Danio rerio

106 known processes

mcl1a

myeloid cell leukemia sequence 1a

(Aliases: wu:fb70a08,zgc:109835,zfMLP1,wu:fb72f02,fb72f02,zfMcl-1a)

mcl1a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of mitosis GO:0045839 3 0.719
positive regulation of cell death GO:0010942 29 0.691
Human Zebrafish Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.683
Human
response to transition metal nanoparticle GO:1990267 28 0.637
Zebrafish
organelle fusion GO:0048284 3 0.624
Worm
response to cadmium ion GO:0046686 14 0.610
Zebrafish
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.583
Zebrafish
chordate embryonic development GO:0043009 271 0.576
single organism membrane fusion GO:0044801 2 0.576
Worm
gene expression GO:0010467 252 0.548
positive regulation of neuron apoptotic process GO:0043525 1 0.533
Human Mouse
positive regulation of biological process GO:0048518 253 0.518
Human Zebrafish Mouse Worm
regulation of mitochondrion organization GO:0010821 1 0.512
Worm
regulation of developmental process GO:0050793 247 0.505
Worm
regulation of primary metabolic process GO:0080090 311 0.431
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.426
Human Mouse
regulation of cell communication GO:0010646 232 0.406
Human Zebrafish Mouse
positive regulation of transport GO:0051050 2 0.398
response to organic substance GO:0010033 153 0.381
Human Zebrafish
mitochondrion organization GO:0007005 4 0.370
Mouse Worm
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.363
Human
regulation of signaling GO:0023051 235 0.357
Human Zebrafish Mouse
positive regulation of neuron death GO:1901216 1 0.334
Human Mouse
regulation of apoptotic process GO:0042981 98 0.330
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 8 0.330
Zebrafish
response to stress GO:0006950 263 0.329
Human Mouse
positive regulation of apoptotic signaling pathway GO:2001235 1 0.328
Human Mouse
apoptotic process GO:0006915 116 0.326
organic cyclic compound metabolic process GO:1901360 301 0.325
Worm
regulation of cell death GO:0010941 103 0.308
programmed cell death GO:0012501 119 0.306
negative regulation of biological process GO:0048519 304 0.302
regulation of rna biosynthetic process GO:2001141 213 0.301
response to chemical GO:0042221 320 0.298
Human Zebrafish Mouse
cellular macromolecule metabolic process GO:0044260 391 0.294
negative regulation of cellular process GO:0048523 283 0.286
negative regulation of gene expression GO:0010629 65 0.281
gland development GO:0048732 143 0.279
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.278
Worm
regulation of cellular response to oxidative stress GO:1900407 2 0.272
Human Mouse
signal transduction in absence of ligand GO:0038034 1 0.268
Human Mouse
regulation of gene expression GO:0010468 265 0.259
positive regulation of gtp catabolic process GO:0033126 1 0.257
Worm
response to metal ion GO:0010038 34 0.253
Zebrafish
regulation of cell cycle GO:0051726 52 0.250
heterocycle metabolic process GO:0046483 290 0.247
Worm
cellular amide metabolic process GO:0043603 4 0.240
cellular aromatic compound metabolic process GO:0006725 295 0.237
Worm
positive regulation of apoptotic process GO:0043065 29 0.236
Human Zebrafish Mouse
signal transduction GO:0007165 455 0.232
Human Zebrafish Mouse
regulation of protein import into nucleus GO:0042306 2 0.228
cell surface receptor signaling pathway GO:0007166 325 0.227
Human Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.221
Human Mouse
negative regulation of signaling GO:0023057 96 0.219
Human Zebrafish
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.214
Human Mouse
negative regulation of nuclear division GO:0051784 3 0.207
embryo development ending in birth or egg hatching GO:0009792 271 0.206
death GO:0016265 121 0.206
regulation of metabolic process GO:0019222 359 0.204
regulation of response to oxidative stress GO:1902882 2 0.203
Human Mouse
response to inorganic substance GO:0010035 38 0.200
Zebrafish
regulation of programmed cell death GO:0043067 101 0.200
establishment of localization GO:0051234 244 0.196
