Danio rerio

0 known processes

lrwd1

leucine-rich repeats and WD repeat domain containing 1

(Aliases: wu:ft31b04,wu:fb78b03,si:dkey-261j4.9)

lrwd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.485
organic cyclic compound metabolic process GO:1901360 301 0.476
negative regulation of cellular process GO:0048523 283 0.401
nucleic acid metabolic process GO:0090304 244 0.382
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.365
cellular aromatic compound metabolic process GO:0006725 295 0.307
cellular nitrogen compound metabolic process GO:0034641 290 0.291
nitrogen compound metabolic process GO:0006807 319 0.281
cellular macromolecule biosynthetic process GO:0034645 224 0.281
regulation of nitrogen compound metabolic process GO:0051171 251 0.272
nucleobase containing compound metabolic process GO:0006139 274 0.265
cellular biosynthetic process GO:0044249 286 0.264
regulation of primary metabolic process GO:0080090 311 0.254
heterocycle biosynthetic process GO:0018130 215 0.230
negative regulation of biological process GO:0048519 304 0.227
macromolecule biosynthetic process GO:0009059 227 0.195
organic substance biosynthetic process GO:1901576 289 0.194
meiotic cell cycle process GO:1903046 3 0.185
regulation of cellular metabolic process GO:0031323 320 0.175
larval development GO:0002164 2 0.167
regulation of gene expression GO:0010468 265 0.167
positive regulation of biological process GO:0048518 253 0.165
nucleic acid templated transcription GO:0097659 181 0.163
regulation of metabolic process GO:0019222 359 0.161
gene expression GO:0010467 252 0.155
single organism organelle organization GO:1902589 199 0.145
maintenance of location GO:0051235 4 0.143
regulation of cellular biosynthetic process GO:0031326 245 0.143
heterocycle metabolic process GO:0046483 290 0.139
organelle organization GO:0006996 227 0.129
Human
meiotic nuclear division GO:0007126 4 0.120
single organism metabolic process GO:0044710 217 0.120
cellular nitrogen compound biosynthetic process GO:0044271 218 0.113
nucleobase containing compound biosynthetic process GO:0034654 205 0.112
transcription dna templated GO:0006351 181 0.107
response to stress GO:0006950 263 0.105
nucleoside monophosphate catabolic process GO:0009125 4 0.105
cell cycle GO:0007049 93 0.104
chromosome organization GO:0051276 31 0.095
Human
mitotic dna damage checkpoint GO:0044773 4 0.092
regulation of biosynthetic process GO:0009889 250 0.092
regulation of biological quality GO:0065008 263 0.089
purine nucleoside monophosphate catabolic process GO:0009128 4 0.089
regulation of macromolecule metabolic process GO:0060255 317 0.084
regulation of rna metabolic process GO:0051252 224 0.081
meiosis i GO:0007127 1 0.080
regulation of macromolecule biosynthetic process GO:0010556 225 0.080
regulation of nucleic acid templated transcription GO:1903506 213 0.078
regulation of transcription dna templated GO:0006355 213 0.074
regulation of rna biosynthetic process GO:2001141 213 0.073
biosynthetic process GO:0009058 294 0.072
g2 dna damage checkpoint GO:0031572 3 0.068
aromatic compound biosynthetic process GO:0019438 217 0.068
organic cyclic compound biosynthetic process GO:1901362 223 0.067
rna localization GO:0006403 4 0.066
cytoskeleton organization GO:0007010 96 0.064
double strand break repair via homologous recombination GO:0000724 1 0.063
organonitrogen compound metabolic process GO:1901564 74 0.062
signal transduction GO:0007165 455 0.060
ribonucleoside monophosphate catabolic process GO:0009158 4 0.060
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.059
multi organism process GO:0051704 134 0.056
negative regulation of metabolic process GO:0009892 86 0.055
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.055
mitotic dna integrity checkpoint GO:0044774 4 0.054
lipid storage GO:0019915 1 0.054
negative regulation of cellular metabolic process GO:0031324 77 0.053
positive regulation of cellular metabolic process GO:0031325 94 0.051
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.051
cellular response to stress GO:0033554 62 0.050
regulation of signaling GO:0023051 235 0.047
cellular component biogenesis GO:0044085 178 0.045
protein metabolic process GO:0019538 183 0.045
atp catabolic process GO:0006200 4 0.045
single organism reproductive process GO:0044702 40 0.044
negative regulation of gene expression GO:0010629 65 0.041
negative regulation of transcription dna templated GO:0045892 45 0.041
rna metabolic process GO:0016070 219 0.040
g1 s transition of mitotic cell cycle GO:0000082 1 0.040
negative regulation of mitosis GO:0045839 3 0.040
actin filament based process GO:0030029 64 0.039
cellular protein metabolic process GO:0044267 129 0.039
negative regulation of macromolecule metabolic process GO:0010605 76 0.039
carbohydrate derivative metabolic process GO:1901135 61 0.038
aging GO:0007568 2 0.038
positive regulation of cell cycle GO:0045787 3 0.038
