Danio rerio

0 known processes

laptm4a

lysosomal-associated protein transmembrane 4 alpha

(Aliases: MGC63847,wu:fj99e08,wu:fb57c07)

laptm4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.224
lipid storage GO:0019915 1 0.171
maternal determination of anterior posterior axis embryo GO:0008358 4 0.159
maintenance of location GO:0051235 4 0.149
single organism localization GO:1902578 225 0.116
guanosine containing compound metabolic process GO:1901068 4 0.111
embryo development ending in birth or egg hatching GO:0009792 271 0.107
pole plasm assembly GO:0007315 4 0.100
purine containing compound metabolic process GO:0072521 29 0.097
guanosine containing compound catabolic process GO:1901069 2 0.094
aging GO:0007568 2 0.090
establishment of protein localization to organelle GO:0072594 4 0.088
organelle fusion GO:0048284 3 0.088
single organism membrane fusion GO:0044801 2 0.085
meiotic cell cycle process GO:1903046 3 0.083
regulation of macromolecule metabolic process GO:0060255 317 0.081
stem cell division GO:0017145 1 0.079
germ cell development GO:0007281 22 0.077
germ line stem cell maintenance GO:0030718 2 0.077
stem cell maintenance GO:0019827 4 0.072
positive regulation of transport GO:0051050 2 0.069
establishment of protein localization to plasma membrane GO:0090002 1 0.065
oocyte anterior posterior axis specification GO:0007314 4 0.065
regionalization GO:0003002 274 0.063
positive regulation of cell cycle GO:0045787 3 0.063
single organism metabolic process GO:0044710 217 0.063
regulation of protein transport GO:0051223 3 0.060
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.058
apoptotic process GO:0006915 116 0.057
segmentation GO:0035282 97 0.055
organonitrogen compound metabolic process GO:1901564 74 0.054
regulation of cytoplasmic transport GO:1903649 4 0.052
golgi vesicle transport GO:0048193 3 0.052
small molecule metabolic process GO:0044281 77 0.051
regulation of establishment of protein localization GO:0070201 4 0.051
meiotic chromosome segregation GO:0045132 3 0.048
cellular carbohydrate metabolic process GO:0044262 4 0.048
carbohydrate derivative metabolic process GO:1901135 61 0.046
neuron neuron synaptic transmission GO:0007270 1 0.046
establishment of localization GO:0051234 244 0.046
cognition GO:0050890 1 0.046
cellular macromolecule biosynthetic process GO:0034645 224 0.045
gtp catabolic process GO:0006184 2 0.045
cytoplasm organization GO:0007028 4 0.044
organophosphate biosynthetic process GO:0090407 23 0.044
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.044
regulation of localization GO:0032879 104 0.044
cellular aromatic compound metabolic process GO:0006725 295 0.044
gtp metabolic process GO:0046039 4 0.042
regulation of primary metabolic process GO:0080090 311 0.042
spermatid development GO:0007286 2 0.042
nitrogen compound metabolic process GO:0006807 319 0.042
spermatid differentiation GO:0048515 2 0.041
nucleobase containing compound metabolic process GO:0006139 274 0.041
tube morphogenesis GO:0035239 349 0.041
regulation of metabolic process GO:0019222 359 0.040
protein import into nucleus GO:0006606 3 0.040
meiotic nuclear division GO:0007126 4 0.040
muscle cell differentiation GO:0042692 139 0.039
regulation of dendrite development GO:0050773 3 0.039
regulation of oocyte development GO:0060281 3 0.039
purine nucleotide metabolic process GO:0006163 27 0.038
post golgi vesicle mediated transport GO:0006892 1 0.038
oogenesis GO:0048477 14 0.038
multi organism process GO:0051704 134 0.038
phagocytosis GO:0006909 3 0.038
hepaticobiliary system development GO:0061008 98 0.038
female meiotic division GO:0007143 2 0.038
cortical actin cytoskeleton organization GO:0030866 1 0.037
blood vessel development GO:0001568 246 0.037
establishment or maintenance of apical basal cell polarity GO:0035088 12 0.036
signal transduction GO:0007165 455 0.036
purine ribonucleotide metabolic process GO:0009150 27 0.035
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.035
single organism nuclear import GO:1902593 3 0.035
programmed cell death GO:0012501 119 0.034
embryonic axis specification GO:0000578 12 0.034
heterocycle metabolic process GO:0046483 290 0.034
oocyte axis specification GO:0007309 5 0.034
nuclear transport GO:0051169 4 0.033
cellular nitrogen compound metabolic process GO:0034641 290 0.033
response to external stimulus GO:0009605 264 0.033
protein import GO:0017038 3 0.033
protein targeting to nucleus GO:0044744 3 0.033
central nervous system development GO:0007417 387 0.032
intracellular mrna localization GO:0008298 1 0.032
vasculature development GO:0001944 278 0.032
calcium ion transport into cytosol GO:0060402 3 0.032
regulation of cell development GO:0060284 100 0.032
ribose phosphate metabolic process GO:0019693 27 0.032
gamete generation GO:0007276 33 0.032
endosomal transport GO:0016197 2 0.032
digestive tract development GO:0048565 265 0.031
synaptic growth at neuromuscular junction GO:0051124 2 0.031