regulation of protein localization to nucleus GO:1900180 2 0.188
negative regulation of proteolysis GO:0045861 10 0.187
homeostatic process GO:0042592 142 0.183
cell death GO:0008219 121 0.182
regulation of protein targeting GO:1903533 2 0.175
modulation by virus of host morphology or physiology GO:0019048 1 0.174
cellular nitrogen compound metabolic process GO:0034641 290 0.169
Worm
positive regulation of cellular process GO:0048522 201 0.164
Human Zebrafish Mouse Worm
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.164
Human
regulation of biological quality GO:0065008 263 0.163
regulation of cellular metabolic process GO:0031323 320 0.162
regulation of gtp catabolic process GO:0033124 2 0.161
Worm
immune system development GO:0002520 191 0.161
positive regulation of cell killing GO:0031343 2 0.161
negative regulation of cell communication GO:0010648 96 0.156
Human Zebrafish
thyroid gland development GO:0030878 12 0.156
Zebrafish
protein metabolic process GO:0019538 183 0.155
regulation of nucleotide catabolic process GO:0030811 2 0.154
Worm
establishment of protein localization to organelle GO:0072594 4 0.154
nitrogen compound metabolic process GO:0006807 319 0.152
Worm
regulation of nucleoside metabolic process GO:0009118 2 0.150
Worm
positive regulation of cellular metabolic process GO:0031325 94 0.150
Zebrafish Worm
negative regulation of cysteine type endopeptidase activity GO:2000117 8 0.150
regulation of cysteine type endopeptidase activity GO:2000116 21 0.148
nuclear import GO:0051170 3 0.148
protein targeting to nucleus GO:0044744 3 0.146
nucleocytoplasmic transport GO:0006913 4 0.146
regulation of macromolecule metabolic process GO:0060255 317 0.143
negative regulation of response to stimulus GO:0048585 104 0.143
Human Zebrafish
negative regulation of metabolic process GO:0009892 86 0.142
regulation of establishment of protein localization GO:0070201 4 0.140
hematopoietic or lymphoid organ development GO:0048534 191 0.139
gtp catabolic process GO:0006184 2 0.138
Worm
positive regulation of metabolic process GO:0009893 108 0.137
Zebrafish Worm
positive regulation of cellular catabolic process GO:0031331 3 0.135
Worm
positive regulation of cysteine type endopeptidase activity GO:2001056 10 0.133
Zebrafish
single organism nuclear import GO:1902593 3 0.128
guanosine containing compound catabolic process GO:1901069 2 0.125
Worm
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.122
embryonic organ development GO:0048568 381 0.121
positive regulation of macromolecule metabolic process GO:0010604 93 0.120
Zebrafish
cell death in response to oxidative stress GO:0036473 2 0.118
Human Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.117
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.115
Worm
regulation of response to stimulus GO:0048583 269 0.115
Human Zebrafish Mouse
cellular protein metabolic process GO:0044267 129 0.114
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.113
Human
regulation of cytokine production GO:0001817 3 0.109
gtp metabolic process GO:0046039 4 0.109
Worm
negative regulation of protein processing GO:0010955 10 0.108
interaction with host GO:0051701 4 0.108
negative regulation of protein phosphorylation GO:0001933 4 0.108
positive regulation of programmed cell death GO:0043068 29 0.107
Human Zebrafish Mouse
mitotic nuclear division GO:0007067 18 0.105
regulation of protein metabolic process GO:0051246 56 0.105
cellular response to stress GO:0033554 62 0.103
Human Mouse
regulation of signal transduction GO:0009966 225 0.102
Human Zebrafish Mouse
regulation of protein transport GO:0051223 3 0.101
cellular response to external stimulus GO:0071496 2 0.100
amide transport GO:0042886 12 0.100
regulation of nucleocytoplasmic transport GO:0046822 2 0.099
organonitrogen compound metabolic process GO:1901564 74 0.098
Worm
aromatic compound biosynthetic process GO:0019438 217 0.096
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.094
positive regulation of developmental process GO:0051094 50 0.092
