Danio rerio

31 known processes

nek2

NIMA (never in mitosis gene a)-related kinase 2

(Aliases: zgc:55602,MGC55602)

nek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of biological process GO:0048519 304 0.172
Human
larval development GO:0002164 2 0.156
mitotic cell cycle embryonic GO:0045448 2 0.101
organelle organization GO:0006996 227 0.093
Human Mouse Fly
regulation of transcription dna templated GO:0006355 213 0.092
microtubule organizing center organization GO:0031023 1 0.089
Human
regulation of nitrogen compound metabolic process GO:0051171 251 0.084
nucleobase containing compound biosynthetic process GO:0034654 205 0.081
organic cyclic compound biosynthetic process GO:1901362 223 0.075
regulation of nucleic acid templated transcription GO:1903506 213 0.075
negative regulation of cellular process GO:0048523 283 0.074
Human
gene expression GO:0010467 252 0.074
Fly
nucleic acid templated transcription GO:0097659 181 0.072
regulation of metabolic process GO:0019222 359 0.070
Fly
cytokinesis GO:0000910 3 0.068
tube morphogenesis GO:0035239 349 0.067
positive regulation of cell cycle GO:0045787 3 0.065
cellular nitrogen compound biosynthetic process GO:0044271 218 0.062
cellular macromolecule metabolic process GO:0044260 391 0.062
Human Yeast Mouse Fly
regulation of gene expression GO:0010468 265 0.061
Fly
cytoskeleton dependent cytokinesis GO:0061640 3 0.058
rna biosynthetic process GO:0032774 181 0.058
nucleobase containing compound metabolic process GO:0006139 274 0.057
rna metabolic process GO:0016070 219 0.056
macromolecule biosynthetic process GO:0009059 227 0.056
regulation of macromolecule biosynthetic process GO:0010556 225 0.056
maintenance of location GO:0051235 4 0.056
Human
transcription dna templated GO:0006351 181 0.055
regulation of rna biosynthetic process GO:2001141 213 0.054
regulation of cellular biosynthetic process GO:0031326 245 0.053
cellular nitrogen compound metabolic process GO:0034641 290 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.052
Fly
regulation of binding GO:0051098 3 0.050
Mouse
single organism organelle organization GO:1902589 199 0.050
Human Mouse Fly
digestive system development GO:0055123 289 0.050
heart development GO:0007507 313 0.047
regulation of rna metabolic process GO:0051252 224 0.046
aging GO:0007568 2 0.046
organic substance biosynthetic process GO:1901576 289 0.045
cellular macromolecule biosynthetic process GO:0034645 224 0.045
heterocycle biosynthetic process GO:0018130 215 0.045
aromatic compound biosynthetic process GO:0019438 217 0.045
cell substrate adhesion GO:0031589 4 0.044
regulation of developmental process GO:0050793 247 0.044
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.043
determination of bilateral symmetry GO:0009855 204 0.042
single organism nuclear import GO:1902593 3 0.042
regulation of primary metabolic process GO:0080090 311 0.042
biosynthetic process GO:0009058 294 0.040
heterocycle metabolic process GO:0046483 290 0.039
cellular protein catabolic process GO:0044257 4 0.038
regulation of cellular metabolic process GO:0031323 320 0.037
cellular aromatic compound metabolic process GO:0006725 295 0.037
regulation of chromosome segregation GO:0051983 1 0.036
Human
embryonic organ development GO:0048568 381 0.036
regulation of cell communication GO:0010646 232 0.036
Fly
establishment of localization GO:0051234 244 0.035
cellular protein metabolic process GO:0044267 129 0.035
Human Yeast Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.035
cellular biosynthetic process GO:0044249 286 0.034
protein localization to nucleus GO:0034504 3 0.033
central nervous system development GO:0007417 387 0.033
protein polyubiquitination GO:0000209 4 0.033
digestive tract morphogenesis GO:0048546 231 0.032
regulation of intracellular protein transport GO:0033157 3 0.032
nucleic acid metabolic process GO:0090304 244 0.032
determination of left right symmetry GO:0007368 179 0.032
regulation of establishment of protein localization GO:0070201 4 0.032
establishment of protein localization to organelle GO:0072594 4 0.032
adult behavior GO:0030534 2 0.031
regulation of protein transport GO:0051223 3 0.031
mitotic cytokinesis GO:0000281 3 0.031
eye development GO:0001654 277 0.031
modification dependent macromolecule catabolic process GO:0043632 3 0.031
ubiquitin dependent protein catabolic process GO:0006511 3 0.031
regulation of multicellular organism growth GO:0040014 4 0.031
mitotic cell cycle GO:0000278 64 0.031
Mouse Fly
negative regulation of protein complex assembly GO:0031333 1 0.030
positive regulation of biological process GO:0048518 253 0.030
Fly
morphogenesis of an epithelium GO:0002009 333 0.030
regulation of biological quality GO:0065008 263 0.030
Human Fly
regulation of microtubule cytoskeleton organization GO:0070507 3 0.030
Human
cellular component movement GO:0006928 335 0.030
