Danio rerio

69 known processes

mlh1

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

(Aliases: zgc:66301,MGC66301)

mlh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.435
cellular aromatic compound metabolic process GO:0006725 295 0.324
organelle organization GO:0006996 227 0.248
nucleic acid metabolic process GO:0090304 244 0.236
regionalization GO:0003002 274 0.218
rna biosynthetic process GO:0032774 181 0.207
organic cyclic compound metabolic process GO:1901360 301 0.184
nucleobase containing compound metabolic process GO:0006139 274 0.156
chromosome organization GO:0051276 31 0.146
meiotic cell cycle process GO:1903046 3 0.129
nucleobase containing compound biosynthetic process GO:0034654 205 0.127
meiosis i GO:0007127 1 0.120
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.111
Mouse
nitrogen compound metabolic process GO:0006807 319 0.110
single organism transport GO:0044765 206 0.108
single organism metabolic process GO:0044710 217 0.099
aging GO:0007568 2 0.098
heterocycle metabolic process GO:0046483 290 0.097
signal transduction GO:0007165 455 0.096
Mouse
heterocycle biosynthetic process GO:0018130 215 0.091
negative regulation of cellular process GO:0048523 283 0.091
Mouse
rna metabolic process GO:0016070 219 0.088
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.084
Mouse
cellular biosynthetic process GO:0044249 286 0.081
nucleocytoplasmic transport GO:0006913 4 0.080
larval development GO:0002164 2 0.076
cell surface receptor signaling pathway GO:0007166 325 0.075
cellular component morphogenesis GO:0032989 336 0.075
regulation of gene expression GO:0010468 265 0.074
cellular nitrogen compound metabolic process GO:0034641 290 0.073
aromatic compound biosynthetic process GO:0019438 217 0.073
regulation of transcription dna templated GO:0006355 213 0.072
positive regulation of cell cycle GO:0045787 3 0.071
regulation of macromolecule biosynthetic process GO:0010556 225 0.068
organic substance biosynthetic process GO:1901576 289 0.065
single organism organelle organization GO:1902589 199 0.065
negative regulation of dna recombination GO:0045910 2 0.065
Mouse
regulation of rna metabolic process GO:0051252 224 0.064
regulation of dna recombination GO:0000018 2 0.063
Mouse
nuclear transport GO:0051169 4 0.061
cellular nitrogen compound biosynthetic process GO:0044271 218 0.059
regulation of rna biosynthetic process GO:2001141 213 0.059
regulation of cell communication GO:0010646 232 0.057
positive regulation of biological process GO:0048518 253 0.057
multicellular organism growth GO:0035264 4 0.057
cellular macromolecule biosynthetic process GO:0034645 224 0.055
cellular response to dna damage stimulus GO:0006974 24 0.055
Human Yeast Mouse
cell projection morphogenesis GO:0048858 244 0.055
enzyme linked receptor protein signaling pathway GO:0007167 106 0.053
positive regulation of catabolic process GO:0009896 4 0.053
positive regulation of stem cell proliferation GO:2000648 1 0.052
regulation of metabolic process GO:0019222 359 0.051
Mouse
cell cycle g2 m phase transition GO:0044839 4 0.050
regulation of cellular metabolic process GO:0031323 320 0.050
Mouse
cell part morphogenesis GO:0032990 246 0.050
lipid storage GO:0019915 1 0.050
transcription dna templated GO:0006351 181 0.049
macromolecule biosynthetic process GO:0009059 227 0.049
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.049
regulation of nucleic acid templated transcription GO:1903506 213 0.048
purine nucleoside monophosphate catabolic process GO:0009128 4 0.047
Yeast
regulation of cellular biosynthetic process GO:0031326 245 0.047
telomere organization GO:0032200 1 0.047
programmed cell death GO:0012501 119 0.047
Mouse
response to uv GO:0009411 3 0.046
nucleic acid templated transcription GO:0097659 181 0.046
regulation of biosynthetic process GO:0009889 250 0.046
dorsal ventral pattern formation GO:0009953 125 0.045
stem cell division GO:0017145 1 0.045
negative regulation of biological process GO:0048519 304 0.045
Mouse
embryonic organ morphogenesis GO:0048562 274 0.044
regulation of meiotic cell cycle GO:0051445 1 0.044
biosynthetic process GO:0009058 294 0.043
positive regulation of cellular process GO:0048522 201 0.042
nucleoside monophosphate catabolic process GO:0009125 4 0.042