positive regulation of cellular process GO:0048522 201 0.031
organic cyclic compound metabolic process GO:1901360 301 0.031
organic substance biosynthetic process GO:1901576 289 0.031
adult behavior GO:0030534 2 0.031
negative regulation of biological process GO:0048519 304 0.031
immune system process GO:0002376 241 0.031
response to external biotic stimulus GO:0043207 97 0.031
membrane fusion GO:0061025 2 0.030
membrane invagination GO:0010324 1 0.030
carboxylic acid metabolic process GO:0019752 22 0.030
organelle organization GO:0006996 227 0.030
organic acid metabolic process GO:0006082 31 0.030
death GO:0016265 121 0.030
cellular macromolecule metabolic process GO:0044260 391 0.029
regulation of carbohydrate metabolic process GO:0006109 4 0.029
muscle structure development GO:0061061 196 0.029
carbohydrate derivative biosynthetic process GO:1901137 43 0.029
regulation of intracellular protein transport GO:0033157 3 0.029
protein metabolic process GO:0019538 183 0.029
establishment of organelle localization GO:0051656 45 0.029
protein localization to nucleus GO:0034504 3 0.029
nucleotide metabolic process GO:0009117 28 0.028
nuclear import GO:0051170 3 0.028
stem cell proliferation GO:0072089 4 0.027
regulation of binding GO:0051098 3 0.027
heart development GO:0007507 313 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.026
single organism transport GO:0044765 206 0.026
regulation of synapse organization GO:0050807 3 0.026
organonitrogen compound biosynthetic process GO:1901566 47 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.025
nucleoside phosphate metabolic process GO:0006753 28 0.025
cellular respiration GO:0045333 3 0.025
cell surface receptor signaling pathway GO:0007166 325 0.024
compound eye development GO:0048749 2 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
carbohydrate biosynthetic process GO:0016051 1 0.024
cell substrate adhesion GO:0031589 4 0.024
transport GO:0006810 220 0.024
regulation of cell shape GO:0008360 1 0.023
phagocytosis engulfment GO:0006911 1 0.023
phagosome maturation GO:0090382 1 0.023
regulation of reproductive process GO:2000241 4 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
establishment of synaptic vesicle localization GO:0097480 1 0.023
regulation of cell maturation GO:1903429 1 0.023
microtubule organizing center organization GO:0031023 1 0.022
catabolic process GO:0009056 32 0.022
small gtpase mediated signal transduction GO:0007264 8 0.022
organophosphate metabolic process GO:0019637 37 0.022
digestive system development GO:0055123 289 0.022
multicellular organism growth GO:0035264 4 0.022
cellular protein catabolic process GO:0044257 4 0.022
response to biotic stimulus GO:0009607 97 0.022
cellular amino acid metabolic process GO:0006520 7 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
respiratory electron transport chain GO:0022904 2 0.022
cell death GO:0008219 121 0.021
response to chemical GO:0042221 320 0.021
growth GO:0040007 174 0.021
axis specification GO:0009798 43 0.021
regulation of synapse assembly GO:0051963 3 0.021
negative regulation of catabolic process GO:0009895 3 0.021
intracellular transport GO:0046907 32 0.021
striated muscle tissue development GO:0014706 110 0.021
synaptic vesicle transport GO:0048489 1 0.021
oxoacid metabolic process GO:0043436 31 0.021
tissue remodeling GO:0048771 4 0.021
peptidyl serine phosphorylation GO:0018105 1 0.021
cell cycle g1 s phase transition GO:0044843 1 0.021
ras protein signal transduction GO:0007265 7 0.021
regulation of protein binding GO:0043393 3 0.021
nucleic acid transport GO:0050657 2 0.021
proteasomal protein catabolic process GO:0010498 2 0.020
angiogenesis GO:0001525 158 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
ribonucleotide metabolic process GO:0009259 27 0.020
regulation of neural precursor cell proliferation GO:2000177 3 0.020
adherens junction organization GO:0034332 4 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
response to abiotic stimulus GO:0009628 122 0.020
anterior posterior pattern specification GO:0009952 152 0.020
regulation of cell differentiation GO:0045595 142 0.019
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.019
tissue regeneration GO:0042246 74 0.019
muscle cell development GO:0055001 115 0.019
single organism reproductive process GO:0044702 40 0.019
synaptic vesicle recycling GO:0036465 1 0.019
cation transport GO:0006812 81 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
cellular component maintenance GO:0043954 3 0.019
negative regulation of heart contraction GO:0045822 2 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
regulation of biological quality GO:0065008 263 0.019
cytosolic calcium ion transport GO:0060401 3 0.019
regulation of cell projection assembly GO:0060491 4 0.018
cellular biosynthetic process GO:0044249 286 0.018
positive regulation of muscle cell differentiation GO:0051149 1 0.018
sensory perception of chemical stimulus GO:0007606 3 0.018
