Danio rerio

38 known processes

irf8

interferon regulatory factor 8

(Aliases: zgc:92252)

irf8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of inflammatory response GO:0050729 1 0.224
central nervous system development GO:0007417 387 0.177
aging GO:0007568 2 0.149
response to stress GO:0006950 263 0.137
response to external stimulus GO:0009605 264 0.137
regulation of cellular extravasation GO:0002691 1 0.110
multicellular organismal metabolic process GO:0044236 2 0.103
larval development GO:0002164 2 0.103
sleep GO:0030431 1 0.082
homeostatic process GO:0042592 142 0.079
locomotion GO:0040011 313 0.079
regulation of inflammatory response GO:0050727 2 0.077
regulation of erythrocyte differentiation GO:0045646 2 0.073
regulation of multicellular organismal process GO:0051239 277 0.072
immune system process GO:0002376 241 0.071
female sex differentiation GO:0046660 4 0.068
transmembrane transport GO:0055085 120 0.067
homeostasis of number of cells GO:0048872 62 0.066
regulation of cell activation GO:0050865 1 0.063
regulation of apoptotic process GO:0042981 98 0.061
signal transduction GO:0007165 455 0.061
hematopoietic or lymphoid organ development GO:0048534 191 0.059
negative regulation of leukocyte differentiation GO:1902106 1 0.058
tube morphogenesis GO:0035239 349 0.056
regulation of protein catabolic process GO:0042176 1 0.055
regulation of biological quality GO:0065008 263 0.054
female gonad development GO:0008585 4 0.054
hemopoiesis GO:0030097 183 0.054
immune system development GO:0002520 191 0.053
fin development GO:0033333 77 0.053
response to alkaloid GO:0043279 2 0.052
development of primary female sexual characteristics GO:0046545 4 0.051
regulation of multicellular organism growth GO:0040014 4 0.050
taxis GO:0042330 109 0.050
regulation of developmental process GO:0050793 247 0.049
negative regulation of biological process GO:0048519 304 0.048
head development GO:0060322 303 0.047
g protein coupled receptor signaling pathway GO:0007186 74 0.047
regulation of bone remodeling GO:0046850 2 0.047
vasculature development GO:0001944 278 0.046
multicellular organism growth GO:0035264 4 0.045
regulation of circadian sleep wake cycle GO:0042749 1 0.045
negative regulation of cellular process GO:0048523 283 0.045
negative regulation of myeloid cell differentiation GO:0045638 1 0.045
phagocytosis GO:0006909 3 0.044
regulation of cell differentiation GO:0045595 142 0.043
regulation of mrna splicing via spliceosome GO:0048024 3 0.042
erythrocyte homeostasis GO:0034101 55 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.042
myeloid leukocyte differentiation GO:0002573 15 0.041
response to chemical GO:0042221 320 0.041
regulation of mrna processing GO:0050684 3 0.041
regulation of chronic inflammatory response GO:0002676 1 0.040
positive regulation of catabolic process GO:0009896 4 0.039
cellular amide metabolic process GO:0043603 4 0.039
cell surface receptor signaling pathway GO:0007166 325 0.039
positive regulation of map kinase activity GO:0043406 3 0.038
embryonic heart tube development GO:0035050 133 0.038
cell aging GO:0007569 2 0.038
embryonic organ development GO:0048568 381 0.038
stem cell maintenance GO:0019827 4 0.038
circadian sleep wake cycle GO:0042745 2 0.037
sensory organ development GO:0007423 393 0.036
regulation of metabolic process GO:0019222 359 0.036
eye development GO:0001654 277 0.035
cell migration GO:0016477 237 0.035
cellular response to external stimulus GO:0071496 2 0.034
epithelial tube morphogenesis GO:0060562 148 0.034
nuclear transport GO:0051169 4 0.034
positive regulation of cell activation GO:0050867 1 0.033
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.033
response to nutrient GO:0007584 3 0.032
nuclear export GO:0051168 1 0.032
regulation of primary metabolic process GO:0080090 311 0.032
regulation of programmed cell death GO:0043067 101 0.031
nucleocytoplasmic transport GO:0006913 4 0.031
digestive tract morphogenesis GO:0048546 231 0.031
neuron development GO:0048666 262 0.031
regulation of metal ion transport GO:0010959 4 0.030
centrosome organization GO:0051297 1 0.030
response to amine GO:0014075 1 0.030
