Danio rerio

34 known processes

mif

macrophage migration inhibitory factor

mif biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of macromolecule metabolic process GO:0060255 317 0.508
Mouse
neuron differentiation GO:0030182 353 0.455
nucleobase containing compound biosynthetic process GO:0034654 205 0.420
cellular biosynthetic process GO:0044249 286 0.395
central nervous system development GO:0007417 387 0.294
signal transduction GO:0007165 455 0.289
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.280
regulation of primary metabolic process GO:0080090 311 0.269
Mouse
multicellular organism growth GO:0035264 4 0.236
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.187
biosynthetic process GO:0009058 294 0.185
aromatic compound biosynthetic process GO:0019438 217 0.176
response to drug GO:0042493 3 0.174
regulation of gene expression GO:0010468 265 0.170
cellular nitrogen compound biosynthetic process GO:0044271 218 0.161
brain development GO:0007420 293 0.150
response to chemical GO:0042221 320 0.143
Mouse
cellular response to oxygen radical GO:0071450 2 0.140
cellular macromolecule metabolic process GO:0044260 391 0.138
Mouse
regulation of metabolic process GO:0019222 359 0.138
Mouse
macromolecule biosynthetic process GO:0009059 227 0.137
cellular aromatic compound metabolic process GO:0006725 295 0.130
regulation of rna metabolic process GO:0051252 224 0.128
hydrogen peroxide metabolic process GO:0042743 2 0.123
nucleic acid metabolic process GO:0090304 244 0.117
organonitrogen compound metabolic process GO:1901564 74 0.109
regulation of cellular metabolic process GO:0031323 320 0.105
Mouse
regulation of biosynthetic process GO:0009889 250 0.104
regulation of receptor activity GO:0010469 2 0.103
heterocycle biosynthetic process GO:0018130 215 0.102
peptidyl serine phosphorylation GO:0018105 1 0.102
Mouse
aging GO:0007568 2 0.100
Mouse
heterocycle metabolic process GO:0046483 290 0.100
organic cyclic compound biosynthetic process GO:1901362 223 0.097
organic cyclic compound metabolic process GO:1901360 301 0.097
erythrocyte differentiation GO:0030218 54 0.096
regulation of biological quality GO:0065008 263 0.092
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.091
peptidyl serine modification GO:0018209 2 0.091
Mouse
head development GO:0060322 303 0.089
cell death in response to oxidative stress GO:0036473 2 0.088
nitrogen compound metabolic process GO:0006807 319 0.088
regulation of transcription dna templated GO:0006355 213 0.085
neuron development GO:0048666 262 0.085
response to oxygen radical GO:0000305 2 0.085
oxoacid metabolic process GO:0043436 31 0.084
regulation of cellular amine metabolic process GO:0033238 0 0.084
amine metabolic process GO:0009308 2 0.083
regulation of multicellular organism growth GO:0040014 4 0.082
embryonic organ development GO:0048568 381 0.080
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.080
regulation of cell communication GO:0010646 232 0.074
Mouse
regulation of cellular response to oxidative stress GO:1900407 2 0.073
regulation of transmembrane transporter activity GO:0022898 2 0.072
cell projection organization GO:0030030 284 0.071
regulation of nucleic acid templated transcription GO:1903506 213 0.071
adult behavior GO:0030534 2 0.071
cellular amino acid metabolic process GO:0006520 7 0.070
gene expression GO:0010467 252 0.070
cellular amine metabolic process GO:0044106 2 0.069
transcription dna templated GO:0006351 181 0.068
nucleoside monophosphate catabolic process GO:0009125 4 0.067
homeostasis of number of cells GO:0048872 62 0.064
Mouse
sensory organ morphogenesis GO:0090596 200 0.062
hematopoietic or lymphoid organ development GO:0048534 191 0.062
generation of neurons GO:0048699 385 0.060
response to stress GO:0006950 263 0.060
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.059
membrane hyperpolarization GO:0060081 1 0.059
cellular catabolic process GO:0044248 27 0.059
extrinsic apoptotic signaling pathway GO:0097191 3 0.058
small molecule metabolic process GO:0044281 77 0.058
cell death GO:0008219 121 0.057
positive regulation of biological process GO:0048518 253 0.057
Mouse
organic substance biosynthetic process GO:1901576 289 0.055
blood circulation GO:0008015 87 0.054
response to superoxide GO:0000303 2 0.054
