Danio rerio

25 known processes

msh2

mutS homolog 2 (E. coli)

(Aliases: zgc:55333,wu:fc06b02,wu:fc13e09)

msh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular aromatic compound metabolic process GO:0006725 295 0.891
organic cyclic compound metabolic process GO:1901360 301 0.813
cellular nitrogen compound metabolic process GO:0034641 290 0.794
meiotic nuclear division GO:0007126 4 0.746
Yeast
nitrogen compound metabolic process GO:0006807 319 0.607
larval development GO:0002164 2 0.572
regulation of dna recombination GO:0000018 2 0.434
Human Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.400
biosynthetic process GO:0009058 294 0.390
Yeast
aromatic compound biosynthetic process GO:0019438 217 0.348
Yeast
regulation of macromolecule metabolic process GO:0060255 317 0.340
Human Yeast Mouse
heterocycle biosynthetic process GO:0018130 215 0.329
Yeast
heterocycle metabolic process GO:0046483 290 0.319
cellular macromolecule metabolic process GO:0044260 391 0.316
single organism metabolic process GO:0044710 217 0.306
mitotic recombination GO:0006312 2 0.290
Yeast
cellular biosynthetic process GO:0044249 286 0.268
Yeast
response to uv GO:0009411 3 0.251
Mouse
nucleic acid templated transcription GO:0097659 181 0.248
Yeast
signal transduction GO:0007165 455 0.246
Mouse Worm
regulation of nitrogen compound metabolic process GO:0051171 251 0.234
Human Yeast Mouse
rna biosynthetic process GO:0032774 181 0.225
Yeast
meiosis i GO:0007127 1 0.223
Yeast
organic substance biosynthetic process GO:1901576 289 0.220
Yeast
aging GO:0007568 2 0.220
Mouse
dna metabolic process GO:0006259 27 0.196
sister chromatid cohesion GO:0007062 2 0.189
locomotion GO:0040011 313 0.181
immune system process GO:0002376 241 0.168
Mouse
dna catabolic process GO:0006308 1 0.157
Yeast
organonitrogen compound metabolic process GO:1901564 74 0.153
Human Yeast Mouse
positive regulation of biological process GO:0048518 253 0.152
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.151
Mouse
double strand break repair via homologous recombination GO:0000724 1 0.150
cellular macromolecule biosynthetic process GO:0034645 224 0.136
Yeast
double strand break repair via nonhomologous end joining GO:0006303 1 0.132
regulation of cellular metabolic process GO:0031323 320 0.130
Human Yeast Mouse
meiotic cell cycle process GO:1903046 3 0.130
Yeast
regulation of dna replication GO:0006275 3 0.126
cell morphogenesis GO:0000902 289 0.115
negative regulation of cellular metabolic process GO:0031324 77 0.114
Human Yeast Mouse
immune system development GO:0002520 191 0.114
Mouse
double strand break repair GO:0006302 3 0.107
Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.107
Human Yeast Mouse
nucleic acid metabolic process GO:0090304 244 0.102
non recombinational repair GO:0000726 2 0.100
small molecule metabolic process GO:0044281 77 0.098
Human Yeast Mouse
negative regulation of dna recombination GO:0045910 2 0.098
Human Mouse
negative regulation of cellular process GO:0048523 283 0.095
Human Yeast Mouse
negative regulation of biological process GO:0048519 304 0.092
Human Yeast Mouse
response to light stimulus GO:0009416 46 0.089
Mouse
macromolecule biosynthetic process GO:0009059 227 0.088
Yeast
negative regulation of dna metabolic process GO:0051053 4 0.087
Human Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.087
Yeast
sensory organ development GO:0007423 393 0.086
immunoglobulin mediated immune response GO:0016064 3 0.084
Mouse
regulation of dna metabolic process GO:0051052 11 0.083
Human Mouse
histone h3 k4 methylation GO:0051568 2 0.082
purine containing compound metabolic process GO:0072521 29 0.081
Human Yeast Mouse
camera type eye development GO:0043010 222 0.081
eye development GO:0001654 277 0.080
organic cyclic compound biosynthetic process GO:1901362 223 0.078
Yeast
regulation of transcription dna templated GO:0006355 213 0.078
Yeast
regulation of metabolic process GO:0019222 359 0.077
Human Yeast Mouse
establishment of localization GO:0051234 244 0.075
death GO:0016265 121 0.075
Mouse Worm
protein metabolic process GO:0019538 183 0.072
cellular response to stress GO:0033554 62 0.072
Human Yeast Mouse Worm
b cell mediated immunity GO:0019724 3 0.071
