Danio rerio

39 known processes

melk

maternal embryonic leucine zipper kinase

(Aliases: fb71b01,wu:fb71b01,wu:fe01f04,fe01f04)

melk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.801
Worm
negative regulation of mitosis GO:0045839 3 0.701
meiotic nuclear division GO:0007126 4 0.456
organelle fission GO:0048285 23 0.391
cellular aromatic compound metabolic process GO:0006725 295 0.335
stem cell proliferation GO:0072089 4 0.319
Worm
regulation of multicellular organismal process GO:0051239 277 0.259
determination of bilateral symmetry GO:0009855 204 0.256
heterocycle metabolic process GO:0046483 290 0.244
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.243
nucleobase containing compound metabolic process GO:0006139 274 0.239
regulation of protein catabolic process GO:0042176 1 0.239
embryo development ending in birth or egg hatching GO:0009792 271 0.237
vasculature development GO:0001944 278 0.226
regulation of primary metabolic process GO:0080090 311 0.225
organelle organization GO:0006996 227 0.218
cellular nitrogen compound metabolic process GO:0034641 290 0.216
regulation of nitrogen compound metabolic process GO:0051171 251 0.211
regulation of biological quality GO:0065008 263 0.210
aromatic compound biosynthetic process GO:0019438 217 0.206
regulation of cellular metabolic process GO:0031323 320 0.205
programmed cell death GO:0012501 119 0.197
Human Mouse Worm
positive regulation of cell cycle GO:0045787 3 0.191
meiotic cell cycle process GO:1903046 3 0.188
muscle structure development GO:0061061 196 0.187
nuclear division GO:0000280 23 0.186
maintenance of location GO:0051235 4 0.166
cell death GO:0008219 121 0.159
Human Mouse Worm
blood vessel development GO:0001568 246 0.158
nitrogen compound metabolic process GO:0006807 319 0.157
cellular component movement GO:0006928 335 0.155
apoptotic process GO:0006915 116 0.155
Human Mouse Worm
modification dependent protein catabolic process GO:0019941 3 0.149
cell migration GO:0016477 237 0.149
cytoskeleton organization GO:0007010 96 0.148
biosynthetic process GO:0009058 294 0.145
sister chromatid segregation GO:0000819 6 0.138
blood vessel morphogenesis GO:0048514 216 0.138
meiotic chromosome segregation GO:0045132 3 0.137
cell projection organization GO:0030030 284 0.137
immune system development GO:0002520 191 0.131
regulation of gene expression GO:0010468 265 0.126
chromosome organization GO:0051276 31 0.126
heterocycle biosynthetic process GO:0018130 215 0.116
organic cyclic compound metabolic process GO:1901360 301 0.114
negative regulation of nuclear division GO:0051784 3 0.113
generation of neurons GO:0048699 385 0.112
Worm
signal transduction GO:0007165 455 0.112
Mouse
rna biosynthetic process GO:0032774 181 0.108
regulation of multicellular organism growth GO:0040014 4 0.104
regulation of programmed cell death GO:0043067 101 0.102
Mouse
nucleic acid metabolic process GO:0090304 244 0.102
immune system process GO:0002376 241 0.099
cellular response to chemical stimulus GO:0070887 157 0.097
Mouse
regulation of mitosis GO:0007088 9 0.097
single organism organelle organization GO:1902589 199 0.096
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.095
cellular component assembly GO:0022607 170 0.094
Worm
spindle assembly involved in mitosis GO:0090307 1 0.092
nucleobase containing compound biosynthetic process GO:0034654 205 0.091
cell cycle process GO:0022402 53 0.088
cellular macromolecule metabolic process GO:0044260 391 0.087
Human Mouse
positive regulation of biological process GO:0048518 253 0.086
Mouse
single organism metabolic process GO:0044710 217 0.086
regulation of macromolecule metabolic process GO:0060255 317 0.085
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.084
neuron differentiation GO:0030182 353 0.084
chromosome segregation GO:0007059 12 0.082
stem cell maintenance GO:0019827 4 0.081
hematopoietic or lymphoid organ development GO:0048534 191 0.080
regulation of apoptotic process GO:0042981 98 0.077
Mouse
chordate embryonic development GO:0043009 271 0.077
stem cell differentiation GO:0048863 117 0.076
regulation of chromosome segregation GO:0051983 1 0.075
cell proliferation GO:0008283 80 0.075
Human Mouse Worm
mitotic sister chromatid segregation GO:0000070 6 0.074
cellular biosynthetic process GO:0044249 286 0.073
