Danio rerio

0 known processes

kdm4b

lysine (K)-specific demethylase 4B

(Aliases: jmjd2b,si:ch211-124a3.4)

kdm4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein demethylation GO:0006482 2 0.458
Yeast Fly
histone demethylation GO:0016577 2 0.351
Yeast Fly
larval development GO:0002164 2 0.282
locomotion GO:0040011 313 0.214
cognition GO:0050890 1 0.190
histone lysine demethylation GO:0070076 2 0.132
Yeast Fly
sensory perception of touch GO:0050975 2 0.115
cellular biosynthetic process GO:0044249 286 0.114
Yeast
regulation of macromolecule biosynthetic process GO:0010556 225 0.108
Yeast
chordate embryonic development GO:0043009 271 0.098
brain development GO:0007420 293 0.085
circadian sleep wake cycle process GO:0022410 2 0.084
histone h3 k9 demethylation GO:0033169 2 0.081
Yeast Fly
detection of mechanical stimulus involved in sensory perception of touch GO:0050976 2 0.079
cellular amide metabolic process GO:0043603 4 0.075
head development GO:0060322 303 0.074
heterocycle metabolic process GO:0046483 290 0.073
Yeast
circadian sleep wake cycle GO:0042745 2 0.072
heterocycle biosynthetic process GO:0018130 215 0.071
Yeast
regulation of synapse organization GO:0050807 3 0.071
protein dealkylation GO:0008214 2 0.067
Yeast Fly
biosynthetic process GO:0009058 294 0.066
Yeast
striated muscle cell development GO:0055002 108 0.064
neuron projection development GO:0031175 180 0.064
central nervous system development GO:0007417 387 0.062
chemotaxis GO:0006935 104 0.062
regionalization GO:0003002 274 0.061
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.061
regulation of multicellular organismal development GO:2000026 223 0.061
stem cell maintenance GO:0019827 4 0.061
rna biosynthetic process GO:0032774 181 0.059
Yeast
regulation of stem cell differentiation GO:2000736 4 0.059
cell part morphogenesis GO:0032990 246 0.056
negative regulation of signal transduction GO:0009968 94 0.056
maintenance of location GO:0051235 4 0.054
cellular nitrogen compound metabolic process GO:0034641 290 0.054
Yeast
cell morphogenesis GO:0000902 289 0.053
striated muscle tissue development GO:0014706 110 0.053
circadian sleep wake cycle sleep GO:0050802 1 0.053
nucleic acid metabolic process GO:0090304 244 0.053
Yeast
cellular nitrogen compound biosynthetic process GO:0044271 218 0.052
Yeast
synaptic target recognition GO:0008039 1 0.048
macromolecule modification GO:0043412 111 0.048
Yeast Fly
response to drug GO:0042493 3 0.047
regulation of gene expression GO:0010468 265 0.044
Yeast Fly
electron transport chain GO:0022900 2 0.044
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.044
cell morphogenesis involved in differentiation GO:0000904 195 0.044
positive regulation of stem cell proliferation GO:2000648 1 0.044
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.044
negative regulation of multicellular organismal process GO:0051241 69 0.044
regulation of response to stimulus GO:0048583 269 0.043
specification of organ identity GO:0010092 2 0.042
regulation of cell matrix adhesion GO:0001952 1 0.041
regulation of biological quality GO:0065008 263 0.041
Yeast
chromatin organization GO:0006325 22 0.041
Yeast Fly
cellular response to chemical stimulus GO:0070887 157 0.041
positive regulation of neural precursor cell proliferation GO:2000179 1 0.041
regulation of synapse assembly GO:0051963 3 0.041
hormone transport GO:0009914 2 0.041
organic cyclic compound metabolic process GO:1901360 301 0.041
Yeast
aging GO:0007568 2 0.040
Yeast
protein import into nucleus GO:0006606 3 0.040
regulation of binding GO:0051098 3 0.039
tube morphogenesis GO:0035239 349 0.039
convergent extension GO:0060026 118 0.039
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.039
signal transduction GO:0007165 455 0.038
positive regulation of cellular process GO:0048522 201 0.037
Yeast
localization of cell GO:0051674 244 0.037
atp synthesis coupled electron transport GO:0042773 1 0.037
