Danio rerio

0 known processes

matn4

matrilin 4

(Aliases: im:7137546,matrilin-4)

matn4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cartilage development GO:0051216 96 0.684
Zebrafish
skeletal system development GO:0001501 181 0.533
Zebrafish
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.462
negative regulation of cellular process GO:0048523 283 0.392
connective tissue development GO:0061448 99 0.386
Zebrafish
blood vessel development GO:0001568 246 0.366
collagen fibril organization GO:0030199 1 0.360
response to chemical GO:0042221 320 0.311
regulation of signaling GO:0023051 235 0.310
response to stress GO:0006950 263 0.286
Mouse
embryonic organ morphogenesis GO:0048562 274 0.241
embryonic organ development GO:0048568 381 0.238
vasculature development GO:0001944 278 0.236
multicellular organismal metabolic process GO:0044236 2 0.232
ameboidal type cell migration GO:0001667 143 0.214
regulation of developmental process GO:0050793 247 0.198
regulation of multicellular organismal development GO:2000026 223 0.192
outflow tract morphogenesis GO:0003151 1 0.184
regulation of epithelial cell proliferation GO:0050678 3 0.183
collagen metabolic process GO:0032963 2 0.179
regulation of cytokine production GO:0001817 3 0.171
cell migration GO:0016477 237 0.154
regulation of cell differentiation GO:0045595 142 0.154
response to amino acid GO:0043200 2 0.148
cell substrate adhesion GO:0031589 4 0.144
cell proliferation GO:0008283 80 0.139
chordate embryonic development GO:0043009 271 0.132
cell surface receptor signaling pathway GO:0007166 325 0.131
morphogenesis of an epithelium GO:0002009 333 0.128
positive regulation of cytokine production GO:0001819 2 0.127
skeletal system morphogenesis GO:0048705 102 0.123
negative regulation of epithelial cell proliferation GO:0050680 1 0.121
organic substance biosynthetic process GO:1901576 289 0.116
response to drug GO:0042493 3 0.116
appendage morphogenesis GO:0035107 56 0.115
multicellular organismal macromolecule metabolic process GO:0044259 2 0.114
ossification GO:0001503 23 0.113
cellular macromolecule metabolic process GO:0044260 391 0.112
angiogenesis GO:0001525 158 0.112
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.110
regulation of cell communication GO:0010646 232 0.107
basement membrane assembly GO:0070831 3 0.101
regulation of cell proliferation GO:0042127 37 0.100
regulation of cell substrate adhesion GO:0010810 1 0.097
cellular response to growth factor stimulus GO:0071363 39 0.096
negative regulation of biological process GO:0048519 304 0.096
negative regulation of metabolic process GO:0009892 86 0.090
gene expression GO:0010467 252 0.090
response to wounding GO:0009611 116 0.088
Mouse
positive regulation of cell adhesion GO:0045785 1 0.087
regulation of chondrocyte differentiation GO:0032330 1 0.086
muscle fiber development GO:0048747 52 0.084
zymogen activation GO:0031638 3 0.082
cellular response to chemical stimulus GO:0070887 157 0.082
biosynthetic process GO:0009058 294 0.081
extracellular matrix organization GO:0030198 27 0.079
blood vessel morphogenesis GO:0048514 216 0.079
negative regulation of protein phosphorylation GO:0001933 4 0.078
sprouting angiogenesis GO:0002040 53 0.076
muscle structure development GO:0061061 196 0.075
appendage development GO:0048736 80 0.074
aging GO:0007568 2 0.071
response to nutrient GO:0007584 3 0.071
phagocytosis GO:0006909 3 0.070
cellular nitrogen compound biosynthetic process GO:0044271 218 0.069
regulation of metabolic process GO:0019222 359 0.069
cell morphogenesis involved in differentiation GO:0000904 195 0.069
positive regulation of immune effector process GO:0002699 3 0.068
signal transduction GO:0007165 455 0.068
heart morphogenesis GO:0003007 156 0.067
extrinsic apoptotic signaling pathway GO:0097191 3 0.067
eye morphogenesis GO:0048592 144 0.066
protein metabolic process GO:0019538 183 0.065
direct ossification GO:0036072 3 0.064
cell matrix adhesion GO:0007160 4 0.064
positive regulation of cellular metabolic process GO:0031325 94 0.063
embryo development ending in birth or egg hatching GO:0009792 271 0.063
regulation of response to stimulus GO:0048583 269 0.062
collagen biosynthetic process GO:0032964 2 0.061
positive regulation of cell communication GO:0010647 56 0.061
regulation of cellular ketone metabolic process GO:0010565 7 0.061
negative regulation of catalytic activity GO:0043086 21 0.060
embryonic skeletal system development GO:0048706 97 0.060
positive regulation of cell differentiation GO:0045597 30 0.058
