Danio rerio

36 known processes

ihhb

Indian hedgehog homolog b

(Aliases: zgc:113262,IHH,MGC113262,ehh)

ihhb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
biosynthetic process GO:0009058 294 0.555
Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.497
Mouse Fly
embryonic organ development GO:0048568 381 0.465
Zebrafish Mouse
regulation of metabolic process GO:0019222 359 0.461
Zebrafish Mouse Fly
negative regulation of biological process GO:0048519 304 0.434
Zebrafish Mouse Fly
striated muscle tissue development GO:0014706 110 0.395
Zebrafish
nucleic acid metabolic process GO:0090304 244 0.387
Mouse Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.383
Zebrafish Mouse Fly
nitrogen compound metabolic process GO:0006807 319 0.371
Mouse Fly
cell surface receptor signaling pathway GO:0007166 325 0.347
Zebrafish Mouse Fly
regulation of rna metabolic process GO:0051252 224 0.343
Zebrafish Mouse Fly
embryonic organ morphogenesis GO:0048562 274 0.335
Zebrafish Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.315
Zebrafish Mouse Fly
transcription dna templated GO:0006351 181 0.313
Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.313
Zebrafish Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.311
Mouse Fly
rna metabolic process GO:0016070 219 0.305
Mouse Fly
macromolecule biosynthetic process GO:0009059 227 0.301
Mouse Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.298
Mouse Fly
angiogenesis GO:0001525 158 0.290
Mouse
regulation of transcription dna templated GO:0006355 213 0.287
Zebrafish Mouse Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.280
Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.277
Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.262
Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.260
Mouse Fly
developmental growth GO:0048589 166 0.243
Worm
regulation of gene expression GO:0010468 265 0.222
Zebrafish Mouse Fly
brain development GO:0007420 293 0.217
Zebrafish Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.201
Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.187
Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.185
Zebrafish Mouse Fly
cellular component movement GO:0006928 335 0.183
Zebrafish Fly
cell migration GO:0016477 237 0.181
Fly
multi organism reproductive process GO:0044703 36 0.178
Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.175
Zebrafish Mouse Fly
cell fate specification GO:0001708 68 0.168
positive regulation of biological process GO:0048518 253 0.164
Mouse Worm Fly
regulation of biosynthetic process GO:0009889 250 0.162
Zebrafish Mouse Fly
aging GO:0007568 2 0.161
response to chemical GO:0042221 320 0.155
Zebrafish Fly
regulation of developmental process GO:0050793 247 0.154
Zebrafish Mouse Worm Fly
specification of symmetry GO:0009799 204 0.143
Zebrafish Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.142
Zebrafish Mouse Worm
organic substance biosynthetic process GO:1901576 289 0.141
Mouse Fly
cell projection organization GO:0030030 284 0.140
Zebrafish Fly
diencephalon development GO:0021536 58 0.137
Zebrafish
negative regulation of gene expression GO:0010629 65 0.134
Fly
morphogenesis of an epithelium GO:0002009 333 0.133
Zebrafish Mouse Fly
connective tissue development GO:0061448 99 0.130
Zebrafish Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.129
Zebrafish Mouse Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.126
Zebrafish Mouse Fly
signal transduction GO:0007165 455 0.126
Zebrafish Mouse Fly
growth plate cartilage development GO:0003417 2 0.123
cell fate commitment GO:0045165 99 0.116
head development GO:0060322 303 0.114
Zebrafish Mouse Fly
regulation of response to stimulus GO:0048583 269 0.112
Zebrafish Mouse Fly
response to external biotic stimulus GO:0043207 97 0.112