axonogenesis GO:0007409 152 0.036
neuron projection morphogenesis GO:0048812 161 0.036
negative regulation of biological process GO:0048519 304 0.035
Yeast
peptide metabolic process GO:0006518 1 0.035
regulation of erk1 and erk2 cascade GO:0070372 4 0.035
morphogenesis of an epithelium GO:0002009 333 0.034
establishment of synaptic vesicle localization GO:0097480 1 0.034
muscle cell development GO:0055001 115 0.034
generation of neurons GO:0048699 385 0.034
neurotransmitter transport GO:0006836 2 0.034
cell projection morphogenesis GO:0048858 244 0.033
regulation of developmental process GO:0050793 247 0.033
developmental growth GO:0048589 166 0.033
transcription dna templated GO:0006351 181 0.033
Yeast
blood vessel development GO:0001568 246 0.032
cellular carbohydrate metabolic process GO:0044262 4 0.032
negative regulation of cell communication GO:0010648 96 0.032
somitogenesis GO:0001756 87 0.032
cellular protein metabolic process GO:0044267 129 0.031
Yeast Fly
embryonic limb morphogenesis GO:0030326 2 0.031
neuron differentiation GO:0030182 353 0.031
startle response GO:0001964 4 0.031
small molecule metabolic process GO:0044281 77 0.031
cell migration GO:0016477 237 0.030
negative regulation of cellular process GO:0048523 283 0.030
Yeast
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.030
histone modification GO:0016570 20 0.030
Yeast Fly
positive regulation of cell adhesion GO:0045785 1 0.030
extrinsic apoptotic signaling pathway GO:0097191 3 0.030
regulation of protein catabolic process GO:0042176 1 0.030
regulation of stem cell proliferation GO:0072091 2 0.030
positive regulation of wound healing GO:0090303 1 0.030
axon development GO:0061564 166 0.030
synaptic growth at neuromuscular junction GO:0051124 2 0.030
negative regulation of autophagy GO:0010507 1 0.030
single organism nuclear import GO:1902593 3 0.029
neural crest formation GO:0014029 14 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.029
aromatic compound biosynthetic process GO:0019438 217 0.029
Yeast
regulation of neural precursor cell proliferation GO:2000177 3 0.029
rna localization GO:0006403 4 0.028
regulation of cellular biosynthetic process GO:0031326 245 0.028
Yeast
neural crest cell differentiation GO:0014033 72 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
regulation of cell differentiation GO:0045595 142 0.028
negative regulation of developmental process GO:0051093 65 0.028
cellular response to external stimulus GO:0071496 2 0.027
cardiac cell fate commitment GO:0060911 1 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
regulation of cell communication GO:0010646 232 0.027
regulation of cellular ketone metabolic process GO:0010565 7 0.027
enzyme linked receptor protein signaling pathway GO:0007167 106 0.027
chromatin modification GO:0016568 21 0.027
Yeast Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.026
Yeast
positive regulation of cellular catabolic process GO:0031331 3 0.026
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.026
Yeast
mesenchymal cell development GO:0014031 78 0.026
negative regulation of cellular catabolic process GO:0031330 3 0.026
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.026
positive regulation of gliogenesis GO:0014015 2 0.026
cellular component movement GO:0006928 335 0.026
somite development GO:0061053 96 0.026
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.026
negative regulation of synapse assembly GO:0051964 2 0.025
regulation of signal transduction GO:0009966 225 0.025
lipid storage GO:0019915 1 0.025
protein modification process GO:0036211 100 0.025
Yeast Fly
vasculature development GO:0001944 278 0.025
regulation of cellular metabolic process GO:0031323 320 0.025
Yeast
embryo development ending in birth or egg hatching GO:0009792 271 0.025
positive regulation of map kinase activity GO:0043406 3 0.025
positive regulation of secretion by cell GO:1903532 1 0.025
