Danio rerio

0 known processes

nlgn2a

neuroligin 2a

(Aliases: nlgn2b)

nlgn2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of postsynaptic membrane potential GO:0060078 1 0.830
glutamate receptor signaling pathway GO:0007215 1 0.756
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.740
neuron neuron synaptic transmission GO:0007270 1 0.657
regulation of glutamate receptor signaling pathway GO:1900449 1 0.638
cellular component maintenance GO:0043954 3 0.622
regulation of synaptic plasticity GO:0048167 1 0.600
regulation of dendrite development GO:0050773 3 0.519
regulation of dendrite morphogenesis GO:0048814 3 0.497
regulation of receptor activity GO:0010469 2 0.488
cognition GO:0050890 1 0.448
regulation of ion transmembrane transporter activity GO:0032412 2 0.432
membrane hyperpolarization GO:0060081 1 0.406
regulation of transmembrane transport GO:0034762 18 0.398
neuromuscular synaptic transmission GO:0007274 2 0.359
regulation of synapse organization GO:0050807 3 0.353
transmembrane transport GO:0055085 120 0.273
ion transmembrane transport GO:0034220 91 0.249
synaptic growth at neuromuscular junction GO:0051124 2 0.245
cell part morphogenesis GO:0032990 246 0.240
regulation of system process GO:0044057 40 0.219
ion transport GO:0006811 114 0.185
regulation of transporter activity GO:0032409 2 0.181
response to light stimulus GO:0009416 46 0.179
central nervous system development GO:0007417 387 0.165
response to radiation GO:0009314 51 0.162
regulation of neuron differentiation GO:0045664 56 0.147
regulation of transmembrane transporter activity GO:0022898 2 0.146
locomotory behavior GO:0007626 34 0.145
branching morphogenesis of a nerve GO:0048755 4 0.138
adult behavior GO:0030534 2 0.138
postsynaptic membrane organization GO:0001941 3 0.130
neurological system process GO:0050877 62 0.129
neuron projection development GO:0031175 180 0.129
regulation of inhibitory postsynaptic membrane potential GO:0060080 1 0.122
regulation of ion transmembrane transport GO:0034765 18 0.120
synaptic transmission cholinergic GO:0007271 4 0.116
positive regulation of biological process GO:0048518 253 0.116
neuron differentiation GO:0030182 353 0.116
generation of neurons GO:0048699 385 0.113
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.113
regulation of multicellular organismal development GO:2000026 223 0.110
regulation of neuron projection development GO:0010975 40 0.109
single organism localization GO:1902578 225 0.108
positive regulation of transport GO:0051050 2 0.107
establishment of localization GO:0051234 244 0.106
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.095
regulation of signal transduction GO:0009966 225 0.092
regulation of cell development GO:0060284 100 0.092
cell projection morphogenesis GO:0048858 244 0.089
purine containing compound biosynthetic process GO:0072522 20 0.085
regulation of nervous system development GO:0051960 90 0.082
cell surface receptor signaling pathway GO:0007166 325 0.082
cell morphogenesis GO:0000902 289 0.080
synapse assembly GO:0007416 9 0.080
cell projection organization GO:0030030 284 0.078
developmental maturation GO:0021700 34 0.077
single organism transport GO:0044765 206 0.077
cell morphogenesis involved in differentiation GO:0000904 195 0.075
neuron projection morphogenesis GO:0048812 161 0.075
system process GO:0003008 185 0.074
response to external stimulus GO:0009605 264 0.072
cellular component biogenesis GO:0044085 178 0.070
regulation of biological quality GO:0065008 263 0.069
regulation of ion transport GO:0043269 22 0.068
startle response GO:0001964 4 0.063
cellular component morphogenesis GO:0032989 336 0.063
positive regulation of cell communication GO:0010647 56 0.062
transport GO:0006810 220 0.062
signal transduction GO:0007165 455 0.060
cellular response to organic cyclic compound GO:0071407 38 0.060
regulation of anatomical structure morphogenesis GO:0022603 130 0.059
visual behavior GO:0007632 10 0.059
regulation of developmental process GO:0050793 247 0.057
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.055
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.054
synaptic transmission GO:0007268 35 0.054
larval development GO:0002164 2 0.053
cell cell signaling GO:0007267 52 0.053
regulation of synaptic transmission GO:0050804 4 0.052
response to amino acid GO:0043200 2 0.050
cellular component assembly GO:0022607 170 0.049
negative regulation of multicellular organismal process GO:0051241 69 0.048
glial cell differentiation GO:0010001 42 0.047
embryonic skeletal system development GO:0048706 97 0.047
response to amine GO:0014075 1 0.046
behavior GO:0007610 74 0.046
regulation of cell projection organization GO:0031344 44 0.045
positive regulation of molecular function GO:0044093 33 0.045
neuron development GO:0048666 262 0.044
multi organism process GO:0051704 134 0.044
dendrite development GO:0016358 9 0.043
