Danio rerio

58 known processes

mtm1

myotubularin 1

(Aliases: wu:fb19c01,MGC123266,zgc:123266)

mtm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myotube differentiation GO:0014902 45 0.167
skeletal muscle tissue development GO:0007519 67 0.143
response to transition metal nanoparticle GO:1990267 28 0.130
inorganic ion transmembrane transport GO:0098660 57 0.110
myotube cell development GO:0014904 35 0.107
response to zinc ion GO:0010043 6 0.095
ion transmembrane transport GO:0034220 91 0.093
transmembrane transport GO:0055085 120 0.084
single organism localization GO:1902578 225 0.083
Human Fly
inorganic cation transmembrane transport GO:0098662 50 0.082
autophagy GO:0006914 4 0.078
skeletal muscle fiber development GO:0048741 35 0.075
central nervous system development GO:0007417 387 0.074
skeletal muscle organ development GO:0060538 78 0.061
mechanosensory behavior GO:0007638 2 0.059
cation transport GO:0006812 81 0.056
multicellular organism growth GO:0035264 4 0.055
zinc ion transport GO:0006829 2 0.053
ion transport GO:0006811 114 0.053
metal ion transport GO:0030001 58 0.053
striated muscle tissue development GO:0014706 110 0.051
regulation of autophagy GO:0010506 3 0.051
adult behavior GO:0030534 2 0.047
rna modification GO:0009451 2 0.046
maintenance of location GO:0051235 4 0.046
establishment of localization GO:0051234 244 0.045
Human Fly
striated muscle cell differentiation GO:0051146 129 0.044
organic cyclic compound metabolic process GO:1901360 301 0.044
zinc ion transmembrane transport GO:0071577 1 0.043
cognition GO:0050890 1 0.043
response to chemical GO:0042221 320 0.042
aging GO:0007568 2 0.041
regulation of protein ubiquitination GO:0031396 3 0.041
generation of neurons GO:0048699 385 0.041
cation transmembrane transport GO:0098655 65 0.039
heterocycle metabolic process GO:0046483 290 0.039
larval development GO:0002164 2 0.038
transcription dna templated GO:0006351 181 0.038
regulation of multicellular organism growth GO:0040014 4 0.038
nitrogen compound metabolic process GO:0006807 319 0.037
regulation of wound healing GO:0061041 2 0.037
rna metabolic process GO:0016070 219 0.036
regulation of nitrogen compound metabolic process GO:0051171 251 0.036
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
head development GO:0060322 303 0.035
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.035
sensory organ development GO:0007423 393 0.034
negative regulation of biological process GO:0048519 304 0.034
muscle cell development GO:0055001 115 0.034
somite development GO:0061053 96 0.033
nucleobase containing compound metabolic process GO:0006139 274 0.033
cellular aromatic compound metabolic process GO:0006725 295 0.033
regionalization GO:0003002 274 0.032
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.032
striated muscle cell development GO:0055002 108 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
regulation of metal ion transport GO:0010959 4 0.031
nucleobase containing compound biosynthetic process GO:0034654 205 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
regulation of developmental process GO:0050793 247 0.030
single organism membrane fusion GO:0044801 2 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.029
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.029
muscle fiber development GO:0048747 52 0.029
brain development GO:0007420 293 0.029
regulation of ion transmembrane transporter activity GO:0032412 2 0.028
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.028
locomotion GO:0040011 313 0.028
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.027
regulation of metabolic process GO:0019222 359 0.027
cellular nitrogen compound metabolic process GO:0034641 290 0.027
positive regulation of transport GO:0051050 2 0.027
monovalent inorganic cation transport GO:0015672 42 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
cellular biosynthetic process GO:0044249 286 0.027
embryonic organ development GO:0048568 381 0.026
heterocycle biosynthetic process GO:0018130 215 0.026
regulation of transcription dna templated GO:0006355 213 0.026
eye development GO:0001654 277 0.025
regulation of response to stimulus GO:0048583 269 0.025
muscle structure development GO:0061061 196 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
negative regulation of kinase activity GO:0033673 4 0.025
signal transduction GO:0007165 455 0.025
muscle organ development GO:0007517 101 0.025
negative regulation of protein kinase activity GO:0006469 4 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.025
cellular transition metal ion homeostasis GO:0046916 3 0.025
embryonic organ morphogenesis GO:0048562 274 0.024
rna biosynthetic process GO:0032774 181 0.024
rna localization GO:0006403 4 0.024
blood vessel development GO:0001568 246 0.024
