Danio rerio

192 known processes

lef1

lymphocyte enhancer binding factor 1

lef1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neural tube patterning GO:0021532 33 0.998
Zebrafish
head development GO:0060322 303 0.997
central nervous system development GO:0007417 387 0.993
regionalization GO:0003002 274 0.992
brain development GO:0007420 293 0.991
regulation of transcription dna templated GO:0006355 213 0.986
Human Mouse Worm Fly
eye development GO:0001654 277 0.984
Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.983
Human Mouse Worm Fly
digestive tract development GO:0048565 265 0.982
Zebrafish Mouse Worm
embryonic organ development GO:0048568 381 0.981
Zebrafish Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.979
Human Mouse Worm Fly
somitogenesis GO:0001756 87 0.976
fin morphogenesis GO:0033334 53 0.976
cell motility GO:0048870 244 0.975
locomotion GO:0040011 313 0.975
cell surface receptor signaling pathway GO:0007166 325 0.970
sensory organ morphogenesis GO:0090596 200 0.968
Zebrafish
diencephalon development GO:0021536 58 0.968
embryonic pattern specification GO:0009880 44 0.967
Zebrafish Worm Fly
cellular biosynthetic process GO:0044249 286 0.966
cellular aromatic compound metabolic process GO:0006725 295 0.966
Human Mouse Worm Fly
lateral line system development GO:0048925 76 0.965
regulation of gene expression GO:0010468 265 0.958
rostrocaudal neural tube patterning GO:0021903 29 0.952
Zebrafish
heart development GO:0007507 313 0.945
Fly
forebrain generation of neurons GO:0021872 14 0.944
cell fate commitment GO:0045165 99 0.944
Worm
signal transduction GO:0007165 455 0.943
aromatic compound biosynthetic process GO:0019438 217 0.940
Human Mouse Worm Fly
response to chemical GO:0042221 320 0.938
Human
nucleobase containing compound metabolic process GO:0006139 274 0.937
Human Mouse Worm Fly
nucleic acid metabolic process GO:0090304 244 0.936
Human Mouse Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.935
forebrain development GO:0030900 96 0.933
dorsal ventral pattern formation GO:0009953 125 0.929
Zebrafish
camera type eye morphogenesis GO:0048593 108 0.924
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.911
Human Mouse Worm Fly
negative regulation of cellular process GO:0048523 283 0.911
digestive tract morphogenesis GO:0048546 231 0.909
Zebrafish Mouse Worm
sensory system development GO:0048880 76 0.904
midbrain hindbrain boundary development GO:0030917 23 0.900
heterocycle biosynthetic process GO:0018130 215 0.898
Human Mouse Worm Fly
fin development GO:0033333 77 0.898
sensory organ development GO:0007423 393 0.892
mesoderm formation GO:0001707 43 0.891
Mouse Worm
cellular component movement GO:0006928 335 0.888
regulation of rna metabolic process GO:0051252 224 0.881
Human Mouse Worm Fly
muscle organ development GO:0007517 101 0.878
Mouse Worm
appendage morphogenesis GO:0035107 56 0.877
nitrogen compound metabolic process GO:0006807 319 0.876
Human Mouse Worm Fly
nucleic acid templated transcription GO:0097659 181 0.873
Human Mouse Worm Fly
localization of cell GO:0051674 244 0.872
kidney development GO:0001822 92 0.871
anterior posterior pattern specification GO:0009952 152 0.870
mesenchymal cell differentiation GO:0048762 87 0.868
endocrine system development GO:0035270 65 0.865
neuromast development GO:0048884 46 0.865
lateral line development GO:0048882 66 0.862
regulation of macromolecule biosynthetic process GO:0010556 225 0.860
Human Mouse Worm Fly
neuroblast proliferation GO:0007405 2 0.860
Mouse
generation of neurons GO:0048699 385 0.858
rna metabolic process GO:0016070 219 0.838
Human Mouse Worm Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.830
Human Mouse Worm Fly
mesenchymal cell development GO:0014031 78 0.830
regulation of axon guidance GO:1902667 8 0.826
cellular nitrogen compound biosynthetic process GO:0044271 218 0.804
Human Mouse Worm Fly
appendage development GO:0048736 80 0.804
axon guidance GO:0007411 86 0.797
neural crest cell development GO:0014032 62 0.796
