Danio rerio

9 known processes

ik

IK cytokine

(Aliases: zgc:56500,wu:fb54c03)

ik biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic nuclear division GO:0007126 4 0.240
larval development GO:0002164 2 0.229
Worm
organelle organization GO:0006996 227 0.196
regulation of meiotic cell cycle GO:0051445 1 0.190
regulation of primary metabolic process GO:0080090 311 0.169
Worm
regulation of cellular biosynthetic process GO:0031326 245 0.162
ubiquitin dependent protein catabolic process GO:0006511 3 0.160
proteasomal protein catabolic process GO:0010498 2 0.159
negative regulation of protein phosphorylation GO:0001933 4 0.150
small molecule metabolic process GO:0044281 77 0.119
cellular macromolecule metabolic process GO:0044260 391 0.111
Worm
negative regulation of kinase activity GO:0033673 4 0.110
negative regulation of protein kinase activity GO:0006469 4 0.110
cellular nitrogen compound metabolic process GO:0034641 290 0.106
Worm
heterocycle metabolic process GO:0046483 290 0.106
Worm
single organism metabolic process GO:0044710 217 0.097
Worm
gene expression GO:0010467 252 0.097
Worm
regulation of metabolic process GO:0019222 359 0.096
Worm
positive regulation of metabolic process GO:0009893 108 0.090
meiotic chromosome segregation GO:0045132 3 0.090
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.087
regulation of epithelial cell proliferation GO:0050678 3 0.086
cell motility GO:0048870 244 0.084
dna templated transcription initiation GO:0006352 1 0.081
nucleic acid metabolic process GO:0090304 244 0.080
Worm
negative regulation of biological process GO:0048519 304 0.079
negative regulation of cellular process GO:0048523 283 0.079
cellular nitrogen compound biosynthetic process GO:0044271 218 0.078
organonitrogen compound metabolic process GO:1901564 74 0.078
cellular component movement GO:0006928 335 0.076
modification dependent macromolecule catabolic process GO:0043632 3 0.076
amine metabolic process GO:0009308 2 0.075
negative regulation of metabolic process GO:0009892 86 0.075
cellular amine metabolic process GO:0044106 2 0.074
modification dependent protein catabolic process GO:0019941 3 0.072
regulation of molecular function GO:0065009 70 0.071
regulation of cellular amine metabolic process GO:0033238 0 0.069
cell projection morphogenesis GO:0048858 244 0.068
single organism organelle organization GO:1902589 199 0.067
regulation of cellular amino acid metabolic process GO:0006521 0 0.066
regulation of macromolecule metabolic process GO:0060255 317 0.066
Worm
biosynthetic process GO:0009058 294 0.065
regulation of binding GO:0051098 3 0.065
cellular amino acid metabolic process GO:0006520 7 0.063
embryo development ending in birth or egg hatching GO:0009792 271 0.063
Worm
chromosome organization GO:0051276 31 0.062
stem cell division GO:0017145 1 0.062
maintenance of location GO:0051235 4 0.062
Worm
meiotic cell cycle process GO:1903046 3 0.062
regulation of cellular ketone metabolic process GO:0010565 7 0.061
regulation of cell cycle GO:0051726 52 0.061
stem cell proliferation GO:0072089 4 0.061
localization of cell GO:0051674 244 0.060
positive regulation of cellular process GO:0048522 201 0.060
cell migration GO:0016477 237 0.059
multicellular organism growth GO:0035264 4 0.058
regulation of rna metabolic process GO:0051252 224 0.058
Worm
cellular ketone metabolic process GO:0042180 11 0.057
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.057
organic cyclic compound metabolic process GO:1901360 301 0.056
Worm
neuroblast proliferation GO:0007405 2 0.055
positive regulation of rna biosynthetic process GO:1902680 57 0.053
regulation of cellular metabolic process GO:0031323 320 0.053
Worm
rna metabolic process GO:0016070 219 0.053
Worm
cellular biosynthetic process GO:0044249 286 0.052
heterocycle biosynthetic process GO:0018130 215 0.052
cellular protein modification process GO:0006464 100 0.051
positive regulation of macromolecule metabolic process GO:0010604 93 0.049
immune system development GO:0002520 191 0.048
cellular response to chemical stimulus GO:0070887 157 0.047