Worm
protein complex localization GO:0031503 1 0.091
regulation of endopeptidase activity GO:0052548 23 0.090
regulation of cytoplasmic transport GO:1903649 4 0.090
single organism transport GO:0044765 206 0.090
response to biotic stimulus GO:0009607 97 0.090
membrane fusion GO:0061025 2 0.089
Worm
cellular response to chemical stimulus GO:0070887 157 0.088
Human Mouse
renal system development GO:0072001 94 0.083
kidney development GO:0001822 92 0.082
apoptotic process involved in development GO:1902742 2 0.081
positive regulation of gtpase activity GO:0043547 1 0.079
Worm
cellular response to dna damage stimulus GO:0006974 24 0.078
Human Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.078
Worm
single organism metabolic process GO:0044710 217 0.076
Worm
mitotic cell cycle process GO:1903047 48 0.076
regulation of metal ion transport GO:0010959 4 0.076
response to drug GO:0042493 3 0.076
regulation of cellular biosynthetic process GO:0031326 245 0.076
protein import GO:0017038 3 0.075
mitochondrion morphogenesis GO:0070584 2 0.074
response to virus GO:0009615 21 0.074
positive regulation of protein metabolic process GO:0051247 23 0.074
Zebrafish
mitotic cell cycle GO:0000278 64 0.073
protein localization to nucleus GO:0034504 3 0.072
axon regeneration GO:0031103 14 0.071
nucleic acid templated transcription GO:0097659 181 0.071
negative regulation of protein transport GO:0051224 3 0.071
organic substance biosynthetic process GO:1901576 289 0.070
organelle organization GO:0006996 227 0.070
organic substance transport GO:0071702 58 0.070
regulation of cell differentiation GO:0045595 142 0.069
response to methylmercury GO:0051597 11 0.069
Zebrafish
regulation of protein maturation GO:1903317 10 0.069
regulation of cellular component organization GO:0051128 86 0.068
female sex differentiation GO:0046660 4 0.068
maintenance of location GO:0051235 4 0.068
positive regulation of catabolic process GO:0009896 4 0.067
Worm
regulation of peptidase activity GO:0052547 23 0.067
negative regulation of hydrolase activity GO:0051346 10 0.067
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.067
Human
regulation of multicellular organismal process GO:0051239 277 0.066
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.065
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.065
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.064
negative regulation of cytoplasmic transport GO:1903650 2 0.064
tube morphogenesis GO:0035239 349 0.064
nuclear transport GO:0051169 4 0.063
negative regulation of protein localization to nucleus GO:1900181 2 0.063
transcription dna templated GO:0006351 181 0.063
phosphate containing compound metabolic process GO:0006796 108 0.063
Worm
cellular nitrogen compound biosynthetic process GO:0044271 218 0.063
negative regulation of response to cytokine stimulus GO:0060761 2 0.062
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.062
developmental programmed cell death GO:0010623 4 0.061
purine nucleotide metabolic process GO:0006163 27 0.060
Worm
response to external stimulus GO:0009605 264 0.059
modification by symbiont of host morphology or physiology GO:0044003 4 0.059
negative regulation of cell division GO:0051782 4 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.058
Worm
defense response GO:0006952 47 0.058
negative regulation of protein maturation GO:1903318 10 0.058
multicellular organism growth GO:0035264 4 0.058
regulation of macromolecule biosynthetic process GO:0010556 225 0.057
protein import into nucleus GO:0006606 3 0.056
transport GO:0006810 220 0.056
regulation of gtpase activity GO:0043087 2 0.056
Worm
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.056
positive regulation of jnk cascade GO:0046330 3 0.055
aging GO:0007568 2 0.055
peptide transport GO:0015833 1 0.055
cellular biosynthetic process GO:0044249 286 0.055
heterocycle biosynthetic process GO:0018130 215 0.055
brain development GO:0007420 293 0.055
peptide metabolic process GO:0006518 1 0.055
regulation of synaptic plasticity GO:0048167 1 0.054