regulation of tube size GO:0035150 2 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
regulation of cellular component movement GO:0051270 55 0.029
programmed cell death GO:0012501 119 0.029
tissue remodeling GO:0048771 4 0.029
leukocyte differentiation GO:0002521 25 0.028
positive regulation of cytokine production GO:0001819 2 0.028
regulation of response to stimulus GO:0048583 269 0.028
cell morphogenesis GO:0000902 289 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
regulation of myeloid leukocyte differentiation GO:0002761 5 0.028
nucleic acid templated transcription GO:0097659 181 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
brain development GO:0007420 293 0.027
cellular protein catabolic process GO:0044257 4 0.027
amine metabolic process GO:0009308 2 0.027
gene expression GO:0010467 252 0.027
cellular response to nutrient levels GO:0031669 2 0.027
negative regulation of gene expression GO:0010629 65 0.027
transport GO:0006810 220 0.026
chemotaxis GO:0006935 104 0.026
response to organic substance GO:0010033 153 0.026
cellular component movement GO:0006928 335 0.026
neuron differentiation GO:0030182 353 0.025
cellular response to starvation GO:0009267 1 0.025
homeostasis of number of cells within a tissue GO:0048873 4 0.025
cell motility GO:0048870 244 0.025
proteolysis GO:0006508 38 0.025
regulation of blood vessel size GO:0050880 2 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
membrane hyperpolarization GO:0060081 1 0.025
myeloid leukocyte migration GO:0097529 12 0.025
negative regulation of protein kinase activity GO:0006469 4 0.024
digestive system development GO:0055123 289 0.024
organic acid metabolic process GO:0006082 31 0.024
response to endogenous stimulus GO:0009719 83 0.024
eye morphogenesis GO:0048592 144 0.024
mitochondrion organization GO:0007005 4 0.024
retina development in camera type eye GO:0060041 146 0.024
regulation of cell shape GO:0008360 1 0.024
smooth muscle contraction GO:0006939 2 0.023
lateral line system development GO:0048925 76 0.023
monocyte differentiation GO:0030224 2 0.023
regulation of transcription dna templated GO:0006355 213 0.023
generation of neurons GO:0048699 385 0.023
regulation of cell development GO:0060284 100 0.023
myeloid cell development GO:0061515 32 0.022
myeloid cell differentiation GO:0030099 86 0.022
internal peptidyl lysine acetylation GO:0018393 2 0.022
blood vessel development GO:0001568 246 0.022
cellular component morphogenesis GO:0032989 336 0.022
cellular macromolecule metabolic process GO:0044260 391 0.022
positive regulation of translation GO:0045727 1 0.022
protein acetylation GO:0006473 2 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
antimicrobial humoral response GO:0019730 2 0.022
regulation of cell death GO:0010941 103 0.022
circadian sleep wake cycle sleep GO:0050802 1 0.021
heart development GO:0007507 313 0.021
neuron neuron synaptic transmission GO:0007270 1 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
regulation of rna metabolic process GO:0051252 224 0.021
protein targeting to nucleus GO:0044744 3 0.021
bone remodeling GO:0046849 2 0.021
regulation of cytokine production GO:0001817 3 0.021
hepaticobiliary system development GO:0061008 98 0.021
collagen metabolic process GO:0032963 2 0.021
nucleobase containing compound biosynthetic process GO:0034654 205 0.021
cell projection organization GO:0030030 284 0.021
regulation of cell motility GO:2000145 46 0.020
regulation of transmembrane transporter activity GO:0022898 2 0.020
one carbon compound transport GO:0019755 14 0.020
angiogenesis GO:0001525 158 0.020
internal protein amino acid acetylation GO:0006475 2 0.020
stem cell development GO:0048864 82 0.020
compound eye development GO:0048749 2 0.020
neuron projection development GO:0031175 180 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
regulation of biosynthetic process GO:0009889 250 0.020
camera type eye development GO:0043010 222 0.020
response to oxygen containing compound GO:1901700 55 0.020
single organism transport GO:0044765 206 0.020
sensory system development GO:0048880 76 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
regulation of circadian rhythm GO:0042752 4 0.020
