Danio rerio

9 known processes

mcm4

MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)

(Aliases: cb1025,fj85g09,zeh1616,wu:fc12c09,wu:fj85g09,hm:zeh1616,fc12c09)

mcm4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
biosynthetic process GO:0009058 294 0.769
Mouse Fly
heterocycle metabolic process GO:0046483 290 0.704
Human Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.603
Human Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.536
Human Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.525
Human Mouse Fly
aging GO:0007568 2 0.506
larval development GO:0002164 2 0.495
organic substance biosynthetic process GO:1901576 289 0.495
Mouse Fly
cellular biosynthetic process GO:0044249 286 0.484
Mouse Fly
nucleobase containing compound metabolic process GO:0006139 274 0.481
Human Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.435
nucleic acid metabolic process GO:0090304 244 0.431
Human Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.339
cellular nitrogen compound biosynthetic process GO:0044271 218 0.313
reciprocal meiotic recombination GO:0007131 1 0.293
macromolecule biosynthetic process GO:0009059 227 0.286
Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.284
cellular nitrogen compound metabolic process GO:0034641 290 0.278
Human Mouse Fly
heterocycle biosynthetic process GO:0018130 215 0.264
embryo development ending in birth or egg hatching GO:0009792 271 0.249
regulation of primary metabolic process GO:0080090 311 0.241
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.233
dna biosynthetic process GO:0071897 3 0.230
organelle organization GO:0006996 227 0.221
Fly
regulation of biosynthetic process GO:0009889 250 0.219
organic cyclic compound biosynthetic process GO:1901362 223 0.212
nitrogen compound metabolic process GO:0006807 319 0.211
Human Mouse Fly
rna metabolic process GO:0016070 219 0.209
meiotic chromosome segregation GO:0045132 3 0.196
regulation of macromolecule metabolic process GO:0060255 317 0.189
maintenance of dna repeat elements GO:0043570 2 0.175
negative regulation of biological process GO:0048519 304 0.168
regulation of transcription dna templated GO:0006355 213 0.166
cellular macromolecule biosynthetic process GO:0034645 224 0.165
Mouse Fly
reciprocal dna recombination GO:0035825 1 0.157
regulation of metabolic process GO:0019222 359 0.157
locomotion GO:0040011 313 0.154
single organism biosynthetic process GO:0044711 71 0.145
double strand break repair GO:0006302 3 0.145
cell migration GO:0016477 237 0.142
dna catabolic process GO:0006308 1 0.140
response to cadmium ion GO:0046686 14 0.133
aromatic compound biosynthetic process GO:0019438 217 0.132
protein metabolic process GO:0019538 183 0.131
nucleotide biosynthetic process GO:0009165 21 0.112
double strand break repair via homologous recombination GO:0000724 1 0.108
regulation of cellular biosynthetic process GO:0031326 245 0.100
negative regulation of cellular process GO:0048523 283 0.095
regulation of rna metabolic process GO:0051252 224 0.095
single organism metabolic process GO:0044710 217 0.092
Human
double strand break repair via nonhomologous end joining GO:0006303 1 0.092
negative regulation of programmed cell death GO:0043069 58 0.088
single organism organelle organization GO:1902589 199 0.084
Fly
camera type eye development GO:0043010 222 0.083
rna biosynthetic process GO:0032774 181 0.080
nucleotide metabolic process GO:0009117 28 0.080
Human
transport GO:0006810 220 0.078
sensory organ development GO:0007423 393 0.077
response to xenobiotic stimulus GO:0009410 45 0.075
eye development GO:0001654 277 0.074
chordate embryonic development GO:0043009 271 0.074
mitotic dna integrity checkpoint GO:0044774 4 0.074
cellular response to chemical stimulus GO:0070887 157 0.072
meiotic cell cycle process GO:1903046 3 0.072
cellular response to external stimulus GO:0071496 2 0.071
tube morphogenesis GO:0035239 349 0.071
mitotic cell cycle GO:0000278 64 0.070
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.067
regulation of nucleic acid templated transcription GO:1903506 213 0.065
response to external stimulus GO:0009605 264 0.065
regulation of rna biosynthetic process GO:2001141 213 0.060
dicarboxylic acid metabolic process GO:0043648 1 0.057
response to drug GO:0042493 3 0.057
transcription dna templated GO:0006351 181 0.056
gene expression GO:0010467 252 0.056
cellular component biogenesis GO:0044085 178 0.055
modification dependent protein catabolic process GO:0019941 3 0.055
organonitrogen compound metabolic process GO:1901564 74 0.055
Human
carboxylic acid metabolic process GO:0019752 22 0.054
positive regulation of transport GO:0051050 2 0.053
response to biotic stimulus GO:0009607 97 0.052
chromosome organization GO:0051276 31 0.050
dna metabolic process GO:0006259 27 0.050
Human Mouse Fly