nuclear envelope organization GO:0006998 2 0.029
nucleocytoplasmic transport GO:0006913 4 0.029
phagocytosis GO:0006909 3 0.029
nitrogen compound metabolic process GO:0006807 319 0.028
regulation of protein complex assembly GO:0043254 3 0.028
specification of symmetry GO:0009799 204 0.028
cellular component morphogenesis GO:0032989 336 0.028
protein import into nucleus GO:0006606 3 0.028
oocyte maturation GO:0001556 4 0.027
negative regulation of mitosis GO:0045839 3 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.027
regulation of biosynthetic process GO:0009889 250 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
generation of neurons GO:0048699 385 0.027
positive regulation of transport GO:0051050 2 0.027
stem cell proliferation GO:0072089 4 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.026
transcription from rna polymerase ii promoter GO:0006366 80 0.026
multicellular organism growth GO:0035264 4 0.026
negative regulation of nuclear division GO:0051784 3 0.026
nuclear transport GO:0051169 4 0.025
locomotion GO:0040011 313 0.025
cellular ketone metabolic process GO:0042180 11 0.025
digestive tract development GO:0048565 265 0.024
brain development GO:0007420 293 0.024
macromolecular complex disassembly GO:0032984 1 0.024
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.024
regulation of synapse organization GO:0050807 3 0.023
sensory organ development GO:0007423 393 0.023
lipid storage GO:0019915 1 0.023
protein modification process GO:0036211 100 0.023
Human Yeast Mouse Fly
microtubule depolymerization GO:0007019 1 0.023
protein acylation GO:0043543 3 0.023
protein targeting to nucleus GO:0044744 3 0.023
regulation of signal transduction GO:0009966 225 0.023
Fly
positive regulation of cellular component biogenesis GO:0044089 3 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.022
microtubule polymerization or depolymerization GO:0031109 3 0.022
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.022
negative regulation of rna metabolic process GO:0051253 48 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
Mouse
cellular component disassembly GO:0022411 1 0.022
transport GO:0006810 220 0.022
single organism localization GO:1902578 225 0.022
Human
developmental growth GO:0048589 166 0.022
regulation of multicellular organismal development GO:2000026 223 0.022
regulation of protein targeting GO:1903533 2 0.022
amine metabolic process GO:0009308 2 0.021
multi organism process GO:0051704 134 0.021
cell motility GO:0048870 244 0.021
head development GO:0060322 303 0.021
protein polymerization GO:0051258 4 0.021
protein import GO:0017038 3 0.021
mitotic cell cycle process GO:1903047 48 0.021
Mouse Fly
signal transduction GO:0007165 455 0.021
Fly
negative regulation of cellular biosynthetic process GO:0031327 55 0.021
neuron development GO:0048666 262 0.021
protein complex disassembly GO:0043241 1 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.020
organelle assembly GO:0070925 110 0.020
Mouse
g2 m transition of mitotic cell cycle GO:0000086 4 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
regulation of protein complex disassembly GO:0043244 1 0.019
regulation of protein catabolic process GO:0042176 1 0.019
embryonic organ morphogenesis GO:0048562 274 0.019
regulation of response to stimulus GO:0048583 269 0.019
Fly
determination of heart left right asymmetry GO:0061371 117 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
negative regulation of gene expression GO:0010629 65 0.019
peptidyl serine phosphorylation GO:0018105 1 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
regulation of nucleocytoplasmic transport GO:0046822 2 0.019
localization of cell GO:0051674 244 0.018
meiotic nuclear division GO:0007126 4 0.018
regulation of protein depolymerization GO:1901879 1 0.018
protein localization to microtubule cytoskeleton GO:0072698 1 0.018
response to drug GO:0042493 3 0.018
heart morphogenesis GO:0003007 156 0.018
mitotic dna integrity checkpoint GO:0044774 4 0.018
regulation of protein import into nucleus GO:0042306 2 0.018
meiosis i GO:0007127 1 0.017
positive regulation of nucleoside metabolic process GO:0045979 1 0.017
negative regulation of rna biosynthetic process GO:1902679 45 0.017
positive regulation of catabolic process GO:0009896 4 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
response to external stimulus GO:0009605 264 0.017
cell cycle process GO:0022402 53 0.017
Human Mouse Fly
positive regulation of cytoskeleton organization GO:0051495 3 0.017
regulation of protein ubiquitination GO:0031396 3 0.017
neuroblast proliferation GO:0007405 2 0.017
negative regulation of nucleic acid templated transcription GO:1903507 45 0.017
regulation of reactive oxygen species metabolic process GO:2000377 2 0.016
cell morphogenesis GO:0000902 289 0.016
lateral inhibition GO:0046331 1 0.016
regionalization GO:0003002 274 0.016