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.070
somatic cell dna recombination GO:0016444 1 0.070
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.069
Yeast
single organism organelle organization GO:1902589 199 0.067
neuron development GO:0048666 262 0.067
nucleotide metabolic process GO:0009117 28 0.067
Human Yeast Mouse
regulation of histone h3 k9 methylation GO:0051570 2 0.065
immunoglobulin production GO:0002377 1 0.065
Mouse
response to amino acid GO:0043200 2 0.064
reciprocal meiotic recombination GO:0007131 1 0.062
regulation of cellular biosynthetic process GO:0031326 245 0.061
Yeast
organic substance catabolic process GO:1901575 28 0.059
Human Yeast Mouse
positive regulation of chromatin modification GO:1903310 1 0.059
axon development GO:0061564 166 0.059
aromatic compound catabolic process GO:0019439 15 0.059
Human Yeast Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.059
Human Yeast Mouse
regulation of rna biosynthetic process GO:2001141 213 0.059
Yeast
behavior GO:0007610 74 0.058
single organism biosynthetic process GO:0044711 71 0.058
rna metabolic process GO:0016070 219 0.057
Yeast
cognition GO:0050890 1 0.057
methylation GO:0032259 22 0.054
regulation of primary metabolic process GO:0080090 311 0.054
Human Yeast Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.053
Yeast
positive regulation of macromolecule metabolic process GO:0010604 93 0.053
regulation of meiotic cell cycle GO:0051445 1 0.052
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.051
Human Yeast Mouse
cellular component morphogenesis GO:0032989 336 0.051
reciprocal dna recombination GO:0035825 1 0.048
nucleoside monophosphate catabolic process GO:0009125 4 0.048
Human Yeast Mouse
negative regulation of signal transduction GO:0009968 94 0.047
recombinational repair GO:0000725 1 0.047
cell part morphogenesis GO:0032990 246 0.047
oxoacid metabolic process GO:0043436 31 0.046
transcription from rna polymerase ii promoter GO:0006366 80 0.046
meiotic chromosome segregation GO:0045132 3 0.045
macromolecular complex assembly GO:0065003 35 0.045
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.045
Human Yeast Mouse
response to stress GO:0006950 263 0.045
Human Yeast Mouse Worm
regulation of macromolecule biosynthetic process GO:0010556 225 0.044
Yeast
response to external biotic stimulus GO:0043207 97 0.042
positive regulation of histone modification GO:0031058 1 0.042
response to chemical GO:0042221 320 0.042
nucleobase containing small molecule metabolic process GO:0055086 32 0.042
Human Yeast Mouse
blood vessel development GO:0001568 246 0.040
neuron differentiation GO:0030182 353 0.040
cellular protein metabolic process GO:0044267 129 0.039
chromosome organization involved in meiosis GO:0070192 1 0.039
protein alkylation GO:0008213 13 0.038
organelle organization GO:0006996 227 0.038
retina morphogenesis in camera type eye GO:0060042 79 0.037
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.037
cellular response to molecule of bacterial origin GO:0071219 3 0.037
hematopoietic or lymphoid organ development GO:0048534 191 0.037
Mouse
histone methylation GO:0016571 13 0.036
regulation of histone methylation GO:0031060 3 0.036
atp catabolic process GO:0006200 4 0.036
Human Yeast Mouse
axonogenesis GO:0007409 152 0.035
cellular response to dna damage stimulus GO:0006974 24 0.035
Human Yeast Mouse Worm
response to other organism GO:0051707 97 0.035
transcription dna templated GO:0006351 181 0.035
Yeast
response to external stimulus GO:0009605 264 0.035
transport GO:0006810 220 0.035
phosphorus metabolic process GO:0006793 109 0.035
Human Yeast Mouse
nucleobase containing compound catabolic process GO:0034655 15 0.035
Human Yeast Mouse
cell projection morphogenesis GO:0048858 244 0.035
carbohydrate derivative metabolic process GO:1901135 61 0.035
Human Yeast Mouse
regulation of multicellular organism growth GO:0040014 4 0.035
sensory organ morphogenesis GO:0090596 200 0.034
chromosome organization GO:0051276 31 0.034
hepaticobiliary system development GO:0061008 98 0.033
immune effector process GO:0002252 23 0.033
Mouse
regulation of multicellular organismal process GO:0051239 277 0.033
organic acid metabolic process GO:0006082 31 0.032