cellular amino acid metabolic process GO:0006520 7 0.024
spermatid development GO:0007286 2 0.024
cell surface receptor signaling pathway GO:0007166 325 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.024
Yeast
sleep GO:0030431 1 0.024
sialylation GO:0097503 4 0.024
lamellipodium assembly GO:0030032 1 0.024
connective tissue development GO:0061448 99 0.024
internal protein amino acid acetylation GO:0006475 2 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
Yeast
negative regulation of response to stimulus GO:0048585 104 0.024
modification dependent protein catabolic process GO:0019941 3 0.023
lamellipodium organization GO:0097581 1 0.023
positive regulation of secretion GO:0051047 1 0.023
cell projection organization GO:0030030 284 0.023
protein metabolic process GO:0019538 183 0.023
Yeast Fly
cellular ketone metabolic process GO:0042180 11 0.023
organonitrogen compound metabolic process GO:1901564 74 0.023
positive regulation of cell proliferation GO:0008284 15 0.023
negative regulation of gliogenesis GO:0014014 1 0.023
regulation of dendrite development GO:0050773 3 0.023
organic substance biosynthetic process GO:1901576 289 0.023
Yeast
erk1 and erk2 cascade GO:0070371 4 0.023
stem cell differentiation GO:0048863 117 0.022
somatic stem cell maintenance GO:0035019 1 0.022
regulation of skeletal muscle tissue development GO:0048641 4 0.022
locomotor rhythm GO:0045475 3 0.022
stem cell development GO:0048864 82 0.021
negative regulation of cellular metabolic process GO:0031324 77 0.021
Yeast
cell substrate adhesion GO:0031589 4 0.021
protein localization to nucleus GO:0034504 3 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.021
Yeast
cellular response to molecule of bacterial origin GO:0071219 3 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.020
Yeast
regulation of autophagy GO:0010506 3 0.020
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
cellular response to growth factor stimulus GO:0071363 39 0.020
regulation of dendrite morphogenesis GO:0048814 3 0.020
regulation of response to nutrient levels GO:0032107 1 0.020
cellular amine metabolic process GO:0044106 2 0.020
positive regulation of catabolic process GO:0009896 4 0.020
chromosome organization GO:0051276 31 0.020
Yeast Fly
ear development GO:0043583 127 0.020
positive regulation of biological process GO:0048518 253 0.020
Yeast Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.020
immune system process GO:0002376 241 0.019
regulation of mitotic cell cycle embryonic GO:0009794 2 0.019
behavior GO:0007610 74 0.019
post golgi vesicle mediated transport GO:0006892 1 0.019
positive regulation of cell cycle GO:0045787 3 0.019
single organism organelle organization GO:1902589 199 0.019
Yeast Fly
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.019
outflow tract morphogenesis GO:0003151 1 0.019
protein targeting to nucleus GO:0044744 3 0.019
regulation of protein binding GO:0043393 3 0.019
response to organic substance GO:0010033 153 0.019
regulation of postsynaptic membrane potential GO:0060078 1 0.018
ameboidal type cell migration GO:0001667 143 0.018
stem cell proliferation GO:0072089 4 0.018
negative regulation of signaling GO:0023057 96 0.018
gastrulation GO:0007369 208 0.018
cartilage development GO:0051216 96 0.018
segmentation GO:0035282 97 0.017
epidermis morphogenesis GO:0048730 4 0.017
protein complex disassembly GO:0043241 1 0.017
mitotic cell cycle embryonic GO:0045448 2 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
Yeast Fly
organelle organization GO:0006996 227 0.017
Yeast Fly
regulation of cellular protein catabolic process GO:1903362 1 0.017
transport GO:0006810 220 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
cellular response to nutrient levels GO:0031669 2 0.017
cilium morphogenesis GO:0060271 85 0.016
protein secretion GO:0009306 1 0.016
response to chemical GO:0042221 320 0.016