muscle tissue development GO:0060537 110 0.024
nucleic acid metabolic process GO:0090304 244 0.024
i kappab kinase nf kappab signaling GO:0007249 4 0.024
cell projection morphogenesis GO:0048858 244 0.024
protein metabolic process GO:0019538 183 0.024
Human
positive regulation of cell cycle GO:0045787 3 0.024
microtubule organizing center organization GO:0031023 1 0.024
transport GO:0006810 220 0.024
Human Fly
cellular amine metabolic process GO:0044106 2 0.024
sequestering of metal ion GO:0051238 3 0.023
cellular macromolecule biosynthetic process GO:0034645 224 0.023
chemosensory behavior GO:0007635 1 0.023
amine metabolic process GO:0009308 2 0.023
regulation of transmembrane transporter activity GO:0022898 2 0.023
response to external stimulus GO:0009605 264 0.023
neuron differentiation GO:0030182 353 0.022
nucleic acid templated transcription GO:0097659 181 0.022
regulation of nucleoside metabolic process GO:0009118 2 0.022
peptidyl serine modification GO:0018209 2 0.022
nuclear transport GO:0051169 4 0.022
development of primary female sexual characteristics GO:0046545 4 0.022
digestive system development GO:0055123 289 0.022
single organism transport GO:0044765 206 0.022
Human Fly
ribosomal small subunit biogenesis GO:0042274 2 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
regulation of mrna processing GO:0050684 3 0.022
cellular ketone metabolic process GO:0042180 11 0.022
lipid storage GO:0019915 1 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
response to stress GO:0006950 263 0.021
Fly
protein polymerization GO:0051258 4 0.021
cellular respiration GO:0045333 3 0.021
zinc ion homeostasis GO:0055069 1 0.021
positive regulation of cytoskeleton organization GO:0051495 3 0.021
regulation of dna templated transcription in response to stress GO:0043620 0 0.021
regulation of organelle assembly GO:1902115 4 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
macroautophagy GO:0016236 1 0.020
cell substrate adhesion GO:0031589 4 0.020
regulation of biological quality GO:0065008 263 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.020
cell substrate junction assembly GO:0007044 2 0.020
regulation of epithelial cell proliferation GO:0050678 3 0.020
muscle cell differentiation GO:0042692 139 0.020
macromolecule biosynthetic process GO:0009059 227 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
vasculature development GO:0001944 278 0.019
cell matrix adhesion GO:0007160 4 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
organic cyclic compound biosynthetic process GO:1901362 223 0.019
regulation of nucleic acid templated transcription GO:1903506 213 0.019
regulation of biosynthetic process GO:0009889 250 0.019
negative regulation of catabolic process GO:0009895 3 0.019
stem cell maintenance GO:0019827 4 0.019
cellular response to external stimulus GO:0071496 2 0.019
regulation of rna metabolic process GO:0051252 224 0.019
hindbrain formation GO:0021576 3 0.019
gene expression GO:0010467 252 0.019
gtp metabolic process GO:0046039 4 0.019
peptidyl serine phosphorylation GO:0018105 1 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
regulation of synapse organization GO:0050807 3 0.018
female sex differentiation GO:0046660 4 0.018
biosynthetic process GO:0009058 294 0.018
organelle organization GO:0006996 227 0.018
Human Fly
regulation of protein catabolic process GO:0042176 1 0.018
positive regulation of cellular catabolic process GO:0031331 3 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
cell part morphogenesis GO:0032990 246 0.018
Human
regulation of cell activation GO:0050865 1 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
retina development in camera type eye GO:0060041 146 0.018
membrane fusion GO:0061025 2 0.018
regulation of neurogenesis GO:0050767 87 0.018
regulation of jak stat cascade GO:0046425 3 0.018
negative regulation of protein transport GO:0051224 3 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
centrosome organization GO:0051297 1 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
positive regulation of wound healing GO:0090303 1 0.017
regulation of macromolecule metabolic process GO:0060255 317 0.017
regulation of protein complex assembly GO:0043254 3 0.017
protein stabilization GO:0050821 2 0.017
carbon dioxide transport GO:0015670 3 0.017
regulation of stem cell proliferation GO:0072091 2 0.017
sensory organ morphogenesis GO:0090596 200 0.017
regulation of neural precursor cell proliferation GO:2000177 3 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
cellular component movement GO:0006928 335 0.017
exocytosis GO:0006887 1 0.017
regulation of reproductive process GO:2000241 4 0.017
regulation of muscle contraction GO:0006937 3 0.016
positive regulation of translation GO:0045727 1 0.016