regulation of cell differentiation GO:0045595 142 0.032
deoxyribonucleotide biosynthetic process GO:0009263 1 0.032
determination of bilateral symmetry GO:0009855 204 0.032
cell projection organization GO:0030030 284 0.031
synapsis GO:0007129 1 0.030
negative regulation of macromolecule metabolic process GO:0010605 76 0.030
Human Yeast Mouse
retina development in camera type eye GO:0060041 146 0.030
carboxylic acid metabolic process GO:0019752 22 0.030
positive regulation of metabolic process GO:0009893 108 0.029
Human
multicellular organism growth GO:0035264 4 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
Yeast
camera type eye morphogenesis GO:0048593 108 0.029
response to biotic stimulus GO:0009607 97 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
Human Yeast Mouse
positive regulation of dna metabolic process GO:0051054 1 0.028
eye morphogenesis GO:0048592 144 0.028
dna alkylation GO:0006305 8 0.028
response to organic substance GO:0010033 153 0.028
cellular catabolic process GO:0044248 27 0.028
Human Yeast Mouse
branching morphogenesis of a nerve GO:0048755 4 0.027
ion transport GO:0006811 114 0.027
cell death GO:0008219 121 0.027
Mouse Worm
regulation of peptidase activity GO:0052547 23 0.027
negative regulation of cellular biosynthetic process GO:0031327 55 0.027
Yeast
striated muscle cell differentiation GO:0051146 129 0.026
ribose phosphate metabolic process GO:0019693 27 0.026
Human Yeast Mouse
liver development GO:0001889 96 0.026
muscle cell development GO:0055001 115 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.026
cellular response to lipopolysaccharide GO:0071222 3 0.026
photoreceptor cell differentiation GO:0046530 55 0.026
cellular nitrogen compound catabolic process GO:0044270 15 0.025
Human Yeast Mouse
cellular response to external stimulus GO:0071496 2 0.025
cell motility GO:0048870 244 0.025
embryonic organ morphogenesis GO:0048562 274 0.025
intracellular signal transduction GO:0035556 85 0.025
Mouse Worm
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.025
regulation of rna metabolic process GO:0051252 224 0.025
Yeast
regionalization GO:0003002 274 0.025
cell migration GO:0016477 237 0.025
adaptive immune response GO:0002250 5 0.024
Mouse
response to endogenous stimulus GO:0009719 83 0.024
dicarboxylic acid metabolic process GO:0043648 1 0.024
multi organism process GO:0051704 134 0.024
Mouse
taxis GO:0042330 109 0.024
anatomical structure homeostasis GO:0060249 36 0.024
deoxyribonucleotide metabolic process GO:0009262 1 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
regulation of biosynthetic process GO:0009889 250 0.024
Yeast
definitive hemopoiesis GO:0060216 18 0.024
regulation of gene expression GO:0010468 265 0.024
Yeast
positive regulation of cellular process GO:0048522 201 0.023
lipid catabolic process GO:0016042 4 0.023
cellular amine metabolic process GO:0044106 2 0.023
cellular component biogenesis GO:0044085 178 0.023
positive regulation of chromosome organization GO:2001252 1 0.022
dna biosynthetic process GO:0071897 3 0.022
cellular component disassembly GO:0022411 1 0.022
heterocycle catabolic process GO:0046700 15 0.022
Human Yeast Mouse
lipid storage GO:0019915 1 0.022
embryonic organ development GO:0048568 381 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.021
apoptotic process GO:0006915 116 0.021
Mouse Worm
lymphocyte mediated immunity GO:0002449 5 0.021
Mouse
dna modification GO:0006304 8 0.021
positive regulation of hydrolase activity GO:0051345 13 0.021
Human
growth GO:0040007 174 0.021
cell proliferation GO:0008283 80 0.021
positive regulation of catabolic process GO:0009896 4 0.021
regulation of biological quality GO:0065008 263 0.021
regulation of systemic arterial blood pressure GO:0003073 1 0.021
b cell activation GO:0042113 2 0.021
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.021
maintenance of dna repeat elements GO:0043570 2 0.021
negative regulation of chromatin modification GO:1903309 1 0.020
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.020
positive regulation of rna biosynthetic process GO:1902680 57 0.020
regulation of gene silencing GO:0060968 1 0.020
generation of neurons GO:0048699 385 0.020
negative regulation of biosynthetic process GO:0009890 55 0.020