cellular nitrogen compound metabolic process GO:0034641 290 0.053
cellular response to superoxide GO:0071451 2 0.053
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.052
carboxylic acid metabolic process GO:0019752 22 0.052
response to oxygen containing compound GO:1901700 55 0.051
Mouse
intracellular signal transduction GO:0035556 85 0.051
Mouse
regulation of phosphorylation GO:0042325 26 0.051
Mouse
response to bacterium GO:0009617 58 0.051
Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.050
rna biosynthetic process GO:0032774 181 0.049
cellular response to chemical stimulus GO:0070887 157 0.049
Mouse
negative regulation of biological process GO:0048519 304 0.049
nucleic acid templated transcription GO:0097659 181 0.049
negative regulation of cellular metabolic process GO:0031324 77 0.048
Mouse
hemopoiesis GO:0030097 183 0.046
programmed cell death GO:0012501 119 0.046
monovalent inorganic cation transport GO:0015672 42 0.046
organelle organization GO:0006996 227 0.046
apoptotic process GO:0006915 116 0.046
negative regulation of signaling GO:0023057 96 0.045
Mouse
myeloid cell homeostasis GO:0002262 56 0.045
positive regulation of map kinase activity GO:0043406 3 0.044
Mouse
cell morphogenesis GO:0000902 289 0.044
single organism localization GO:1902578 225 0.044
Mouse
transmembrane transport GO:0055085 120 0.044
removal of superoxide radicals GO:0019430 2 0.043
negative regulation of response to stimulus GO:0048585 104 0.043
Mouse
cation transport GO:0006812 81 0.043
cellular modified amino acid metabolic process GO:0006575 3 0.042
ribonucleoside monophosphate catabolic process GO:0009158 4 0.042
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.042
purine nucleoside monophosphate catabolic process GO:0009128 4 0.041
cell migration GO:0016477 237 0.040
regulation of multicellular organismal process GO:0051239 277 0.040
Mouse
positive regulation of signal transduction GO:0009967 56 0.040
Mouse
cellular amide metabolic process GO:0043603 4 0.039
positive regulation of programmed cell death GO:0043068 29 0.039
cellular response to reactive oxygen species GO:0034614 2 0.038
cell fate commitment GO:0045165 99 0.038
positive regulation of cell cycle GO:0045787 3 0.038
nucleobase containing compound metabolic process GO:0006139 274 0.037
regulation of cytokine production GO:0001817 3 0.037
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.037
single organism metabolic process GO:0044710 217 0.036
Mouse
positive regulation of cytokine production GO:0001819 2 0.036
Mouse
negative regulation of cellular biosynthetic process GO:0031327 55 0.036
nuclear transport GO:0051169 4 0.036
positive regulation of cell death GO:0010942 29 0.036
photoreceptor cell differentiation GO:0046530 55 0.036
death GO:0016265 121 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.035
rna metabolic process GO:0016070 219 0.035
homeostatic process GO:0042592 142 0.034
Mouse
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.034
regulation of oxidative stress induced cell death GO:1903201 2 0.034
developmental growth GO:0048589 166 0.034
negative regulation of intracellular protein transport GO:0090317 3 0.034
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.034
atp catabolic process GO:0006200 4 0.033
ribonucleotide metabolic process GO:0009259 27 0.033
regulation of signal transduction GO:0009966 225 0.033
Mouse
larval development GO:0002164 2 0.033
inorganic cation transmembrane transport GO:0098662 50 0.032
cellular response to drug GO:0035690 1 0.032
stem cell development GO:0048864 82 0.032
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.031
retina development in camera type eye GO:0060041 146 0.031
regulation of response to extracellular stimulus GO:0032104 1 0.031
regulation of transporter activity GO:0032409 2 0.030
action potential GO:0001508 19 0.030
regulation of rna biosynthetic process GO:2001141 213 0.030
protein import GO:0017038 3 0.030
positive regulation of cellular amine metabolic process GO:0033240 0 0.030
modification dependent macromolecule catabolic process GO:0043632 3 0.030
response to organic substance GO:0010033 153 0.029
Mouse
regulation of cellular ketone metabolic process GO:0010565 7 0.029
developmental process involved in reproduction GO:0003006 27 0.029
cellular response to lipopolysaccharide GO:0071222 3 0.029
Mouse