negative regulation of multicellular organismal process GO:0051241 69 0.111
Mouse
regulation of signal transduction GO:0009966 225 0.110
Zebrafish Mouse Fly
response to external stimulus GO:0009605 264 0.110
Zebrafish
regulation of localization GO:0032879 104 0.109
Fly
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.109
Zebrafish Fly
nucleobase containing compound metabolic process GO:0006139 274 0.108
Mouse Fly
cardiac cell fate commitment GO:0060911 1 0.106
regulation of nucleic acid templated transcription GO:1903506 213 0.105
Zebrafish Mouse Fly
negative regulation of cellular metabolic process GO:0031324 77 0.104
Fly
negative regulation of rna metabolic process GO:0051253 48 0.102
divalent inorganic cation homeostasis GO:0072507 22 0.101
cartilage development GO:0051216 96 0.098
Zebrafish Mouse
positive regulation of signal transduction GO:0009967 56 0.098
Mouse Fly
muscle cell differentiation GO:0042692 139 0.095
cell differentiation in spinal cord GO:0021515 40 0.089
negative regulation of cellular process GO:0048523 283 0.088
Zebrafish Mouse Fly
muscle structure development GO:0061061 196 0.088
hematopoietic or lymphoid organ development GO:0048534 191 0.088
Mouse
notochord development GO:0030903 54 0.088
positive regulation of signaling GO:0023056 56 0.086
Mouse Fly
post embryonic morphogenesis GO:0009886 4 0.085
Zebrafish Fly
gene expression GO:0010467 252 0.085
Zebrafish Mouse Fly
cell adhesion GO:0007155 40 0.084
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.081
Mouse
gastrulation GO:0007369 208 0.081
vasculature development GO:0001944 278 0.081
Mouse
appendage development GO:0048736 80 0.080
Zebrafish
protein metabolic process GO:0019538 183 0.079
Mouse Fly
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.079
response to lipid GO:0033993 60 0.079
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.078
transcription from rna polymerase ii promoter GO:0006366 80 0.075
Mouse
hindbrain development GO:0030902 91 0.073
Zebrafish
endochondral bone growth GO:0003416 2 0.073
negative regulation of metabolic process GO:0009892 86 0.073
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.072
heterocycle metabolic process GO:0046483 290 0.071
Mouse Fly
determination of left right symmetry GO:0007368 179 0.071
Zebrafish Mouse
regulation of multicellular organism growth GO:0040014 4 0.069
Worm
cellular protein catabolic process GO:0044257 4 0.069
nucleic acid templated transcription GO:0097659 181 0.069
Mouse Fly
regulation of cell death GO:0010941 103 0.069
positive regulation of biosynthetic process GO:0009891 68 0.068
Mouse
ion homeostasis GO:0050801 41 0.068
negative regulation of cellular biosynthetic process GO:0031327 55 0.068
positive regulation of metabolic process GO:0009893 108 0.068
Mouse
wound healing GO:0042060 90 0.067
skeletal system morphogenesis GO:0048705 102 0.066
Zebrafish
negative regulation of macromolecule metabolic process GO:0010605 76 0.065
Fly
cellular response to endogenous stimulus GO:0071495 68 0.063
Fly
taxis GO:0042330 109 0.063
Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 130 0.063
Zebrafish
developmental growth involved in morphogenesis GO:0060560 86 0.062
regulation of blood pressure GO:0008217 1 0.062
central nervous system development GO:0007417 387 0.061
forebrain development GO:0030900 96 0.061
Zebrafish Fly
cell motility GO:0048870 244 0.060
Fly
neural tube patterning GO:0021532 33 0.060
convergent extension involved in organogenesis GO:0060029 10 0.059
regulation of signaling GO:0023051 235 0.059
Zebrafish Mouse Fly
chordate embryonic development GO:0043009 271 0.058
Zebrafish Mouse
tissue regeneration GO:0042246 74 0.054
digestive system development GO:0055123 289 0.054
Zebrafish Mouse Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.054
Zebrafish Mouse
regulation of cell differentiation GO:0045595 142 0.053
