Danio rerio

0 known processes

mll2

myeloid/lymphoid or mixed-lineage leukemia 2

(Aliases: im:7157663)

mll2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
histone h4 k20 methylation GO:0034770 2 0.470
histone lysine methylation GO:0034968 12 0.303
protein methylation GO:0006479 13 0.233
methylation GO:0032259 22 0.230
histone h3 k36 methylation GO:0010452 2 0.215
chromatin modification GO:0016568 21 0.190
histone h3 k4 methylation GO:0051568 2 0.180
protein alkylation GO:0008213 13 0.172
peptidyl lysine methylation GO:0018022 3 0.161
nucleic acid metabolic process GO:0090304 244 0.158
nitrogen compound metabolic process GO:0006807 319 0.157
regulation of metabolic process GO:0019222 359 0.147
organic substance biosynthetic process GO:1901576 289 0.143
nucleobase containing compound biosynthetic process GO:0034654 205 0.141
macromolecule methylation GO:0043414 19 0.139
peptidyl lysine dimethylation GO:0018027 1 0.125
regulation of cellular metabolic process GO:0031323 320 0.120
heterocycle biosynthetic process GO:0018130 215 0.116
macromolecule biosynthetic process GO:0009059 227 0.111
histone methylation GO:0016571 13 0.103
cellular nitrogen compound biosynthetic process GO:0044271 218 0.100
single organism metabolic process GO:0044710 217 0.098
aromatic compound biosynthetic process GO:0019438 217 0.098
regulation of macromolecule metabolic process GO:0060255 317 0.097
peptidyl lysine trimethylation GO:0018023 1 0.094
biosynthetic process GO:0009058 294 0.094
regulation of macromolecule biosynthetic process GO:0010556 225 0.092
organelle organization GO:0006996 227 0.091
heterocycle metabolic process GO:0046483 290 0.090
rna biosynthetic process GO:0032774 181 0.086
histone modification GO:0016570 20 0.086
gene expression GO:0010467 252 0.085
negative regulation of biological process GO:0048519 304 0.084
nucleic acid templated transcription GO:0097659 181 0.084
cellular aromatic compound metabolic process GO:0006725 295 0.083
cellular macromolecule metabolic process GO:0044260 391 0.082
nucleobase containing compound metabolic process GO:0006139 274 0.082
histone h3 k9 methylation GO:0051567 5 0.080
covalent chromatin modification GO:0016569 20 0.077
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.076
regulation of transcription dna templated GO:0006355 213 0.076
cellular biosynthetic process GO:0044249 286 0.075
organic cyclic compound metabolic process GO:1901360 301 0.074
regulation of nitrogen compound metabolic process GO:0051171 251 0.074
transcription dna templated GO:0006351 181 0.074
regulation of primary metabolic process GO:0080090 311 0.072
rna metabolic process GO:0016070 219 0.066
cellular nitrogen compound metabolic process GO:0034641 290 0.063
regulation of gene expression GO:0010468 265 0.063
cellular protein metabolic process GO:0044267 129 0.062
regulation of rna biosynthetic process GO:2001141 213 0.061
single organism organelle organization GO:1902589 199 0.059
organic cyclic compound biosynthetic process GO:1901362 223 0.056
chromosome organization GO:0051276 31 0.056
regulation of biosynthetic process GO:0009889 250 0.053
multicellular organism growth GO:0035264 4 0.053
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.052
macromolecule modification GO:0043412 111 0.051
protein modification process GO:0036211 100 0.049
regulation of rna metabolic process GO:0051252 224 0.049
cellular protein modification process GO:0006464 100 0.048
protein metabolic process GO:0019538 183 0.046
negative regulation of metabolic process GO:0009892 86 0.042
regulation of multicellular organism growth GO:0040014 4 0.042
response to chemical GO:0042221 320 0.042
response to stress GO:0006950 263 0.042
aging GO:0007568 2 0.041
chromatin organization GO:0006325 22 0.040
response to external stimulus GO:0009605 264 0.040
regulation of response to stimulus GO:0048583 269 0.038
positive regulation of transport GO:0051050 2 0.038
larval development GO:0002164 2 0.037
regulation of cellular biosynthetic process GO:0031326 245 0.037
negative regulation of macromolecule metabolic process GO:0010605 76 0.037
peptidyl serine phosphorylation GO:0018105 1 0.036
meiotic nuclear division GO:0007126 4 0.036
skeletal system development GO:0001501 181 0.035