Yeast
cellular amino acid metabolic process GO:0006520 7 0.020
regulation of signal transduction GO:0009966 225 0.020
mitotic dna integrity checkpoint GO:0044774 4 0.020
Mouse
tube morphogenesis GO:0035239 349 0.020
axon guidance GO:0007411 86 0.019
specification of symmetry GO:0009799 204 0.019
amine metabolic process GO:0009308 2 0.019
protein modification process GO:0036211 100 0.019
chromosome segregation GO:0007059 12 0.019
cellular component assembly involved in morphogenesis GO:0010927 107 0.019
photoreceptor cell development GO:0042461 40 0.018
wound healing GO:0042060 90 0.018
negative regulation of response to stimulus GO:0048585 104 0.018
regulation of response to stimulus GO:0048583 269 0.018
developmental growth GO:0048589 166 0.018
histone h3 k9 methylation GO:0051567 5 0.018
gland development GO:0048732 143 0.018
system process GO:0003008 185 0.018
negative regulation of rna biosynthetic process GO:1902679 45 0.018
Yeast
cellular response to reactive oxygen species GO:0034614 2 0.018
muscle cell differentiation GO:0042692 139 0.018
positive regulation of cell cycle GO:0045787 3 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.018
neural retina development GO:0003407 49 0.018
neuron projection development GO:0031175 180 0.018
regulation of developmental process GO:0050793 247 0.018
membrane hyperpolarization GO:0060081 1 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
positive regulation of cytokine production GO:0001819 2 0.017
hematopoietic stem cell migration GO:0035701 4 0.017
neuron projection guidance GO:0097485 86 0.017
positive regulation of cellular biosynthetic process GO:0031328 68 0.017
cilium morphogenesis GO:0060271 85 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
protein stabilization GO:0050821 2 0.017
nuclear division GO:0000280 23 0.017
Yeast
leukocyte proliferation GO:0070661 1 0.017
cellular response to chemical stimulus GO:0070887 157 0.017
positive regulation of lipid metabolic process GO:0045834 1 0.017
localization of cell GO:0051674 244 0.016
neuron projection morphogenesis GO:0048812 161 0.016
macromolecule methylation GO:0043414 19 0.016
response to drug GO:0042493 3 0.016
response to abiotic stimulus GO:0009628 122 0.016
Mouse
heart development GO:0007507 313 0.016
cellular component assembly GO:0022607 170 0.016
negative regulation of cell communication GO:0010648 96 0.016
positive regulation of biosynthetic process GO:0009891 68 0.016
regulation of signaling GO:0023051 235 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
regulation of cell cycle GO:0051726 52 0.015
Mouse
cellular protein modification process GO:0006464 100 0.015
striated muscle cell development GO:0055002 108 0.015
programmed cell death GO:0012501 119 0.015
Mouse Worm
cell migration involved in gastrulation GO:0042074 79 0.015
negative regulation of histone modification GO:0031057 1 0.015
protein acetylation GO:0006473 2 0.015
regulation of carbohydrate biosynthetic process GO:0043255 1 0.015
negative regulation of signaling GO:0023057 96 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
chordate embryonic development GO:0043009 271 0.015
Mouse
negative regulation of gene expression GO:0010629 65 0.015
Yeast
cellular component movement GO:0006928 335 0.015
leukocyte activation GO:0045321 12 0.015
Mouse
purine nucleotide metabolic process GO:0006163 27 0.015
Human Yeast Mouse
histone lysine methylation GO:0034968 12 0.015
circulatory system process GO:0003013 87 0.015
regulation of gene expression epigenetic GO:0040029 11 0.015
Yeast
cell surface receptor signaling pathway GO:0007166 325 0.014
negative regulation of chromosome organization GO:2001251 1 0.014
gtp metabolic process GO:0046039 4 0.014
regulation of mitotic cell cycle GO:0007346 25 0.014
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.014
Yeast
dna methylation GO:0006306 8 0.014
chemosensory behavior GO:0007635 1 0.014
pyrimidine containing compound metabolic process GO:0072527 3 0.014
regulation of molecular function GO:0065009 70 0.014
Human
brain development GO:0007420 293 0.014
cartilage development GO:0051216 96 0.014
regulation of protein catabolic process GO:0042176 1 0.014
positive regulation of transcription dna templated GO:0045893 57 0.014