cellular component morphogenesis GO:0032989 336 0.029
regulation of nuclease activity GO:0032069 1 0.029
cellular response to oxygen containing compound GO:1901701 20 0.029
Mouse
maintenance of location GO:0051235 4 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.028
meiotic cell cycle process GO:1903046 3 0.028
phosphorylation GO:0016310 69 0.028
Mouse
guanosine containing compound metabolic process GO:1901068 4 0.028
negative regulation of protein phosphorylation GO:0001933 4 0.027
negative regulation of kinase activity GO:0033673 4 0.027
negative regulation of macromolecule metabolic process GO:0010605 76 0.026
Mouse
cellular protein metabolic process GO:0044267 129 0.026
Mouse
phosphorus metabolic process GO:0006793 109 0.026
Mouse
nucleoside phosphate metabolic process GO:0006753 28 0.026
heart contraction GO:0060047 71 0.026
regulation of protein ubiquitination GO:0031396 3 0.026
signal transduction by p53 class mediator GO:0072331 13 0.026
Mouse
regulation of cell death GO:0010941 103 0.026
regulation of translational initiation GO:0006446 1 0.025
sensory organ development GO:0007423 393 0.025
growth GO:0040007 174 0.025
positive regulation of transport GO:0051050 2 0.025
Mouse
organic acid metabolic process GO:0006082 31 0.025
purine containing compound metabolic process GO:0072521 29 0.024
leukocyte proliferation GO:0070661 1 0.024
stem cell differentiation GO:0048863 117 0.024
synaptic transmission cholinergic GO:0007271 4 0.024
cellular macromolecule biosynthetic process GO:0034645 224 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.023
positive regulation of cellular process GO:0048522 201 0.023
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
nucleobase containing small molecule metabolic process GO:0055086 32 0.023
heterocycle catabolic process GO:0046700 15 0.023
mesenchyme development GO:0060485 127 0.023
nuclear envelope organization GO:0006998 2 0.023
regulation of protein binding GO:0043393 3 0.023
positive regulation of response to stimulus GO:0048584 80 0.023
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
negative regulation of cell communication GO:0010648 96 0.022
Mouse
regulation of programmed cell death GO:0043067 101 0.022
regulation of signaling GO:0023051 235 0.022
Mouse
regulation of protein metabolic process GO:0051246 56 0.022
Mouse
protein sumoylation GO:0016925 2 0.022
cellular localization GO:0051641 97 0.022
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.022
regulation of phosphate metabolic process GO:0019220 43 0.022
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.022
Mouse
single organism nuclear import GO:1902593 3 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
superoxide metabolic process GO:0006801 2 0.022
cellular ketone metabolic process GO:0042180 11 0.022
protein secretion GO:0009306 1 0.022
neurotransmitter transport GO:0006836 2 0.022
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9 0.022
blood vessel development GO:0001568 246 0.022
regulation of dna replication GO:0006275 3 0.021
positive regulation of metabolic process GO:0009893 108 0.021
Mouse
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.021
negative regulation of protein transport GO:0051224 3 0.021
cellular response to organic substance GO:0071310 105 0.021
Mouse
regulation of heart growth GO:0060420 2 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
regulation of organelle assembly GO:1902115 4 0.021
purine nucleotide metabolic process GO:0006163 27 0.021
positive regulation of multicellular organismal process GO:0051240 52 0.021
Mouse
positive regulation of muscle organ development GO:0048636 1 0.021
circulatory system process GO:0003013 87 0.021
regulation of response to oxidative stress GO:1902882 2 0.021
negative regulation of catabolic process GO:0009895 3 0.021
regulation of response to stimulus GO:0048583 269 0.021
Mouse
nucleotide metabolic process GO:0009117 28 0.021
regulation of intracellular signal transduction GO:1902531 57 0.020
Mouse
cellular nitrogen compound catabolic process GO:0044270 15 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
peripheral nervous system development GO:0007422 55 0.020
single organism biosynthetic process GO:0044711 71 0.020
positive regulation of intracellular signal transduction GO:1902533 15 0.020
Mouse
