Danio rerio

36 known processes

mdka

midkine-related growth factor

(Aliases: fb05b02,zgc:86655,wu:fc32h11,mdk1,plei1,wu:fb05b02)

mdka biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
morphogenesis of an epithelium GO:0002009 333 0.959
embryo development ending in birth or egg hatching GO:0009792 271 0.798
skeletal muscle organ development GO:0060538 78 0.673
sensory organ development GO:0007423 393 0.660
neuron differentiation GO:0030182 353 0.449
Zebrafish
camera type eye development GO:0043010 222 0.377
blood vessel morphogenesis GO:0048514 216 0.353
axon ensheathment GO:0008366 18 0.351
blood vessel development GO:0001568 246 0.292
transmission of nerve impulse GO:0019226 19 0.285
astrocyte differentiation GO:0048708 1 0.282
eye development GO:0001654 277 0.282
lens development in camera type eye GO:0002088 22 0.253
epithelial tube morphogenesis GO:0060562 148 0.252
embryonic organ development GO:0048568 381 0.250
neurological system process GO:0050877 62 0.240
Mouse
chordate embryonic development GO:0043009 271 0.223
actin cytoskeleton organization GO:0030036 63 0.214
determination of left right symmetry GO:0007368 179 0.205
endochondral bone morphogenesis GO:0060350 8 0.185
system process GO:0003008 185 0.182
Mouse
vasculature development GO:0001944 278 0.180
epithelial tube formation GO:0072175 19 0.180
somite development GO:0061053 96 0.165
gene expression GO:0010467 252 0.162
Mouse
response to stress GO:0006950 263 0.157
Mouse
digestive system development GO:0055123 289 0.147
regulation of biological quality GO:0065008 263 0.145
detection of abiotic stimulus GO:0009582 24 0.137
response to chemical GO:0042221 320 0.135
skeletal system development GO:0001501 181 0.132
response to radiation GO:0009314 51 0.129
determination of bilateral symmetry GO:0009855 204 0.127
sprouting angiogenesis GO:0002040 53 0.127
eye morphogenesis GO:0048592 144 0.122
axon ensheathment in central nervous system GO:0032291 2 0.118
regulation of metabolic process GO:0019222 359 0.113
Mouse
neuron projection development GO:0031175 180 0.106
embryonic cranial skeleton morphogenesis GO:0048701 90 0.096
response to vitamin GO:0033273 3 0.093
glial cell migration GO:0008347 3 0.093
generation of neurons GO:0048699 385 0.091
Zebrafish
specification of symmetry GO:0009799 204 0.091
organelle assembly GO:0070925 110 0.086
regulation of signaling GO:0023051 235 0.084
regulation of locomotion GO:0040012 55 0.084
cellular component assembly GO:0022607 170 0.084
action potential GO:0001508 19 0.081
extracellular matrix organization GO:0030198 27 0.079
regulation of membrane potential GO:0042391 23 0.079
striated muscle cell development GO:0055002 108 0.078
myelination GO:0042552 18 0.078
epiboly GO:0090504 41 0.078
central nervous system myelination GO:0022010 2 0.073
small molecule metabolic process GO:0044281 77 0.073
neural tube development GO:0021915 62 0.072
digestive tract development GO:0048565 265 0.067
glial cell proliferation GO:0014009 4 0.067
glial cell development GO:0021782 20 0.066
response to carbohydrate GO:0009743 3 0.065
ensheathment of neurons GO:0007272 18 0.065
positive regulation of response to stimulus GO:0048584 80 0.065
positive regulation of biological process GO:0048518 253 0.064
Zebrafish Mouse
multicellular organismal signaling GO:0035637 22 0.064
cellular component biogenesis GO:0044085 178 0.064
cellular nitrogen compound metabolic process GO:0034641 290 0.063
Mouse
camera type eye morphogenesis GO:0048593 108 0.063
regulation of cell migration GO:0030334 40 0.063
tube morphogenesis GO:0035239 349 0.061
nucleobase containing compound metabolic process GO:0006139 274 0.061
Mouse
muscle structure development GO:0061061 196 0.060
positive regulation of cell cycle GO:0045787 3 0.060
neuron projection morphogenesis GO:0048812 161 0.057
neuron development GO:0048666 262 0.052
carboxylic acid metabolic process GO:0019752 22 0.051
locomotion GO:0040011 313 0.051
muscle cell development GO:0055001 115 0.051
mitochondrion organization GO:0007005 4 0.050
neuroblast proliferation GO:0007405 2 0.050
actomyosin structure organization GO:0031032 53 0.050
embryonic organ morphogenesis GO:0048562 274 0.049
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.049
adherens junction organization GO:0034332 4 0.048
regulation of macromolecule metabolic process GO:0060255 317 0.048
Mouse
regulation of multicellular organismal development GO:2000026 223 0.047