embryonic pectoral fin morphogenesis GO:0035118 24 0.790
regulation of stem cell proliferation GO:0072091 2 0.788
Fly
taxis GO:0042330 109 0.787
Human
regulation of rna biosynthetic process GO:2001141 213 0.785
Human Mouse Worm Fly
cellular component morphogenesis GO:0032989 336 0.770
Human Mouse
hypothalamus cell differentiation GO:0021979 4 0.757
angiogenesis GO:0001525 158 0.751
Mouse
posterior lateral line development GO:0048916 38 0.745
neural crest cell differentiation GO:0014033 72 0.743
muscle structure development GO:0061061 196 0.742
stem cell development GO:0048864 82 0.741
negative regulation of multicellular organismal process GO:0051241 69 0.736
Human Mouse Worm
neuron development GO:0048666 262 0.733
Worm
regulation of nervous system development GO:0051960 90 0.732
regulation of nucleic acid templated transcription GO:1903506 213 0.728
Human Mouse Worm Fly
posterior lateral line system development GO:0048915 46 0.726
regulation of molecular function GO:0065009 70 0.724
Human
regulation of cellular biosynthetic process GO:0031326 245 0.718
renal system development GO:0072001 94 0.717
dorsal ventral axis specification GO:0009950 14 0.709
forebrain neuron differentiation GO:0021879 14 0.707
biosynthetic process GO:0009058 294 0.698
single organism reproductive process GO:0044702 40 0.696
Mouse Worm
regulation of cellular metabolic process GO:0031323 320 0.695
axonal fasciculation GO:0007413 11 0.692
intracellular signal transduction GO:0035556 85 0.691
specification of axis polarity GO:0065001 4 0.686
Worm
cellular response to organic substance GO:0071310 105 0.679
Human
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.678
ear morphogenesis GO:0042471 64 0.676
hypothalamus development GO:0021854 14 0.675
organic cyclic compound metabolic process GO:1901360 301 0.673
Human Mouse Worm Fly
negative regulation of cell communication GO:0010648 96 0.672
Human Zebrafish
formation of primary germ layer GO:0001704 62 0.671
Mouse Worm
mesenchyme development GO:0060485 127 0.667
regulation of multicellular organismal development GO:2000026 223 0.661
regulation of signal transduction GO:0009966 225 0.660
Human Zebrafish Mouse Fly
neural tube development GO:0021915 62 0.658
Zebrafish
forebrain regionalization GO:0021871 4 0.657
macromolecule biosynthetic process GO:0009059 227 0.657
Human Mouse Worm Fly
somite development GO:0061053 96 0.651
anterior head development GO:0097065 2 0.649
nephron tubule morphogenesis GO:0072078 1 0.647
embryo development ending in birth or egg hatching GO:0009792 271 0.644
rna biosynthetic process GO:0032774 181 0.643
Human Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.643
Human Mouse Worm Fly
olfactory bulb development GO:0021772 4 0.639
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.637
Human Mouse Worm Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.637
Human Mouse Worm Fly
anterior posterior axis specification GO:0009948 20 0.619
patterning of blood vessels GO:0001569 15 0.611
Mouse
axonogenesis GO:0007409 152 0.610
epithelial cell differentiation GO:0030855 116 0.608
regulation of oligodendrocyte differentiation GO:0048713 1 0.602
spinal cord anterior posterior patterning GO:0021512 1 0.593
spinal cord development GO:0021510 46 0.589
Zebrafish
regulation of vitamin metabolic process GO:0030656 6 0.589
limbic system development GO:0021761 16 0.589
phosphorylation GO:0016310 69 0.587
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.578
cell cycle process GO:0022402 53 0.575
Human Worm
neuromast primordium migration GO:0048883 12 0.574
olfactory lobe development GO:0021988 4 0.568
tissue regeneration GO:0042246 74 0.563
cell migration GO:0016477 237 0.562
negative regulation of programmed cell death GO:0043069 58 0.562
Human
response to external stimulus GO:0009605 264 0.548
Human
caudal fin development GO:0033336 9 0.541
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.538
mechanosensory lateral line system development GO:0048881 49 0.536