cellular macromolecule biosynthetic process GO:0034645 224 0.034
regulation of nucleic acid templated transcription GO:1903506 213 0.033
cellular response to external stimulus GO:0071496 2 0.033
cell projection morphogenesis GO:0048858 244 0.033
neuron differentiation GO:0030182 353 0.033
cell morphogenesis GO:0000902 289 0.032
negative regulation of kinase activity GO:0033673 4 0.032
generation of neurons GO:0048699 385 0.032
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.031
cellular amine metabolic process GO:0044106 2 0.031
negative regulation of cellular process GO:0048523 283 0.031
amine metabolic process GO:0009308 2 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
cellular response to nutrient levels GO:0031669 2 0.030
negative regulation of protein phosphorylation GO:0001933 4 0.030
negative regulation of gene expression GO:0010629 65 0.029
regulation of cellular amine metabolic process GO:0033238 0 0.029
protein acetylation GO:0006473 2 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.027
internal peptidyl lysine acetylation GO:0018393 2 0.027
female sex differentiation GO:0046660 4 0.027
macromolecular complex subunit organization GO:0043933 74 0.026
cellular response to chemical stimulus GO:0070887 157 0.026
neuron development GO:0048666 262 0.025
central nervous system development GO:0007417 387 0.025
internal protein amino acid acetylation GO:0006475 2 0.025
cell projection organization GO:0030030 284 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.025
maintenance of location GO:0051235 4 0.025
cellular ketone metabolic process GO:0042180 11 0.024
peptidyl lysine acetylation GO:0018394 2 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
cellular component morphogenesis GO:0032989 336 0.024
peptidyl lysine monomethylation GO:0018026 1 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.024
negative regulation of biosynthetic process GO:0009890 55 0.024
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.023
positive regulation of catabolic process GO:0009896 4 0.023
cell part morphogenesis GO:0032990 246 0.023
oxoacid metabolic process GO:0043436 31 0.023
histone h3 k9 modification GO:0061647 5 0.023
regulation of cellular component organization GO:0051128 86 0.023
signal transduction GO:0007165 455 0.023
cellular amino acid metabolic process GO:0006520 7 0.022
negative regulation of cellular biosynthetic process GO:0031327 55 0.022
chordate embryonic development GO:0043009 271 0.022
digestive system development GO:0055123 289 0.022
response to drug GO:0042493 3 0.022
negative regulation of cellular metabolic process GO:0031324 77 0.022
female gonad development GO:0008585 4 0.022
regulation of dna templated transcription elongation GO:0032784 3 0.022
phagocytosis GO:0006909 3 0.022
gtp catabolic process GO:0006184 2 0.022
growth GO:0040007 174 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.021
positive regulation of gtpase activity GO:0043547 1 0.021
regulation of developmental process GO:0050793 247 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
dna templated transcription elongation GO:0006354 3 0.021
positive regulation of dna templated transcription elongation GO:0032786 1 0.021
negative regulation of nucleic acid templated transcription GO:1903507 45 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
response to nutrient GO:0007584 3 0.021
regulation of meiotic cell cycle GO:0051445 1 0.020
positive regulation of biological process GO:0048518 253 0.020
axonogenesis GO:0007409 152 0.020
positive regulation of macromolecule metabolic process GO:0010604 93 0.020
establishment of localization GO:0051234 244 0.020
mitochondrion organization GO:0007005 4 0.020
head development GO:0060322 303 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
axon development GO:0061564 166 0.020
cognition GO:0050890 1 0.020
small molecule metabolic process GO:0044281 77 0.019
organic acid metabolic process GO:0006082 31 0.019
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.019
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.019
stem cell maintenance GO:0019827 4 0.019
regulation of protein transport GO:0051223 3 0.019
positive regulation of cellular component biogenesis GO:0044089 3 0.019
protein acylation GO:0043543 3 0.019
response to organic substance GO:0010033 153 0.019