mesenchymal cell development GO:0014031 78 0.058
digestive system development GO:0055123 289 0.057
multicellular organism growth GO:0035264 4 0.056
transcription from rna polymerase ii promoter GO:0006366 80 0.056
cellular response to organic substance GO:0071310 105 0.056
negative regulation of multicellular organismal process GO:0051241 69 0.056
regulation of multicellular organismal process GO:0051239 277 0.054
regulation of cellular biosynthetic process GO:0031326 245 0.054
mesenchymal cell differentiation GO:0048762 87 0.053
localization of cell GO:0051674 244 0.052
response to monosaccharide GO:0034284 3 0.052
trabecula formation GO:0060343 2 0.051
response to carbohydrate GO:0009743 3 0.051
negative regulation of signal transduction GO:0009968 94 0.051
sensory organ development GO:0007423 393 0.051
regeneration GO:0031099 91 0.050
positive regulation of map kinase activity GO:0043406 3 0.050
retinal rod cell development GO:0046548 4 0.049
extracellular structure organization GO:0043062 27 0.049
cellular response to external stimulus GO:0071496 2 0.048
glycosaminoglycan metabolic process GO:0030203 9 0.048
regulation of primary metabolic process GO:0080090 311 0.048
regulation of cell death GO:0010941 103 0.047
response to hexose GO:0009746 3 0.047
positive regulation of cellular process GO:0048522 201 0.047
regulation of endothelial cell proliferation GO:0001936 1 0.047
negative regulation of developmental process GO:0051093 65 0.047
oxoacid metabolic process GO:0043436 31 0.046
cellular response to extracellular stimulus GO:0031668 2 0.045
regulation of multicellular organism growth GO:0040014 4 0.045
regulation of biological quality GO:0065008 263 0.044
cellular amino acid metabolic process GO:0006520 7 0.043
embryonic skeletal system morphogenesis GO:0048704 93 0.043
negative regulation of signaling GO:0023057 96 0.042
response to organic substance GO:0010033 153 0.041
developmental growth involved in morphogenesis GO:0060560 86 0.041
regulation of signal transduction GO:0009966 225 0.041
regulation of rna biosynthetic process GO:2001141 213 0.041
positive regulation of cell substrate adhesion GO:0010811 1 0.040
growth plate cartilage development GO:0003417 2 0.040
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.040
locomotion GO:0040011 313 0.040
cell projection organization GO:0030030 284 0.039
negative regulation of protein maturation GO:1903318 10 0.039
growth GO:0040007 174 0.039
chondrocyte development GO:0002063 4 0.039
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.039
tube morphogenesis GO:0035239 349 0.038
response to glucose GO:0009749 3 0.038
neurological system process GO:0050877 62 0.038
negative regulation of macromolecule metabolic process GO:0010605 76 0.038
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.037
regulation of cellular amine metabolic process GO:0033238 0 0.037
limb bud formation GO:0060174 2 0.037
larval development GO:0002164 2 0.036
response to axon injury GO:0048678 14 0.036
Mouse
negative regulation of map kinase activity GO:0043407 2 0.036
positive regulation of multicellular organismal process GO:0051240 52 0.036
positive regulation of biological process GO:0048518 253 0.036
chemotaxis GO:0006935 104 0.036
developmental growth GO:0048589 166 0.036
positive regulation of signal transduction GO:0009967 56 0.036
cellular macromolecule biosynthetic process GO:0034645 224 0.035
endochondral bone morphogenesis GO:0060350 8 0.035
bone morphogenesis GO:0060349 11 0.035
cellular response to endogenous stimulus GO:0071495 68 0.035
negative regulation of chemotaxis GO:0050922 4 0.035
epithelial to mesenchymal transition GO:0001837 21 0.035
extracellular matrix constituent secretion GO:0070278 3 0.034
regulation of programmed cell death GO:0043067 101 0.034
response to corticosteroid GO:0031960 1 0.034
regulation of rna metabolic process GO:0051252 224 0.033
erk1 and erk2 cascade GO:0070371 4 0.033
negative regulation of cell proliferation GO:0008285 8 0.033
regulation of epithelial to mesenchymal transition GO:0010717 3 0.032
transport GO:0006810 220 0.032
cell projection assembly GO:0030031 64 0.031
negative regulation of intracellular signal transduction GO:1902532 22 0.031
regulation of erk1 and erk2 cascade GO:0070372 4 0.031
response to external stimulus GO:0009605 264 0.031
negative regulation of cell communication GO:0010648 96 0.031
urogenital system development GO:0001655 97 0.031
single organism metabolic process GO:0044710 217 0.031
