellular component organization GO:0051128 86 0.011
cellular component assembly GO:0022607 170 0.011
morphogenesis of an epithelial fold GO:0060571 1 0.011
cellular response to organic cyclic compound GO:0071407 38 0.011
meiotic chromosome segregation GO:0045132 3 0.011
negative regulation of myeloid cell differentiation GO:0045638 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
hemopoiesis GO:0030097 183 0.011
chemotaxis GO:0006935 104 0.011
generation of neurons GO:0048699 385 0.011
cardiac muscle tissue development GO:0048738 48 0.011
negative regulation of hormone secretion GO:0046888 2 0.011
regulation of reproductive process GO:2000241 4 0.011
membrane invagination GO:0010324 1 0.011
cellular modified amino acid metabolic process GO:0006575 3 0.011
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.011
cell migration GO:0016477 237 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
fin morphogenesis GO:0033334 53 0.011
cell cycle process GO:0022402 53 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
cytokine metabolic process GO:0042107 1 0.011
sensory perception GO:0007600 39 0.011
cellular protein modification process GO:0006464 100 0.011
mesoderm development GO:0007498 88 0.011
adult behavior GO:0030534 2 0.010
macroautophagy GO:0016236 1 0.010
nerve development GO:0021675 45 0.010
sphingolipid metabolic process GO:0006665 9 0.010
Yeast
sphingolipid biosynthetic process GO:0030148 2 0.010
Yeast
regulation of cell cycle GO:0051726 52 0.010
positive regulation of cell death GO:0010942 29 0.010
regulation of protein catabolic process GO:0042176 1 0.010
regulation of oxidative stress induced cell death GO:1903201 2 0.010
muscle organ development GO:0007517 101 0.010
hormone mediated signaling pathway GO:0009755 9 0.010
skin development GO:0043588 54 0.010
positive regulation of neuron death GO:1901216 1 0.010
immune effector process GO:0002252 23 0.010
positive regulation of chromosome organization GO:2001252 1 0.010

hsd17b12a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.052
inherited metabolic disorder DOID:655 0 0.052
disease of anatomical entity DOID:7 0 0.011
breast cancer DOID:1612 0 0.011
thoracic cancer DOID:5093 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
musculoskeletal system disease DOID:17 0 0.010