cell cycle g1 s phase transition GO:0044843 1 0.037
cell part morphogenesis GO:0032990 246 0.036
embryo development ending in birth or egg hatching GO:0009792 271 0.036
purine nucleotide metabolic process GO:0006163 27 0.036
cell cycle process GO:0022402 53 0.035
cellular response to dna damage stimulus GO:0006974 24 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.034
tube morphogenesis GO:0035239 349 0.034
regulation of mrna splicing via spliceosome GO:0048024 3 0.033
internal protein amino acid acetylation GO:0006475 2 0.033
regulation of response to stimulus GO:0048583 269 0.033
cellular component assembly GO:0022607 170 0.033
mitotic recombination GO:0006312 2 0.033
single organism localization GO:1902578 225 0.032
regulation of meiotic cell cycle GO:0051445 1 0.030
macromolecule localization GO:0033036 54 0.030
Human
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
negative regulation of biosynthetic process GO:0009890 55 0.030
regulation of binding GO:0051098 3 0.029
nucleotide metabolic process GO:0009117 28 0.029
neuron differentiation GO:0030182 353 0.029
ribose phosphate metabolic process GO:0019693 27 0.029
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
digestive tract development GO:0048565 265 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.028
amine metabolic process GO:0009308 2 0.028
multicellular organism growth GO:0035264 4 0.027
double strand break repair GO:0006302 3 0.027
sequestering of metal ion GO:0051238 3 0.027
positive regulation of cellular process GO:0048522 201 0.027
mitotic cell cycle process GO:1903047 48 0.027
protein acylation GO:0043543 3 0.026
regulation of dna replication GO:0006275 3 0.026
neuron development GO:0048666 262 0.026
response to uv GO:0009411 3 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.025
regulation of cell communication GO:0010646 232 0.025
transport GO:0006810 220 0.024
death GO:0016265 121 0.024
regulation of cellular component organization GO:0051128 86 0.024
regulation of cell death GO:0010941 103 0.023
b cell activation GO:0042113 2 0.023
cell death GO:0008219 121 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
microtubule organizing center organization GO:0031023 1 0.023
regulation of signal transduction GO:0009966 225 0.023
negative regulation of rna metabolic process GO:0051253 48 0.022
protein complex localization GO:0031503 1 0.022
muscle structure development GO:0061061 196 0.022
recombinational repair GO:0000725 1 0.022
regulation of multicellular organism growth GO:0040014 4 0.022
gtp catabolic process GO:0006184 2 0.022
negative regulation of nucleic acid templated transcription GO:1903507 45 0.022
apoptotic process GO:0006915 116 0.022
regulation of protein complex assembly GO:0043254 3 0.022
cytokinesis GO:0000910 3 0.022
sister chromatid cohesion GO:0007062 2 0.022
regulation of dna recombination GO:0000018 2 0.022
programmed cell death GO:0012501 119 0.021
multi organism reproductive process GO:0044703 36 0.021
response to chemical GO:0042221 320 0.021
positive regulation of catabolic process GO:0009896 4 0.021
meiotic chromosome segregation GO:0045132 3 0.021
regulation of cellular protein catabolic process GO:1903362 1 0.021
telomere organization GO:0032200 1 0.021
rna processing GO:0006396 25 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
regulation of cell cycle GO:0051726 52 0.021
cell morphogenesis GO:0000902 289 0.021
cellular amine metabolic process GO:0044106 2 0.020
cell surface receptor signaling pathway GO:0007166 325 0.020
organophosphate metabolic process GO:0019637 37 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.020
rna biosynthetic process GO:0032774 181 0.020
mitotic cell cycle GO:0000278 64 0.020
telomere maintenance GO:0000723 1 0.020
dna catabolic process GO:0006308 1 0.019
purine containing compound metabolic process GO:0072521 29 0.019
positive regulation of metabolic process GO:0009893 108 0.019
negative regulation of cellular biosynthetic process GO:0031327 55 0.019
female gamete generation GO:0007292 14 0.019
actin cytoskeleton organization GO:0030036 63 0.019
nuclear division GO:0000280 23 0.019
regulation of protein catabolic process GO:0042176 1 0.018
cellular protein catabolic process GO:0044257 4 0.018
chromosome segregation GO:0007059 12 0.018
muscle organ development GO:0007517 101 0.018
regulation of chromosome segregation GO:0051983 1 0.018
growth GO:0040007 174 0.018
organelle fission GO:0048285 23 0.018
digestive system development GO:0055123 289 0.018
phosphate containing compound metabolic process GO:0006796 108 0.017
cellular component morphogenesis GO:0032989 336 0.017
multicellular organismal reproductive process GO:0048609 35 0.017
cellular response to radiation GO:0071478 4 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
cell projection morphogenesis GO:0048858 244 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.017
negative regulation of dna metabolic process GO:0051053 4 0.017