skeletal muscle organ development GO:0060538 78 0.030
heart development GO:0007507 313 0.030
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.030
regulation of peptidase activity GO:0052547 23 0.030
cell motility GO:0048870 244 0.029
macromolecule biosynthetic process GO:0009059 227 0.029
positive regulation of metabolic process GO:0009893 108 0.029
muscle organ development GO:0007517 101 0.029
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 7 0.029
rna biosynthetic process GO:0032774 181 0.029
response to vitamin GO:0033273 3 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
regulation of bmp signaling pathway GO:0030510 39 0.028
muscle attachment GO:0016203 9 0.028
photoreceptor cell fate commitment GO:0046552 1 0.028
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.028
nitrogen compound metabolic process GO:0006807 319 0.028
mesoderm development GO:0007498 88 0.028
positive regulation of protein kinase b signaling GO:0051897 1 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
determination of heart left right asymmetry GO:0061371 117 0.027
specification of symmetry GO:0009799 204 0.027
positive regulation of gene expression GO:0010628 71 0.027
regulation of apoptotic process GO:0042981 98 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
enzyme linked receptor protein signaling pathway GO:0007167 106 0.026
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.026
regulation of stem cell differentiation GO:2000736 4 0.026
cellular response to retinoic acid GO:0071300 1 0.025
positive regulation of response to stimulus GO:0048584 80 0.025
cellular component movement GO:0006928 335 0.025
positive regulation of apoptotic signaling pathway GO:2001235 1 0.025
regulation of intracellular signal transduction GO:1902531 57 0.025
positive regulation of macromolecule metabolic process GO:0010604 93 0.025
cartilage morphogenesis GO:0060536 13 0.025
positive regulation of signaling GO:0023056 56 0.024
negative regulation of response to stimulus GO:0048585 104 0.024
regulation of intracellular protein transport GO:0033157 3 0.024
skin development GO:0043588 54 0.024
transcription dna templated GO:0006351 181 0.024
embryonic eye morphogenesis GO:0048048 30 0.024
mesenchyme development GO:0060485 127 0.024
positive regulation of epithelial cell migration GO:0010634 2 0.024
regulation of cysteine type endopeptidase activity GO:2000116 21 0.024
cell death GO:0008219 121 0.023
cellular biosynthetic process GO:0044249 286 0.023
embryonic limb morphogenesis GO:0030326 2 0.023
regulation of production of molecular mediator of immune response GO:0002700 1 0.023
multicellular organismal water homeostasis GO:0050891 1 0.023
renal system process GO:0003014 14 0.023
sympathetic nervous system development GO:0048485 3 0.022
positive regulation of jnk cascade GO:0046330 3 0.022
transforming growth factor beta receptor signaling pathway GO:0007179 7 0.022
fatty acid transport GO:0015908 1 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
cellular amine metabolic process GO:0044106 2 0.022
positive regulation of cellular component movement GO:0051272 11 0.022
small molecule metabolic process GO:0044281 77 0.021
protein targeting to nucleus GO:0044744 3 0.021
digestive tract morphogenesis GO:0048546 231 0.021
regulation of gene expression GO:0010468 265 0.021
bleb assembly GO:0032060 1 0.020
embryonic appendage morphogenesis GO:0035113 30 0.020
amine metabolic process GO:0009308 2 0.020
primary neural tube formation GO:0014020 1 0.020
intramembranous ossification GO:0001957 3 0.020
positive regulation of immune system process GO:0002684 17 0.020
negative regulation of molecular function GO:0044092 23 0.020
positive regulation of translation GO:0045727 1 0.020
regulation of vasculature development GO:1901342 33 0.020
digestive tract development GO:0048565 265 0.019
regionalization GO:0003002 274 0.019
striated muscle tissue development GO:0014706 110 0.019
protein localization to nucleus GO:0034504 3 0.019
bone development GO:0060348 14 0.019
protein modification process GO:0036211 100 0.019
regulation of nervous system development GO:0051960 90 0.019
homeostatic process GO:0042592 142 0.019
endodermal digestive tract morphogenesis GO:0061031 2 0.019
inner ear development GO:0048839 126 0.019
mucopolysaccharide metabolic process GO:1903510 2 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.019
negative regulation of cellular metabolic process GO:0031324 77 0.019
organic acid metabolic process GO:0006082 31 0.019