regulation of transporter activity GO:0032409 2 0.016
negative regulation of cellular process GO:0048523 283 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
cell projection organization GO:0030030 284 0.016
Fly
regulation of membrane potential GO:0042391 23 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
organelle fusion GO:0048284 3 0.016
cellular component morphogenesis GO:0032989 336 0.016
Human
stem cell proliferation GO:0072089 4 0.016
negative regulation of mapk cascade GO:0043409 4 0.016
meiotic nuclear division GO:0007126 4 0.016
adherens junction organization GO:0034332 4 0.016
protein dephosphorylation GO:0006470 3 0.016
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.016
regulation of calcium ion transport GO:0051924 2 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
cell aging GO:0007569 2 0.016
cellular response to starvation GO:0009267 1 0.016
superoxide metabolic process GO:0006801 2 0.016
positive regulation of cell activation GO:0050867 1 0.016
negative regulation of metabolic process GO:0009892 86 0.016
adherens junction assembly GO:0034333 1 0.015
digestive tract morphogenesis GO:0048546 231 0.015
nuclear export GO:0051168 1 0.015
gtp catabolic process GO:0006184 2 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
regulation of reactive oxygen species metabolic process GO:2000377 2 0.015
somitogenesis GO:0001756 87 0.015
heart looping GO:0001947 94 0.015
regulation of microtubule cytoskeleton organization GO:0070507 3 0.015
cellular component disassembly GO:0022411 1 0.015
regulation of signaling GO:0023051 235 0.015
regulation of binding GO:0051098 3 0.015
chordate embryonic development GO:0043009 271 0.015
regulation of primary metabolic process GO:0080090 311 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
cell morphogenesis GO:0000902 289 0.015
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.015
positive regulation of catabolic process GO:0009896 4 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
synaptic transmission cholinergic GO:0007271 4 0.015
endosomal transport GO:0016197 2 0.015
Human Fly
cellular response to reactive oxygen species GO:0034614 2 0.015
response to superoxide GO:0000303 2 0.015
organic substance biosynthetic process GO:1901576 289 0.015
cellular protein metabolic process GO:0044267 129 0.015
Human
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.015
protein acetylation GO:0006473 2 0.015
female gonad development GO:0008585 4 0.015
neuron development GO:0048666 262 0.014
regulation of protein transport GO:0051223 3 0.014
response to inorganic substance GO:0010035 38 0.014
protein complex disassembly GO:0043241 1 0.014
macromolecular complex disassembly GO:0032984 1 0.014
regulation of transmembrane transport GO:0034762 18 0.014
transition metal ion transport GO:0000041 6 0.014
response to nutrient GO:0007584 3 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
regulation of blood vessel size GO:0050880 2 0.014
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.014
cellular protein catabolic process GO:0044257 4 0.014
anterior posterior pattern specification GO:0009952 152 0.014
protein homooligomerization GO:0051260 3 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
notochord development GO:0030903 54 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
segmentation GO:0035282 97 0.013
regulation of cytokine production GO:0001817 3 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.013
protein acylation GO:0043543 3 0.013
immune system process GO:0002376 241 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
cell substrate adherens junction assembly GO:0007045 1 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
single organism metabolic process GO:0044710 217 0.013
Human
regulation of carbohydrate metabolic process GO:0006109 4 0.013
negative regulation of mrna metabolic process GO:1903312 3 0.013
b cell differentiation GO:0030183 1 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
b cell activation GO:0042113 2 0.013
response to abiotic stimulus GO:0009628 122 0.013
centrosome cycle GO:0007098 1 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
angiogenesis GO:0001525 158 0.013
homeostatic process GO:0042592 142 0.013
anion transport GO:0006820 38 0.013
tube morphogenesis GO:0035239 349 0.013
developmental growth GO:0048589 166 0.013
regulation of synapse assembly GO:0051963 3 0.013
potassium ion transport GO:0006813 10 0.013
regulation of ion transmembrane transport GO:0034765 18 0.013
macromolecule modification GO:0043412 111 0.013
Human
lateral inhibition GO:0046331 1 0.013
mitochondrion organization GO:0007005 4 0.012
Human
cell surface receptor signaling pathway GO:0007166 325 0.012
smooth muscle contraction GO:0006939 2 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