cellular response to oxygen containing compound GO:1901701 20 0.050
meiotic nuclear division GO:0007126 4 0.049
response to stress GO:0006950 263 0.049
cell surface receptor signaling pathway GO:0007166 325 0.048
muscle structure development GO:0061061 196 0.048
nucleoside monophosphate catabolic process GO:0009125 4 0.047
Human
mitotic recombination GO:0006312 2 0.046
pronuclear migration GO:0035046 1 0.046
response to virus GO:0009615 21 0.046
protein acetylation GO:0006473 2 0.045
death GO:0016265 121 0.045
immunoglobulin mediated immune response GO:0016064 3 0.044
wound healing GO:0042060 90 0.044
cytokinesis GO:0000910 3 0.044
mitotic dna damage checkpoint GO:0044773 4 0.044
cellular component movement GO:0006928 335 0.043
fertilization GO:0009566 3 0.043
recombinational repair GO:0000725 1 0.043
response to uv GO:0009411 3 0.042
nucleobase containing compound biosynthetic process GO:0034654 205 0.042
sensory organ morphogenesis GO:0090596 200 0.041
cellular amino acid metabolic process GO:0006520 7 0.040
response to chemical GO:0042221 320 0.040
regulation of meiotic cell cycle GO:0051445 1 0.040
positive regulation of rna metabolic process GO:0051254 59 0.040
cellular macromolecular complex assembly GO:0034622 24 0.039
positive regulation of cellular process GO:0048522 201 0.038
carbohydrate derivative metabolic process GO:1901135 61 0.038
Human
transcription from rna polymerase ii promoter GO:0006366 80 0.038
regulation of apoptotic process GO:0042981 98 0.038
regulation of cellular ketone metabolic process GO:0010565 7 0.037
b cell mediated immunity GO:0019724 3 0.037
regulation of protein transport GO:0051223 3 0.037
organelle assembly GO:0070925 110 0.037
meiosis i GO:0007127 1 0.037
apoptotic process GO:0006915 116 0.035
amine metabolic process GO:0009308 2 0.035
centrosome organization GO:0051297 1 0.035
camera type eye morphogenesis GO:0048593 108 0.034
cell motility GO:0048870 244 0.034
regulation of dna replication GO:0006275 3 0.034
small molecule metabolic process GO:0044281 77 0.034
Human
regulation of cellular amine metabolic process GO:0033238 0 0.033
regulation of gene expression GO:0010468 265 0.033
g1 s transition of mitotic cell cycle GO:0000082 1 0.032
phosphorus metabolic process GO:0006793 109 0.032
Human
regulation of gene expression epigenetic GO:0040029 11 0.031
positive regulation of cellular catabolic process GO:0031331 3 0.031
retina morphogenesis in camera type eye GO:0060042 79 0.031
signal transduction GO:0007165 455 0.031
negative regulation of cell death GO:0060548 60 0.030
positive regulation of catabolic process GO:0009896 4 0.030
regulation of mitotic cell cycle GO:0007346 25 0.030
digestive system development GO:0055123 289 0.030
response to organic substance GO:0010033 153 0.030
retina development in camera type eye GO:0060041 146 0.030
positive regulation of cell cycle GO:0045787 3 0.030
negative regulation of dna recombination GO:0045910 2 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.029
cell fate commitment GO:0045165 99 0.029
localization of cell GO:0051674 244 0.028
cellular amine metabolic process GO:0044106 2 0.028
response to organic cyclic compound GO:0014070 51 0.028
positive regulation of cellular metabolic process GO:0031325 94 0.028
negative regulation of chromosome organization GO:2001251 1 0.028
phosphate containing compound metabolic process GO:0006796 108 0.027
Human
negative regulation of histone modification GO:0031057 1 0.027
positive regulation of nuclease activity GO:0032075 1 0.027
immunoglobulin production GO:0002377 1 0.027
cellular protein modification process GO:0006464 100 0.027
muscle organ development GO:0007517 101 0.027
digestive tract development GO:0048565 265 0.027
positive regulation of rna biosynthetic process GO:1902680 57 0.026
regulation of cell death GO:0010941 103 0.026
b cell activation GO:0042113 2 0.026
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.026
negative regulation of apoptotic process GO:0043066 55 0.026
cell death GO:0008219 121 0.026
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.026
oxoacid metabolic process GO:0043436 31 0.025
urogenital system development GO:0001655 97 0.025
microtubule polymerization GO:0046785 2 0.025
muscle cell differentiation GO:0042692 139 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.025
negative regulation of cellular metabolic process GO:0031324 77 0.024
centrosome cycle GO:0007098 1 0.024
somatic cell dna recombination GO:0016444 1 0.024
maintenance of location GO:0051235 4 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.024
proteasomal protein catabolic process GO:0010498 2 0.024
proteolysis GO:0006508 38 0.024
regulation of cell cycle GO:0051726 52 0.024
cellular response to organic substance GO:0071310 105 0.024
response to endogenous stimulus GO:0009719 83 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.023