peptidyl serine modification GO:0018209 2 0.018
single organism nuclear import GO:1902593 3 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.018
response to corticosteroid GO:0031960 1 0.018
regulation of cell activation GO:0050865 1 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.017
negative regulation of rna biosynthetic process GO:1902679 45 0.017
regulation of signal transduction GO:0009966 225 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
negative regulation of transcription dna templated GO:0045892 45 0.017
response to glucocorticoid GO:0051384 1 0.017
autophagy GO:0006914 4 0.017
neuron projection development GO:0031175 180 0.017
homeostatic process GO:0042592 142 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
lipid storage GO:0019915 1 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.017
nuclear transport GO:0051169 4 0.017
adult behavior GO:0030534 2 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
gtp metabolic process GO:0046039 4 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
central nervous system neuron differentiation GO:0021953 74 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
stem cell division GO:0017145 1 0.016
ovulation cycle GO:0042698 2 0.016
hemopoiesis GO:0030097 183 0.016
system process GO:0003008 185 0.016
gastrulation GO:0007369 208 0.016
cellular protein catabolic process GO:0044257 4 0.016
multi organism process GO:0051704 134 0.015
regulation of signaling GO:0023051 235 0.015
cell migration GO:0016477 237 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
regulation of circadian rhythm GO:0042752 4 0.015
immune system process GO:0002376 241 0.015
protein import into nucleus GO:0006606 3 0.015
regulation of cell communication GO:0010646 232 0.015
developmental growth GO:0048589 166 0.015
organelle fusion GO:0048284 3 0.015
endosomal transport GO:0016197 2 0.015
ubiquitin dependent protein catabolic process GO:0006511 3 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cellular response to organic substance GO:0071310 105 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
positive regulation of cellular process GO:0048522 201 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
nuclear import GO:0051170 3 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
cellular response to starvation GO:0009267 1 0.015
regulation of metal ion transport GO:0010959 4 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.014
positive regulation of nucleoside metabolic process GO:0045979 1 0.014
mitotic cell cycle embryonic GO:0045448 2 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
regulation of protein complex assembly GO:0043254 3 0.014
cellular component biogenesis GO:0044085 178 0.014
cell motility GO:0048870 244 0.014
single organism membrane fusion GO:0044801 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
protein import GO:0017038 3 0.014
atp catabolic process GO:0006200 4 0.014
positive regulation of cell cycle GO:0045787 3 0.014
ribonucleoside monophosphate catabolic process GO:0009158 4 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
cellular response to oxygen levels GO:0071453 1 0.014
cellular component movement GO:0006928 335 0.014
regulation of synapse assembly GO:0051963 3 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
locomotion GO:0040011 313 0.014
exocytosis GO:0006887 1 0.014
meiotic cell cycle process GO:1903046 3 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
regulation of cell development GO:0060284 100 0.013
regulation of cytokine production GO:0001817 3 0.013
positive regulation of cell activation GO:0050867 1 0.013
golgi vesicle transport GO:0048193 3 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
fertilization GO:0009566 3 0.013
neuron projection morphogenesis GO:0048812 161 0.013
mesenchyme development GO:0060485 127 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
germ line stem cell maintenance GO:0030718 2 0.013
cytokinesis GO:0000910 3 0.013
heart development GO:0007507 313 0.013
dna alkylation GO:0006305 8 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
regulation of protein catabolic process GO:0042176 1 0.013
regulation of synapse organization GO:0050807 3 0.013
positive regulation of secretion GO:0051047 1 0.013
