Danio rerio

38 known processes

lgmn

legumain

(Aliases: cb173,wu:fa98g05,cb460,zgc:76953,wu:fj92g08,sb:cb173)

lgmn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.133
Mouse
multi organism process GO:0051704 134 0.116
extrinsic apoptotic signaling pathway GO:0097191 3 0.114
larval development GO:0002164 2 0.107
aging GO:0007568 2 0.105
regulation of intracellular ph GO:0051453 1 0.096
ribonucleoside monophosphate catabolic process GO:0009158 4 0.086
neuron projection development GO:0031175 180 0.079
regulation of multicellular organismal process GO:0051239 277 0.077
Mouse
lipid catabolic process GO:0016042 4 0.072
purine nucleoside monophosphate catabolic process GO:0009128 4 0.070
developmental growth GO:0048589 166 0.067
establishment of localization GO:0051234 244 0.066
organonitrogen compound metabolic process GO:1901564 74 0.060
rna localization GO:0006403 4 0.060
multicellular organism growth GO:0035264 4 0.054
Mouse
cytoplasm organization GO:0007028 4 0.054
transport GO:0006810 220 0.052
morphogenesis of an epithelium GO:0002009 333 0.052
blood vessel development GO:0001568 246 0.051
autophagy GO:0006914 4 0.050
regulation of reproductive process GO:2000241 4 0.049
cell morphogenesis GO:0000902 289 0.048
cellular component morphogenesis GO:0032989 336 0.048
system process GO:0003008 185 0.048
Mouse
single organism metabolic process GO:0044710 217 0.047
regulation of signaling GO:0023051 235 0.044
Mouse
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.044
cellular response to external stimulus GO:0071496 2 0.043
regulation of cytokine production GO:0001817 3 0.043
epithelial cell differentiation GO:0030855 116 0.042
neuron development GO:0048666 262 0.042
regulation of biological quality GO:0065008 263 0.042
organelle organization GO:0006996 227 0.041
single organism localization GO:1902578 225 0.041
response to chemical GO:0042221 320 0.041
nitrogen compound metabolic process GO:0006807 319 0.040
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.039
cellular catabolic process GO:0044248 27 0.038
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.038
response to stress GO:0006950 263 0.038
endosomal transport GO:0016197 2 0.037
atp catabolic process GO:0006200 4 0.036
response to external stimulus GO:0009605 264 0.035
regulation of synapse assembly GO:0051963 3 0.035
cellular response to molecule of bacterial origin GO:0071219 3 0.035
single organism nuclear import GO:1902593 3 0.034
neuron differentiation GO:0030182 353 0.034
cellular macromolecule metabolic process GO:0044260 391 0.033
Mouse
cellular response to biotic stimulus GO:0071216 3 0.033
small molecule metabolic process GO:0044281 77 0.032
blood vessel morphogenesis GO:0048514 216 0.032
regulation of cell communication GO:0010646 232 0.031
Mouse
response to biotic stimulus GO:0009607 97 0.031
growth GO:0040007 174 0.030
angiogenesis GO:0001525 158 0.030
oxoacid metabolic process GO:0043436 31 0.030
response to copper ion GO:0046688 13 0.030
positive regulation of transport GO:0051050 2 0.029
small molecule biosynthetic process GO:0044283 16 0.029
response to other organism GO:0051707 97 0.029
response to organic substance GO:0010033 153 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
negative regulation of cellular process GO:0048523 283 0.029
Mouse
protein metabolic process GO:0019538 183 0.028
Mouse
regulation of sodium ion transport GO:0002028 2 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
Mouse
generation of neurons GO:0048699 385 0.027
tube morphogenesis GO:0035239 349 0.026
central nervous system development GO:0007417 387 0.026
lipid metabolic process GO:0006629 52 0.026
positive regulation of catabolic process GO:0009896 4 0.026
regulation of developmental process GO:0050793 247 0.026
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.026
Mouse
lipid storage GO:0019915 1 0.025
organic acid metabolic process GO:0006082 31 0.025
cellular response to nutrient levels GO:0031669 2 0.025
cell projection morphogenesis GO:0048858 244 0.025
pole plasm assembly GO:0007315 4 0.024
regulation of purine nucleotide catabolic process GO:0033121 2 0.024
regulation of multicellular organism growth GO:0040014 4 0.024
Mouse
catabolic process GO:0009056 32 0.024
Mouse
response to corticosteroid GO:0031960 1 0.024
cellular protein metabolic process GO:0044267 129 0.024
Mouse
positive regulation of cellular catabolic process GO:0031331 3 0.024
nucleoside monophosphate catabolic process GO:0009125 4 0.023
regulation of metabolic process GO:0019222 359 0.023
dicarboxylic acid metabolic process GO:0043648 1 0.023
synaptic growth at neuromuscular junction GO:0051124 2 0.023
regulation of protein catabolic process GO:0042176 1 0.023
apoptotic process involved in development GO:1902742 2 0.022
compound eye development GO:0048749 2 0.021
long chain fatty acid metabolic process GO:0001676 1 0.021
nuclear transport GO:0051169 4 0.020
regulation of cellular component organization GO:0051128 86 0.020
muscle tissue development GO:0060537 110 0.020
striated muscle tissue development GO:0014706 110 0.020
biosynthetic process GO:0009058 294 0.020
lytic vacuole organization GO:0080171 1 0.020
regulation of metal ion transport GO:0010959 4 0.020