epithalamus development GO:0021538 10 0.533
stem cell proliferation GO:0072089 4 0.529
Mouse Fly
regulation of muscle organ development GO:0048634 9 0.525
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.524
digestive system development GO:0055123 289 0.524
Zebrafish Mouse Worm
cell fate specification GO:0001708 68 0.524
Worm
transcription dna templated GO:0006351 181 0.520
Human Mouse Worm Fly
chemosensory behavior GO:0007635 1 0.520
embryonic appendage morphogenesis GO:0035113 30 0.512
Mouse
hemopoiesis GO:0030097 183 0.499
Human Mouse
regulation of cell morphogenesis GO:0022604 42 0.498
Human
muscle cell development GO:0055001 115 0.493
regulation of cell cycle GO:0051726 52 0.484
Human
positive regulation of cellular metabolic process GO:0031325 94 0.482
Human Mouse Worm Fly
axon extension GO:0048675 45 0.475
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 9 0.472
canonical wnt signaling pathway GO:0060070 48 0.470
positive regulation of stem cell proliferation GO:2000648 1 0.464
system process GO:0003008 185 0.462
Zebrafish Mouse Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.462
Human Mouse Worm Fly
nephron epithelium morphogenesis GO:0072088 1 0.461
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.454
nucleocytoplasmic transport GO:0006913 4 0.452
positive regulation of programmed cell death GO:0043068 29 0.451
fin regeneration GO:0031101 51 0.447
negative regulation of rna metabolic process GO:0051253 48 0.447
Human Mouse Worm Fly
olfactory placode development GO:0071698 12 0.446
regulation of multicellular organismal process GO:0051239 277 0.436
negative regulation of cellular metabolic process GO:0031324 77 0.434
Human Mouse Worm Fly
hepaticobiliary system development GO:0061008 98 0.433
response to organic substance GO:0010033 153 0.433
Human
regulation of cellular ketone metabolic process GO:0010565 7 0.430
autonomic nervous system development GO:0048483 19 0.430
immune system development GO:0002520 191 0.425
Human Mouse
forebrain cell migration GO:0021885 1 0.423
protein localization to nucleus GO:0034504 3 0.423
cardiocyte differentiation GO:0035051 44 0.419
negative regulation of signaling GO:0023057 96 0.416
Human Zebrafish
post anal tail morphogenesis GO:0036342 19 0.412
forebrain neuron development GO:0021884 7 0.411
bmp signaling pathway GO:0030509 52 0.408
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.407
Human Mouse Worm Fly
neuron fate commitment GO:0048663 26 0.406
dorsal convergence GO:0060030 14 0.403
small molecule metabolic process GO:0044281 77 0.402
cartilage development GO:0051216 96 0.398
heterocycle metabolic process GO:0046483 290 0.395
Human Mouse Worm Fly
regulation of cell differentiation GO:0045595 142 0.394
stem cell differentiation GO:0048863 117 0.393
homeostatic process GO:0042592 142 0.392
anterior posterior axon guidance GO:0033564 5 0.391
regulation of synapse assembly GO:0051963 3 0.386
gastrulation GO:0007369 208 0.385
Mouse Worm
programmed cell death GO:0012501 119 0.380
Human Mouse Worm
vasculature development GO:0001944 278 0.379
Mouse
regulation of response to stimulus GO:0048583 269 0.373
Human Zebrafish Mouse Fly
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.373
pectoral fin development GO:0033339 50 0.369
single organism metabolic process GO:0044710 217 0.368
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.364
neuron projection guidance GO:0097485 86 0.356
sex differentiation GO:0007548 5 0.355
Worm
microtubule based process GO:0007017 60 0.352
Worm
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.344
dopaminergic neuron differentiation GO:0071542 14 0.343
striated muscle cell development GO:0055002 108 0.341
negative regulation of response to stimulus GO:0048585 104 0.340
Human Zebrafish
regulation of cellular response to growth factor stimulus GO:0090287 35 0.339
segmentation GO:0035282 97 0.337
central nervous system neuron development GO:0021954 29 0.336
phosphorus metabolic process GO:0006793 109 0.330
hepatocyte proliferation GO:0072574 2 0.330