macromolecule biosynthetic process GO:0009059 227 0.054
response to nutrient GO:0007584 3 0.053
neuron death GO:0070997 21 0.053
Human Mouse
nik nf kappab signaling GO:0038061 1 0.053
response to external biotic stimulus GO:0043207 97 0.052
cellular response to radiation GO:0071478 4 0.052
regulation of intracellular protein transport GO:0033157 3 0.052
single organism membrane organization GO:0044802 20 0.051
Worm
regulation of response to interferon gamma GO:0060330 1 0.051
regulation of multicellular organism growth GO:0040014 4 0.050
regulation of organ growth GO:0046620 3 0.050
regulation of rna metabolic process GO:0051252 224 0.050
apoptotic process involved in morphogenesis GO:0060561 2 0.050
positive regulation of molecular function GO:0044093 33 0.050
Zebrafish Worm
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 7 0.050
positive regulation of endopeptidase activity GO:0010950 10 0.049
Zebrafish
negative regulation of protein import into nucleus GO:0042308 2 0.049
cell type specific apoptotic process GO:0097285 22 0.049
Human Mouse
positive regulation of nucleoside metabolic process GO:0045979 1 0.048
Worm
negative regulation of intracellular signal transduction GO:1902532 22 0.048
Zebrafish
developmental growth GO:0048589 166 0.047
response to glucocorticoid GO:0051384 1 0.047
multicellular organismal homeostasis GO:0048871 29 0.046
regulation of response to cytokine stimulus GO:0060759 3 0.046
positive regulation of cell communication GO:0010647 56 0.046
Human Mouse
hemopoiesis GO:0030097 183 0.045
negative regulation of mitotic cell cycle GO:0045930 11 0.045
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.045
calcium ion transport GO:0006816 18 0.044
negative regulation of cellular metabolic process GO:0031324 77 0.044
cellular response to lipopolysaccharide GO:0071222 3 0.044
modification of morphology or physiology of other organism GO:0035821 4 0.044
regulation of biosynthetic process GO:0009889 250 0.043
regulation of catalytic activity GO:0050790 55 0.043
regulation of molecular function GO:0065009 70 0.043
immune system process GO:0002376 241 0.043
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.042
regulation of reactive oxygen species metabolic process GO:2000377 2 0.042
cellular response to endogenous stimulus GO:0071495 68 0.042
urogenital system development GO:0001655 97 0.042
cellular component disassembly GO:0022411 1 0.042
regulation of oxidative stress induced cell death GO:1903201 2 0.042
Human Mouse
cellular response to decreased oxygen levels GO:0036294 1 0.042
cellular macromolecule biosynthetic process GO:0034645 224 0.042
cellular component morphogenesis GO:0032989 336 0.041
killing of cells of other organism GO:0031640 1 0.041
regulation of multicellular organismal development GO:2000026 223 0.041
b cell activation GO:0042113 2 0.041
reactive oxygen species metabolic process GO:0072593 6 0.041
negative regulation of neuron projection regeneration GO:0070571 4 0.040
growth GO:0040007 174 0.040
rna biosynthetic process GO:0032774 181 0.039
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.039
cell cycle process GO:0022402 53 0.039
positive regulation of cell cycle GO:0045787 3 0.038
carboxylic acid metabolic process GO:0019752 22 0.038
positive regulation of multi organism process GO:0043902 3 0.038
cellular localization GO:0051641 97 0.038
larval development GO:0002164 2 0.038
negative regulation of macromolecule metabolic process GO:0010605 76 0.037
embryonic skeletal system morphogenesis GO:0048704 93 0.037
cell cycle GO:0007049 93 0.036
cell killing GO:0001906 2 0.036
transcription from rna polymerase ii promoter GO:0006366 80 0.036
positive regulation of hydrolase activity GO:0051345 13 0.036
Zebrafish Worm
generation of neurons GO:0048699 385 0.036
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.036
reciprocal meiotic recombination GO:0007131 1 0.036
positive regulation of peptidase activity GO:0010952 10 0.036
Zebrafish
female gonad development GO:0008585 4 0.036