Zebrafish
extracellular structure organization GO:0043062 27 0.047
epithelial cell development GO:0002064 42 0.047
regulation of primary metabolic process GO:0080090 311 0.044
Mouse
cell proliferation GO:0008283 80 0.043
response to glucose GO:0009749 3 0.043
cell substrate adhesion GO:0031589 4 0.043
negative regulation of epithelial cell migration GO:0010633 1 0.042
cellular component movement GO:0006928 335 0.041
regulation of rna metabolic process GO:0051252 224 0.040
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.040
cell projection assembly GO:0030031 64 0.039
regulation of cell development GO:0060284 100 0.039
Zebrafish
sensory organ morphogenesis GO:0090596 200 0.039
regulation of cell projection assembly GO:0060491 4 0.039
retina morphogenesis in camera type eye GO:0060042 79 0.038
signal transduction GO:0007165 455 0.037
single organism metabolic process GO:0044710 217 0.037
negative regulation of endothelial cell migration GO:0010596 1 0.036
regulation of cellular amine metabolic process GO:0033238 0 0.036
modification dependent macromolecule catabolic process GO:0043632 3 0.036
neuronal action potential GO:0019228 18 0.035
macromolecule modification GO:0043412 111 0.034
response to nutrient GO:0007584 3 0.033
positive regulation of glial cell proliferation GO:0060252 1 0.033
negative regulation of metabolic process GO:0009892 86 0.033
establishment or maintenance of cell polarity GO:0007163 29 0.032
gliogenesis GO:0042063 45 0.032
mitotic nuclear division GO:0007067 18 0.032
morphogenesis of embryonic epithelium GO:0016331 30 0.032
negative regulation of cellular component organization GO:0051129 16 0.032
skeletal system morphogenesis GO:0048705 102 0.031
regulation of localization GO:0032879 104 0.031
glial cell differentiation GO:0010001 42 0.031
negative regulation of cellular process GO:0048523 283 0.031
Mouse
beta amyloid metabolic process GO:0050435 1 0.031
positive regulation of multicellular organismal process GO:0051240 52 0.030
Zebrafish
response to monosaccharide GO:0034284 3 0.030
response to oxygen containing compound GO:1901700 55 0.030
regulation of response to stimulus GO:0048583 269 0.030
Mouse
striated muscle cell differentiation GO:0051146 129 0.030
amine metabolic process GO:0009308 2 0.029
positive regulation of cellular process GO:0048522 201 0.029
Zebrafish Mouse
nitrogen compound metabolic process GO:0006807 319 0.029
Mouse
angiogenesis GO:0001525 158 0.029
growth GO:0040007 174 0.029
oligodendrocyte development GO:0014003 7 0.029
cellular macromolecule metabolic process GO:0044260 391 0.028
Mouse
regulation of cellular component organization GO:0051128 86 0.028
detection of stimulus GO:0051606 29 0.028
fin morphogenesis GO:0033334 53 0.028
regulation of developmental process GO:0050793 247 0.028
Zebrafish
negative regulation of developmental process GO:0051093 65 0.028
wnt signaling pathway GO:0016055 80 0.027
negative regulation of biological process GO:0048519 304 0.027
Mouse
bmp signaling pathway GO:0030509 52 0.027
lateral line system development GO:0048925 76 0.027
peptidyl serine modification GO:0018209 2 0.027
regulation of canonical wnt signaling pathway GO:0060828 34 0.027
positive regulation of cellular metabolic process GO:0031325 94 0.027
Mouse
regulation of blood vessel endothelial cell migration GO:0043535 5 0.026
peptidyl serine phosphorylation GO:0018105 1 0.025
response to hexose GO:0009746 3 0.025
cell morphogenesis GO:0000902 289 0.025
Zebrafish
single organism organelle organization GO:1902589 199 0.025
regulation of cytokine production GO:0001817 3 0.025
sex determination GO:0007530 1 0.025
regulation of wnt signaling pathway GO:0030111 53 0.025
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.025
tube formation GO:0035148 25 0.025
cell projection organization GO:0030030 284 0.024
axon development GO:0061564 166 0.024
embryonic skeletal joint morphogenesis GO:0060272 3 0.024
cell migration GO:0016477 237 0.024
muscle cell differentiation GO:0042692 139 0.024
response to external stimulus GO:0009605 264 0.024
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.023
cellular amine metabolic process GO:0044106 2 0.023
regulation of cell activation GO:0050865 1 0.023
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.023
Mouse
actin filament based process GO:0030029 64 0.023
axon guidance GO:0007411 86 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