female meiotic division GO:0007143 2 0.073
oocyte maturation GO:0001556 4 0.072
death GO:0016265 121 0.071
Human Mouse Worm
negative regulation of cell division GO:0051782 4 0.071
cell motility GO:0048870 244 0.068
specification of symmetry GO:0009799 204 0.068
angiogenesis GO:0001525 158 0.068
cell fate commitment GO:0045165 99 0.065
Worm
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.064
muscle organ development GO:0007517 101 0.064
gene expression GO:0010467 252 0.064
regulation of protein metabolic process GO:0051246 56 0.063
positive regulation of catabolic process GO:0009896 4 0.062
regulation of cellular component organization GO:0051128 86 0.061
protein targeting to nucleus GO:0044744 3 0.061
modification dependent macromolecule catabolic process GO:0043632 3 0.061
spindle assembly GO:0051225 2 0.059
cytoskeleton dependent cytokinesis GO:0061640 3 0.059
behavior GO:0007610 74 0.059
small molecule metabolic process GO:0044281 77 0.057
regulation of meiotic cell cycle GO:0051445 1 0.057
peptidyl serine phosphorylation GO:0018105 1 0.057
regulation of cell development GO:0060284 100 0.056
regulation of metabolic process GO:0019222 359 0.056
single organism nuclear import GO:1902593 3 0.055
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.055
positive regulation of cellular catabolic process GO:0031331 3 0.054
establishment of localization GO:0051234 244 0.052
regulation of transcription dna templated GO:0006355 213 0.051
cellular nitrogen compound biosynthetic process GO:0044271 218 0.051
localization of cell GO:0051674 244 0.051
negative regulation of cell cycle process GO:0010948 9 0.050
mitotic nuclear division GO:0007067 18 0.050
cellular response to endogenous stimulus GO:0071495 68 0.050
male meiosis GO:0007140 2 0.050
regulation of heart growth GO:0060420 2 0.050
negative regulation of catabolic process GO:0009895 3 0.049
establishment of protein localization to organelle GO:0072594 4 0.049
cell division GO:0051301 20 0.048
Worm
regulation of rna metabolic process GO:0051252 224 0.048
protein processing GO:0016485 12 0.048
regulation of nucleoside metabolic process GO:0009118 2 0.047
camera type eye development GO:0043010 222 0.047
cell cycle GO:0007049 93 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.047
single organism localization GO:1902578 225 0.046
neuron projection development GO:0031175 180 0.046
regulation of response to stimulus GO:0048583 269 0.045
determination of left right symmetry GO:0007368 179 0.045
multi organism process GO:0051704 134 0.045
regulation of nucleic acid templated transcription GO:1903506 213 0.045
regulation of signal transduction GO:0009966 225 0.044
head development GO:0060322 303 0.044
striated muscle tissue development GO:0014706 110 0.044
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.044
somatic muscle development GO:0007525 4 0.043
regulation of developmental process GO:0050793 247 0.043
negative regulation of cellular process GO:0048523 283 0.043
cell surface receptor signaling pathway GO:0007166 325 0.043
central nervous system development GO:0007417 387 0.042
cellular response to organic substance GO:0071310 105 0.042
positive regulation of chromosome organization GO:2001252 1 0.042
muscle cell differentiation GO:0042692 139 0.042
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.041
regulation of neurogenesis GO:0050767 87 0.040
nuclear import GO:0051170 3 0.040
neuron development GO:0048666 262 0.040
neuroblast proliferation GO:0007405 2 0.040
Worm
regulation of cell cycle GO:0051726 52 0.039
cellular protein catabolic process GO:0044257 4 0.039
regulation of rna biosynthetic process GO:2001141 213 0.039
single organism transport GO:0044765 206 0.039
negative regulation of apoptotic process GO:0043066 55 0.038
cellular component morphogenesis GO:0032989 336 0.038
locomotion GO:0040011 313 0.038
muscle cell development GO:0055001 115 0.038
regulation of binding GO:0051098 3 0.037
negative regulation of chromosome organization GO:2001251 1 0.037
multicellular organism growth GO:0035264 4 0.036
mitotic metaphase plate congression GO:0007080 1 0.036
regulation of nuclear division GO:0051783 9 0.036
response to stress GO:0006950 263 0.036
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.036
regulation of microtubule cytoskeleton organization GO:0070507 3 0.035