regulation of cellular amine metabolic process GO:0033238 0 0.042
aging GO:0007568 2 0.041
regulation of localization GO:0032879 104 0.040
regulation of cell communication GO:0010646 232 0.038
regulation of neuronal synaptic plasticity GO:0048168 1 0.037
cellular aromatic compound metabolic process GO:0006725 295 0.036
oligodendrocyte differentiation GO:0048709 23 0.035
positive regulation of response to stimulus GO:0048584 80 0.035
forebrain development GO:0030900 96 0.035
regulation of signaling GO:0023051 235 0.034
response to food GO:0032094 1 0.034
response to chemical GO:0042221 320 0.034
positive regulation of signaling GO:0023056 56 0.034
nucleotide biosynthetic process GO:0009165 21 0.033
small molecule metabolic process GO:0044281 77 0.033
regulation of reproductive process GO:2000241 4 0.033
dendrite morphogenesis GO:0048813 5 0.032
regulation of synapse structure and activity GO:0050803 5 0.031
regulation of cell morphogenesis GO:0022604 42 0.031
developmental growth GO:0048589 166 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
muscle cell development GO:0055001 115 0.030
regulation of cell differentiation GO:0045595 142 0.030
organonitrogen compound metabolic process GO:1901564 74 0.029
regulation of molecular function GO:0065009 70 0.029
cell migration GO:0016477 237 0.029
ameboidal type cell migration GO:0001667 143 0.028
regulation of multicellular organismal process GO:0051239 277 0.027
tube morphogenesis GO:0035239 349 0.027
synapse organization GO:0050808 21 0.027
regulation of calcium ion transport GO:0051924 2 0.027
nucleoside phosphate biosynthetic process GO:1901293 21 0.027
digestive tract development GO:0048565 265 0.026
maintenance of location GO:0051235 4 0.026
embryonic organ development GO:0048568 381 0.026
catecholamine metabolic process GO:0006584 2 0.025
multicellular organism growth GO:0035264 4 0.025
astrocyte differentiation GO:0048708 1 0.025
neurotransmitter transport GO:0006836 2 0.025
gliogenesis GO:0042063 45 0.025
mechanosensory behavior GO:0007638 2 0.025
morphogenesis of an epithelium GO:0002009 333 0.024
death GO:0016265 121 0.024
positive regulation of signal transduction GO:0009967 56 0.024
response to abiotic stimulus GO:0009628 122 0.024
endocrine hormone secretion GO:0060986 2 0.024
ribonucleotide biosynthetic process GO:0009260 20 0.023
regulation of neurogenesis GO:0050767 87 0.023
regulation of response to stimulus GO:0048583 269 0.023
actomyosin structure organization GO:0031032 53 0.022
response to amphetamine GO:0001975 1 0.022
muscle organ development GO:0007517 101 0.022
cellular response to xenobiotic stimulus GO:0071466 35 0.022
regulation of metal ion transport GO:0010959 4 0.022
single organism behavior GO:0044708 24 0.021
brain development GO:0007420 293 0.021
cellular response to estrogen stimulus GO:0071391 24 0.020
response to stress GO:0006950 263 0.020
cell matrix adhesion GO:0007160 4 0.020
negative regulation of catabolic process GO:0009895 3 0.020
sensory perception of chemical stimulus GO:0007606 3 0.019
synaptic vesicle transport GO:0048489 1 0.019
positive regulation of neural precursor cell proliferation GO:2000179 1 0.019
cation transmembrane transport GO:0098655 65 0.019
endomembrane system organization GO:0010256 13 0.019
oxoacid metabolic process GO:0043436 31 0.019
regulation of neural precursor cell proliferation GO:2000177 3 0.019
response to xenobiotic stimulus GO:0009410 45 0.018
monoamine transport GO:0015844 1 0.018
response to glucose GO:0009749 3 0.018
embryonic cranial skeleton morphogenesis GO:0048701 90 0.018
single organism membrane organization GO:0044802 20 0.018
head development GO:0060322 303 0.018
establishment of synaptic vesicle localization GO:0097480 1 0.017
positive regulation of cellular process GO:0048522 201 0.017
locomotion GO:0040011 313 0.017
purine nucleotide biosynthetic process GO:0006164 20 0.017
purine nucleotide metabolic process GO:0006163 27 0.016
positive regulation of locomotion GO:0040017 14 0.016
response to vitamin b3 GO:0033552 2 0.016
cellular respiration GO:0045333 3 0.016
sleep GO:0030431 1 0.016
phagocytosis GO:0006909 3 0.016
striated muscle cell development GO:0055002 108 0.016
regulation of apoptotic process GO:0042981 98 0.016
nitrogen compound metabolic process GO:0006807 319 0.016
epiboly GO:0090504 41 0.016
purine ribonucleotide biosynthetic process GO:0009152 20 0.016
membrane organization GO:0061024 21 0.016
response to carbohydrate GO:0009743 3 0.016
cellular component disassembly GO:0022411 1 0.015
cell substrate adhesion GO:0031589 4 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
amine metabolic process GO:0009308 2 0.015
cell motility GO:0048870 244 0.015
sensory perception GO:0007600 39 0.015
response to endogenous stimulus GO:0009719 83 0.015
synapse maturation GO:0060074 1 0.015
response to wounding GO:0009611 116 0.015