neuron projection morphogenesis GO:0048812 161 0.325
axon development GO:0061564 166 0.324
organic substance biosynthetic process GO:1901576 289 0.322
regulation of apoptotic process GO:0042981 98 0.320
Human
negative regulation of signal transduction GO:0009968 94 0.320
Human Zebrafish
negative regulation of protein import into nucleus GO:0042308 2 0.318
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.316
Human Mouse Worm Fly
blood vessel morphogenesis GO:0048514 216 0.313
Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.313
Human Mouse Worm Fly
regulation of glial cell differentiation GO:0045685 4 0.311
negative regulation of axon guidance GO:1902668 1 0.307
establishment of protein localization to organelle GO:0072594 4 0.301
tube morphogenesis GO:0035239 349 0.300
Zebrafish Mouse Worm
cell growth GO:0016049 57 0.299
Human
diterpenoid biosynthetic process GO:0016102 7 0.290
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.290
Worm
determination of dorsal ventral asymmetry GO:0048262 34 0.290
regulation of cell development GO:0060284 100 0.290
neural precursor cell proliferation GO:0061351 20 0.289
Zebrafish Mouse
neuron differentiation GO:0030182 353 0.289
heart looping GO:0001947 94 0.287
t cell differentiation GO:0030217 6 0.285
Mouse
ventricular system development GO:0021591 12 0.285
pancreas development GO:0031016 84 0.282
cellular response to endogenous stimulus GO:0071495 68 0.282
Human
axon extension involved in axon guidance GO:0048846 10 0.281
eye morphogenesis GO:0048592 144 0.279
Zebrafish
developmental pigmentation GO:0048066 48 0.278
chordate embryonic development GO:0043009 271 0.276
muscle cell differentiation GO:0042692 139 0.275
positive regulation of map kinase activity GO:0043406 3 0.275
embryonic limb morphogenesis GO:0030326 2 0.274
Mouse
stem cell division GO:0017145 1 0.274
Mouse
inner ear development GO:0048839 126 0.273
ear development GO:0043583 127 0.271
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.271
ameboidal type cell migration GO:0001667 143 0.271
nephron development GO:0072006 31 0.270
urogenital system development GO:0001655 97 0.270
regulation of phosphorus metabolic process GO:0051174 43 0.269
regulation of biosynthetic process GO:0009889 250 0.267
heart morphogenesis GO:0003007 156 0.265
proximal distal pattern formation GO:0009954 1 0.262
Worm
regulation of binding GO:0051098 3 0.262
Human
heparan sulfate proteoglycan metabolic process GO:0030201 6 0.262
behavior GO:0007610 74 0.260
negative regulation of neurogenesis GO:0050768 20 0.256
cell migration involved in gastrulation GO:0042074 79 0.255
regulation of neurogenesis GO:0050767 87 0.254
extrinsic apoptotic signaling pathway GO:0097191 3 0.253
circulatory system process GO:0003013 87 0.251
inner ear morphogenesis GO:0042472 63 0.250
neuron projection extension GO:1990138 45 0.246
enteroendocrine cell differentiation GO:0035883 9 0.240
posterior lateral line neuromast deposition GO:0048922 5 0.240
negative regulation of biological process GO:0048519 304 0.239
nephron morphogenesis GO:0072028 2 0.238
regulation of establishment of protein localization GO:0070201 4 0.234
skeletal muscle organ development GO:0060538 78 0.232
lymphocyte proliferation GO:0046651 1 0.229
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.225
Human Mouse
regulation of intracellular protein transport GO:0033157 3 0.224
cellular response to growth factor stimulus GO:0071363 39 0.224
wound healing GO:0042060 90 0.222
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.222
positive regulation of molecular function GO:0044093 33 0.222
regulation of programmed cell death GO:0043067 101 0.220
Human
developmental cell growth GO:0048588 52 0.217
regulation of wnt signaling pathway GO:0030111 53 0.214
Human Zebrafish Mouse Fly
habenula development GO:0021986 9 0.213
mesoderm morphogenesis GO:0048332 51 0.212
Mouse Worm
regulation of nucleocytoplasmic transport GO:0046822 2 0.212
positive regulation of epithelial cell proliferation GO:0050679 1 0.210