macrophage differentiation GO:0030225 7 0.019
regulation of protein transport GO:0051223 3 0.019
response to drug GO:0042493 3 0.019
negative regulation of defense response GO:0031348 2 0.019
cell cycle g2 m phase transition GO:0044839 4 0.019
sprouting angiogenesis GO:0002040 53 0.019
microtubule organizing center organization GO:0031023 1 0.019
regulation of rna biosynthetic process GO:2001141 213 0.019
regulation of synapse assembly GO:0051963 3 0.019
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.019
establishment of localization GO:0051234 244 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
adherens junction organization GO:0034332 4 0.018
single organism localization GO:1902578 225 0.018
regulation of leukocyte migration GO:0002685 8 0.018
response to lipid GO:0033993 60 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
nucleic acid metabolic process GO:0090304 244 0.018
regulation of gene expression GO:0010468 265 0.018
maintenance of location GO:0051235 4 0.018
rna localization GO:0006403 4 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
positive regulation of response to external stimulus GO:0032103 9 0.018
leukocyte chemotaxis GO:0030595 12 0.018
protein acylation GO:0043543 3 0.018
cell death GO:0008219 121 0.018
phosphatidylinositol mediated signaling GO:0048015 2 0.018
regulation of erk1 and erk2 cascade GO:0070372 4 0.018
response to inorganic substance GO:0010035 38 0.017
protein secretion GO:0009306 1 0.017
regulation of transporter activity GO:0032409 2 0.017
regulation of binding GO:0051098 3 0.017
hindbrain development GO:0030902 91 0.017
sensory organ morphogenesis GO:0090596 200 0.017
ion transport GO:0006811 114 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
protein import into nucleus GO:0006606 3 0.017
regulation of cell communication GO:0010646 232 0.017
regulation of signal transduction GO:0009966 225 0.017
response to wounding GO:0009611 116 0.017
positive regulation of cell adhesion GO:0045785 1 0.017
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
response to glucocorticoid GO:0051384 1 0.017
death GO:0016265 121 0.017
b cell activation GO:0042113 2 0.017
cellular extravasation GO:0045123 1 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.017
response to food GO:0032094 1 0.017
pectoral fin development GO:0033339 50 0.016
regulation of locomotion GO:0040012 55 0.016
embryonic skeletal system morphogenesis GO:0048704 93 0.016
circadian sleep wake cycle process GO:0022410 2 0.016
response to vitamin GO:0033273 3 0.016
monoamine transport GO:0015844 1 0.016
phagocytosis engulfment GO:0006911 1 0.016
regulation of postsynaptic membrane potential GO:0060078 1 0.016
cellular response to organic substance GO:0071310 105 0.016
organelle organization GO:0006996 227 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
myeloid cell homeostasis GO:0002262 56 0.016
regulation of blood pressure GO:0008217 1 0.016
lymph vessel morphogenesis GO:0036303 25 0.016
regulation of synaptic plasticity GO:0048167 1 0.016
liver development GO:0001889 96 0.016
activation of mapk activity GO:0000187 3 0.016
response to amphetamine GO:0001975 1 0.016
cellular modified amino acid metabolic process GO:0006575 3 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
cell matrix adhesion GO:0007160 4 0.016
peptidyl lysine acetylation GO:0018394 2 0.016
neutrophil differentiation GO:0030223 6 0.016
positive regulation of secretion GO:0051047 1 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
regulation of signaling GO:0023051 235 0.016
regulation of cell migration GO:0030334 40 0.016
positive regulation of transport GO:0051050 2 0.015
regulation of organelle assembly GO:1902115 4 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
astrocyte differentiation GO:0048708 1 0.015
response to external biotic stimulus GO:0043207 97 0.015
blood vessel morphogenesis GO:0048514 216 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
negative regulation of kinase activity GO:0033673 4 0.015
cellular component disassembly GO:0022411 1 0.015
regulation of tissue remodeling GO:0034103 2 0.015
response to amino acid GO:0043200 2 0.015
nucleic acid transport GO:0050657 2 0.015