Mouse
regulation of cell communication GO:0010646 232 0.052
Zebrafish Mouse Fly
negative regulation of biosynthetic process GO:0009890 55 0.052
embryonic skeletal system morphogenesis GO:0048704 93 0.051
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.051
Zebrafish Mouse Worm Fly
calcium ion homeostasis GO:0055074 19 0.050
regulation of cytoplasmic transport GO:1903649 4 0.050
Fly
growth GO:0040007 174 0.049
Mouse Worm
response to organic substance GO:0010033 153 0.048
Zebrafish Fly
negative regulation of nucleic acid templated transcription GO:1903507 45 0.047
oligodendrocyte differentiation GO:0048709 23 0.047
rna biosynthetic process GO:0032774 181 0.047
Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.046
Zebrafish Mouse Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.046
programmed cell death GO:0012501 119 0.045
positive regulation of cellular biosynthetic process GO:0031328 68 0.045
Mouse
response to alkaloid GO:0043279 2 0.045
single organism transport GO:0044765 206 0.044
Fly
regulation of multicellular organismal development GO:2000026 223 0.043
Zebrafish Mouse Fly
negative regulation of cell death GO:0060548 60 0.043
odontogenesis of dentin containing tooth GO:0042475 1 0.042
regulation of neurological system process GO:0031644 2 0.042
negative regulation of rna biosynthetic process GO:1902679 45 0.042
homeostatic process GO:0042592 142 0.042
Zebrafish Mouse
protein import GO:0017038 3 0.041
Fly
positive regulation of cell adhesion GO:0045785 1 0.041
positive regulation of cell activation GO:0050867 1 0.041
Mouse
skeletal system development GO:0001501 181 0.040
Zebrafish Mouse
cell cell signaling GO:0007267 52 0.040
Fly
protein secretion GO:0009306 1 0.040
female sex differentiation GO:0046660 4 0.039
cellular component morphogenesis GO:0032989 336 0.039
Zebrafish Mouse Fly
response to steroid hormone GO:0048545 35 0.039
negative regulation of signal transduction GO:0009968 94 0.038
localization of cell GO:0051674 244 0.038
Fly
establishment of localization GO:0051234 244 0.038
Fly
response to organic cyclic compound GO:0014070 51 0.038
reproductive process GO:0022414 40 0.037
Mouse Fly
appendage morphogenesis GO:0035107 56 0.037
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 107 0.037
Mouse Fly
immune system development GO:0002520 191 0.037
Mouse
pancreatic a cell development GO:0003322 2 0.037
development of primary female sexual characteristics GO:0046545 4 0.036
chemical homeostasis GO:0048878 49 0.036
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.036
type b pancreatic cell development GO:0003323 4 0.036
positive regulation of stem cell proliferation GO:2000648 1 0.036
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.035
Mouse
neurological system process GO:0050877 62 0.035
positive regulation of response to stimulus GO:0048584 80 0.035
Mouse Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.034
cellular biosynthetic process GO:0044249 286 0.034
Mouse Fly
cell death GO:0008219 121 0.034
neuron differentiation GO:0030182 353 0.034
Zebrafish Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.034
Zebrafish Mouse Fly
determination of bilateral symmetry GO:0009855 204 0.033
Zebrafish Mouse
epithelial cell differentiation GO:0030855 116 0.033
Zebrafish Mouse
oxoacid metabolic process GO:0043436 31 0.033
positive regulation of rna metabolic process GO:0051254 59 0.033
Mouse
ubiquitin dependent protein catabolic process GO:0006511 3 0.032
extracellular structure organization GO:0043062 27 0.032
Mouse
generation of neurons GO:0048699 385 0.032
Zebrafish Mouse Fly
multicellular organism reproduction GO:0032504 35 0.031
Mouse Fly
positive regulation of developmental process GO:0051094 50 0.031
Mouse Worm
negative regulation of transcription dna templated GO:0045892 45 0.031