stem cell proliferation GO:0072089 4 0.020
negative regulation of programmed cell death GO:0043069 58 0.020
tube morphogenesis GO:0035239 349 0.020
cell morphogenesis involved in differentiation GO:0000904 195 0.020
regulation of meiotic cell cycle GO:0051445 1 0.019
protein complex localization GO:0031503 1 0.019
dna catabolic process GO:0006308 1 0.019
regulation of epithelial cell proliferation GO:0050678 3 0.019
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.019
mesenchymal cell differentiation GO:0048762 87 0.019
erythrocyte homeostasis GO:0034101 55 0.019
positive regulation of apoptotic process GO:0043065 29 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
lipid metabolic process GO:0006629 52 0.018
positive regulation of striated muscle cell differentiation GO:0051155 1 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
eye development GO:0001654 277 0.018
signal transduction by phosphorylation GO:0023014 18 0.018
Mouse
regulation of dna catabolic process GO:1903624 1 0.018
negative regulation of metabolic process GO:0009892 86 0.018
Mouse
insulin like growth factor receptor signaling pathway GO:0048009 4 0.018
positive regulation of wound healing GO:0090303 1 0.018
protein import into nucleus GO:0006606 3 0.018
camera type eye development GO:0043010 222 0.017
adherens junction organization GO:0034332 4 0.017
aromatic compound catabolic process GO:0019439 15 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
negative regulation of biosynthetic process GO:0009890 55 0.017
intracellular transport GO:0046907 32 0.017
lipid storage GO:0019915 1 0.017
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.017
response to lipid GO:0033993 60 0.017
Mouse
positive regulation of striated muscle tissue development GO:0045844 1 0.017
cellular protein modification process GO:0006464 100 0.017
Mouse
ion transmembrane transport GO:0034220 91 0.017
oocyte maturation GO:0001556 4 0.017
retina morphogenesis in camera type eye GO:0060042 79 0.017
exocrine pancreas development GO:0031017 28 0.017
stem cell maintenance GO:0019827 4 0.016
ribosomal small subunit biogenesis GO:0042274 2 0.016
positive regulation of signaling GO:0023056 56 0.016
Mouse
negative regulation of signal transduction GO:0009968 94 0.016
Mouse
positive regulation of muscle tissue development GO:1901863 1 0.016
cellular response to stress GO:0033554 62 0.016
Mouse
pancreas development GO:0031016 84 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
specification of symmetry GO:0009799 204 0.016
negative regulation of rna metabolic process GO:0051253 48 0.016
cell aging GO:0007569 2 0.016
Mouse
cell projection morphogenesis GO:0048858 244 0.015
regulation of metal ion transport GO:0010959 4 0.015
reproduction GO:0000003 40 0.015
cellular macromolecular complex assembly GO:0034622 24 0.015
nucleobase containing compound catabolic process GO:0034655 15 0.015
heart morphogenesis GO:0003007 156 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
cell substrate junction assembly GO:0007044 2 0.015
reactive oxygen species metabolic process GO:0072593 6 0.015
positive regulation of epithelial cell differentiation GO:0030858 2 0.015
negative regulation of dna metabolic process GO:0051053 4 0.015
regulation of wound healing GO:0061041 2 0.015
cellular component movement GO:0006928 335 0.015
cell proliferation in forebrain GO:0021846 3 0.015
sensory system development GO:0048880 76 0.015
protein targeting to nucleus GO:0044744 3 0.015
regulation of cardiac muscle tissue development GO:0055024 1 0.015
response to other organism GO:0051707 97 0.015
Mouse
negative regulation of cellular catabolic process GO:0031330 3 0.015
cell part morphogenesis GO:0032990 246 0.015
urogenital system development GO:0001655 97 0.014
regulation of erythrocyte differentiation GO:0045646 2 0.014
negative regulation of cell death GO:0060548 60 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
regulation of kinase activity GO:0043549 15 0.014
Mouse
neurotransmitter secretion GO:0007269 2 0.014
autophagy GO:0006914 4 0.014
positive regulation of myeloid cell differentiation GO:0045639 2 0.014
inner ear development GO:0048839 126 0.014
positive regulation of nuclease activity GO:0032075 1 0.014
neuron fate determination GO:0048664 2 0.014
negative regulation of cytoplasmic transport GO:1903650 2 0.014