carbon dioxide transmembrane transport GO:0035378 1 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
Mouse
regulation of cellular metabolic process GO:0031323 320 0.021
Mouse
oxoacid metabolic process GO:0043436 31 0.021
cellular component assembly involved in morphogenesis GO:0010927 107 0.021
taxis GO:0042330 109 0.021
chemotaxis GO:0006935 104 0.021
regulation of nervous system development GO:0051960 90 0.021
Zebrafish
regulation of cgmp biosynthetic process GO:0030826 6 0.021
negative regulation of secretion by cell GO:1903531 2 0.021
protein modification process GO:0036211 100 0.021
muscle tissue development GO:0060537 110 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
Zebrafish
amyloid precursor protein catabolic process GO:0042987 1 0.021
stem cell differentiation GO:0048863 117 0.021
Zebrafish
regulation of wound healing GO:0061041 2 0.021
localization of cell GO:0051674 244 0.021
negative regulation of cellular metabolic process GO:0031324 77 0.021
endodermal cell fate determination GO:0007493 2 0.020
negative regulation of cell migration GO:0030336 17 0.020
determination of heart left right asymmetry GO:0061371 117 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
cellular protein catabolic process GO:0044257 4 0.020
cell motility GO:0048870 244 0.020
cell surface receptor signaling pathway GO:0007166 325 0.019
cell part morphogenesis GO:0032990 246 0.019
cell growth GO:0016049 57 0.019
somitogenesis GO:0001756 87 0.019
regulation of rho protein signal transduction GO:0035023 2 0.019
axonogenesis GO:0007409 152 0.019
muscle organ development GO:0007517 101 0.019
meiotic nuclear division GO:0007126 4 0.019
negative regulation of locomotion GO:0040013 18 0.019
visual perception GO:0007601 17 0.019
wound healing GO:0042060 90 0.018
regulation of protein localization to nucleus GO:1900180 2 0.018
positive regulation of secretion by cell GO:1903532 1 0.018
positive regulation of transport GO:0051050 2 0.018
lipid metabolic process GO:0006629 52 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
regulation of myotube differentiation GO:0010830 2 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
regulation of jak stat cascade GO:0046425 3 0.018
spermatid development GO:0007286 2 0.018
negative regulation of signal transduction GO:0009968 94 0.018
neutrophil homeostasis GO:0001780 1 0.018
heart looping GO:0001947 94 0.017
appendage development GO:0048736 80 0.017
water homeostasis GO:0030104 4 0.017
cellular component morphogenesis GO:0032989 336 0.017
Zebrafish
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.017
protein secretion GO:0009306 1 0.017
developmental growth GO:0048589 166 0.017
regulation of cellular component movement GO:0051270 55 0.017
positive regulation of developmental process GO:0051094 50 0.017
Zebrafish
stem cell proliferation GO:0072089 4 0.017
regulation of filopodium assembly GO:0051489 2 0.017
bone development GO:0060348 14 0.017
regulation of gene expression GO:0010468 265 0.017
Mouse
epithelial cell differentiation GO:0030855 116 0.017
cellular ketone metabolic process GO:0042180 11 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
positive regulation of cell activation GO:0050867 1 0.016
modification dependent protein catabolic process GO:0019941 3 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
negative regulation of cell communication GO:0010648 96 0.016
response to light stimulus GO:0009416 46 0.016
gastrulation GO:0007369 208 0.016
organelle organization GO:0006996 227 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
response to wounding GO:0009611 116 0.015
Mouse
blood circulation GO:0008015 87 0.015
gtp metabolic process GO:0046039 4 0.015
calcium ion dependent exocytosis GO:0017156 1 0.015
regionalization GO:0003002 274 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
liver development GO:0001889 96 0.015
neuron projection guidance GO:0097485 86 0.015
cellular component maintenance GO:0043954 3 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
Mouse
head development GO:0060322 303 0.014
Zebrafish Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
biological adhesion GO:0022610 40 0.014
mitotic dna integrity checkpoint GO:0044774 4 0.014
organic acid metabolic process GO:0006082 31 0.014
morphogenesis of an epithelial sheet GO:0002011 49 0.014
lymph vessel development GO:0001945 27 0.014