organic substance biosynthetic process GO:1901576 289 0.035
ubiquitin dependent protein catabolic process GO:0006511 3 0.035
organonitrogen compound metabolic process GO:1901564 74 0.035
guanosine containing compound metabolic process GO:1901068 4 0.034
aging GO:0007568 2 0.034
positive regulation of metabolic process GO:0009893 108 0.034
cellular macromolecule biosynthetic process GO:0034645 224 0.034
regulation of purine nucleotide catabolic process GO:0033121 2 0.033
neural retina development GO:0003407 49 0.033
regulation of cellular biosynthetic process GO:0031326 245 0.033
regulation of cell division GO:0051302 12 0.033
regulation of cellular protein metabolic process GO:0032268 52 0.033
guanosine containing compound catabolic process GO:1901069 2 0.033
regulation of signaling GO:0023051 235 0.032
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.032
protein localization to nucleus GO:0034504 3 0.031
cell morphogenesis GO:0000902 289 0.031
cell morphogenesis involved in differentiation GO:0000904 195 0.031
pancreas development GO:0031016 84 0.031
chromosome organization involved in meiosis GO:0070192 1 0.031
regulation of cell death GO:0010941 103 0.030
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.030
developmental process involved in reproduction GO:0003006 27 0.030
cell proliferation in forebrain GO:0021846 3 0.030
negative regulation of cellular catabolic process GO:0031330 3 0.030
developmental growth GO:0048589 166 0.030
positive regulation of multicellular organismal process GO:0051240 52 0.029
regulation of cell communication GO:0010646 232 0.029
cellular protein metabolic process GO:0044267 129 0.028
Human Mouse
regulation of biosynthetic process GO:0009889 250 0.028
macromolecule biosynthetic process GO:0009059 227 0.028
single organism reproductive process GO:0044702 40 0.028
peptidyl serine modification GO:0018209 2 0.027
regulation of organelle assembly GO:1902115 4 0.027
response to biotic stimulus GO:0009607 97 0.027
negative regulation of metabolic process GO:0009892 86 0.027
brain development GO:0007420 293 0.027
sensory organ development GO:0007423 393 0.027
negative regulation of cytoplasmic transport GO:1903650 2 0.026
negative regulation of protein localization to nucleus GO:1900181 2 0.026
positive regulation of nucleoside metabolic process GO:0045979 1 0.026
positive regulation of cell division GO:0051781 2 0.026
ribonucleoside monophosphate catabolic process GO:0009158 4 0.026
dorsal ventral pattern formation GO:0009953 125 0.026
embryonic organ development GO:0048568 381 0.026
stem cell development GO:0048864 82 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
microtubule based process GO:0007017 60 0.026
regulation of nucleotide catabolic process GO:0030811 2 0.025
gland development GO:0048732 143 0.025
meiosis i GO:0007127 1 0.025
cytokinetic process GO:0032506 2 0.025
chromosome localization GO:0050000 2 0.025
regulation of protein ubiquitination GO:0031396 3 0.025
positive regulation of macromolecule metabolic process GO:0010604 93 0.025
cellular protein modification process GO:0006464 100 0.025
Human Mouse
proteasomal protein catabolic process GO:0010498 2 0.025
pharyngeal system development GO:0060037 18 0.025
female meiosis chromosome segregation GO:0016321 1 0.024
negative regulation of gene expression GO:0010629 65 0.024
negative regulation of mitotic cell cycle GO:0045930 11 0.023
negative regulation of multicellular organismal process GO:0051241 69 0.023
rna metabolic process GO:0016070 219 0.023
transcription dna templated GO:0006351 181 0.023
zymogen activation GO:0031638 3 0.023
regulation of nervous system development GO:0051960 90 0.023
regulation of organelle organization GO:0033043 29 0.023
response to wounding GO:0009611 116 0.022
macromolecule modification GO:0043412 111 0.022
Human Mouse
protein complex disassembly GO:0043241 1 0.022
neural precursor cell proliferation GO:0061351 20 0.022
Mouse Worm
growth GO:0040007 174 0.021
cellular component disassembly GO:0022411 1 0.021
organelle assembly GO:0070925 110 0.021
positive regulation of cellular process GO:0048522 201 0.021
Mouse
somitogenesis GO:0001756 87 0.021
fertilization GO:0009566 3 0.021
homologous chromosome segregation GO:0045143 1 0.021
negative regulation of protein kinase activity GO:0006469 4 0.021