protein import GO:0017038 3 0.015
gtp catabolic process GO:0006184 2 0.015
gliogenesis GO:0042063 45 0.015
negative regulation of mapk cascade GO:0043409 4 0.015
cognition GO:0050890 1 0.015
retina morphogenesis in camera type eye GO:0060042 79 0.015
cellular response to oxygen levels GO:0071453 1 0.015
somatic stem cell maintenance GO:0035019 1 0.015
regulation of myeloid cell differentiation GO:0045637 8 0.015
erythrocyte differentiation GO:0030218 54 0.015
adult behavior GO:0030534 2 0.015
gland development GO:0048732 143 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.014
regulation of neurotransmitter transport GO:0051588 1 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
multicellular organismal homeostasis GO:0048871 29 0.014
calcium ion transport into cytosol GO:0060402 3 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
apoptotic process GO:0006915 116 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
cellular amine metabolic process GO:0044106 2 0.014
endocrine system development GO:0035270 65 0.014
response to monosaccharide GO:0034284 3 0.014
regulation of hormone secretion GO:0046883 2 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
gtp metabolic process GO:0046039 4 0.014
leukocyte proliferation GO:0070661 1 0.014
multicellular organismal macromolecule metabolic process GO:0044259 2 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
transcription dna templated GO:0006351 181 0.014
definitive hemopoiesis GO:0060216 18 0.013
positive regulation of cellular process GO:0048522 201 0.013
positive regulation of cell cycle GO:0045787 3 0.013
retinal ganglion cell axon guidance GO:0031290 35 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
regulation of muscle contraction GO:0006937 3 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
regulation of rho protein signal transduction GO:0035023 2 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
positive regulation of leukocyte differentiation GO:1902107 1 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
regulation of autophagy GO:0010506 3 0.013
regulation of neurogenesis GO:0050767 87 0.013
regulation of reproductive process GO:2000241 4 0.013
growth GO:0040007 174 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
regulation of cell matrix adhesion GO:0001952 1 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
intracellular signal transduction GO:0035556 85 0.013
single organism metabolic process GO:0044710 217 0.013
cell chemotaxis GO:0060326 17 0.013
nerve development GO:0021675 45 0.013
lymphocyte proliferation GO:0046651 1 0.013
regulation of nucleotide biosynthetic process GO:0030808 15 0.013
t cell differentiation in thymus GO:0033077 6 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
cellular component biogenesis GO:0044085 178 0.013
establishment of protein localization to plasma membrane GO:0090002 1 0.013
ovulation cycle process GO:0022602 2 0.013
amino acid transport GO:0006865 2 0.013
protein metabolic process GO:0019538 183 0.012
cell projection morphogenesis GO:0048858 244 0.012
oxoacid metabolic process GO:0043436 31 0.012
negative regulation of cell differentiation GO:0045596 46 0.012
localization of cell GO:0051674 244 0.012
locomotor rhythm GO:0045475 3 0.012
positive regulation of leukocyte migration GO:0002687 2 0.012
cell part morphogenesis GO:0032990 246 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
developmental growth GO:0048589 166 0.012
regulation of dna metabolic process GO:0051052 11 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
rna metabolic process GO:0016070 219 0.012
regulation of calcium ion transport GO:0051924 2 0.012
ribosomal small subunit biogenesis GO:0042274 2 0.012
regulation of type b pancreatic cell proliferation GO:0061469 1 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
response to hexose GO:0009746 3 0.012
multi organism process GO:0051704 134 0.012
rna export from nucleus GO:0006405 1 0.012
b cell differentiation GO:0030183 1 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
macromolecule modification GO:0043412 111 0.012
regulation of meiotic cell cycle GO:0051445 1 0.012
cell substrate adhesion GO:0031589 4 0.012