Yeast
regulation of primary metabolic process GO:0080090 311 0.041
Mouse
regulation of signal transduction GO:0009966 225 0.041
gastrulation GO:0007369 208 0.041
ribonucleoside monophosphate catabolic process GO:0009158 4 0.040
Yeast
maintenance of location GO:0051235 4 0.039
telomere maintenance GO:0000723 1 0.039
cellular amine metabolic process GO:0044106 2 0.038
cellular response to stress GO:0033554 62 0.038
Human Yeast Mouse
single organism nuclear import GO:1902593 3 0.038
transport GO:0006810 220 0.038
cellular protein metabolic process GO:0044267 129 0.037
regulation of protein transport GO:0051223 3 0.037
embryonic heart tube morphogenesis GO:0003143 108 0.037
regulation of cellular amino acid metabolic process GO:0006521 0 0.037
response to stress GO:0006950 263 0.037
Human Yeast Mouse
regulation of multicellular organism growth GO:0040014 4 0.036
regulation of macromolecule metabolic process GO:0060255 317 0.036
Mouse
protein metabolic process GO:0019538 183 0.036
female sex differentiation GO:0046660 4 0.036
single organism localization GO:1902578 225 0.036
establishment of localization GO:0051234 244 0.035
amine metabolic process GO:0009308 2 0.035
macromolecular complex subunit organization GO:0043933 74 0.035
Mouse
tube morphogenesis GO:0035239 349 0.034
cell projection organization GO:0030030 284 0.034
regulation of signaling GO:0023051 235 0.034
immune system process GO:0002376 241 0.034
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.033
regulation of establishment of protein localization GO:0070201 4 0.033
hemopoiesis GO:0030097 183 0.033
gene expression GO:0010467 252 0.033
Mouse
determination of bilateral symmetry GO:0009855 204 0.033
meiotic nuclear division GO:0007126 4 0.033
response to chemical GO:0042221 320 0.032
atp catabolic process GO:0006200 4 0.032
Yeast
heart morphogenesis GO:0003007 156 0.032
g2 dna damage checkpoint GO:0031572 3 0.032
protein import GO:0017038 3 0.032
brain development GO:0007420 293 0.031
transcription from rna polymerase ii promoter GO:0006366 80 0.031
specification of symmetry GO:0009799 204 0.031
cellular localization GO:0051641 97 0.031
cellular amino acid metabolic process GO:0006520 7 0.030
spermatid development GO:0007286 2 0.030
developmental programmed cell death GO:0010623 4 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
intracellular signal transduction GO:0035556 85 0.030
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.029
nuclear import GO:0051170 3 0.029
morphogenesis of an epithelium GO:0002009 333 0.029
regulation of stem cell proliferation GO:0072091 2 0.029
regulation of protein localization to nucleus GO:1900180 2 0.028
positive regulation of transport GO:0051050 2 0.028
regulation of cytoplasmic transport GO:1903649 4 0.028
sensory organ development GO:0007423 393 0.028
mitotic dna damage checkpoint GO:0044773 4 0.027
spermatid differentiation GO:0048515 2 0.027
stem cell proliferation GO:0072089 4 0.027
embryo development ending in birth or egg hatching GO:0009792 271 0.026
Worm
golgi vesicle transport GO:0048193 3 0.026
regulation of response to stimulus GO:0048583 269 0.026
embryonic organ development GO:0048568 381 0.026
chromosome organization involved in meiosis GO:0070192 1 0.026
positive regulation of cellular component biogenesis GO:0044089 3 0.026
regulation of biological quality GO:0065008 263 0.026
nuclear export GO:0051168 1 0.025
sex determination GO:0007530 1 0.025
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.025
b cell activation GO:0042113 2 0.025
Mouse
cellular response to external stimulus GO:0071496 2 0.025
cell cycle process GO:0022402 53 0.025
synapsis GO:0007129 1 0.025
macromolecule modification GO:0043412 111 0.024
golgi organization GO:0007030 1 0.024
neuron differentiation GO:0030182 353 0.024
centrosome duplication GO:0051298 1 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.024
Yeast
protein import into nucleus GO:0006606 3 0.024
development of primary female sexual characteristics GO:0046545 4 0.024
response to drug GO:0042493 3 0.023
g2 m transition of mitotic cell cycle GO:0000086 4 0.023
regulation of protein targeting GO:1903533 2 0.023
regulation of cellular component organization GO:0051128 86 0.023