response to topologically incorrect protein GO:0035966 2 0.018
rna localization GO:0006403 4 0.018
negative regulation of synapse assembly GO:0051964 2 0.018
amine metabolic process GO:0009308 2 0.018
cellular component biogenesis GO:0044085 178 0.018
regulation of calcium ion transport GO:0051924 2 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
neurotransmitter transport GO:0006836 2 0.018
protein secretion GO:0009306 1 0.018
cellular component assembly GO:0022607 170 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
regulation of mrna splicing via spliceosome GO:0048024 3 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.018
cellular response to starvation GO:0009267 1 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
intracellular signal transduction GO:0035556 85 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
synaptic vesicle localization GO:0097479 1 0.017
cellular ketone metabolic process GO:0042180 11 0.017
liver development GO:0001889 96 0.017
pigmentation GO:0043473 85 0.017
regulation of mrna processing GO:0050684 3 0.017
bone remodeling GO:0046849 2 0.017
release of sequestered calcium ion into cytosol GO:0051209 3 0.017
regulation of protein localization to plasma membrane GO:1903076 1 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
establishment or maintenance of cell polarity GO:0007163 29 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
response to other organism GO:0051707 97 0.016
determination of left right symmetry GO:0007368 179 0.016
blood vessel morphogenesis GO:0048514 216 0.016
nucleobase containing compound transport GO:0015931 2 0.016
cell morphogenesis GO:0000902 289 0.016
electron transport chain GO:0022900 2 0.016
transmembrane transport GO:0055085 120 0.016
regulation of metal ion transport GO:0010959 4 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
response to stress GO:0006950 263 0.016
regulation of programmed cell death GO:0043067 101 0.016
oocyte differentiation GO:0009994 14 0.016
myotube differentiation GO:0014902 45 0.016
regulation of biosynthetic process GO:0009889 250 0.016
cellular localization GO:0051641 97 0.015
single organism intracellular transport GO:1902582 25 0.015
organelle localization GO:0051640 49 0.015
cellular amine metabolic process GO:0044106 2 0.015
stem cell development GO:0048864 82 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
negative regulation of cellular process GO:0048523 283 0.015
kupffer s vesicle development GO:0070121 50 0.015
pronuclear migration GO:0035046 1 0.015
macromolecule localization GO:0033036 54 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
oocyte development GO:0048599 14 0.015
system process GO:0003008 185 0.015
biosynthetic process GO:0009058 294 0.015
peptidyl serine modification GO:0018209 2 0.015
female gamete generation GO:0007292 14 0.015
positive regulation of secretion by cell GO:1903532 1 0.014
neuroblast proliferation GO:0007405 2 0.014
nucleobase containing small molecule metabolic process GO:0055086 32 0.014
neurological system process GO:0050877 62 0.014
cellular response to external stimulus GO:0071496 2 0.014
connective tissue development GO:0061448 99 0.014
establishment of localization in cell GO:0051649 77 0.014
single organism cellular localization GO:1902580 46 0.014
antimicrobial humoral response GO:0019730 2 0.014
multi organism reproductive process GO:0044703 36 0.014
autophagy GO:0006914 4 0.014
sexual reproduction GO:0019953 36 0.014
positive regulation of secretion GO:0051047 1 0.014
regulation of muscle contraction GO:0006937 3 0.014
response to organic substance GO:0010033 153 0.014
cellular component morphogenesis GO:0032989 336 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
canonical wnt signaling pathway GO:0060070 48 0.014
regulation of cellular component organization GO:0051128 86 0.014
organelle assembly GO:0070925 110 0.014
regulation of cell motility GO:2000145 46 0.014
cellular catabolic process GO:0044248 27 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
regulation of sequestering of calcium ion GO:0051282 4 0.014
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
muscle organ development GO:0007517 101 0.014
regulation of synaptic plasticity GO:0048167 1 0.013
centrosome organization GO:0051297 1 0.013
striated muscle cell differentiation GO:0051146 129 0.013
anterior posterior axis specification GO:0009948 20 0.013
negative regulation of protein localization to nucleus GO:1900181 2 0.013
embryonic pattern specification GO:0009880 44 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
digestive tract morphogenesis GO:0048546 231 0.013
striated muscle cell development GO:0055002 108 0.013
endosome organization GO:0007032 2 0.013
neutrophil mediated immunity GO:0002446 1 0.013
sequestering of calcium ion GO:0051208 3 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
vacuolar transport GO:0007034 2 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
protein localization to plasma membrane GO:0072659 1 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