digestive tract development GO:0048565 265 0.021
actomyosin structure organization GO:0031032 53 0.021
myofibril assembly GO:0030239 48 0.021
morphogenesis of an epithelium GO:0002009 333 0.020
heart development GO:0007507 313 0.020
phosphorus metabolic process GO:0006793 109 0.020
Human Mouse
regulation of gtp catabolic process GO:0033124 2 0.020
negative regulation of programmed cell death GO:0043069 58 0.020
microtubule depolymerization GO:0007019 1 0.020
regulation of reproductive process GO:2000241 4 0.020
regulation of catalytic activity GO:0050790 55 0.020
regulation of stem cell proliferation GO:0072091 2 0.020
protein import GO:0017038 3 0.020
dna metabolic process GO:0006259 27 0.020
striated muscle cell development GO:0055002 108 0.020
microtubule organizing center organization GO:0031023 1 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
heart process GO:0003015 71 0.020
response to other organism GO:0051707 97 0.019
negative regulation of cell death GO:0060548 60 0.019
cellular ketone metabolic process GO:0042180 11 0.019
positive regulation of developmental process GO:0051094 50 0.019
regulation of protein targeting GO:1903533 2 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
protein import into nucleus GO:0006606 3 0.019
enzyme linked receptor protein signaling pathway GO:0007167 106 0.019
regulation of protein import into nucleus GO:0042306 2 0.019
regulation of cell differentiation GO:0045595 142 0.019
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
reciprocal dna recombination GO:0035825 1 0.018
positive regulation of stem cell proliferation GO:2000648 1 0.018
negative regulation of cell cycle GO:0045786 14 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
muscle tissue development GO:0060537 110 0.018
macromolecular complex disassembly GO:0032984 1 0.018
response to corticosteroid GO:0031960 1 0.018
neural tube patterning GO:0021532 33 0.018
striated muscle cell differentiation GO:0051146 129 0.018
digestive system development GO:0055123 289 0.018
single fertilization GO:0007338 3 0.018
amine metabolic process GO:0009308 2 0.018
mitotic cytokinesis GO:0000281 3 0.018
microtubule cytoskeleton organization GO:0000226 33 0.018
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.017
cytokinesis GO:0000910 3 0.017
gtp catabolic process GO:0006184 2 0.017
mitotic dna integrity checkpoint GO:0044774 4 0.017
regulation of mitotic cell cycle GO:0007346 25 0.017
response to chemical GO:0042221 320 0.017
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
response to ketone GO:1901654 1 0.017
response to endogenous stimulus GO:0009719 83 0.017
regulation of cardiac muscle tissue development GO:0055024 1 0.017
anterior posterior pattern specification GO:0009952 152 0.016
regulation of cell cycle process GO:0010564 20 0.016
regulation of molecular function GO:0065009 70 0.016
macromolecule localization GO:0033036 54 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
hepaticobiliary system development GO:0061008 98 0.016
protein phosphorylation GO:0006468 47 0.016
Human Mouse
organelle fusion GO:0048284 3 0.016
organic acid metabolic process GO:0006082 31 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
cellular component biogenesis GO:0044085 178 0.016
Worm
retina development in camera type eye GO:0060041 146 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
digestive tract morphogenesis GO:0048546 231 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
positive regulation of cell differentiation GO:0045597 30 0.015
meiotic cell cycle GO:0051321 5 0.015
purine nucleotide metabolic process GO:0006163 27 0.015
regulation of growth GO:0040008 42 0.015
regulation of organ growth GO:0046620 3 0.014
positive regulation of muscle organ development GO:0048636 1 0.014
regulation of cell proliferation GO:0042127 37 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
mitotic cell cycle GO:0000278 64 0.014
negative regulation of cell cycle phase transition GO:1901988 5 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
protein homooligomerization GO:0051260 3 0.014
regeneration GO:0031099 91 0.014
positive regulation of nervous system development GO:0051962 25 0.013
regionalization GO:0003002 274 0.013
axon development GO:0061564 166 0.013