positive regulation of nucleic acid templated transcription GO:1903508 57 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
protein maturation GO:0051604 12 0.018
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.018
organic substance transport GO:0071702 58 0.018
cellular nitrogen compound metabolic process GO:0034641 290 0.018
positive regulation of endothelial cell migration GO:0010595 2 0.018
activation of mapk activity GO:0000187 3 0.018
ion transport GO:0006811 114 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
hemopoiesis GO:0030097 183 0.018
defense response to fungus GO:0050832 2 0.018
regulation of anatomical structure morphogenesis GO:0022603 130 0.017
single organism nuclear import GO:1902593 3 0.017
cell adhesion mediated by integrin GO:0033627 1 0.017
protein import into nucleus GO:0006606 3 0.017
protein dephosphorylation GO:0006470 3 0.017
positive regulation of immune response GO:0050778 11 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
regulation of neurogenesis GO:0050767 87 0.017
proteoglycan metabolic process GO:0006029 14 0.017
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.017
regulation of cell activation GO:0050865 1 0.017
cognition GO:0050890 1 0.017
neural crest cell development GO:0014032 62 0.017
regulation of cytokine biosynthetic process GO:0042035 1 0.017
cellular component disassembly GO:0022411 1 0.017
positive regulation of cell activation GO:0050867 1 0.017
establishment of localization in cell GO:0051649 77 0.017
positive regulation of cell development GO:0010720 25 0.017
positive regulation of leukocyte chemotaxis GO:0002690 1 0.017
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.017
regulation of protein localization to nucleus GO:1900180 2 0.016
regulation of cell matrix adhesion GO:0001952 1 0.016
negative regulation of angiogenesis GO:0016525 7 0.016
production of molecular mediator of immune response GO:0002440 2 0.016
negative regulation of cell migration GO:0030336 17 0.016
cell part morphogenesis GO:0032990 246 0.016
regulation of protein transport GO:0051223 3 0.016
apoptotic process GO:0006915 116 0.016
response to abiotic stimulus GO:0009628 122 0.016
single organism transport GO:0044765 206 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
cytokine metabolic process GO:0042107 1 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
tube closure GO:0060606 1 0.015
response to copper ion GO:0046688 13 0.015
cytosolic calcium ion transport GO:0060401 3 0.015
embryonic cranial skeleton morphogenesis GO:0048701 90 0.015
peptidyl serine modification GO:0018209 2 0.015
negative regulation of cell death GO:0060548 60 0.015
regulation of synapse organization GO:0050807 3 0.015
cellular response to nutrient levels GO:0031669 2 0.015
heart valve development GO:0003170 14 0.015
cell cycle arrest GO:0007050 1 0.014
somatic muscle development GO:0007525 4 0.014
wound healing GO:0042060 90 0.014
myeloid leukocyte migration GO:0097529 12 0.014
regulation of cell development GO:0060284 100 0.014
response to other organism GO:0051707 97 0.014
cell morphogenesis GO:0000902 289 0.014
inner ear morphogenesis GO:0042472 63 0.014
bmp signaling pathway GO:0030509 52 0.014
positive regulation of blood circulation GO:1903524 2 0.014
skin morphogenesis GO:0043589 7 0.014
heart valve morphogenesis GO:0003179 8 0.014
positive regulation of cell motility GO:2000147 11 0.014
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.014
heterocycle biosynthetic process GO:0018130 215 0.014
system process GO:0003008 185 0.014
positive regulation of apoptotic process GO:0043065 29 0.014
long chain fatty acid transport GO:0015909 1 0.014
determination of left right symmetry GO:0007368 179 0.014
cardiac chamber development GO:0003205 19 0.014
cellular component biogenesis GO:0044085 178 0.014
chondroitin sulfate metabolic process GO:0030204 2 0.014
regulation of binding GO:0051098 3 0.013
hindbrain development GO:0030902 91 0.013
intracellular signal transduction GO:0035556 85 0.013
negative regulation of dna replication GO:0008156 2 0.013
notochord development GO:0030903 54 0.013
rna metabolic process GO:0016070 219 0.013
cellular response to vitamin GO:0071295 1 0.013
stem cell differentiation GO:0048863 117 0.013
response to bacterium GO:0009617 58 0.013
regulation of angiogenesis GO:0045765 26 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
ceramide biosynthetic process GO:0046513 1 0.013
macromolecule modification GO:0043412 111 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