small gtpase mediated signal transduction GO:0007264 8 0.016
neuron differentiation GO:0030182 353 0.016
gtp catabolic process GO:0006184 2 0.016
growth GO:0040007 174 0.016
cellular response to biotic stimulus GO:0071216 3 0.015
membrane invagination GO:0010324 1 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
gastrulation GO:0007369 208 0.015
stem cell maintenance GO:0019827 4 0.015
regulation of cell cycle GO:0051726 52 0.015
Fly
positive regulation of dna metabolic process GO:0051054 1 0.015
regulation of protein binding GO:0043393 3 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
regulation of cytokine production GO:0001817 3 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
regulation of reproductive process GO:2000241 4 0.014
cellular amine metabolic process GO:0044106 2 0.014
guanosine containing compound catabolic process GO:1901069 2 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.014
negative regulation of metabolic process GO:0009892 86 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
single organism membrane fusion GO:0044801 2 0.014
convergent extension GO:0060026 118 0.014
secondary metabolic process GO:0019748 3 0.014
ameboidal type cell migration GO:0001667 143 0.014
protein metabolic process GO:0019538 183 0.013
Human Yeast Mouse Fly
protein depolymerization GO:0051261 1 0.013
peptidyl serine modification GO:0018209 2 0.013
cellular component assembly GO:0022607 170 0.013
Mouse
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
regulation of gtpase activity GO:0043087 2 0.013
cell cycle g2 m phase transition GO:0044839 4 0.013
centrosome organization GO:0051297 1 0.013
Human
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
g2 dna damage checkpoint GO:0031572 3 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
regulation of cellular component movement GO:0051270 55 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
cellular extravasation GO:0045123 1 0.013
cellular response to extracellular stimulus GO:0031668 2 0.012
cytokinetic process GO:0032506 2 0.012
single fertilization GO:0007338 3 0.012
phagocytosis engulfment GO:0006911 1 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
organic acid metabolic process GO:0006082 31 0.012
microtubule based process GO:0007017 60 0.012
Human Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
positive regulation of cell division GO:0051781 2 0.012
single organism transport GO:0044765 206 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
regulation of signaling GO:0023051 235 0.012
Fly
cell projection organization GO:0030030 284 0.012
negative regulation of transcription dna templated GO:0045892 45 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.012
negative regulation of kinase activity GO:0033673 4 0.012
meiotic cell cycle process GO:1903046 3 0.012
gtp metabolic process GO:0046039 4 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
translational initiation GO:0006413 3 0.012
regulation of dendrite development GO:0050773 3 0.012
primary neural tube formation GO:0014020 1 0.012
phosphorylation GO:0016310 69 0.012
Human Yeast Mouse Fly
regulation of cell differentiation GO:0045595 142 0.012
regulation of locomotion GO:0040012 55 0.012
spermatid differentiation GO:0048515 2 0.011
nuclear export GO:0051168 1 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
regulation of neurogenesis GO:0050767 87 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
regulation of nervous system development GO:0051960 90 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
establishment of endothelial barrier GO:0061028 3 0.011
reproduction GO:0000003 40 0.011
protein acetylation GO:0006473 2 0.011
cellular protein complex disassembly GO:0043624 1 0.011
meiosis ii GO:0007135 1 0.011
protein complex subunit organization GO:0071822 46 0.011
Mouse
centrosome cycle GO:0007098 1 0.011
Human
female sex differentiation GO:0046660 4 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
regulation of dna replication GO:0006275 3 0.011
cell cycle arrest GO:0007050 1 0.011
negative regulation of chromosome organization GO:2001251 1 0.010
interspecies interaction between organisms GO:0044419 4 0.010
spermatid development GO:0007286 2 0.010
sensory organ morphogenesis GO:0090596 200 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
regulation of cell death GO:0010941 103 0.010
regulation of cell shape GO:0008360 1 0.010
positive regulation of metabolic process GO:0009893 108 0.010
autophagy GO:0006914 4 0.010
single organism metabolic process GO:0044710 217 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
ras protein signal transduction GO:0007265 7 0.010
regulation of translational initiation GO:0006446 1 0.010
cytoskeleton organization GO:0007010 96 0.010
Human Mouse
protein localization to plasma membrane GO:0072659 1 0.010

nek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018