growth GO:0040007 174 0.012
regulation of signal transduction GO:0009966 225 0.012
cellular macromolecule metabolic process GO:0044260 391 0.012
Human
meiotic cell cycle process GO:1903046 3 0.012
cell motility GO:0048870 244 0.012
protein modification process GO:0036211 100 0.012
Human
oxoacid metabolic process GO:0043436 31 0.012
germ line stem cell maintenance GO:0030718 2 0.012
response to amine GO:0014075 1 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
locomotory behavior GO:0007626 34 0.012
peptidyl lysine methylation GO:0018022 3 0.012
regulation of protein binding GO:0043393 3 0.012
retina layer formation GO:0010842 24 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
multicellular organismal signaling GO:0035637 22 0.012
intracellular signal transduction GO:0035556 85 0.012
cell migration GO:0016477 237 0.012
cellular response to nutrient levels GO:0031669 2 0.012
cellular protein modification process GO:0006464 100 0.012
Human
heart development GO:0007507 313 0.012
camera type eye development GO:0043010 222 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
centrosome duplication GO:0051298 1 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
calcium ion import GO:0070509 4 0.011
ovulation cycle GO:0042698 2 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
phagocytosis GO:0006909 3 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
protein import GO:0017038 3 0.011
secondary metabolic process GO:0019748 3 0.011
cellular component biogenesis GO:0044085 178 0.011
Fly
organic acid metabolic process GO:0006082 31 0.011
negative regulation of programmed cell death GO:0043069 58 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
regulation of multicellular organismal process GO:0051239 277 0.011
dna catabolic process GO:0006308 1 0.011
cellular response to dsrna GO:0071359 1 0.011
golgi vesicle transport GO:0048193 3 0.011
regulation of tube size GO:0035150 2 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
regulation of gtpase activity GO:0043087 2 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
glucose homeostasis GO:0042593 1 0.011
ovulation cycle process GO:0022602 2 0.011
regulation of cell differentiation GO:0045595 142 0.011
actin mediated cell contraction GO:0070252 1 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
intracellular mrna localization GO:0008298 1 0.011
protein localization to nucleus GO:0034504 3 0.011
regulation of gene expression GO:0010468 265 0.011
digestive tract development GO:0048565 265 0.011
regulation of cell development GO:0060284 100 0.011
regulation of nervous system development GO:0051960 90 0.011
translational initiation GO:0006413 3 0.011
gas transport GO:0015669 3 0.011
convergent extension GO:0060026 118 0.011
regulation of receptor activity GO:0010469 2 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
regulation of dendrite development GO:0050773 3 0.011
rna 3 end processing GO:0031123 2 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
glial cell proliferation GO:0014009 4 0.011
actin filament based movement GO:0030048 1 0.011
lipid catabolic process GO:0016042 4 0.011
positive regulation of cellular process GO:0048522 201 0.011
embryonic heart tube development GO:0035050 133 0.011
regulation of dna replication GO:0006275 3 0.011
locomotor rhythm GO:0045475 3 0.010
neurotransmitter transport GO:0006836 2 0.010
post embryonic organ development GO:0048569 4 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
endosome organization GO:0007032 2 0.010
cytokinesis GO:0000910 3 0.010
catabolic process GO:0009056 32 0.010
neuron neuron synaptic transmission GO:0007270 1 0.010
somatic muscle development GO:0007525 4 0.010
regulation of intracellular ph GO:0051453 1 0.010
transition metal ion homeostasis GO:0055076 5 0.010
epithelial tube morphogenesis GO:0060562 148 0.010
regulation of neurological system process GO:0031644 2 0.010
regulation of sodium ion transport GO:0002028 2 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
cellular response to oxygen levels GO:0071453 1 0.010
nuclear import GO:0051170 3 0.010
regulation of protein polymerization GO:0032271 2 0.010
carbohydrate homeostasis GO:0033500 1 0.010

mtm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.073
disease of anatomical entity DOID:7 0 0.073
Human
bone marrow disease DOID:4961 0 0.073
hematopoietic system disease DOID:74 0 0.073
aplastic anemia DOID:12449 0 0.040
anemia DOID:2355 0 0.040
congenital hypoplastic anemia DOID:1342 0 0.026
disease of cellular proliferation DOID:14566 0 0.018
cancer DOID:162 0 0.015
nervous system disease DOID:863 0 0.013
organ system cancer DOID:0050686 0 0.013
fanconi s anemia DOID:13636 0 0.012
disease of metabolism DOID:0014667 0 0.012
musculoskeletal system disease DOID:17 0 0.011
Human