adherens junction organization GO:0034332 4 0.016
regulation of biosynthetic process GO:0009889 250 0.016
Yeast
regulation of primary metabolic process GO:0080090 311 0.016
Yeast
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.016
Yeast
regulation of response to cytokine stimulus GO:0060759 3 0.016
cellular response to biotic stimulus GO:0071216 3 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of rna metabolic process GO:0051252 224 0.015
Yeast
cellular component assembly GO:0022607 170 0.015
negative regulation of kinase activity GO:0033673 4 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
macromolecular complex disassembly GO:0032984 1 0.015
activation of jun kinase activity GO:0007257 2 0.015
regulation of production of molecular mediator of immune response GO:0002700 1 0.015
response to external stimulus GO:0009605 264 0.015
Yeast
regulation of cellular amine metabolic process GO:0033238 0 0.015
cellular macromolecule metabolic process GO:0044260 391 0.015
Yeast Fly
internal peptidyl lysine acetylation GO:0018393 2 0.015
meiotic cell cycle process GO:1903046 3 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
Yeast
negative regulation of muscle cell differentiation GO:0051148 1 0.015
positive regulation of transport GO:0051050 2 0.015
growth GO:0040007 174 0.015
cellular component disassembly GO:0022411 1 0.015
chemosensory behavior GO:0007635 1 0.015
embryonic organ development GO:0048568 381 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
negative regulation of cellular biosynthetic process GO:0031327 55 0.015
Yeast
organic acid metabolic process GO:0006082 31 0.015
heart contraction GO:0060047 71 0.015
pigmentation GO:0043473 85 0.015
anterior posterior pattern specification GO:0009952 152 0.015
heart development GO:0007507 313 0.014
determination of heart left right asymmetry GO:0061371 117 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
cellular protein modification process GO:0006464 100 0.014
Yeast Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.014
nitrogen compound metabolic process GO:0006807 319 0.014
Yeast
negative regulation of catabolic process GO:0009895 3 0.014
meiotic nuclear division GO:0007126 4 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
ventricular cardiac muscle tissue development GO:0003229 3 0.014
amine metabolic process GO:0009308 2 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
Yeast
nucleocytoplasmic transport GO:0006913 4 0.014
regulation of cell substrate adhesion GO:0010810 1 0.014
adult behavior GO:0030534 2 0.014
autophagy GO:0006914 4 0.014
nuclear transport GO:0051169 4 0.014
oxoacid metabolic process GO:0043436 31 0.014
tissue remodeling GO:0048771 4 0.014
specification of symmetry GO:0009799 204 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
neuron projection guidance GO:0097485 86 0.014
glial cell proliferation GO:0014009 4 0.014
skin morphogenesis GO:0043589 7 0.013
commissural neuron axon guidance GO:0071679 3 0.013
regulation of hormone secretion GO:0046883 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
positive regulation of response to stimulus GO:0048584 80 0.013
sequestering of metal ion GO:0051238 3 0.013
osteoclast development GO:0036035 1 0.013
membrane invagination GO:0010324 1 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
Yeast
hindbrain development GO:0030902 91 0.013
macroautophagy GO:0016236 1 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
Yeast
epithelial cell differentiation GO:0030855 116 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
calcium ion transport into cytosol GO:0060402 3 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
protein acetylation GO:0006473 2 0.013
neurological system process GO:0050877 62 0.013
meiotic chromosome segregation GO:0045132 3 0.013
positive regulation of cell division GO:0051781 2 0.013
cell differentiation in spinal cord GO:0021515 40 0.013
gtp catabolic process GO:0006184 2 0.013