cellular response to organic substance GO:0071310 105 0.023
somatic muscle development GO:0007525 4 0.023
mitotic dna integrity checkpoint GO:0044774 4 0.022
regulation of nucleocytoplasmic transport GO:0046822 2 0.022
cellular component biogenesis GO:0044085 178 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
anterior posterior pattern specification GO:0009952 152 0.022
regulation of cytokine production GO:0001817 3 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
centrosome organization GO:0051297 1 0.022
determination of heart left right asymmetry GO:0061371 117 0.022
cellular response to radiation GO:0071478 4 0.022
cellular protein modification process GO:0006464 100 0.021
organic acid metabolic process GO:0006082 31 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
central nervous system development GO:0007417 387 0.021
small molecule metabolic process GO:0044281 77 0.021
Yeast
protein localization to nucleus GO:0034504 3 0.021
developmental growth GO:0048589 166 0.021
meiotic chromosome segregation GO:0045132 3 0.021
embryonic limb morphogenesis GO:0030326 2 0.021
heart development GO:0007507 313 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.021
apoptotic process GO:0006915 116 0.021
Mouse
organelle fission GO:0048285 23 0.020
cilium organization GO:0044782 71 0.020
cellular component assembly GO:0022607 170 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
regulation of cell differentiation GO:0045595 142 0.020
spindle assembly GO:0051225 2 0.020
Mouse
reciprocal dna recombination GO:0035825 1 0.020
cell morphogenesis GO:0000902 289 0.020
macromolecular complex disassembly GO:0032984 1 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
protein targeting to nucleus GO:0044744 3 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
homeostatic process GO:0042592 142 0.019
regulation of epithelial cell proliferation GO:0050678 3 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
epithelial tube morphogenesis GO:0060562 148 0.019
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.019
cellular component movement GO:0006928 335 0.019
cellular component disassembly GO:0022411 1 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
establishment of localization in cell GO:0051649 77 0.018
skeletal system development GO:0001501 181 0.018
double strand break repair GO:0006302 3 0.018
Mouse
heart looping GO:0001947 94 0.018
protein dephosphorylation GO:0006470 3 0.018
regulation of protein catabolic process GO:0042176 1 0.018
negative regulation of dna metabolic process GO:0051053 4 0.018
Mouse
sequestering of calcium ion GO:0051208 3 0.018
female gonad development GO:0008585 4 0.018
positive regulation of dna metabolic process GO:0051054 1 0.018
oxoacid metabolic process GO:0043436 31 0.018
organelle assembly GO:0070925 110 0.018
Mouse
autophagy GO:0006914 4 0.018
cell cycle GO:0007049 93 0.018
er to golgi vesicle mediated transport GO:0006888 1 0.018
positive regulation of cytokine production GO:0001819 2 0.018
mitotic g2 dna damage checkpoint GO:0007095 3 0.018
protein complex assembly GO:0006461 30 0.017
Mouse
regulation of protein complex disassembly GO:0043244 1 0.017
locomotion GO:0040011 313 0.017
segmentation GO:0035282 97 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
positive regulation of cellular metabolic process GO:0031325 94 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
cilium morphogenesis GO:0060271 85 0.017
proteasomal protein catabolic process GO:0010498 2 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
digestive system development GO:0055123 289 0.017
regulation of cell activation GO:0050865 1 0.017
response to radiation GO:0009314 51 0.017
mitotic recombination GO:0006312 2 0.017
Mouse
neuron projection development GO:0031175 180 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
pericardium morphogenesis GO:0003344 1 0.017
protein modification process GO:0036211 100 0.017
male meiosis GO:0007140 2 0.016
gamete generation GO:0007276 33 0.016
regulation of protein complex assembly GO:0043254 3 0.016
mitochondrion organization GO:0007005 4 0.016
regulation of circadian rhythm GO:0042752 4 0.016
somatic cell dna recombination GO:0016444 1 0.016
Mouse
cytoskeleton organization GO:0007010 96 0.016