regulation of peptidase activity GO:0052547 23 0.023
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
Human
centrosome duplication GO:0051298 1 0.022
cellular ketone metabolic process GO:0042180 11 0.022
multicellular organism growth GO:0035264 4 0.022
regulation of nuclease activity GO:0032069 1 0.022
cellular protein metabolic process GO:0044267 129 0.022
macromolecular complex assembly GO:0065003 35 0.022
positive regulation of chromosome segregation GO:0051984 1 0.022
male meiosis GO:0007140 2 0.022
macromolecule methylation GO:0043414 19 0.022
pancreas development GO:0031016 84 0.021
response to metal ion GO:0010038 34 0.021
cell cycle GO:0007049 93 0.021
Fly
organic acid metabolic process GO:0006082 31 0.021
positive regulation of chromatin modification GO:1903310 1 0.021
mitotic metaphase plate congression GO:0007080 1 0.021
negative regulation of biosynthetic process GO:0009890 55 0.021
negative regulation of gene expression GO:0010629 65 0.021
nuclear migration GO:0007097 3 0.021
cellular response to organic cyclic compound GO:0071407 38 0.020
determination of heart left right asymmetry GO:0061371 117 0.020
regulation of cellular component organization GO:0051128 86 0.020
establishment of localization GO:0051234 244 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.020
cell morphogenesis GO:0000902 289 0.020
cell cycle g1 s phase transition GO:0044843 1 0.020
regulation of deoxyribonuclease activity GO:0032070 1 0.020
response to lipid GO:0033993 60 0.020
nucleobase containing small molecule metabolic process GO:0055086 32 0.019
Human
dna alkylation GO:0006305 8 0.019
zymogen activation GO:0031638 3 0.019
production of molecular mediator of immune response GO:0002440 2 0.019
heart contraction GO:0060047 71 0.019
positive regulation of immune effector process GO:0002699 3 0.019
response to steroid hormone GO:0048545 35 0.019
organophosphate metabolic process GO:0019637 37 0.019
Human
macromolecular complex subunit organization GO:0043933 74 0.019
Fly
gene silencing GO:0016458 4 0.019
deoxyribonucleotide biosynthetic process GO:0009263 1 0.019
negative regulation of metabolic process GO:0009892 86 0.019
embryonic organ development GO:0048568 381 0.019
vasculature development GO:0001944 278 0.019
immune system process GO:0002376 241 0.018
single organism localization GO:1902578 225 0.018
muscle cell development GO:0055001 115 0.018
regulation of dna recombination GO:0000018 2 0.018
regulation of dna catabolic process GO:1903624 1 0.018
cell proliferation GO:0008283 80 0.018
programmed cell death GO:0012501 119 0.018
skeletal system development GO:0001501 181 0.018
regulation of protein metabolic process GO:0051246 56 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
regulation of leukocyte mediated immunity GO:0002703 1 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.018
intracellular signal transduction GO:0035556 85 0.017
positive regulation of macromolecule metabolic process GO:0010604 93 0.017
chromatin organization GO:0006325 22 0.017
cell part morphogenesis GO:0032990 246 0.017
negative regulation of cellular biosynthetic process GO:0031327 55 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
regulation of catalytic activity GO:0050790 55 0.017
negative regulation of rna metabolic process GO:0051253 48 0.017
response to amino acid GO:0043200 2 0.017
regulation of apoptotic signaling pathway GO:2001233 12 0.016
non recombinational repair GO:0000726 2 0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.016
regulation of programmed cell death GO:0043067 101 0.016
negative regulation of dna metabolic process GO:0051053 4 0.016
heart process GO:0003015 71 0.016
heart looping GO:0001947 94 0.016
ion transport GO:0006811 114 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.016
determination of bilateral symmetry GO:0009855 204 0.016
lipid homeostasis GO:0055088 3 0.016
reproduction GO:0000003 40 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
dna methylation on cytosine GO:0032776 3 0.016
striated muscle cell development GO:0055002 108 0.016
lipid storage GO:0019915 1 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.016
myofibril assembly GO:0030239 48 0.016
response to external biotic stimulus GO:0043207 97 0.015
embryonic digestive tract morphogenesis GO:0048557 3 0.015
circulatory system process GO:0003013 87 0.015
cellular response to oxygen levels GO:0071453 1 0.015
g2 m transition of mitotic cell cycle GO:0000086 4 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
negative regulation of cellular catabolic process GO:0031330 3 0.015
multi organism process GO:0051704 134 0.015
regulation of proteolysis GO:0030162 24 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.015
positive regulation of leukocyte mediated immunity GO:0002705 1 0.015