osteoblast differentiation GO:0001649 5 0.013
single organism biosynthetic process GO:0044711 71 0.013
membrane invagination GO:0010324 1 0.013
gland development GO:0048732 143 0.013
regulation of proteolysis GO:0030162 24 0.013
negative regulation of cellular component movement GO:0051271 18 0.013
regulation of molecular function GO:0065009 70 0.013
septum transversum development GO:0003343 4 0.013
regulation of cell projection assembly GO:0060491 4 0.013
regulation of reproductive process GO:2000241 4 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
regulation of apoptotic signaling pathway GO:2001233 12 0.012
regulation of cellular metabolic process GO:0031323 320 0.012
regulation of dna replication GO:0006275 3 0.012
positive regulation of leukocyte migration GO:0002687 2 0.012
regulation of hydrolase activity GO:0051336 28 0.012
locus ceruleus development GO:0021703 3 0.012
mapk cascade GO:0000165 18 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 6 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
pigmentation GO:0043473 85 0.012
circulatory system process GO:0003013 87 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
embryonic digestive tract morphogenesis GO:0048557 3 0.012
glucose homeostasis GO:0042593 1 0.012
positive regulation of catalytic activity GO:0043085 25 0.012
endochondral bone growth GO:0003416 2 0.012
neuronal action potential GO:0019228 18 0.012
positive regulation of molecular function GO:0044093 33 0.012
cellular protein metabolic process GO:0044267 129 0.012
negative regulation of rna biosynthetic process GO:1902679 45 0.012
basement membrane organization GO:0071711 5 0.011
ventricular cardiac muscle tissue development GO:0003229 3 0.011
photoreceptor cell fate specification GO:0043704 1 0.011
somitogenesis GO:0001756 87 0.011
cell projection morphogenesis GO:0048858 244 0.011
positive regulation of developmental process GO:0051094 50 0.011
negative regulation of endothelial cell migration GO:0010596 1 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
regulation of nitrogen compound metabolic process GO:0051171 251 0.011
single organism localization GO:1902578 225 0.011
stem cell proliferation GO:0072089 4 0.011
tissue regeneration GO:0042246 74 0.011
regulation of biosynthetic process GO:0009889 250 0.011
taurine metabolic process GO:0019530 1 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
nuclear transport GO:0051169 4 0.011
phosphorus metabolic process GO:0006793 109 0.011
nuclear import GO:0051170 3 0.011
regulation of cellular component movement GO:0051270 55 0.011
stem cell development GO:0048864 82 0.011
negative regulation of cellular protein metabolic process GO:0032269 16 0.011
establishment of localization GO:0051234 244 0.011
immune response GO:0006955 28 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
multicellular organismal response to stress GO:0033555 2 0.011
protein processing GO:0016485 12 0.011
protein import GO:0017038 3 0.011
macromolecule localization GO:0033036 54 0.011
regulation of transcription dna templated GO:0006355 213 0.010
taxis GO:0042330 109 0.010
cellular ketone metabolic process GO:0042180 11 0.010
antimicrobial humoral response GO:0019730 2 0.010
epithelial tube formation GO:0072175 19 0.010
regulation of cell adhesion GO:0030155 15 0.010
regulation of protein targeting GO:1903533 2 0.010
pericardium morphogenesis GO:0003344 1 0.010
hard palate development GO:0060022 4 0.010
neuron projection development GO:0031175 180 0.010
endodermal cell differentiation GO:0035987 19 0.010
negative regulation of protein processing GO:0010955 10 0.010
generation of neurons GO:0048699 385 0.010
cellular response to radiation GO:0071478 4 0.010
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.010
morphogenesis of an epithelial sheet GO:0002011 49 0.010
phagocytosis engulfment GO:0006911 1 0.010

matn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.108
disease of anatomical entity DOID:7 0 0.108
musculoskeletal system disease DOID:17 0 0.108
connective tissue disease DOID:65 0 0.108
charcot marie tooth disease type 4 DOID:0050541 0 0.039
neuromuscular disease DOID:440 0 0.039
charcot marie tooth disease DOID:10595 0 0.039
nervous system disease DOID:863 0 0.039
neuropathy DOID:870 0 0.039
osteochondrodysplasia DOID:2256 0 0.032
bone development disease DOID:0080006 0 0.032
bone remodeling disease DOID:0080005 0 0.016
disease of metabolism DOID:0014667 0 0.010
inherited metabolic disorder DOID:655 0 0.010