negative regulation of translation GO:0017148 1 0.013
rna metabolic process GO:0016070 219 0.013
Yeast
nuclear import GO:0051170 3 0.013
heart morphogenesis GO:0003007 156 0.013
multicellular organism growth GO:0035264 4 0.013
sensory perception of pain GO:0019233 1 0.013
response to vitamin GO:0033273 3 0.013
inner ear development GO:0048839 126 0.012
golgi vesicle transport GO:0048193 3 0.012
muscle fiber development GO:0048747 52 0.012
protein import GO:0017038 3 0.012
positive regulation of developmental process GO:0051094 50 0.012
determination of bilateral symmetry GO:0009855 204 0.012
positive regulation of multicellular organismal process GO:0051240 52 0.012
respiratory electron transport chain GO:0022904 2 0.012
negative regulation of immune response GO:0050777 2 0.012
multicellular organismal response to stress GO:0033555 2 0.012
neuron development GO:0048666 262 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.012
cell migration involved in gastrulation GO:0042074 79 0.012
pigment cell differentiation GO:0050931 38 0.012
amide biosynthetic process GO:0043604 1 0.012
peptide transport GO:0015833 1 0.012
hormone secretion GO:0046879 2 0.012
regulation of receptor activity GO:0010469 2 0.012
regulation of organ morphogenesis GO:2000027 35 0.012
negative regulation of cell differentiation GO:0045596 46 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.011
cellular component biogenesis GO:0044085 178 0.011
antimicrobial humoral response GO:0019730 2 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.011
regulation of neurological system process GO:0031644 2 0.011
taxis GO:0042330 109 0.011
cytosolic calcium ion transport GO:0060401 3 0.011
alpha amino acid metabolic process GO:1901605 3 0.011
mesenchymal cell differentiation GO:0048762 87 0.011
cell adhesion mediated by integrin GO:0033627 1 0.011
single organism localization GO:1902578 225 0.011
positive regulation of metabolic process GO:0009893 108 0.011
Yeast Fly
convergent extension involved in axis elongation GO:0060028 26 0.011
epithelial to mesenchymal transition GO:0001837 21 0.011
exocytosis GO:0006887 1 0.011
mesenchyme development GO:0060485 127 0.011
regulation of calcium ion transport GO:0051924 2 0.011
negative regulation of stem cell differentiation GO:2000737 2 0.011
intracellular mrna localization GO:0008298 1 0.011
cell matrix adhesion GO:0007160 4 0.011
cilium assembly GO:0042384 58 0.011
synaptic vesicle localization GO:0097479 1 0.011
regulation of response to extracellular stimulus GO:0032104 1 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
single organism carbohydrate metabolic process GO:0044723 12 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
regulation of embryonic development GO:0045995 47 0.011
response to mechanical stimulus GO:0009612 24 0.011
spermatid differentiation GO:0048515 2 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
neuron migration GO:0001764 22 0.011
somatic muscle development GO:0007525 4 0.011
nuclear export GO:0051168 1 0.011
organelle localization GO:0051640 49 0.011
regulation of protein transport GO:0051223 3 0.010
macromolecule deacylation GO:0098732 3 0.010
axon guidance GO:0007411 86 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
regulation of establishment of planar polarity GO:0090175 4 0.010
regulation of nervous system development GO:0051960 90 0.010
post anal tail morphogenesis GO:0036342 19 0.010
cell substrate adherens junction assembly GO:0007045 1 0.010
regulation of response to oxidative stress GO:1902882 2 0.010
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
actin polymerization or depolymerization GO:0008154 2 0.010
neuroblast proliferation GO:0007405 2 0.010
negative regulation of neurogenesis GO:0050768 20 0.010
spindle assembly GO:0051225 2 0.010

kdm4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
organ system cancer DOID:0050686 0 0.013