regulation of rna biosynthetic process GO:2001141 213 0.047
negative regulation of molecular function GO:0044092 23 0.047
response to chemical GO:0042221 320 0.047
generation of neurons GO:0048699 385 0.047
Worm
cell part morphogenesis GO:0032990 246 0.046
protein metabolic process GO:0019538 183 0.045
organic acid metabolic process GO:0006082 31 0.045
organic cyclic compound biosynthetic process GO:1901362 223 0.044
response to stress GO:0006950 263 0.044
fertilization GO:0009566 3 0.044
negative regulation of macromolecule metabolic process GO:0010605 76 0.043
regulation of gene expression GO:0010468 265 0.043
Worm
lipid storage GO:0019915 1 0.042
Worm
cellular component morphogenesis GO:0032989 336 0.042
hematopoietic or lymphoid organ development GO:0048534 191 0.042
cell morphogenesis GO:0000902 289 0.042
mitotic cell cycle GO:0000278 64 0.040
organelle localization GO:0051640 49 0.040
regulation of cell proliferation GO:0042127 37 0.040
nucleobase containing compound metabolic process GO:0006139 274 0.040
Worm
negative regulation of gene expression GO:0010629 65 0.039
cytokinesis GO:0000910 3 0.039
cellular protein catabolic process GO:0044257 4 0.038
carboxylic acid metabolic process GO:0019752 22 0.038
hepaticobiliary system development GO:0061008 98 0.038
cellular aromatic compound metabolic process GO:0006725 295 0.038
Worm
immune system process GO:0002376 241 0.038
histone modification GO:0016570 20 0.037
gland development GO:0048732 143 0.037
rna biosynthetic process GO:0032774 181 0.037
positive regulation of transport GO:0051050 2 0.037
neuron development GO:0048666 262 0.036
Worm
cell cycle GO:0007049 93 0.036
transport GO:0006810 220 0.036
regulation of multicellular organism growth GO:0040014 4 0.036
chromatin modification GO:0016568 21 0.036
oxoacid metabolic process GO:0043436 31 0.035
regulation of protein ubiquitination GO:0031396 3 0.035
aromatic compound biosynthetic process GO:0019438 217 0.035
nucleobase containing compound biosynthetic process GO:0034654 205 0.034
establishment of localization GO:0051234 244 0.034
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.033
hemopoiesis GO:0030097 183 0.033
positive regulation of biological process GO:0048518 253 0.033
negative regulation of histone modification GO:0031057 1 0.032
positive regulation of cell cycle GO:0045787 3 0.032
regulation of neural precursor cell proliferation GO:2000177 3 0.031
regulation of establishment of protein localization GO:0070201 4 0.030
aging GO:0007568 2 0.030
transcription dna templated GO:0006351 181 0.030
macromolecule modification GO:0043412 111 0.030
single organism reproductive process GO:0044702 40 0.030
nitrogen compound metabolic process GO:0006807 319 0.030
Worm
negative regulation of cellular biosynthetic process GO:0031327 55 0.030
positive regulation of myeloid cell differentiation GO:0045639 2 0.029
macromolecule biosynthetic process GO:0009059 227 0.029
locomotion GO:0040011 313 0.029
Worm
macromolecular complex subunit organization GO:0043933 74 0.029
nucleocytoplasmic transport GO:0006913 4 0.029
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.029
Worm
ribonucleoside monophosphate catabolic process GO:0009158 4 0.028
phosphate containing compound metabolic process GO:0006796 108 0.028
autophagy GO:0006914 4 0.028
negative regulation of catalytic activity GO:0043086 21 0.028
regulation of biosynthetic process GO:0009889 250 0.028
regulation of apoptotic process GO:0042981 98 0.028
protein polymerization GO:0051258 4 0.028
phosphorus metabolic process GO:0006793 109 0.028
cognition GO:0050890 1 0.027
regulation of nucleic acid templated transcription GO:1903506 213 0.027
cellular localization GO:0051641 97 0.027
regulation of multicellular organismal development GO:2000026 223 0.027
digestive system development GO:0055123 289 0.027
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.027
signal transduction GO:0007165 455 0.027
regulation of multicellular organismal process GO:0051239 277 0.027
regulation of catalytic activity GO:0050790 55 0.027