sprouting angiogenesis GO:0002040 53 0.208
Mouse
developmental growth involved in morphogenesis GO:0060560 86 0.208
regulation of anterior head development GO:2000742 2 0.203
hematopoietic or lymphoid organ development GO:0048534 191 0.202
Human Mouse
regulation of catenin import into nucleus GO:0035412 2 0.202
regulation of primary metabolic process GO:0080090 311 0.201
lymphocyte differentiation GO:0030098 9 0.200
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.199
Human Mouse Worm Fly
posterior lateral line neuromast primordium migration GO:0048920 12 0.196
cellular response to chemical stimulus GO:0070887 157 0.195
Human
notochord development GO:0030903 54 0.194
regulation of retinoic acid biosynthetic process GO:1900052 6 0.193
positive regulation of signal transduction GO:0009967 56 0.193
camera type eye development GO:0043010 222 0.193
Zebrafish
sequestering of calcium ion GO:0051208 3 0.192
regulation of protein localization to nucleus GO:1900180 2 0.192
segment polarity determination GO:0007367 1 0.191
determination of dorsal identity GO:0048263 13 0.191
cell morphogenesis GO:0000902 289 0.189
Human Mouse
cardioblast differentiation GO:0010002 9 0.188
mesodermal cell differentiation GO:0048333 21 0.188
Worm
regulation of epithelial to mesenchymal transition GO:0010717 3 0.188
Human
gland development GO:0048732 143 0.187
Mouse Fly
gliogenesis GO:0042063 45 0.187
Mouse
central nervous system neuron differentiation GO:0021953 74 0.186
response to growth factor GO:0070848 39 0.185
dorsal ventral neural tube patterning GO:0021904 1 0.182
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.181
homeostasis of number of cells within a tissue GO:0048873 4 0.181
female sex differentiation GO:0046660 4 0.180
regulation of cell fate commitment GO:0010453 22 0.179
Worm
positive regulation of cellular process GO:0048522 201 0.178
enzyme linked receptor protein signaling pathway GO:0007167 106 0.178
Mouse
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.177
developmental growth GO:0048589 166 0.177
periodic partitioning GO:0007365 1 0.177
neural plate anterior posterior regionalization GO:0021999 8 0.175
phosphate containing compound metabolic process GO:0006796 108 0.175
regulation of neuron differentiation GO:0045664 56 0.175
protein import into nucleus GO:0006606 3 0.173
endodermal cell differentiation GO:0035987 19 0.173
connective tissue development GO:0061448 99 0.173
regulation of cytoplasmic transport GO:1903649 4 0.173
positive regulation of nucleic acid templated transcription GO:1903508 57 0.172
Human Mouse Worm Fly
specification of symmetry GO:0009799 204 0.171
regulation of axon extension involved in axon guidance GO:0048841 6 0.171
neuron fate specification GO:0048665 20 0.170
negative regulation of apoptotic signaling pathway GO:2001234 10 0.169
nuclear transport GO:0051169 4 0.168
hindbrain morphogenesis GO:0021575 22 0.167
erk1 and erk2 cascade GO:0070371 4 0.167
apoptotic process GO:0006915 116 0.166
Human Mouse Worm
positive regulation of muscle organ development GO:0048636 1 0.166
regulation of signaling GO:0023051 235 0.165
Human Zebrafish Mouse Fly
neuron recognition GO:0008038 18 0.165
embryonic heart tube morphogenesis GO:0003143 108 0.162
liver morphogenesis GO:0072576 8 0.161
mesodermal cell migration GO:0008078 12 0.161
commissural neuron axon guidance GO:0071679 3 0.160
negative regulation of developmental process GO:0051093 65 0.160
Mouse Worm
positive regulation of biological process GO:0048518 253 0.158
negative regulation of nervous system development GO:0051961 22 0.158
negative regulation of cell differentiation GO:0045596 46 0.158
intracellular transport GO:0046907 32 0.157
cerebellum morphogenesis GO:0021587 10 0.156
epithelial to mesenchymal transition GO:0001837 21 0.154
Human Mouse
gamete generation GO:0007276 33 0.153
negative regulation of gene expression GO:0010629 65 0.153
Human Mouse Worm Fly
activation of jun kinase activity GO:0007257 2 0.153