spindle assembly GO:0051225 2 0.014
dna methylation or demethylation GO:0044728 8 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.013
protein methylation GO:0006479 13 0.013
hindbrain development GO:0030902 91 0.013
positive regulation of gene expression GO:0010628 71 0.013
dna repair GO:0006281 6 0.013
Human Yeast Mouse Worm
determination of left right symmetry GO:0007368 179 0.013
regulation of cell activation GO:0050865 1 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
Human Yeast Mouse
negative regulation of metabolic process GO:0009892 86 0.013
Human Yeast Mouse
golgi organization GO:0007030 1 0.013
positive regulation of transport GO:0051050 2 0.013
macromolecule modification GO:0043412 111 0.013
gtp catabolic process GO:0006184 2 0.013
protein homooligomerization GO:0051260 3 0.013
internal protein amino acid acetylation GO:0006475 2 0.012
cell cycle GO:0007049 93 0.012
Yeast Mouse
circadian sleep wake cycle sleep GO:0050802 1 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
hemopoiesis GO:0030097 183 0.012
Mouse
regulation of blood pressure GO:0008217 1 0.012
regulation of cellular response to stress GO:0080135 20 0.012
regulation of hydrolase activity GO:0051336 28 0.012
Human
gene silencing GO:0016458 4 0.012
Yeast
cardiac atrium development GO:0003230 4 0.012
protein complex localization GO:0031503 1 0.012
rna 3 end processing GO:0031123 2 0.011
organ regeneration GO:0031100 1 0.011
peptidyl lysine methylation GO:0018022 3 0.011
protein acylation GO:0043543 3 0.011
negative regulation of meiotic cell cycle GO:0051447 1 0.011
maintenance of location GO:0051235 4 0.011
neuronal action potential GO:0019228 18 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
protein polymerization GO:0051258 4 0.011
heart looping GO:0001947 94 0.011
regeneration GO:0031099 91 0.011
exocrine pancreas development GO:0031017 28 0.011
regulation of myotube differentiation GO:0010830 2 0.011
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.011
response to alkaloid GO:0043279 2 0.011
single organism localization GO:1902578 225 0.011
response to cadmium ion GO:0046686 14 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
Mouse
protein complex subunit organization GO:0071822 46 0.011
negative regulation of rna metabolic process GO:0051253 48 0.011
Yeast
negative regulation of nucleic acid templated transcription GO:1903507 45 0.011
Yeast
positive regulation of nucleic acid templated transcription GO:1903508 57 0.011
zymogen activation GO:0031638 3 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
regulation of circadian rhythm GO:0042752 4 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
positive regulation of response to stimulus GO:0048584 80 0.011
telomere organization GO:0032200 1 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
neuron projection extension GO:1990138 45 0.011
monovalent inorganic cation transport GO:0015672 42 0.011
organic cyclic compound catabolic process GO:1901361 15 0.011
Human Yeast Mouse
positive regulation of leukocyte mediated immunity GO:0002705 1 0.011
chemotaxis GO:0006935 104 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
peptidyl lysine trimethylation GO:0018023 1 0.011
covalent chromatin modification GO:0016569 20 0.010
type i interferon production GO:0032606 2 0.010
multicellular organismal signaling GO:0035637 22 0.010
adult behavior GO:0030534 2 0.010
synaptic growth at neuromuscular junction GO:0051124 2 0.010
positive regulation of immune effector process GO:0002699 3 0.010
negative regulation of gene silencing GO:0060969 1 0.010
mrna 3 end processing GO:0031124 2 0.010
dna templated transcription elongation GO:0006354 3 0.010
intrahepatic bile duct development GO:0035622 11 0.010
histone h3 k9 modification GO:0061647 5 0.010
regulation of establishment of protein localization GO:0070201 4 0.010
retina layer formation GO:0010842 24 0.010
cellular carbohydrate metabolic process GO:0044262 4 0.010
anion transport GO:0006820 38 0.010
cell activation GO:0001775 16 0.010
Mouse
regulation of intracellular signal transduction GO:1902531 57 0.010

msh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.034
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013