cellular macromolecule biosynthetic process GO:0034645 224 0.026
organic substance biosynthetic process GO:1901576 289 0.026
response to external stimulus GO:0009605 264 0.026
Worm
behavior GO:0007610 74 0.026
Worm
regulation of nucleocytoplasmic transport GO:0046822 2 0.026
single fertilization GO:0007338 3 0.026
cell proliferation GO:0008283 80 0.026
nucleoside monophosphate catabolic process GO:0009125 4 0.026
protein modification process GO:0036211 100 0.025
cell projection organization GO:0030030 284 0.025
homeostatic process GO:0042592 142 0.024
positive regulation of cell activation GO:0050867 1 0.024
positive regulation of multicellular organismal process GO:0051240 52 0.024
regulation of reproductive process GO:2000241 4 0.024
positive regulation of protein complex assembly GO:0031334 2 0.024
cell surface receptor signaling pathway GO:0007166 325 0.024
microtubule based process GO:0007017 60 0.024
neuron projection morphogenesis GO:0048812 161 0.024
regulation of signaling GO:0023051 235 0.023
regulation of transcription dna templated GO:0006355 213 0.023
establishment or maintenance of cell polarity GO:0007163 29 0.023
protein localization to nucleus GO:0034504 3 0.023
regulation of biological quality GO:0065008 263 0.023
Worm
cellular response to endogenous stimulus GO:0071495 68 0.023
central nervous system development GO:0007417 387 0.023
cellular protein metabolic process GO:0044267 129 0.023
positive regulation of catabolic process GO:0009896 4 0.023
protein localization to plasma membrane GO:0072659 1 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
Worm
protein acetylation GO:0006473 2 0.022
cilium morphogenesis GO:0060271 85 0.022
cellular component biogenesis GO:0044085 178 0.022
heart development GO:0007507 313 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
urogenital system development GO:0001655 97 0.022
negative regulation of epithelial cell proliferation GO:0050680 1 0.022
reproduction GO:0000003 40 0.022
nuclear transport GO:0051169 4 0.022
cellular response to radiation GO:0071478 4 0.021
atp catabolic process GO:0006200 4 0.021
response to abiotic stimulus GO:0009628 122 0.021
Worm
covalent chromatin modification GO:0016569 20 0.021
positive regulation of gene expression GO:0010628 71 0.021
nucleic acid templated transcription GO:0097659 181 0.021
single organism nuclear import GO:1902593 3 0.021
regulation of protein catabolic process GO:0042176 1 0.021
regulation of organ growth GO:0046620 3 0.020
cellular response to external stimulus GO:0071496 2 0.020
spermatid differentiation GO:0048515 2 0.020
internal protein amino acid acetylation GO:0006475 2 0.020
nuclear migration GO:0007097 3 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
system process GO:0003008 185 0.020
response to organic substance GO:0010033 153 0.020
phosphorylation GO:0016310 69 0.020
regulation of cellular protein metabolic process GO:0032268 52 0.020
internal peptidyl lysine acetylation GO:0018393 2 0.020
regionalization GO:0003002 274 0.020
developmental process involved in reproduction GO:0003006 27 0.019
myeloid cell differentiation GO:0030099 86 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
peptidyl lysine acetylation GO:0018394 2 0.019
multi organism process GO:0051704 134 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
response to oxygen containing compound GO:1901700 55 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.018
chordate embryonic development GO:0043009 271 0.018
response to endogenous stimulus GO:0009719 83 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
establishment of organelle localization GO:0051656 45 0.018
regulation of cell shape GO:0008360 1 0.018
regulation of cell activation GO:0050865 1 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.018
cellular carbohydrate metabolic process GO:0044262 4 0.018
positive regulation of cellular biosynthetic process GO:0031328 68 0.018
regulation of circadian rhythm GO:0042752 4 0.018
response to uv GO:0009411 3 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
positive regulation of transcription dna templated GO:0045893 57 0.018