Mouse
internal protein amino acid acetylation GO:0006475 2 0.016
response to light stimulus GO:0009416 46 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
cilium movement GO:0003341 26 0.016
growth GO:0040007 174 0.016
phosphate containing compound metabolic process GO:0006796 108 0.016
Yeast
protein complex disassembly GO:0043241 1 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
spindle assembly involved in mitosis GO:0090307 1 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
dna biosynthetic process GO:0071897 3 0.016
neuron development GO:0048666 262 0.015
immune system development GO:0002520 191 0.015
Mouse
peptidyl lysine acetylation GO:0018394 2 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
determination of left right symmetry GO:0007368 179 0.015
regulation of blood pressure GO:0008217 1 0.015
dna metabolic process GO:0006259 27 0.015
intracellular transport GO:0046907 32 0.015
head development GO:0060322 303 0.015
hematopoietic stem cell migration GO:0035701 4 0.015
specification of axis polarity GO:0065001 4 0.015
cell death GO:0008219 121 0.015
Mouse
female meiotic division GO:0007143 2 0.015
tissue remodeling GO:0048771 4 0.015
cellular response to starvation GO:0009267 1 0.015
rna transport GO:0050658 2 0.015
cellular ketone metabolic process GO:0042180 11 0.015
death GO:0016265 121 0.015
Mouse
positive regulation of jnk cascade GO:0046330 3 0.015
forebrain regionalization GO:0021871 4 0.015
protein polymerization GO:0051258 4 0.015
vasculature development GO:0001944 278 0.014
rna 3 end processing GO:0031123 2 0.014
Mouse
chemosensory behavior GO:0007635 1 0.014
positive regulation of map kinase activity GO:0043406 3 0.014
regulation of cell proliferation GO:0042127 37 0.014
stem cell maintenance GO:0019827 4 0.014
chromatin organization GO:0006325 22 0.014
adult behavior GO:0030534 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
dna templated transcription initiation GO:0006352 1 0.014
phagocytosis GO:0006909 3 0.014
regulation of jak stat cascade GO:0046425 3 0.014
primary neural tube formation GO:0014020 1 0.014
somite development GO:0061053 96 0.014
striated muscle cell differentiation GO:0051146 129 0.014
negative regulation of nuclear division GO:0051784 3 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of programmed cell death GO:0043067 101 0.013
cytokinesis GO:0000910 3 0.013
double strand break repair via homologous recombination GO:0000724 1 0.013
regulation of synapse assembly GO:0051963 3 0.013
polarized epithelial cell differentiation GO:0030859 4 0.013
positive regulation of cellular biosynthetic process GO:0031328 68 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
positive regulation of metabolic process GO:0009893 108 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
septum transversum development GO:0003343 4 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
response to external biotic stimulus GO:0043207 97 0.013
regulation of localization GO:0032879 104 0.013
positive regulation of cell activation GO:0050867 1 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
convergent extension GO:0060026 118 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
positive regulation of rna metabolic process GO:0051254 59 0.013
negative regulation of metabolic process GO:0009892 86 0.013
Mouse
generation of neurons GO:0048699 385 0.013
positive regulation of signal transduction GO:0009967 56 0.013
myeloid cell differentiation GO:0030099 86 0.013
b cell differentiation GO:0030183 1 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
reproduction GO:0000003 40 0.013
tube closure GO:0060606 1 0.013
proepicardium development GO:0003342 4 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.013
germ line stem cell division GO:0042078 1 0.013
regulation of anatomical structure size GO:0090066 33 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
nuclear division GO:0000280 23 0.012
neurological system process GO:0050877 62 0.012
axonogenesis GO:0007409 152 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
Mouse
recombinational repair GO:0000725 1 0.012
neuron projection morphogenesis GO:0048812 161 0.012
response to organic substance GO:0010033 153 0.012