cell substrate adhesion GO:0031589 4 0.031
regulation of molecular function GO:0065009 70 0.031
Fly
leukocyte proliferation GO:0070661 1 0.031
Mouse
stem cell proliferation GO:0072089 4 0.030
Mouse
regulation of response to cytokine stimulus GO:0060759 3 0.030
positive regulation of cellular process GO:0048522 201 0.030
Mouse Fly
metal ion homeostasis GO:0055065 26 0.030
regulation of apoptotic process GO:0042981 98 0.030
regulation of biological quality GO:0065008 263 0.030
Zebrafish Mouse
cellular response to organic cyclic compound GO:0071407 38 0.030
blood circulation GO:0008015 87 0.029
Zebrafish
embryonic camera type eye formation GO:0060900 10 0.029
locomotion GO:0040011 313 0.029
Zebrafish Worm Fly
regionalization GO:0003002 274 0.029
Zebrafish Fly
cell morphogenesis GO:0000902 289 0.029
Zebrafish Mouse Fly
cation homeostasis GO:0055080 33 0.028
regulation of neurogenesis GO:0050767 87 0.028
otic placode formation GO:0043049 23 0.028
regulation of programmed cell death GO:0043067 101 0.028
specification of organ identity GO:0010092 2 0.028
pharyngeal muscle development GO:0043282 4 0.028
kidney development GO:0001822 92 0.028
Zebrafish
astrocyte differentiation GO:0048708 1 0.028
mesoderm development GO:0007498 88 0.028
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
gland development GO:0048732 143 0.027
Zebrafish
cellular ketone metabolic process GO:0042180 11 0.027
blood vessel morphogenesis GO:0048514 216 0.027
Mouse
death GO:0016265 121 0.027
embryonic cranial skeleton morphogenesis GO:0048701 90 0.027
Zebrafish
chemosensory behavior GO:0007635 1 0.027
single organism localization GO:1902578 225 0.027
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.027
embryonic skeletal system development GO:0048706 97 0.027
Zebrafish Mouse
reproduction GO:0000003 40 0.027
Mouse Worm Fly
response to wounding GO:0009611 116 0.027
protein modification process GO:0036211 100 0.027
Fly
regulation of organ morphogenesis GO:2000027 35 0.027
Zebrafish
positive regulation of cytokine production GO:0001819 2 0.026
cellular response to external stimulus GO:0071496 2 0.026
cell proliferation GO:0008283 80 0.026
Zebrafish Mouse
small molecule metabolic process GO:0044281 77 0.026
formation of primary germ layer GO:0001704 62 0.026
floor plate formation GO:0021508 12 0.026
Zebrafish
positive regulation of secretion GO:0051047 1 0.026
negative regulation of protein complex assembly GO:0031333 1 0.026
negative regulation of cell differentiation GO:0045596 46 0.025
Mouse
regeneration GO:0031099 91 0.025
cardioblast migration GO:0003260 7 0.025
macromolecule modification GO:0043412 111 0.025
Fly
negative regulation of mesodermal cell fate specification GO:0042662 3 0.024
rostrocaudal neural tube patterning GO:0021903 29 0.024
negative regulation of cell communication GO:0010648 96 0.024
positive regulation of transcription dna templated GO:0045893 57 0.024
Mouse
ameboidal type cell migration GO:0001667 143 0.024
Fly
single organism metabolic process GO:0044710 217 0.023
Mouse
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.023
system process GO:0003008 185 0.023
Zebrafish
positive regulation of cell communication GO:0010647 56 0.023
Mouse Fly
response to oxygen containing compound GO:1901700 55 0.023
adenohypophysis development GO:0021984 15 0.023
Zebrafish
cognition GO:0050890 1 0.023
maintenance of location GO:0051235 4 0.023
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.023
regulation of protein catabolic process GO:0042176 1 0.022
regulation of cell fate commitment GO:0010453 22 0.022
response to bacterium GO:0009617 58 0.022
eye morphogenesis GO:0048592 144 0.022
Zebrafish Mouse Fly
axon development GO:0061564 166 0.022
Zebrafish Fly
regulation of receptor activity GO:0010469 2 0.022