protein dephosphorylation GO:0006470 3 0.018
regulation of protein transport GO:0051223 3 0.018
regulation of cellular component organization GO:0051128 86 0.018
organelle assembly GO:0070925 110 0.017
chromatin organization GO:0006325 22 0.017
response to bacterium GO:0009617 58 0.017
response to drug GO:0042493 3 0.017
gastrulation GO:0007369 208 0.017
regulation of cell differentiation GO:0045595 142 0.017
response to hormone GO:0009725 48 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
regulation of protein complex assembly GO:0043254 3 0.017
cell cycle process GO:0022402 53 0.017
regulation of developmental process GO:0050793 247 0.017
regulation of response to stimulus GO:0048583 269 0.016
regulation of mitotic cell cycle GO:0007346 25 0.016
regulation of cell communication GO:0010646 232 0.016
rna localization GO:0006403 4 0.016
dna templated transcription elongation GO:0006354 3 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
cellular response to organic substance GO:0071310 105 0.016
intracellular signal transduction GO:0035556 85 0.016
hormone secretion GO:0046879 2 0.016
multicellular organism reproduction GO:0032504 35 0.016
sleep GO:0030431 1 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
pronuclear migration GO:0035046 1 0.016
neuromuscular synaptic transmission GO:0007274 2 0.016
digestive tract development GO:0048565 265 0.016
regulation of synaptic plasticity GO:0048167 1 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
spermatid development GO:0007286 2 0.015
embryonic organ morphogenesis GO:0048562 274 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.015
cytokinetic process GO:0032506 2 0.015
chromosome organization involved in meiosis GO:0070192 1 0.015
membrane fusion GO:0061025 2 0.015
hormone transport GO:0009914 2 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.015
growth GO:0040007 174 0.015
cellular response to nutrient levels GO:0031669 2 0.015
neurotransmitter transport GO:0006836 2 0.015
response to radiation GO:0009314 51 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
positive regulation of nucleic acid templated transcription GO:1903508 57 0.015
negative regulation of rna metabolic process GO:0051253 48 0.015
negative regulation of rna biosynthetic process GO:1902679 45 0.015
nuclear import GO:0051170 3 0.015
negative regulation of synapse assembly GO:0051964 2 0.014
female gonad development GO:0008585 4 0.014
protein phosphorylation GO:0006468 47 0.014
regulation of inflammatory response GO:0050727 2 0.014
proteolysis GO:0006508 38 0.014
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.014
regulation of protein binding GO:0043393 3 0.014
microtubule cytoskeleton organization GO:0000226 33 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
negative regulation of transcription dna templated GO:0045892 45 0.014
protein acylation GO:0043543 3 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
germ cell development GO:0007281 22 0.014
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
liver development GO:0001889 96 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
reproductive process GO:0022414 40 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
neuron differentiation GO:0030182 353 0.014
Worm
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
regulation of tube size GO:0035150 2 0.014
positive regulation of leukocyte differentiation GO:1902107 1 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
embryonic organ development GO:0048568 381 0.014
stem cell differentiation GO:0048863 117 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.013
epithelial cell differentiation GO:0030855 116 0.013
golgi vesicle transport GO:0048193 3 0.013
cellular response to biotic stimulus GO:0071216 3 0.013
cytoskeleton organization GO:0007010 96 0.013
positive regulation of blood circulation GO:1903524 2 0.013
inositol lipid mediated signaling GO:0048017 2 0.013
protein stabilization GO:0050821 2 0.013
neurotransmitter secretion GO:0007269 2 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