cell projection organization GO:0030030 284 0.017
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.017
small molecule metabolic process GO:0044281 77 0.017
immunoglobulin mediated immune response GO:0016064 3 0.017
small gtpase mediated signal transduction GO:0007264 8 0.016
establishment of localization GO:0051234 244 0.016
Human
hatching GO:0035188 4 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
protein acetylation GO:0006473 2 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
alternative mrna splicing via spliceosome GO:0000380 1 0.016
reciprocal dna recombination GO:0035825 1 0.016
fertilization GO:0009566 3 0.016
ribonucleotide metabolic process GO:0009259 27 0.016
guanosine containing compound metabolic process GO:1901068 4 0.015
negative regulation of kinase activity GO:0033673 4 0.015
organism emergence from protective structure GO:0071684 4 0.015
production of molecular mediator of immune response GO:0002440 2 0.015
negative regulation of signal transduction GO:0009968 94 0.015
neurological system process GO:0050877 62 0.015
gtp metabolic process GO:0046039 4 0.015
phosphorylation GO:0016310 69 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
protein modification process GO:0036211 100 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
nucleoside phosphate metabolic process GO:0006753 28 0.015
cellular macromolecular complex assembly GO:0034622 24 0.015
positive regulation of transport GO:0051050 2 0.015
cognition GO:0050890 1 0.014
purine ribonucleotide metabolic process GO:0009150 27 0.014
oxoacid metabolic process GO:0043436 31 0.014
generation of neurons GO:0048699 385 0.014
cellular protein modification process GO:0006464 100 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
regulation of mitotic cell cycle GO:0007346 25 0.014
reproductive process GO:0022414 40 0.014
locomotion GO:0040011 313 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
negative regulation of rna biosynthetic process GO:1902679 45 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
regulation of mitotic cell cycle phase transition GO:1901990 8 0.014
cytosolic calcium ion transport GO:0060401 3 0.014
sequestering of calcium ion GO:0051208 3 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
intracellular signal transduction GO:0035556 85 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
behavior GO:0007610 74 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
nuclear export GO:0051168 1 0.013
organelle assembly GO:0070925 110 0.013
regulation of catalytic activity GO:0050790 55 0.013
g2 m transition of mitotic cell cycle GO:0000086 4 0.013
macromolecular complex assembly GO:0065003 35 0.013
mitotic cell cycle checkpoint GO:0007093 5 0.013
negative regulation of sequestering of calcium ion GO:0051283 4 0.013
macromolecular complex subunit organization GO:0043933 74 0.012
Human
homeostatic process GO:0042592 142 0.012
regulation of cell cycle phase transition GO:1901987 8 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
actomyosin structure organization GO:0031032 53 0.012
embryonic organ development GO:0048568 381 0.012
macromolecule modification GO:0043412 111 0.012
nucleobase containing compound transport GO:0015931 2 0.012
positive regulation of cell communication GO:0010647 56 0.012
intrinsic apoptotic signaling pathway GO:0097193 20 0.012
negative regulation of nuclear division GO:0051784 3 0.012
developmental growth GO:0048589 166 0.012
cell cycle checkpoint GO:0000075 7 0.011
negative regulation of dna replication GO:0008156 2 0.011
calcium ion transport into cytosol GO:0060402 3 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
meiotic cell cycle GO:0051321 5 0.011
mrna export from nucleus GO:0006406 1 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
dna integrity checkpoint GO:0031570 6 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
dna metabolic process GO:0006259 27 0.011
protein complex subunit organization GO:0071822 46 0.011
negative regulation of cell cycle process GO:0010948 9 0.011
cellular localization GO:0051641 97 0.011
Human
regulation of cell cycle process GO:0010564 20 0.011
regulation of programmed cell death GO:0043067 101 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
establishment of rna localization GO:0051236 3 0.011
negative regulation of mitotic cell cycle GO:0045930 11 0.011
rna export from nucleus GO:0006405 1 0.011
regulation of gene silencing GO:0060968 1 0.011
cell cycle g2 m phase transition GO:0044839 4 0.010
fatty acid biosynthetic process GO:0006633 4 0.010
rna transport GO:0050658 2 0.010
cell proliferation GO:0008283 80 0.010
spermatid development GO:0007286 2 0.010
organic acid metabolic process GO:0006082 31 0.010
sexual reproduction GO:0019953 36 0.010

lrwd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.013
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
inherited metabolic disorder DOID:655 0 0.011