optic placode formation GO:0001743 4 0.021
organ formation GO:0048645 17 0.021
Fly
cartilage morphogenesis GO:0060536 13 0.021
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.021
t cell differentiation GO:0030217 6 0.021
Mouse
regulation of sequestering of calcium ion GO:0051282 4 0.021
regulation of embryonic development GO:0045995 47 0.021
Zebrafish
axon guidance GO:0007411 86 0.020
Zebrafish
bone remodeling GO:0046849 2 0.020
Mouse
positive regulation of transport GO:0051050 2 0.020
Fly
steroid biosynthetic process GO:0006694 5 0.020
cell migration involved in heart formation GO:0060974 10 0.020
ectodermal placode development GO:0071696 37 0.020
cellular component biogenesis GO:0044085 178 0.020
Mouse Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.020
cellular protein metabolic process GO:0044267 129 0.020
Fly
convergent extension GO:0060026 118 0.020
ectodermal placode formation GO:0060788 26 0.020
alcohol biosynthetic process GO:0046165 2 0.020
cardiac chamber formation GO:0003207 4 0.020
negative regulation of signaling GO:0023057 96 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
floor plate development GO:0033504 15 0.019
Zebrafish
hepaticobiliary system development GO:0061008 98 0.019
cellular protein modification process GO:0006464 100 0.019
Fly
sensory perception of pain GO:0019233 1 0.019
regulation of vasculature development GO:1901342 33 0.019
cytosolic calcium ion transport GO:0060401 3 0.019
regulation of cellular component organization GO:0051128 86 0.019
fin morphogenesis GO:0033334 53 0.019
Zebrafish
cellular divalent inorganic cation homeostasis GO:0072503 13 0.019
segment polarity determination GO:0007367 1 0.019
Fly
axial mesoderm formation GO:0048320 4 0.019
positive regulation of cell cycle GO:0045787 3 0.019
negative regulation of programmed cell death GO:0043069 58 0.019
regulation of cell proliferation GO:0042127 37 0.019
Zebrafish Mouse
heart development GO:0007507 313 0.018
Zebrafish Mouse Fly
mitotic cell cycle GO:0000278 64 0.018
Fly
glial cell fate specification GO:0021780 4 0.018
digestive tract development GO:0048565 265 0.018
Zebrafish Mouse Fly
ear development GO:0043583 127 0.018
Zebrafish
positive regulation of cell fate commitment GO:0010455 1 0.018
negative regulation of apoptotic process GO:0043066 55 0.018
optic placode formation involved in camera type eye formation GO:0046619 3 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
mesodermal cell migration GO:0008078 12 0.018
otic vesicle development GO:0071599 42 0.018
neuron fate specification GO:0048665 20 0.018
Zebrafish
negative regulation of blood circulation GO:1903523 2 0.018
developmental process involved in reproduction GO:0003006 27 0.018
Mouse Fly
regulation of endodermal cell fate specification GO:0042663 15 0.018
axonogenesis GO:0007409 152 0.017
Zebrafish Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
regulation of heart morphogenesis GO:2000826 17 0.017
Zebrafish
neuron projection extension GO:1990138 45 0.017
mesodermal cell fate commitment GO:0001710 14 0.017
positive regulation of gliogenesis GO:0014015 2 0.017
peripheral nervous system neuron differentiation GO:0048934 28 0.017
positive regulation of rna biosynthetic process GO:1902680 57 0.017
Mouse
lymphocyte proliferation GO:0046651 1 0.017
Mouse
mitotic cell cycle process GO:1903047 48 0.017
sequestering of calcium ion GO:0051208 3 0.017
gabaergic neuron differentiation GO:0097154 2 0.017
gliogenesis GO:0042063 45 0.017
response to drug GO:0042493 3 0.016
negative regulation of mesoderm development GO:2000381 5 0.016
female gonad development GO:0008585 4 0.016
inner ear development GO:0048839 126 0.016
Zebrafish
growth plate cartilage morphogenesis GO:0003422 1 0.016
muscle organ development GO:0007517 101 0.016
Zebrafish
macromolecule localization GO:0033036 54 0.016