macromolecule localization GO:0033036 54 0.152
regulation of homeostatic process GO:0032844 9 0.151
endoderm development GO:0007492 49 0.149
protein targeting to nucleus GO:0044744 3 0.149
neural crest cell migration GO:0001755 42 0.148
response to other organism GO:0051707 97 0.148
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 20 0.148
regulation of heart growth GO:0060420 2 0.148
positive regulation of striated muscle cell differentiation GO:0051155 1 0.147
spinal cord dorsal ventral patterning GO:0021513 5 0.147
Zebrafish
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.147
single organism nuclear import GO:1902593 3 0.146
response to external biotic stimulus GO:0043207 97 0.145
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.144
Human Mouse Worm Fly
cell death GO:0008219 121 0.143
Human Mouse Worm
regulation of axon extension GO:0030516 24 0.143
positive regulation of response to stimulus GO:0048584 80 0.142
embryonic heart tube development GO:0035050 133 0.141
retina development in camera type eye GO:0060041 146 0.141
exocrine system development GO:0035272 28 0.141
Fly
gene expression GO:0010467 252 0.139
embryonic camera type eye formation GO:0060900 10 0.139
regulation of protein transport GO:0051223 3 0.138
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.138
Zebrafish
negative regulation of chemotaxis GO:0050922 4 0.138
optic placode formation GO:0001743 4 0.138
renal tubule morphogenesis GO:0061333 1 0.137
protein import GO:0017038 3 0.136
organelle organization GO:0006996 227 0.136
Human Worm
response to endogenous stimulus GO:0009719 83 0.136
Human
retinal ganglion cell axon guidance GO:0031290 35 0.134
regulation of growth GO:0040008 42 0.134
Human
otolith development GO:0048840 32 0.133
regulation of skeletal muscle tissue development GO:0048641 4 0.133
forebrain anterior posterior pattern specification GO:0021797 3 0.132
cell proliferation in dorsal spinal cord GO:0010456 2 0.132
Zebrafish
retinoic acid metabolic process GO:0042573 9 0.132
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.130
positive regulation of cell differentiation GO:0045597 30 0.130
mitotic cell cycle GO:0000278 64 0.129
Worm
atrial ventricular junction remodeling GO:0003294 2 0.129
epithelial cell development GO:0002064 42 0.129
embryonic skeletal system morphogenesis GO:0048704 93 0.128
ectodermal placode formation GO:0060788 26 0.128
retinoic acid biosynthetic process GO:0002138 6 0.125
cell proliferation GO:0008283 80 0.123
cerebellar cortex development GO:0021695 5 0.122
embryonic medial fin morphogenesis GO:0035122 6 0.122
regulation of cell death GO:0010941 103 0.122
Human
telencephalon development GO:0021537 14 0.122
Mouse
protein localization GO:0008104 40 0.119
cardiac muscle cell differentiation GO:0055007 30 0.118
single organism organelle organization GO:1902589 199 0.117
Human Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.117
response to wounding GO:0009611 116 0.117
regulation of intracellular signal transduction GO:1902531 57 0.115
regulation of metabolic process GO:0019222 359 0.113
bone remodeling GO:0046849 2 0.113
negative regulation of nucleic acid templated transcription GO:1903507 45 0.112
Human Mouse Worm Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.112
single organism transport GO:0044765 206 0.112
Worm
regulation of protein targeting GO:1903533 2 0.111
regulation of phosphate metabolic process GO:0019220 43 0.110
defense response to other organism GO:0098542 33 0.109
exocrine pancreas development GO:0031017 28 0.108
single organism cellular localization GO:1902580 46 0.107
stem cell maintenance GO:0019827 4 0.107
signal transduction in absence of ligand GO:0038034 1 0.106
semicircular canal development GO:0060872 24 0.105
neuron migration GO:0001764 22 0.105
regulation of organ growth GO:0046620 3 0.104
thalamus development GO:0021794 6 0.104
ras protein signal transduction GO:0007265 7 0.103
cell projection morphogenesis GO:0048858 244 0.103
pigment cell differentiation GO:0050931 38 0.102