peptidyl serine modification GO:0018209 2 0.014
regulation of cysteine type endopeptidase activity GO:2000116 21 0.014
purine containing compound metabolic process GO:0072521 29 0.014
Human
regulation of response to stimulus GO:0048583 269 0.014
regulation of endopeptidase activity GO:0052548 23 0.014
protein modification process GO:0036211 100 0.014
ribonucleoside monophosphate catabolic process GO:0009158 4 0.014
Human
pyrimidine containing compound biosynthetic process GO:0072528 2 0.014
microtubule based process GO:0007017 60 0.013
Fly
brain development GO:0007420 293 0.013
negative regulation of rna biosynthetic process GO:1902679 45 0.013
positive regulation of gene expression GO:0010628 71 0.013
cartilage development GO:0051216 96 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
developmental process involved in reproduction GO:0003006 27 0.013
protein acylation GO:0043543 3 0.013
cell projection organization GO:0030030 284 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
response to ethanol GO:0045471 6 0.013
negative regulation of gene silencing GO:0060969 1 0.013
positive regulation of biological process GO:0048518 253 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
embryonic neurocranium morphogenesis GO:0048702 15 0.013
nucleoside phosphate biosynthetic process GO:1901293 21 0.013
phosphorylation GO:0016310 69 0.013
exocrine pancreas development GO:0031017 28 0.013
cellular component assembly GO:0022607 170 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
positive regulation of metabolic process GO:0009893 108 0.013
meiotic spindle organization GO:0000212 1 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
metal ion transport GO:0030001 58 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
guanosine containing compound catabolic process GO:1901069 2 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.012
negative regulation of histone methylation GO:0031061 1 0.012
blood vessel development GO:0001568 246 0.012
negative regulation of transcription dna templated GO:0045892 45 0.012
positive regulation of histone modification GO:0031058 1 0.012
negative regulation of cell communication GO:0010648 96 0.012
regulation of hydrolase activity GO:0051336 28 0.012
regulation of chromosome segregation GO:0051983 1 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
response to inorganic substance GO:0010035 38 0.012
chromosome organization involved in meiosis GO:0070192 1 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
histone methylation GO:0016571 13 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
epithelial cell differentiation GO:0030855 116 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
cellular localization GO:0051641 97 0.012
response to alkaloid GO:0043279 2 0.012
nucleoside phosphate metabolic process GO:0006753 28 0.011
Human
single fertilization GO:0007338 3 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
regulation of protein catabolic process GO:0042176 1 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
protein polymerization GO:0051258 4 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
regulation of biological quality GO:0065008 263 0.011
cytoskeleton organization GO:0007010 96 0.011
Fly
peptidyl lysine acetylation GO:0018394 2 0.011
response to corticosteroid GO:0031960 1 0.011
monovalent inorganic cation transport GO:0015672 42 0.011
regulation of dna methylation GO:0044030 5 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
protein complex biogenesis GO:0070271 30 0.011
negative regulation of signal transduction GO:0009968 94 0.011
protein complex assembly GO:0006461 30 0.011
positive regulation of striated muscle tissue development GO:0045844 1 0.011
negative regulation of cell division GO:0051782 4 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
posttranscriptional gene silencing by rna GO:0035194 3 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.010
spindle assembly GO:0051225 2 0.010
protein phosphorylation GO:0006468 47 0.010
stem cell maintenance GO:0019827 4 0.010
negative regulation of signaling GO:0023057 96 0.010
regulation of circadian rhythm GO:0042752 4 0.010
rna transport GO:0050658 2 0.010
immune system development GO:0002520 191 0.010
positive regulation of muscle tissue development GO:1901863 1 0.010
response to nitrogen compound GO:1901698 19 0.010
protein import GO:0017038 3 0.010

mcm4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.031
developmental disorder of mental health DOID:0060037 0 0.031
disease of metabolism DOID:0014667 0 0.024
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
disease of anatomical entity DOID:7 0 0.015
large intestine cancer DOID:5672 0 0.014
gastrointestinal system cancer DOID:3119 0 0.014
intestinal cancer DOID:10155 0 0.014
organ system cancer DOID:0050686 0 0.014
colorectal cancer DOID:9256 0 0.014