Fly
heart morphogenesis GO:0003007 156 0.016
Zebrafish Mouse Fly
ion transport GO:0006811 114 0.016
endochondral bone morphogenesis GO:0060350 8 0.016
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.016
response to hexose GO:0009746 3 0.016
positive regulation of cell division GO:0051781 2 0.016
single organism behavior GO:0044708 24 0.016
otic vesicle morphogenesis GO:0071600 34 0.016
glial cell differentiation GO:0010001 42 0.015
response to nutrient GO:0007584 3 0.015
gall bladder development GO:0061010 1 0.015
small molecule biosynthetic process GO:0044283 16 0.015
sensory perception GO:0007600 39 0.015
gamete generation GO:0007276 33 0.015
Mouse Fly
cellular response to chemical stimulus GO:0070887 157 0.015
Zebrafish Fly
regulation of cell cycle GO:0051726 52 0.015
Fly
peptidyl serine modification GO:0018209 2 0.015
regulation of wnt signaling pathway GO:0030111 53 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.015
Mouse
regulation of cell activation GO:0050865 1 0.015
Mouse
biological adhesion GO:0022610 40 0.015
Mouse
positive regulation of secretion by cell GO:1903532 1 0.015
intracellular signal transduction GO:0035556 85 0.015
Fly
modification dependent macromolecule catabolic process GO:0043632 3 0.015
developmental programmed cell death GO:0010623 4 0.015
immune system process GO:0002376 241 0.015
Mouse
cardiac atrium morphogenesis GO:0003209 2 0.015
regulation of anterior head development GO:2000742 2 0.014
blood vessel development GO:0001568 246 0.014
Mouse
cellular amine metabolic process GO:0044106 2 0.014
liver development GO:0001889 96 0.014
developmental cell growth GO:0048588 52 0.014
nephron development GO:0072006 31 0.014
Zebrafish
multi organism process GO:0051704 134 0.014
Mouse Fly
organic acid metabolic process GO:0006082 31 0.014
phosphorus metabolic process GO:0006793 109 0.014
multicellular organismal homeostasis GO:0048871 29 0.014
Zebrafish Mouse
cellular component assembly GO:0022607 170 0.014
Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
sensory organ morphogenesis GO:0090596 200 0.014
Zebrafish Mouse Fly
sexual reproduction GO:0019953 36 0.014
Mouse Fly
cellular chemical homeostasis GO:0055082 17 0.014
amine metabolic process GO:0009308 2 0.014
regulation of protein metabolic process GO:0051246 56 0.014
Fly
posterior lateral line system development GO:0048915 46 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.014
swim bladder development GO:0048794 19 0.014
Zebrafish
chondrocyte development GO:0002063 4 0.014
behavior GO:0007610 74 0.014
specification of axis polarity GO:0065001 4 0.014
spinal cord anterior posterior patterning GO:0021512 1 0.014
positive regulation of neural precursor cell proliferation GO:2000179 1 0.014
dorsal ventral pattern formation GO:0009953 125 0.013
Zebrafish
embryonic digestive tract development GO:0048566 4 0.013
Zebrafish Mouse
cellular carbohydrate metabolic process GO:0044262 4 0.013
sensory perception of chemical stimulus GO:0007606 3 0.013
protein targeting to nucleus GO:0044744 3 0.013
Fly
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.013
bmp signaling pathway GO:0030509 52 0.013
Zebrafish
neurotransmitter transport GO:0006836 2 0.013
heart formation GO:0060914 13 0.013
Fly
monoamine transport GO:0015844 1 0.013
response to nicotine GO:0035094 2 0.013
embryonic digestive tract morphogenesis GO:0048557 3 0.013
Zebrafish Mouse
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.013
morphogenesis of embryonic epithelium GO:0016331 30 0.013
Zebrafish
carbohydrate biosynthetic process GO:0016051 1 0.012
atrioventricular valve formation GO:0003190 3 0.012
positive regulation of nucleic acid templated transcription GO:1903508 57 0.012
Mouse
wnt signaling pathway GO:0016055 80 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