cell part morphogenesis GO:0032990 246 0.102
single organism localization GO:1902578 225 0.101
Worm
peripheral nervous system development GO:0007422 55 0.101
reproduction GO:0000003 40 0.101
Worm
reproductive structure development GO:0048608 5 0.100
Mouse Worm
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.099
positive regulation of cellular amine metabolic process GO:0033240 0 0.099
axis specification GO:0009798 43 0.099
Worm
regulation of bmp signaling pathway GO:0030510 39 0.098
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.098
negative regulation of cellular biosynthetic process GO:0031327 55 0.096
Human Mouse Worm Fly
skin morphogenesis GO:0043589 7 0.095
mesoderm development GO:0007498 88 0.094
Mouse Worm
cellular protein modification process GO:0006464 100 0.093
Human
hindbrain development GO:0030902 91 0.092
Zebrafish Mouse
cell proliferation in forebrain GO:0021846 3 0.090
regulation of anatomical structure morphogenesis GO:0022603 130 0.090
Human
oligodendrocyte differentiation GO:0048709 23 0.089
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.089
glial cell differentiation GO:0010001 42 0.089
Mouse
single organism cell adhesion GO:0098602 29 0.089
Human Mouse
pigmentation GO:0043473 85 0.088
regulation of epithelial cell proliferation GO:0050678 3 0.087
regulation of protein import into nucleus GO:0042306 2 0.087
regulation of catalytic activity GO:0050790 55 0.087
Human
growth GO:0040007 174 0.086
regulation of system process GO:0044057 40 0.086
Worm
cellular ketone metabolic process GO:0042180 11 0.086
erythrocyte differentiation GO:0030218 54 0.086
nuclear import GO:0051170 3 0.086
melanocyte differentiation GO:0030318 26 0.086
convergent extension involved in gastrulation GO:0060027 71 0.085
embryonic hemopoiesis GO:0035162 53 0.084
regulation of mesenchymal cell proliferation GO:0010464 1 0.084
regulation of cell proliferation GO:0042127 37 0.083
negative regulation of sequestering of calcium ion GO:0051283 4 0.083
motor neuron axon guidance GO:0008045 23 0.083
blood vessel endothelial cell migration GO:0043534 18 0.083
positive regulation of neural precursor cell proliferation GO:2000179 1 0.083
negative regulation of transcription dna templated GO:0045892 45 0.082
Human Mouse Worm Fly
forebrain neuron fate commitment GO:0021877 1 0.082
neural plate pattern specification GO:0060896 12 0.082
regulation of cellular amino acid metabolic process GO:0006521 0 0.081
type b pancreatic cell development GO:0003323 4 0.081
optic placode formation involved in camera type eye formation GO:0046619 3 0.081
positive regulation of signaling GO:0023056 56 0.080
osteoclast differentiation GO:0030316 1 0.080
positive regulation of multicellular organismal process GO:0051240 52 0.080
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.079
protein complex subunit organization GO:0071822 46 0.079
Worm
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.078
striated muscle tissue development GO:0014706 110 0.078
Mouse
specification of organ identity GO:0010092 2 0.078
cellular hormone metabolic process GO:0034754 19 0.078
cellular component assembly GO:0022607 170 0.077
regulation of bone remodeling GO:0046850 2 0.077
larval development GO:0002164 2 0.076
Worm
negative regulation of cytoplasmic transport GO:1903650 2 0.076
negative regulation of metabolic process GO:0009892 86 0.076
Human Mouse Worm Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.075
developmental process involved in reproduction GO:0003006 27 0.075
Mouse Worm
artery development GO:0060840 22 0.075
multi organism process GO:0051704 134 0.075
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.074
endocrine pancreas development GO:0031018 27 0.073
endoderm formation GO:0001706 29 0.073

lef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.099
gastrointestinal system cancer DOID:3119 0 0.093
cancer DOID:162 0 0.093
disease of cellular proliferation DOID:14566 0 0.093
organ system cancer DOID:0050686 0 0.093