embryonic skeletal system development GO:0048706 97 0.035
rna metabolic process GO:0016070 219 0.035
negative regulation of cell cycle GO:0045786 14 0.035
disruption of cells of other organism GO:0044364 1 0.035
negative regulation of apoptotic process GO:0043066 55 0.035
cellular response to organic substance GO:0071310 105 0.035
negative regulation of catalytic activity GO:0043086 21 0.034
response to radiation GO:0009314 51 0.034
regulation of inflammatory response GO:0050727 2 0.034
negative regulation of rna metabolic process GO:0051253 48 0.034
camera type eye development GO:0043010 222 0.034
carbohydrate derivative metabolic process GO:1901135 61 0.034
Worm
amine metabolic process GO:0009308 2 0.033
regulation of purine nucleotide catabolic process GO:0033121 2 0.033
Worm
response to light stimulus GO:0009416 46 0.033
response to other organism GO:0051707 97 0.033
positive regulation of nucleotide catabolic process GO:0030813 1 0.033
Worm
regulation of mitotic cell cycle GO:0007346 25 0.033
positive regulation of cellular protein metabolic process GO:0032270 22 0.033
Zebrafish
guanosine containing compound metabolic process GO:1901068 4 0.033
Worm
cellular response to hormone stimulus GO:0032870 39 0.033
cellular response to hypoxia GO:0071456 1 0.033
system process GO:0003008 185 0.032
phosphorus metabolic process GO:0006793 109 0.032
Worm
ion transport GO:0006811 114 0.032
regulation of interferon gamma mediated signaling pathway GO:0060334 1 0.032
regulation of neuron apoptotic process GO:0043523 17 0.032
Human Mouse
developmental growth involved in morphogenesis GO:0060560 86 0.031
neuron apoptotic process GO:0051402 20 0.031
Human Mouse
positive regulation of immune effector process GO:0002699 3 0.031
nucleobase containing compound metabolic process GO:0006139 274 0.031
Worm
negative regulation of intracellular protein transport GO:0090317 3 0.031
regulation of nucleic acid templated transcription GO:1903506 213 0.031
regulation of production of molecular mediator of immune response GO:0002700 1 0.031
nitric oxide biosynthetic process GO:0006809 2 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.031
response to oxygen containing compound GO:1901700 55 0.030
negative regulation of molecular function GO:0044092 23 0.030
nucleic acid metabolic process GO:0090304 244 0.030
leukocyte differentiation GO:0002521 25 0.030
regulation of binding GO:0051098 3 0.030
cellular component assembly GO:0022607 170 0.030
cellular response to oxygen levels GO:0071453 1 0.030
cellular response to light stimulus GO:0071482 4 0.029
regulation of transcription dna templated GO:0006355 213 0.029
anatomical structure homeostasis GO:0060249 36 0.029
cell cycle g2 m phase transition GO:0044839 4 0.029
regulation of mitosis GO:0007088 9 0.029
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.029
regulation of cell proliferation GO:0042127 37 0.029
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.028
regulation of response to biotic stimulus GO:0002831 2 0.028
dorsal ventral pattern formation GO:0009953 125 0.028
tissue homeostasis GO:0001894 25 0.028
cell proliferation GO:0008283 80 0.028
cytokine mediated signaling pathway GO:0019221 7 0.028
regulation of apoptotic signaling pathway GO:2001233 12 0.028
Human Zebrafish Mouse
multi organism process GO:0051704 134 0.028
skeletal system development GO:0001501 181 0.027
response to vitamin GO:0033273 3 0.027
positive regulation of signaling GO:0023056 56 0.027
Human Mouse
intracellular signal transduction GO:0035556 85 0.027
Human Zebrafish Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.027
Human Mouse
locomotor rhythm GO:0045475 3 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
positive regulation of stress activated mapk cascade GO:0032874 3 0.027
posterior lateral line neuromast hair cell development GO:0035677 3 0.027
i kappab kinase nf kappab signaling GO:0007249 4 0.027
negative regulation of cell death GO:0060548 60 0.027
production of molecular mediator of immune response GO:0002440 2 0.026