negative regulation of developmental process GO:0051093 65 0.013
microtubule polymerization or depolymerization GO:0031109 3 0.013
reproductive system development GO:0061458 5 0.013
regulation of dendrite development GO:0050773 3 0.013
negative regulation of signal transduction GO:0009968 94 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
intrinsic apoptotic signaling pathway GO:0097193 20 0.013
Mouse
response to lipid GO:0033993 60 0.013
nucleobase containing small molecule metabolic process GO:0055086 32 0.013
oxoacid metabolic process GO:0043436 31 0.013
camera type eye morphogenesis GO:0048593 108 0.013
urogenital system development GO:0001655 97 0.013
vesicle mediated transport GO:0016192 22 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
wound healing GO:0042060 90 0.012
nuclear transport GO:0051169 4 0.012
germ line stem cell maintenance GO:0030718 2 0.012
cell projection morphogenesis GO:0048858 244 0.012
regulation of neuron differentiation GO:0045664 56 0.012
ameboidal type cell migration GO:0001667 143 0.012
multicellular organismal reproductive process GO:0048609 35 0.012
regulation of phosphorus metabolic process GO:0051174 43 0.012
negative regulation of protein maturation GO:1903318 10 0.012
positive regulation of neurogenesis GO:0050769 24 0.012
regulation of gtpase activity GO:0043087 2 0.012
reproduction GO:0000003 40 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
nucleic acid templated transcription GO:0097659 181 0.012
lymphocyte proliferation GO:0046651 1 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
eye development GO:0001654 277 0.012
retina morphogenesis in camera type eye GO:0060042 79 0.012
transport GO:0006810 220 0.012
reproductive process GO:0022414 40 0.012
protein modification process GO:0036211 100 0.011
Human Mouse
negative regulation of cellular protein metabolic process GO:0032269 16 0.011
response to organic cyclic compound GO:0014070 51 0.011
positive regulation of transport GO:0051050 2 0.011
otic vesicle formation GO:0030916 27 0.011
cardiocyte differentiation GO:0035051 44 0.011
multicellular organism reproduction GO:0032504 35 0.011
protein polyubiquitination GO:0000209 4 0.011
gastrulation GO:0007369 208 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
macromolecular complex assembly GO:0065003 35 0.011
neural crest cell migration GO:0001755 42 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
protein metabolic process GO:0019538 183 0.011
Human Mouse
ribonucleoside metabolic process GO:0009119 11 0.011
sensory organ morphogenesis GO:0090596 200 0.011
regulation of cytokine production GO:0001817 3 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
homeostatic process GO:0042592 142 0.011
response to external biotic stimulus GO:0043207 97 0.011
protein localization GO:0008104 40 0.011
organelle localization GO:0051640 49 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
lipid storage GO:0019915 1 0.011
positive regulation of multi organism process GO:0043902 3 0.011
response to external stimulus GO:0009605 264 0.011
regulation of mrna processing GO:0050684 3 0.011
stem cell fate commitment GO:0048865 1 0.011
establishment of localization in cell GO:0051649 77 0.010
positive regulation of phosphorus metabolic process GO:0010562 21 0.010
intracellular signal transduction GO:0035556 85 0.010
Mouse
cell cycle g2 m phase transition GO:0044839 4 0.010
cell migration involved in gastrulation GO:0042074 79 0.010
liver development GO:0001889 96 0.010
positive regulation of reproductive process GO:2000243 2 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
response to drug GO:0042493 3 0.010
proteolysis GO:0006508 38 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
determination of heart left right asymmetry GO:0061371 117 0.010
meiosis ii GO:0007135 1 0.010
dna biosynthetic process GO:0071897 3 0.010
gliogenesis GO:0042063 45 0.010

melk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.028
cancer DOID:162 0 0.028
organ system cancer DOID:0050686 0 0.025
disease of anatomical entity DOID:7 0 0.023
gastrointestinal system cancer DOID:3119 0 0.019
large intestine cancer DOID:5672 0 0.015
intestinal cancer DOID:10155 0 0.015
colorectal cancer DOID:9256 0 0.015
colon carcinoma DOID:1520 0 0.013
colon cancer DOID:219 0 0.013
nervous system disease DOID:863 0 0.012