central nervous system neuron differentiation GO:0021953 74 0.012
apoptotic process involved in development GO:1902742 2 0.012
ribosome assembly GO:0042255 1 0.012
regulation of mesenchymal cell proliferation GO:0010464 1 0.012
protein acetylation GO:0006473 2 0.012
somitogenesis GO:0001756 87 0.012
protein acylation GO:0043543 3 0.012
regulation of binding GO:0051098 3 0.012
chemotaxis GO:0006935 104 0.012
phagocytosis engulfment GO:0006911 1 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
Mouse
cell aging GO:0007569 2 0.012
positive regulation of signaling GO:0023056 56 0.012
angiogenesis GO:0001525 158 0.012
endosomal transport GO:0016197 2 0.012
transmembrane transport GO:0055085 120 0.012
positive regulation of cell division GO:0051781 2 0.012
chordate embryonic development GO:0043009 271 0.012
cognition GO:0050890 1 0.012
leukocyte proliferation GO:0070661 1 0.012
negative regulation of kinase activity GO:0033673 4 0.012
membrane invagination GO:0010324 1 0.012
regulation of blood vessel size GO:0050880 2 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
immunoglobulin production GO:0002377 1 0.012
Mouse
regulation of apoptotic process GO:0042981 98 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
rna localization GO:0006403 4 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
microtubule polymerization or depolymerization GO:0031109 3 0.011
cellular protein catabolic process GO:0044257 4 0.011
interspecies interaction between organisms GO:0044419 4 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
mesenchymal cell proliferation GO:0010463 1 0.011
embryonic heart tube development GO:0035050 133 0.011
circadian sleep wake cycle sleep GO:0050802 1 0.011
single organism intracellular transport GO:1902582 25 0.011
positive regulation of cell communication GO:0010647 56 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
regulation of cell cycle g2 m phase transition GO:1902749 4 0.011
protein homooligomerization GO:0051260 3 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
pharyngeal muscle development GO:0043282 4 0.011
system process GO:0003008 185 0.011
dna templated transcription elongation GO:0006354 3 0.011
cellular amide metabolic process GO:0043603 4 0.011
regulation of dna templated transcription elongation GO:0032784 3 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
axon development GO:0061564 166 0.011
response to carbohydrate GO:0009743 3 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
peptide transport GO:0015833 1 0.011
regulation of reproductive process GO:2000241 4 0.011
response to vitamin GO:0033273 3 0.011
bmp signaling pathway GO:0030509 52 0.011
histone h3 k4 methylation GO:0051568 2 0.011
mitotic g2 m transition checkpoint GO:0044818 3 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
Mouse
positive regulation of secretion GO:0051047 1 0.011
regulation of stem cell differentiation GO:2000736 4 0.010
response to topologically incorrect protein GO:0035966 2 0.010
lamellipodium organization GO:0097581 1 0.010
regulation of translational initiation GO:0006446 1 0.010
lipid homeostasis GO:0055088 3 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
regulation of mitotic cell cycle GO:0007346 25 0.010
regulation of cell cycle process GO:0010564 20 0.010
axon guidance GO:0007411 86 0.010
nucleic acid transport GO:0050657 2 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
Mouse
dna catabolic process GO:0006308 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
sequestering of metal ion GO:0051238 3 0.010
response to abiotic stimulus GO:0009628 122 0.010
pronephros morphogenesis GO:0072114 14 0.010
protein complex subunit organization GO:0071822 46 0.010
Mouse
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.010
digestive tract morphogenesis GO:0048546 231 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
tissue homeostasis GO:0001894 25 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.010
Mouse

mlh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
disease of cellular proliferation DOID:14566 0 0.022
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.018
nervous system disease DOID:863 0 0.017
immune system disease DOID:2914 0 0.012
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.011