cell proliferation GO:0008283 80 0.013
stem cell differentiation GO:0048863 117 0.013
carboxylic acid catabolic process GO:0046395 3 0.013
cellular component movement GO:0006928 335 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
regulation of cell projection organization GO:0031344 44 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
positive regulation of catabolic process GO:0009896 4 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
organic acid catabolic process GO:0016054 3 0.013
endomembrane system organization GO:0010256 13 0.012
regulation of chromosome segregation GO:0051983 1 0.012
localization of cell GO:0051674 244 0.012
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.012
muscle fiber development GO:0048747 52 0.012
female meiosis chromosome segregation GO:0016321 1 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
macroautophagy GO:0016236 1 0.012
adherens junction maintenance GO:0034334 2 0.012
protein targeting to membrane GO:0006612 1 0.012
regulation of cellular metabolic process GO:0031323 320 0.012
sequestering of metal ion GO:0051238 3 0.012
cell aging GO:0007569 2 0.012
regulation of blood circulation GO:1903522 32 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
regulation of protein catabolic process GO:0042176 1 0.012
ribose phosphate biosynthetic process GO:0046390 20 0.012
nucleoside triphosphate biosynthetic process GO:0009142 2 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
gastrulation with mouth forming second GO:0001702 44 0.012
translational initiation GO:0006413 3 0.012
developmental maturation GO:0021700 34 0.012
ion transport GO:0006811 114 0.012
carbohydrate homeostasis GO:0033500 1 0.012
protein localization to vacuole GO:0072665 1 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
multicellular organism reproduction GO:0032504 35 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
single organism biosynthetic process GO:0044711 71 0.012
regulation of blood vessel size GO:0050880 2 0.012
chemosensory behavior GO:0007635 1 0.012
multicellular organismal response to stress GO:0033555 2 0.012
actin filament based process GO:0030029 64 0.011
cell cycle g2 m phase transition GO:0044839 4 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
trabecula morphogenesis GO:0061383 2 0.011
ion transmembrane transport GO:0034220 91 0.011
regulation of protein complex assembly GO:0043254 3 0.011
locomotor rhythm GO:0045475 3 0.011
regulation of stem cell proliferation GO:0072091 2 0.011
negative regulation of protein complex assembly GO:0031333 1 0.011
oxidation reduction process GO:0055114 41 0.011
cytoskeleton organization GO:0007010 96 0.011
protein polymerization GO:0051258 4 0.011
energy reserve metabolic process GO:0006112 2 0.011
cell fate commitment GO:0045165 99 0.011
regulation of organelle assembly GO:1902115 4 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
neurotransmitter secretion GO:0007269 2 0.011
chordate embryonic development GO:0043009 271 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
regulation of tube size GO:0035150 2 0.011
gastrulation GO:0007369 208 0.011
alcohol biosynthetic process GO:0046165 2 0.011
pyruvate metabolic process GO:0006090 1 0.011
lateral inhibition GO:0046331 1 0.011
single organism organelle organization GO:1902589 199 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
gland development GO:0048732 143 0.011
fertilization GO:0009566 3 0.011
negative regulation of multi organism process GO:0043901 3 0.011
mitochondrion organization GO:0007005 4 0.011
regulation of transporter activity GO:0032409 2 0.011
cellular macromolecule localization GO:0070727 21 0.011
sensory organ development GO:0007423 393 0.011
alpha amino acid metabolic process GO:1901605 3 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
receptor internalization GO:0031623 2 0.010
rho protein signal transduction GO:0007266 5 0.010
lamellipodium organization GO:0097581 1 0.010
regulation of skeletal muscle fiber development GO:0048742 2 0.010
rna metabolic process GO:0016070 219 0.010
regulation of filopodium assembly GO:0051489 2 0.010
multicellular organismal signaling GO:0035637 22 0.010
apoptotic process involved in development GO:1902742 2 0.010
protein polyubiquitination GO:0000209 4 0.010
regulation of cell death GO:0010941 103 0.010
vesicle localization GO:0051648 27 0.010
positive regulation of biological process GO:0048518 253 0.010
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.010
regulation of neurotransmitter transport GO:0051588 1 0.010
regulation of rna metabolic process GO:0051252 224 0.010
negative regulation of blood circulation GO:1903523 2 0.010

laptm4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
disease of metabolism DOID:0014667 0 0.030
nervous system disease DOID:863 0 0.027
inherited metabolic disorder DOID:655 0 0.016
musculoskeletal system disease DOID:17 0 0.015
muscular disease DOID:0080000 0 0.011