negative regulation of leukocyte differentiation GO:1902106 1 0.014
regulation of cellular protein metabolic process GO:0032268 52 0.014
Mouse
immune system process GO:0002376 241 0.013
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
glucose homeostasis GO:0042593 1 0.013
regulation of protein modification process GO:0031399 29 0.013
Mouse
response to uv GO:0009411 3 0.013
protein phosphorylation GO:0006468 47 0.013
Mouse
establishment of protein localization to organelle GO:0072594 4 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
negative regulation of transcription dna templated GO:0045892 45 0.013
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.013
regulation of developmental process GO:0050793 247 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
cation transmembrane transport GO:0098655 65 0.013
liver development GO:0001889 96 0.013
mitochondrion organization GO:0007005 4 0.013
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.013
sodium ion transmembrane transport GO:0035725 21 0.013
metal ion transport GO:0030001 58 0.012
phagocytosis GO:0006909 3 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
Mouse
protein modification process GO:0036211 100 0.012
Mouse
mesenchymal cell development GO:0014031 78 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
entrainment of circadian clock GO:0009649 2 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
macromolecule modification GO:0043412 111 0.012
Mouse
cellular amino acid biosynthetic process GO:0008652 2 0.012
hormone transport GO:0009914 2 0.012
cell proliferation GO:0008283 80 0.012
protein stabilization GO:0050821 2 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
regulation of reproductive process GO:2000241 4 0.012
organic substance transport GO:0071702 58 0.012
Mouse
regulation of autophagy GO:0010506 3 0.012
monoamine transport GO:0015844 1 0.012
inorganic ion transmembrane transport GO:0098660 57 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
protein acylation GO:0043543 3 0.011
ribose phosphate metabolic process GO:0019693 27 0.011
digestive tract development GO:0048565 265 0.011
determination of bilateral symmetry GO:0009855 204 0.011
ovarian follicle development GO:0001541 2 0.011
regulation of postsynaptic membrane potential GO:0060078 1 0.011
eye morphogenesis GO:0048592 144 0.011
small molecule catabolic process GO:0044282 3 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
regulation of transmembrane transport GO:0034762 18 0.011
purine ribonucleotide metabolic process GO:0009150 27 0.011
negative regulation of cellular process GO:0048523 283 0.011
response to hydrogen peroxide GO:0042542 3 0.011
gtp metabolic process GO:0046039 4 0.011
endocardium formation GO:0060214 1 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
angiogenesis GO:0001525 158 0.011
negative regulation of oxidative stress induced cell death GO:1903202 2 0.011
regulation of cell activation GO:0050865 1 0.011
single organism transport GO:0044765 206 0.011
Mouse
regulation of binding GO:0051098 3 0.011
hydrogen transport GO:0006818 7 0.011
mononuclear cell proliferation GO:0032943 1 0.011
otolith development GO:0048840 32 0.011
membrane repolarization GO:0086009 2 0.011
regulation of photoreceptor cell differentiation GO:0046532 2 0.011
nucleoside biosynthetic process GO:0009163 2 0.011
organophosphate metabolic process GO:0019637 37 0.011
regulation of neurotransmitter transport GO:0051588 1 0.010
heart development GO:0007507 313 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
chromosome organization involved in meiosis GO:0070192 1 0.010
intrinsic apoptotic signaling pathway GO:0097193 20 0.010
heart process GO:0003015 71 0.010
organic cyclic compound catabolic process GO:1901361 15 0.010
endocardium morphogenesis GO:0003160 4 0.010
lipid homeostasis GO:0055088 3 0.010
regulation of alcohol biosynthetic process GO:1902930 1 0.010
regulation of protein phosphorylation GO:0001932 18 0.010
Mouse
camera type eye morphogenesis GO:0048593 108 0.010
microtubule based movement GO:0007018 33 0.010
carbon dioxide transport GO:0015670 3 0.010

mif disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
disease of metabolism DOID:0014667 0 0.016
inherited metabolic disorder DOID:655 0 0.016
lysosomal storage disease DOID:3211 0 0.011