cellular response to hormone stimulus GO:0032870 39 0.012
synaptic transmission GO:0007268 35 0.012
modification dependent protein catabolic process GO:0019941 3 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
foregut morphogenesis GO:0007440 4 0.012
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.012
Mouse Fly
somite development GO:0061053 96 0.012
Zebrafish Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.012
Mouse
cell part morphogenesis GO:0032990 246 0.012
Zebrafish Fly
positive regulation of gene expression GO:0010628 71 0.012
Mouse
cellular homeostasis GO:0019725 26 0.012
limbic system development GO:0021761 16 0.012
glucose homeostasis GO:0042593 1 0.012
embryonic heart tube development GO:0035050 133 0.012
Zebrafish Mouse
muscle tissue development GO:0060537 110 0.012
Zebrafish Mouse
regulation of binding GO:0051098 3 0.012
response to decreased oxygen levels GO:0036293 25 0.012
response to endogenous stimulus GO:0009719 83 0.012
Fly
circulatory system process GO:0003013 87 0.012
Zebrafish
response to abiotic stimulus GO:0009628 122 0.012
regulation of reproductive process GO:2000241 4 0.012
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.011
optomotor response GO:0071632 1 0.011
cellular calcium ion homeostasis GO:0006874 13 0.011
response to hypoxia GO:0001666 25 0.011
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.011
single organism nuclear import GO:1902593 3 0.011
Fly
stem cell development GO:0048864 82 0.011
exocytosis GO:0006887 1 0.011
nuclear transport GO:0051169 4 0.011
Fly
cell projection morphogenesis GO:0048858 244 0.011
Zebrafish Fly
digestive tract morphogenesis GO:0048546 231 0.011
Zebrafish Mouse Fly
cellular cation homeostasis GO:0030003 17 0.011
cellular ion homeostasis GO:0006873 17 0.011
axial mesodermal cell fate specification GO:0048327 3 0.011
chromatin modification GO:0016568 21 0.011
notochord morphogenesis GO:0048570 17 0.011
organ growth GO:0035265 12 0.011
sensory organ development GO:0007423 393 0.011
Zebrafish Mouse Fly
cellular localization GO:0051641 97 0.011
Fly
myotube cell development GO:0014904 35 0.011
Zebrafish
negative regulation of sequestering of calcium ion GO:0051283 4 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
skeletal muscle organ development GO:0060538 78 0.011
Zebrafish
single organism organelle organization GO:1902589 199 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
regulation of glial cell differentiation GO:0045685 4 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
Mouse
heart looping GO:0001947 94 0.011
Zebrafish Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.011
response to light stimulus GO:0009416 46 0.010
fin development GO:0033333 77 0.010
Zebrafish
mechanoreceptor differentiation GO:0042490 37 0.010
calcium ion transport GO:0006816 18 0.010
vasculogenesis GO:0001570 41 0.010
regulation of angiogenesis GO:0045765 26 0.010
heart process GO:0003015 71 0.010
enteroendocrine cell differentiation GO:0035883 9 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
morphogenesis of an epithelial sheet GO:0002011 49 0.010
peptide transport GO:0015833 1 0.010
mesoderm morphogenesis GO:0048332 51 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
negative regulation of cell fate specification GO:0009996 11 0.010
organic substance transport GO:0071702 58 0.010
Fly
response to fibroblast growth factor GO:0071774 22 0.010
Fly
regulation of cytokine mediated signaling pathway GO:0001959 3 0.010

ihhb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.079
bone disease DOID:0080001 0 0.079
disease of anatomical entity DOID:7 0 0.079
musculoskeletal system disease DOID:17 0 0.079
connective tissue disease DOID:65 0 0.079
nervous system disease DOID:863 0 0.040
osteochondrodysplasia DOID:2256 0 0.020