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.015
negative regulation of response to cytokine stimulus GO:0060761 2 0.015
organic substance biosynthetic process GO:1901576 289 0.015
compound eye development GO:0048749 2 0.015
positive regulation of metabolic process GO:0009893 108 0.014
carbohydrate derivative biosynthetic process GO:1901137 43 0.014
regulation of cellular component organization GO:0051128 86 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
regulation of circadian rhythm GO:0042752 4 0.014
regulation of neurological system process GO:0031644 2 0.014
nucleobase containing compound metabolic process GO:0006139 274 0.014
response to nitrogen compound GO:1901698 19 0.014
cell death GO:0008219 121 0.014
negative regulation of secretion by cell GO:1903531 2 0.014
regulation of synapse assembly GO:0051963 3 0.014
sensory perception of pain GO:0019233 1 0.014
oxidation reduction process GO:0055114 41 0.014
mitochondrion organization GO:0007005 4 0.014
single organism metabolic process GO:0044710 217 0.014
response to alkaloid GO:0043279 2 0.013
regulation of cytokine production GO:0001817 3 0.013
steroid hormone mediated signaling pathway GO:0043401 9 0.013
cellular response to external stimulus GO:0071496 2 0.013
regulation of skeletal muscle tissue development GO:0048641 4 0.013
cellular amine metabolic process GO:0044106 2 0.013
negative regulation of reproductive process GO:2000242 3 0.013
muscle cell differentiation GO:0042692 139 0.013
membrane fusion GO:0061025 2 0.013
gastrulation GO:0007369 208 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
stem cell maintenance GO:0019827 4 0.013
nucleobase containing compound biosynthetic process GO:0034654 205 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
autophagy GO:0006914 4 0.013
regulation of circadian sleep wake cycle GO:0042749 1 0.012
synaptic vesicle localization GO:0097479 1 0.012
organonitrogen compound biosynthetic process GO:1901566 47 0.012
regulation of nucleotide biosynthetic process GO:0030808 15 0.012
ribonucleoside biosynthetic process GO:0042455 2 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
dicarboxylic acid metabolic process GO:0043648 1 0.012
lipid catabolic process GO:0016042 4 0.012
response to organic substance GO:0010033 153 0.012
nucleoside biosynthetic process GO:0009163 2 0.012
negative regulation of secretion GO:0051048 2 0.012
positive regulation of gliogenesis GO:0014015 2 0.012
dendrite guidance GO:0070983 0 0.012
lipid storage GO:0019915 1 0.012
pigment granule localization GO:0051875 25 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
purine ribonucleoside biosynthetic process GO:0046129 2 0.012
organic acid metabolic process GO:0006082 31 0.011
regulation of axonogenesis GO:0050770 32 0.011
growth GO:0040007 174 0.011
cell migration involved in gastrulation GO:0042074 79 0.011
purine containing compound metabolic process GO:0072521 29 0.011
female gonad development GO:0008585 4 0.011
central nervous system neuron development GO:0021954 29 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
central nervous system neuron axonogenesis GO:0021955 18 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
skeletal system development GO:0001501 181 0.011
renal absorption GO:0070293 1 0.011
neurotransmitter secretion GO:0007269 2 0.011
response to monosaccharide GO:0034284 3 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
programmed cell death GO:0012501 119 0.011
response to hexose GO:0009746 3 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
stem cell differentiation GO:0048863 117 0.011
positive regulation of catabolic process GO:0009896 4 0.011
cellular protein metabolic process GO:0044267 129 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
negative regulation of defense response GO:0031348 2 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
negative regulation of multi organism process GO:0043901 3 0.011
dopamine metabolic process GO:0042417 2 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
regulation of multicellular organism growth GO:0040014 4 0.010
cellular response to nutrient levels GO:0031669 2 0.010
apoptotic process GO:0006915 116 0.010
negative regulation of cytokine production GO:0001818 1 0.010
heart development GO:0007507 313 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.010
smooth muscle contraction GO:0006939 2 0.010

nlgn2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
autistic disorder DOID:12849 0 0.966
pervasive developmental disorder DOID:0060040 0 0.966
autism spectrum disorder DOID:0060041 0 0.966
disease of mental health DOID:150 0 0.966
developmental disorder of mental health DOID:0060037 0 0.966
disease of anatomical entity DOID:7 0 0.026
disease of metabolism DOID:0014667 0 0.023
nervous system disease DOID:863 0 0.016
disease of cellular proliferation DOID:14566 0 0.013
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.011