anterior posterior pattern specification GO:0009952 152 0.019
embryonic heart tube development GO:0035050 133 0.019
single organism transport GO:0044765 206 0.019
oxidoreduction coenzyme metabolic process GO:0006733 1 0.019
programmed cell death GO:0012501 119 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
Worm
organic substance catabolic process GO:1901575 28 0.019
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
intracellular transport GO:0046907 32 0.017
adult behavior GO:0030534 2 0.017
signal transduction in absence of ligand GO:0038034 1 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
muscle structure development GO:0061061 196 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
heart development GO:0007507 313 0.017
ph reduction GO:0045851 1 0.017
maintenance of location GO:0051235 4 0.016
alcohol biosynthetic process GO:0046165 2 0.016
regulation of cell differentiation GO:0045595 142 0.016
cellular amino acid biosynthetic process GO:0008652 2 0.016
regulation of cellular ph GO:0030641 1 0.016
single organism organelle organization GO:1902589 199 0.016
response to external biotic stimulus GO:0043207 97 0.016
intracellular signal transduction GO:0035556 85 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
cellular response to starvation GO:0009267 1 0.015
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
death GO:0016265 121 0.015
syncytium formation GO:0006949 12 0.014
protein stabilization GO:0050821 2 0.014
cell part morphogenesis GO:0032990 246 0.014
gland development GO:0048732 143 0.014
immune system process GO:0002376 241 0.014
myotube differentiation GO:0014902 45 0.014
regulation of membrane potential GO:0042391 23 0.014
leukocyte mediated cytotoxicity GO:0001909 1 0.014
positive regulation of biological process GO:0048518 253 0.014
negative regulation of reproductive process GO:2000242 3 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
oocyte anterior posterior axis specification GO:0007314 4 0.014
multicellular organismal macromolecule metabolic process GO:0044259 2 0.013
synaptic vesicle localization GO:0097479 1 0.013
single organism biosynthetic process GO:0044711 71 0.013
negative regulation of cell communication GO:0010648 96 0.013
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.013
type i interferon biosynthetic process GO:0045351 1 0.013
response to glucocorticoid GO:0051384 1 0.013
cellular protein catabolic process GO:0044257 4 0.013
Mouse
response to bacterium GO:0009617 58 0.013
positive regulation of striated muscle cell differentiation GO:0051155 1 0.013
membrane invagination GO:0010324 1 0.013
protein import into nucleus GO:0006606 3 0.013
ion homeostasis GO:0050801 41 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
immune system development GO:0002520 191 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
septum transversum development GO:0003343 4 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
tissue regeneration GO:0042246 74 0.012
response to inorganic substance GO:0010035 38 0.012
vasculature development GO:0001944 278 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
gtp metabolic process GO:0046039 4 0.012
positive regulation of cell cycle GO:0045787 3 0.012
defense response to bacterium GO:0042742 22 0.012
xenobiotic metabolic process GO:0006805 4 0.012
establishment of blood brain barrier GO:0060856 2 0.012
hepaticobiliary system development GO:0061008 98 0.012
nucleobase containing compound metabolic process GO:0006139 274 0.012
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.012
neurotransmitter transport GO:0006836 2 0.012
cell projection organization GO:0030030 284 0.012
hemopoiesis GO:0030097 183 0.012
transmission of nerve impulse GO:0019226 19 0.012
embryonic organ development GO:0048568 381 0.011
response to endogenous stimulus GO:0009719 83 0.011
regulation of ph GO:0006885 3 0.011
cellular component biogenesis GO:0044085 178 0.011
negative regulation of biological process GO:0048519 304 0.011
Mouse
regionalization GO:0003002 274 0.011
cellular component assembly GO:0022607 170 0.011
lymphocyte proliferation GO:0046651 1 0.011
small molecule catabolic process GO:0044282 3 0.011
interspecies interaction between organisms GO:0044419 4 0.011
regulation of protein transport GO:0051223 3 0.011
nuclear import GO:0051170 3 0.011
response to alkaloid GO:0043279 2 0.011
neuronal action potential GO:0019228 18 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
cell killing GO:0001906 2 0.011
chemical homeostasis GO:0048878 49 0.010
toxin metabolic process GO:0009404 1 0.010
negative regulation of signal transduction GO:0009968 94 0.010
Mouse
negative regulation of multi organism process GO:0043901 3 0.010
regulation of production of molecular mediator of immune response GO:0002700 1 0.010
positive regulation of cytokine production GO:0001819 2 0.010
protein complex localization GO:0031503 1 0.010
regulation of synapse organization GO:0050807 3 0.010
exocytosis GO:0006887 1 0.010

lgmn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.534
inherited metabolic disorder DOID:655 0 0.534
lysosomal storage disease DOID:3211 0 0.373
disease of anatomical entity DOID:7 0 0.093
nervous system disease DOID:863 0 0.049
lipid storage disease DOID:9455 0 0.042