glucose homeostasis GO:0042593 1 0.013
regulation of cytokine production GO:0001817 3 0.013
protein import GO:0017038 3 0.013
negative regulation of map kinase activity GO:0043407 2 0.013
regulation of signal transduction GO:0009966 225 0.013
chemosensory behavior GO:0007635 1 0.013
phagocytosis GO:0006909 3 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
cellular component disassembly GO:0022411 1 0.013
synaptic vesicle localization GO:0097479 1 0.012
peptidyl threonine phosphorylation GO:0018107 1 0.012
regulation of autophagy GO:0010506 3 0.012
single organism membrane fusion GO:0044801 2 0.012
regulation of cell migration GO:0030334 40 0.012
female sex differentiation GO:0046660 4 0.012
response to hydrogen peroxide GO:0042542 3 0.012
regulation of cell motility GO:2000145 46 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
negative regulation of protein transport GO:0051224 3 0.012
mesenchyme development GO:0060485 127 0.012
peptide transport GO:0015833 1 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
positive regulation of secretion GO:0051047 1 0.012
muscle structure development GO:0061061 196 0.012
Worm
cytoplasm organization GO:0007028 4 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
locomotor rhythm GO:0045475 3 0.012
regulation of protein polymerization GO:0032271 2 0.012
regulation of protein targeting GO:1903533 2 0.012
regulation of blood vessel size GO:0050880 2 0.012
death GO:0016265 121 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
cellular response to light stimulus GO:0071482 4 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
regulation of immune system process GO:0002682 34 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
response to glucose GO:0009749 3 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
nuclear division GO:0000280 23 0.011
regulation of localization GO:0032879 104 0.011
cell fate commitment GO:0045165 99 0.011
multicellular organismal reproductive process GO:0048609 35 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
establishment of mitotic spindle orientation GO:0000132 10 0.011
single organism membrane organization GO:0044802 20 0.011
negative regulation of signal transduction GO:0009968 94 0.011
regulation of locomotion GO:0040012 55 0.011
negative regulation of signaling GO:0023057 96 0.011
mitotic cell cycle process GO:1903047 48 0.011
regulation of synapse organization GO:0050807 3 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
positive regulation of signaling GO:0023056 56 0.011
anterior posterior pattern specification GO:0009952 152 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
macromolecular complex disassembly GO:0032984 1 0.011
regulation of hormone secretion GO:0046883 2 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
endocrine process GO:0050886 2 0.011
protein import into nucleus GO:0006606 3 0.011
negative regulation of nucleic acid templated transcription GO:1903507 45 0.011
adult behavior GO:0030534 2 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
regulation of cellular component movement GO:0051270 55 0.011
regulation of organelle organization GO:0033043 29 0.010
positive regulation of biosynthetic process GO:0009891 68 0.010
centrosome organization GO:0051297 1 0.010
immune response GO:0006955 28 0.010
response to topologically incorrect protein GO:0035966 2 0.010
regulation of metal ion transport GO:0010959 4 0.010
cell division GO:0051301 20 0.010
organism emergence from protective structure GO:0071684 4 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.010
regulation of response to biotic stimulus GO:0002831 2 0.010
establishment of cell polarity GO:0030010 18 0.010
positive regulation of rna metabolic process GO:0051254 59 0.010
ameboidal type cell migration GO:0001667 143 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
regulation of protein modification process GO:0031399 29 0.010
positive regulation of apoptotic process GO:0043065 29 0.010
pole plasm assembly GO:0007315 4 0.010

ik disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.016