tyrosine phosphorylation of stat protein GO:0007260 1 0.026
odontogenesis of dentin containing tooth GO:0042475 1 0.026
establishment of localization in cell GO:0051649 77 0.026
regionalization GO:0003002 274 0.026
segmentation GO:0035282 97 0.026
embryonic hemopoiesis GO:0035162 53 0.026
nitric oxide metabolic process GO:0046209 2 0.026
fertilization GO:0009566 3 0.026
phagocytosis GO:0006909 3 0.026
regulation of cell killing GO:0031341 2 0.026
cell morphogenesis GO:0000902 289 0.025
amide biosynthetic process GO:0043604 1 0.025
negative regulation of kinase activity GO:0033673 4 0.025
negative regulation of protein kinase activity GO:0006469 4 0.025
single organism organelle organization GO:1902589 199 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.025
positive regulation of myeloid cell differentiation GO:0045639 2 0.025
cellular response to molecule of bacterial origin GO:0071219 3 0.025
neurological system process GO:0050877 62 0.025
defense response to fungus GO:0050832 2 0.025
membrane organization GO:0061024 21 0.025
Worm
multi organism cellular process GO:0044764 2 0.025
regeneration GO:0031099 91 0.024
response to fatty acid GO:0070542 5 0.024
regulation of sterol transport GO:0032371 3 0.024
g1 s transition of mitotic cell cycle GO:0000082 1 0.024
response to lipid GO:0033993 60 0.024
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.024
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.024
lipid storage GO:0019915 1 0.024
intrinsic apoptotic signaling pathway GO:0097193 20 0.024
Human Zebrafish Mouse
cellular response to starvation GO:0009267 1 0.024
blood vessel morphogenesis GO:0048514 216 0.024
negative regulation of innate immune response GO:0045824 2 0.023
positive regulation of biosynthetic process GO:0009891 68 0.023
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.023
interferon gamma mediated signaling pathway GO:0060333 1 0.023
response to corticosteroid GO:0031960 1 0.023
response to oxidative stress GO:0006979 11 0.023
Human Mouse
macromolecule modification GO:0043412 111 0.023
cellular response to biotic stimulus GO:0071216 3 0.023
cell part morphogenesis GO:0032990 246 0.023
response to amino acid GO:0043200 2 0.023
nuclear division GO:0000280 23 0.023
regulation of dna templated transcription in response to stress GO:0043620 0 0.023
regulation of protein processing GO:0070613 10 0.023
regulation of intracellular signal transduction GO:1902531 57 0.023
Human Zebrafish Mouse
regulation of protein localization to plasma membrane GO:1903076 1 0.023
double strand break repair GO:0006302 3 0.023
regulation of reproductive process GO:2000241 4 0.023
embryonic cranial skeleton morphogenesis GO:0048701 90 0.023
negative regulation of biosynthetic process GO:0009890 55 0.023
regulation of calcium ion transport GO:0051924 2 0.023
meiotic cell cycle process GO:1903046 3 0.023
response to lipopolysaccharide GO:0032496 13 0.022
negative regulation of map kinase activity GO:0043407 2 0.022
negative regulation of myeloid cell differentiation GO:0045638 1 0.022
response to cytokine GO:0034097 7 0.022
Human
cognition GO:0050890 1 0.022
skeletal system morphogenesis GO:0048705 102 0.022
regulation of cellular protein metabolic process GO:0032268 52 0.022
negative regulation of protein metabolic process GO:0051248 16 0.022
small molecule metabolic process GO:0044281 77 0.022
Worm
nucleoside metabolic process GO:0009116 11 0.022
Worm
positive regulation of signal transduction GO:0009967 56 0.022
Human Mouse
viral process GO:0016032 1 0.022
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.022
toll like receptor signaling pathway GO:0002224 4 0.021
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 9 0.021
Worm
response to oxygen radical GO:0000305 2 0.021
regulation of cellular response to stress GO:0080135 20 0.021
Human Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.021
p38mapk cascade GO:0038066 1 0.021
negative regulation of cellular component organization GO:0051129 16 0.021
response to nitrogen compound GO:1901698 19 0.021