olfactory lobe development GO:0021988 4 0.014
nucleic acid metabolic process GO:0090304 244 0.014
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
negative regulation of signaling GO:0023057 96 0.014
protein metabolic process GO:0019538 183 0.014
cellular protein metabolic process GO:0044267 129 0.014
response to abiotic stimulus GO:0009628 122 0.014
regeneration GO:0031099 91 0.014
polarized epithelial cell differentiation GO:0030859 4 0.014
venous blood vessel morphogenesis GO:0048845 3 0.014
regulation of glial cell proliferation GO:0060251 4 0.013
regulation of neuron differentiation GO:0045664 56 0.013
Zebrafish
ear development GO:0043583 127 0.013
neural tube formation GO:0001841 16 0.013
response to endogenous stimulus GO:0009719 83 0.013
embryonic skeletal system morphogenesis GO:0048704 93 0.013
pigmentation GO:0043473 85 0.013
neuronal stem cell maintenance GO:0097150 2 0.013
spermatid differentiation GO:0048515 2 0.013
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.013
organic substance biosynthetic process GO:1901576 289 0.013
Mouse
lymphatic endothelial cell differentiation GO:0060836 1 0.013
photoreceptor cell differentiation GO:0046530 55 0.013
positive regulation of metabolic process GO:0009893 108 0.013
Mouse
cellular biosynthetic process GO:0044249 286 0.013
Mouse
proteasomal protein catabolic process GO:0010498 2 0.013
regulation of cell matrix adhesion GO:0001952 1 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
positive regulation of cell development GO:0010720 25 0.013
Zebrafish
primary neural tube formation GO:0014020 1 0.013
positive regulation of gliogenesis GO:0014015 2 0.013
tissue regeneration GO:0042246 74 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
Mouse
cytoskeleton organization GO:0007010 96 0.012
cell adhesion GO:0007155 40 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
positive regulation of secretion GO:0051047 1 0.012
cellular protein modification process GO:0006464 100 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
positive regulation of locomotion GO:0040017 14 0.012
bone morphogenesis GO:0060349 11 0.012
positive regulation of immune effector process GO:0002699 3 0.012
biosynthetic process GO:0009058 294 0.012
Mouse
regulation of cellular ketone metabolic process GO:0010565 7 0.012
small gtpase mediated signal transduction GO:0007264 8 0.012
protein localization to plasma membrane GO:0072659 1 0.012
positive regulation of stem cell proliferation GO:2000648 1 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
post embryonic organ development GO:0048569 4 0.012
embryonic camera type eye development GO:0031076 29 0.012
tube closure GO:0060606 1 0.011
pronephros development GO:0048793 69 0.011
hypochord development GO:0055016 3 0.011
positive regulation of neurogenesis GO:0050769 24 0.011
Zebrafish
appendage morphogenesis GO:0035107 56 0.011
fin development GO:0033333 77 0.011
regulation of signal transduction GO:0009966 225 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
maintenance of location GO:0051235 4 0.011
immune system process GO:0002376 241 0.011
negative regulation of gastrulation GO:2000542 11 0.011
cell projection morphogenesis GO:0048858 244 0.011
protein localization GO:0008104 40 0.011
lymphoid lineage cell migration into thymus GO:0097535 4 0.011
negative regulation of gliogenesis GO:0014014 1 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
embryonic skeletal joint development GO:0072498 3 0.011
regulation of neurogenesis GO:0050767 87 0.011
Zebrafish
organ regeneration GO:0031100 1 0.011
cranial nerve development GO:0021545 42 0.011
cytokinesis GO:0000910 3 0.011
negative regulation of histone modification GO:0031057 1 0.010
neuron migration GO:0001764 22 0.010
positive regulation of striated muscle tissue development GO:0045844 1 0.010
cell junction maintenance GO:0034331 2 0.010
positive regulation of protein kinase b signaling GO:0051897 1 0.010
hepaticobiliary system development GO:0061008 98 0.010
exocrine system development GO:0035272 28 0.010
mesoderm morphogenesis GO:0048332 51 0.010

mdka disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
musculoskeletal system disease DOID:17 0 0.041
connective tissue disease DOID:65 0 0.041
bone development disease DOID:0080006 0 0.025
bone disease DOID:0080001 0 0.025
dysostosis DOID:1934 0 0.019
nervous system disease DOID:863 0 0.018
cardiovascular system disease DOID:1287 0 0.014