single organism organelle organization GO:1902589 199 0.012
primitive hemopoiesis GO:0060215 27 0.012
dna catabolic process GO:0006308 1 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
lymph vessel development GO:0001945 27 0.012
response to carbohydrate GO:0009743 3 0.012
positive regulation of jak stat cascade GO:0046427 2 0.012
ovulation cycle GO:0042698 2 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
regulation of localization GO:0032879 104 0.012
mesenchymal cell development GO:0014031 78 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
chordate embryonic development GO:0043009 271 0.012
nuclear import GO:0051170 3 0.012
rna transport GO:0050658 2 0.012
regulation of response to external stimulus GO:0032101 31 0.012
negative regulation of locomotion GO:0040013 18 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
small molecule metabolic process GO:0044281 77 0.011
protein polyubiquitination GO:0000209 4 0.011
regulation of synapse organization GO:0050807 3 0.011
developmental programmed cell death GO:0010623 4 0.011
spermatid development GO:0007286 2 0.011
single organism nuclear import GO:1902593 3 0.011
central nervous system neuron differentiation GO:0021953 74 0.011
cellular protein metabolic process GO:0044267 129 0.011
response to alcohol GO:0097305 14 0.011
negative regulation of apoptotic process GO:0043066 55 0.011
translational initiation GO:0006413 3 0.011
granulocyte migration GO:0097530 11 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
regulation of gene expression epigenetic GO:0040029 11 0.011
spermatid differentiation GO:0048515 2 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
regulation of homeostatic process GO:0032844 9 0.011
response to ketone GO:1901654 1 0.011
regulation of protein targeting GO:1903533 2 0.011
skeletal system development GO:0001501 181 0.011
negative regulation of secretion GO:0051048 2 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
dna templated transcription elongation GO:0006354 3 0.011
regulation of neuron differentiation GO:0045664 56 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
actin filament polymerization GO:0030041 2 0.011
negative regulation of cytokine production GO:0001818 1 0.011
cranial ganglion development GO:0061550 3 0.011
cation homeostasis GO:0055080 33 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
cellular response to hypoxia GO:0071456 1 0.011
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.011
erythrocyte development GO:0048821 24 0.011
regulation of protein complex assembly GO:0043254 3 0.011
negative regulation of metabolic process GO:0009892 86 0.011
toll like receptor signaling pathway GO:0002224 4 0.011
meiotic nuclear division GO:0007126 4 0.011
lipid catabolic process GO:0016042 4 0.011
oxidoreduction coenzyme metabolic process GO:0006733 1 0.011
type b pancreatic cell proliferation GO:0044342 1 0.011
regulation of glial cell differentiation GO:0045685 4 0.011
negative regulation of rna splicing GO:0033119 1 0.010
response to hormone GO:0009725 48 0.010
pancreas development GO:0031016 84 0.010
negative regulation of catabolic process GO:0009895 3 0.010
activation of immune response GO:0002253 9 0.010
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.010
cellular component assembly involved in morphogenesis GO:0010927 107 0.010
circulatory system process GO:0003013 87 0.010
system process GO:0003008 185 0.010
membrane invagination GO:0010324 1 0.010
regulation of response to stress GO:0080134 36 0.010
mitochondrial transport GO:0006839 2 0.010
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
heterocycle metabolic process GO:0046483 290 0.010
leukocyte migration GO:0050900 15 0.010
insulin like growth factor receptor signaling pathway GO:0048009 4 0.010
peptide metabolic process GO:0006518 1 0.010
cartilage development GO:0051216 96 0.010

irf8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
disease of cellular proliferation DOID:14566 0 0.016
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
nervous system disease DOID:863 0 0.013
eye disease DOID:5614 0 0.013
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.011
disease of metabolism DOID:0014667 0 0.010