regulation of proteolysis GO:0030162 24 0.021
cellular response to nutrient levels GO:0031669 2 0.021
response to uv GO:0009411 3 0.021
organelle assembly GO:0070925 110 0.021
antimicrobial humoral response GO:0019730 2 0.021
response to ketone GO:1901654 1 0.021
biosynthetic process GO:0009058 294 0.021
digestive system development GO:0055123 289 0.020
negative regulation of secretion by cell GO:1903531 2 0.020
nucleobase containing small molecule metabolic process GO:0055086 32 0.020
Worm
protein localization GO:0008104 40 0.020
cellular component biogenesis GO:0044085 178 0.020
regulation of nucleotide metabolic process GO:0006140 17 0.020
Worm
regulation of protein complex assembly GO:0043254 3 0.020
regulation of phosphate metabolic process GO:0019220 43 0.019
Worm
organic acid metabolic process GO:0006082 31 0.019
regulation of stem cell differentiation GO:2000736 4 0.019
nitrogen compound transport GO:0071705 23 0.019
negative regulation of transcription dna templated GO:0045892 45 0.019
neuron projection regeneration GO:0031102 16 0.019
response to axon injury GO:0048678 14 0.019
myeloid cell differentiation GO:0030099 86 0.019
regulation of heart growth GO:0060420 2 0.019
negative regulation of intracellular transport GO:0032387 3 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.019
innate immune response GO:0045087 13 0.019
response to hypoxia GO:0001666 25 0.019
cellular amine metabolic process GO:0044106 2 0.019
negative regulation of mapk cascade GO:0043409 4 0.019
protein secretion GO:0009306 1 0.019
regulation of protein binding GO:0043393 3 0.018
regulation of jak stat cascade GO:0046425 3 0.018
meiotic nuclear division GO:0007126 4 0.018
cellular response to abiotic stimulus GO:0071214 4 0.018
negative regulation of cellular biosynthetic process GO:0031327 55 0.018
cellular response to topologically incorrect protein GO:0035967 2 0.018
sensory organ development GO:0007423 393 0.018
regulation of localization GO:0032879 104 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.018
negative regulation of nucleic acid templated transcription GO:1903507 45 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
somite development GO:0061053 96 0.018
positive regulation of rna metabolic process GO:0051254 59 0.018
oxoacid metabolic process GO:0043436 31 0.018
negative regulation of axon regeneration GO:0048681 4 0.018
regulation of p38mapk cascade GO:1900744 1 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.018
osteoclast differentiation GO:0030316 1 0.018
immune response GO:0006955 28 0.018
regulation of embryonic development GO:0045995 47 0.017
response to hormone GO:0009725 48 0.017
muscle structure development GO:0061061 196 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
positive regulation of dna metabolic process GO:0051054 1 0.017
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 1 0.017
regulation of lipid transport GO:0032368 4 0.017
positive regulation of catalytic activity GO:0043085 25 0.017
Zebrafish Worm
positive regulation of multicellular organismal process GO:0051240 52 0.017
stem cell proliferation GO:0072089 4 0.017
regulation of neuron death GO:1901214 18 0.017
Human Mouse
muscle cell development GO:0055001 115 0.017
camera type eye morphogenesis GO:0048593 108 0.017
b cell differentiation GO:0030183 1 0.017
mitotic cell cycle phase transition GO:0044772 9 0.017
negative regulation of hormone secretion GO:0046888 2 0.016
organelle fission GO:0048285 23 0.016
peptidyl serine modification GO:0018209 2 0.016
protein modification process GO:0036211 100 0.016

mcl1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
musculoskeletal system disease DOID:17 0 0.023
intestinal cancer DOID:10155 0 0.023
cancer DOID:162 0 0.023
colon carcinoma DOID:1520 0 0.023
colon cancer DOID:219 0 0.023
gastrointestinal system cancer DOID:3119 0 0.023
large intestine cancer DOID:5672 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
colorectal cancer DOID:9256 0 0.023
organ system cancer DOID:0050686 0 0.023