muscle organ development GO:0007517 101 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
neuron projection guidance GO:0097485 86 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
tube morphogenesis GO:0035239 349 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
ovulation cycle process GO:0022602 2 0.013
regulation of intracellular protein transport GO:0033157 3 0.012
regulation of reproductive process GO:2000241 4 0.012
sensory organ development GO:0007423 393 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
brain development GO:0007420 293 0.012
membrane fusion GO:0061025 2 0.012
regulation of transporter activity GO:0032409 2 0.012
chemotaxis GO:0006935 104 0.012
compound eye development GO:0048749 2 0.012
eye development GO:0001654 277 0.012
regulation of histone methylation GO:0031060 3 0.012
protein localization to plasma membrane GO:0072659 1 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
protein localization to nucleus GO:0034504 3 0.012
protein targeting to nucleus GO:0044744 3 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
regulation of binding GO:0051098 3 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
positive regulation of immune effector process GO:0002699 3 0.012
homeostasis of number of cells GO:0048872 62 0.012
striated muscle tissue development GO:0014706 110 0.012
muscle structure development GO:0061061 196 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
rna localization GO:0006403 4 0.012
b cell activation GO:0042113 2 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
regulation of organelle assembly GO:1902115 4 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.012
regulation of mrna processing GO:0050684 3 0.012
ovarian follicle development GO:0001541 2 0.011
stem cell proliferation GO:0072089 4 0.011
cell substrate adhesion GO:0031589 4 0.011
interspecies interaction between organisms GO:0044419 4 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
eye morphogenesis GO:0048592 144 0.011
regulation of gtpase activity GO:0043087 2 0.011
protein secretion GO:0009306 1 0.011
gene silencing GO:0016458 4 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
negative regulation of nuclear division GO:0051784 3 0.011
tissue remodeling GO:0048771 4 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
cellular response to hypoxia GO:0071456 1 0.011
regulation of calcium ion transport GO:0051924 2 0.011
cartilage development GO:0051216 96 0.011
muscle cell differentiation GO:0042692 139 0.011
striated muscle cell development GO:0055002 108 0.011
viral process GO:0016032 1 0.011
positive regulation of gene expression GO:0010628 71 0.011
tube closure GO:0060606 1 0.011
embryonic skeletal system development GO:0048706 97 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
membrane invagination GO:0010324 1 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
response to endogenous stimulus GO:0009719 83 0.010
regulation of dendrite development GO:0050773 3 0.010
phagocytosis engulfment GO:0006911 1 0.010
immune system development GO:0002520 191 0.010
heart contraction GO:0060047 71 0.010
regulation of protein ubiquitination GO:0031396 3 0.010
response to monosaccharide GO:0034284 3 0.010
response to hydrogen peroxide GO:0042542 3 0.010
positive regulation of leukocyte mediated immunity GO:0002705 1 0.010
leukocyte proliferation GO:0070661 1 0.010
cellular response to radiation GO:0071478 4 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
sequestering of calcium ion GO:0051208 3 0.010
phosphorus metabolic process GO:0006793 109 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
synaptic vesicle localization GO:0097479 1 0.010
regulation of gene silencing GO:0060968 1 0.010
cellular component assembly GO:0022607 170 0.010
response to carbohydrate GO:0009743 3 0.010
cellular response to reactive oxygen species GO:0034614 2 0.010
response to external biotic stimulus GO:0043207 97 0.010
neurotransmitter transport GO:0006836 2 0.010

mll2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
disease of cellular proliferation DOID:14566 0 0.018
cancer DOID:162 0 0.016
organ system cancer DOID:0050686 0 0.016
nervous system disease DOID:863 0 0.013
musculoskeletal system disease DOID:17 0 0.012
disease of metabolism DOID:0014667 0 0.012